目的 探讨夏荔芪胶囊联合琥珀酸索利那新片治疗男性肾虚湿热型膀胱过度活动症（OAB）的临床疗效。方法 选取2023年6月—2024年5月在深圳市中医院治疗的男性膀胱过度活动症患者80例，采用区组随机化方式分为对照组（40例）和治疗组（40例）。对照组患者餐后口服琥珀酸索利那新片，5 mg/次，1次/d。治疗组在对照组的基础上餐后口服夏荔芪胶囊，1.35 mg/次，3次/d。两组患者疗程均为4周。观察两组患者临床疗效，比较治疗前后两组患者中医症状积分，OABSS评分，I-QOL评分和不良反应。结果 治疗后，相对于对照组的70.00%，治疗组总有效率（87.50%）更高（P＜0.05）。治疗后，两组患者中医症状各项积分和OABSS评分较治疗前均明显减少，而I-QOL评分明显提升（P＜0.05），且治疗组中医症状各项积分、OABSS评分和I-QOL评分明显好于对照组（P＜0.05）。结论 夏荔芪胶囊联合琥珀酸索利那新片治疗膀胱过度活动症对于改善患者临床症状、提高生活质量和降低不良反应发生率等方面有显著效果。

Objective To evaluate the clinical efficacy of Xialiqi Capsules combined with Solifenacin Succinate Tablets in treatment of male overactive bladder of kidney deficiency and damp-heat type. Methods Patients (80 cases) with overactive bladder of kidney deficiency and damp-heat type in Shenzhen Traditional Chinese Medicine Hospital from June 2023 to May 2024 were divided into control (40 cases) and treatment (40 cases) group by block randomization. Patients in the control group were po administered with Solifenacin Succinate Tablets after meals, 5 mg/time, once daily. Patients in the treatment group were po administered with Xialiqi Capsules after meals on the basis of the control group, 1.35 mg/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, and the TCM symptom scores, overactive bladder symptom score (OABSS), incontinence quality of life (I-QOL) scores and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 87.50%, which was higher than that of the control group (70.00%), the effective rate of the treatment group was significantly higher (P < 0.05). After treatment, the TCM symptoms scores and the OABSS in two groups were significantly decreased compared with those before treatment, while the I-QOL score was significantly increased (P < 0.05). Moreover, the scores of TCM symptoms, OABSS, and I-QOL in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The combination therapy utilizing Xialiqi Capsules along with Solifenacin Succinate Tablets can improve the symptoms, promotion the quality of life of the patients and reduce the incidence of adverse reactions.

R983

中国中医科学院科技创新工程重大攻关项目（CI2021A02208）；深圳市科技计划资助项目（JCYJ20220531092201002）