溃疡性结肠炎是一种慢性非特异性炎症性疾病，药物治疗主要以达到临床缓解、改善患者生存质量为主，但这类药物的长期使用可能会引起耐药性和不良反应的问题。白藜芦醇是一种多酚类化合物，可以通过调节免疫细胞平衡、调节炎症信号通路、抑制肠道氧化应激、调节肠道微生物、保护肠黏膜屏障多种途径缓解溃疡性结肠炎的进展，且临床试验表明补充白藜芦醇可以缓解溃疡性结肠炎患者的症状。总结了白藜芦醇抗溃疡性结肠炎的药理作用和临床研究的研究进展，以期为白藜芦醇治疗溃疡性结肠炎提供理论依据。

Ulcerative colitis is a chronic non-specific inflammatory disease, and drug treatment is mainly aimed at achieving clinical remission and improving patients' quality of life. However, long-term use of drugs may cause drug resistance and adverse reactions. Resveratrol is a polyphenolic compound that can alleviate the progression of ulcerative colitis by regulating immune cell balance, modulating inflammatory signaling pathways, inhibiting intestinal oxidative stress, regulating intestinal microbiota, and protecting the intestinal mucosal barrier. Clinical trials have shown that supplementing with resveratrol can alleviate symptoms in patients with ulcerative colitis. This article summarizes the pharmacological effects and clinical research progress of resveratrol in treatment of ulcerative colitis, in order to provide theoretical basis for the treatment of ulcerative colitis with resveratrol.

R965;R975

国家自然科学基金资助项目（81573990）；四川省中医药管理局项目（2020LC0099）；四川省科技厅项目（24RKX0181）