目的 观察膝骨关节炎采用骨松宝颗粒、艾瑞昔布片联合治疗的临床效果。方法 选取开滦总医院2022年3月—2024年3月收治的96例膝骨关节炎患者，按照随机数字表法将患者分为对照组（48例）和治疗组（48例）。对照组餐后口服艾瑞昔布片，1片/次，2次/d。治疗组在对照组基础上口服骨松宝颗粒，1袋/次，3次/d。两组均治疗8周。对比两组临床疗效、晨僵时间、膝关节活动度、疼痛和症状、血清炎症因子。结果 治疗组的总有效率为93.75%，对照组的总有效率为77.08%，组间对比有差异（P＜0.05）。治疗后，两组晨僵时间缩短，膝关节活动度扩大（P＜0.05），治疗组晨僵时间短于对照组，膝关节活动度大于对照组（P＜0.05）。治疗后，两组疼痛视觉模拟评分法（VAS）评分、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分下降（P＜0.05），治疗组VAS、WOMAC评分低于对照组（P＜0.05）。治疗后，两组血清白细胞介素-1（IL-1）、超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、基质金属蛋白酶-3（MMP-3）水平均下降（P＜0.05），治疗组血清IL-1、hs-CRP、IL-6、MMP-3水平低于对照组（P＜0.05）。结论 膝骨关节炎采用骨松宝颗粒联合艾瑞昔布片治疗，可改善疼痛症状，促进膝关节功能恢复，降低炎症因子水平。

Objective To observe the clinical effect in treatment of knee osteoarthritis with the combination of Ericoxib Tablets and Gusongbao Granules. Methods According to random number table method, 96 patients with knee osteoarthritis admitted to Kailuan General Hospital from March 2022 to March 2024 were divided into a control group (48 cases) and a treatment group (48 cases). The control group took orally Erecoxib Tablets after meals, 1 tablets/time, twice daily. On the basis of the control group, the treatment group took orally Gusongbao Granules, 1 bag/time, 3 times daily. Both groups were treated for 8 weeks. The clinical efficacy, morning stiffness time, knee joint range of motion, pain and symptoms, and serum inflammatory factors were compared between two groups. Results The total effective rate of the treatment group was 93.75%, and the total effective rate of the control group was 77.08%, with a significant difference between two groups (P < 0.05). After treatment, the morning stiffness time of both groups of patients was shortened, but the knee joint range of motion was increased (P < 0.05). The morning stiffness time of the treatment group was shorter than that of the control group, but the knee joint range of motion was greater than that of the control group (P < 0.05). After treatment, the VAS and WOMAC scores of both groups were decreased (P < 0.05), and the VAS and WOMAC scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the levels of IL-1, hs-CRP, IL-6, and MMP-3 in both groups were decreased (P < 0.05), and the levels of IL-1, hs-CRP, IL-6, and MMP-3 in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Gusongbao Granules and Ericoxib Tablets in treatment of knee osteoarthritis can alleviate pain symptoms, promote knee joint function recovery, and reduce levels of inflammatory factors.

R982

河北省医学科学研究课题计划（20241449）