目的 探讨桂枝茯苓胶囊联合氟罗沙星胶囊治疗慢性盆腔炎的疗效。方法 选取秦皇岛市妇幼保健院在2022年2月—2024年12月收治的82例慢性盆腔炎患者，按随机数字表法将患者分为对照组和治疗组，各41例。对照组服用氟罗沙星胶囊，1次/d，1粒/次。治疗组在对照组基础上服用桂枝茯苓胶囊，3次/d，3粒/次。两组患者持续治疗14 d。评估患者的治疗效果、体征改善情况、超声检查指标、血清指标。结果 对照组的总有效率为78.05%，治疗组的总有效率为95.12%，组间比较差异显著（P＜0.05）。治疗组治疗后的盆腔包块、附件增厚、盆腔积液例数显著减少（P＜0.05），且治疗组治疗后的盆腔包块、附件增厚、盆腔积液例数明显少于对照组（P＜0.05）。治疗后，两组患者子宫动脉的平均血流速度明显升高，阻力指数明显降低（P＜0.05）；治疗组治疗后子宫动脉的平均血流速度高于对照组，阻力指数低于对照组（P＜0.05）。两组治疗后的血清前白蛋白（PA）、白细胞介素（IL）-4、IL-10水平比治疗前高，血清IL-8水平比治疗前低（P＜0.05）；治疗组治疗后的血清PA、IL-4、IL-10水平高于对照组，血清IL-8水平低于对照组（P＜0.05）。结论 桂枝茯苓胶囊联合氟罗沙星胶囊可提高慢性盆腔炎的治疗效果，减轻症状体征，改善子宫动脉血流动力学，减轻炎症反应。

Objective To explore the efficacy of Guizhi Fuling Capsules combined with Fleroxacin Capsules in treatment of chronic pelvic inflammatory disease. Methods 82 Patients with chronic pelvic inflammatory disease admitted to Qinhuangdao Maternal and Child Health Hospital from February 2022 to December 2024 were divided into control and treatment group using a random number table method, with 41 cases in each group. Patients in the control group took Fleroxacin Capsules, once daily, one capsule each time. On the basis of the control group, patients in the treatment group took Guizhi Fuling Capsules, 3 times daily, 3 capsules per time. Two groups were treated continuously for 14 d. The treatment effect, improvement of physical signs, ultrasound examination indicators, and serum indicators of the patients were evaluated. Results The total effective rate of the control group was 78.05%, while that of the treatment group was 95.12%, and the difference between groups was significant (P < 0.05). The number of pelvic masses, thickening of attachments, and pelvic fluid accumulation in the treatment group were significantly decreased after treatment (P < 0.05), and these indexes in the treatment group was significantly lower than those in the control group after treatment (P < 0.05). After treatment, the average blood flow velocity of the uterine artery in both groups of patients were significantly increased, but the resistance index was significantly decreased (P < 0.05). The average blood flow velocity of the uterine artery in the treatment group was higher than that in the control group after treatment, but the resistance index in the treatment group was lower than that in the control group (P < 0.05). After treatment, the serum levels of PA, IL-4, and IL-10 in both groups were increased, while IL-8 were decreased (P < 0.05). The serum levels of PA, IL-4, and IL-10 in the treatment group were higher than those in the control group after treatment, while IL-8 levels were lower than those in the control group (P < 0.05). Conclusion Guizhi Fuling Capsules combined with Fleroxacin Capsules can improve the therapeutic effect of chronic pelvic inflammatory disease, alleviate symptoms and signs, improve uterine artery hemodynamics, and alleviate inflammatory reactions.

R984

承德市科技计划项目（202301A006）