目的 探讨参苓白术颗粒联合奥沙拉秦钠胶囊治疗溃疡性结肠炎的疗效。方法 选取天津市中医药研究院附属医院在2022年2月—2024年10月收治的102例溃疡性结肠炎患者，按随机数字表法分为对照组和治疗组，每组51例。对照组服用奥沙拉秦钠胶囊，2粒/次，2次/d。治疗组在对照组基础上温水冲服参芩白术颗粒，1袋/次，3次/d。两组持续治疗3个月。评估患者的临床治疗效果、改良Mayo活动指数、生活质量评分、血清指标。结果 对照组的总有效率为80.39%，治疗组的总有效率为94.12%，组间比较差异显著（P＜0.05）。两组治疗后的改良Mayo活动指数各项评分均低于治疗前（P＜0.05），且治疗组的Mayo各项评分均比对照组治疗后低（P＜0.05）。治疗后，两组患者的炎症性肠病生活质量问卷（IBDQ）评分均明显升高（P＜0.05），且治疗组的IBDQ评分较对照组更高（P＜0.05）。两组治疗后血清chemerin、低氧诱导因子-1α（HIF-1α）、二胺氧化酶（DAO）水平均低于治疗前（P＜0.05）；治疗组治疗后的血清chemerin、HIF-1α、DAO水平均低于对照组（P＜0.05）。结论 参苓白术颗粒联合奥沙拉秦钠胶囊可提高溃疡性结肠炎的治疗效果，提高患者生活质量，减轻疾病活动度和肠道屏障损伤。

Objective To investigate the efficacy of Shenling Baizhu Granules combined with Olsalazine Sodium Capsules in treatment of ulcerative colitis. Methods 102 Patients with ulcerative colitis admitted to Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital from February 2022 to October 2024 were divided into control and treatment group with random number table method, with 51 patients in each group. Patients in the control group took Olsalazine Sodium Capsules 2 capsules/time, twice daily. On the basis of the control group, patients in the treatment group took Shenqin Baizhu Granules in warm water, 3 times daily, 1 bag/time. Both groups continued the treatment for 3 months. The clinical treatment efficacy, modified Mayo activity index, quality of life score, and serum indicators were evaluated. Results The total effective rate (80.39%) of the control group was significantly lower than 94.12% of the treatment group, and the difference between two groups was significant (P < 0.05). The modified Mayo activity index scores in both groups after treatment were decreased, and the modified Mayo activity index scores in the treatment group were lower than those in the control group after treatment (P < 0.05). After treatment, the IBDQ scores of both groups of patients were significantly increased, and the IBDQ scores of the treatment group was higher than that of the control group (P < 0.05). The serum levels of chemerin, HIF-1α, and DAO in both groups after treatment were decreased (P < 0.05), and the serum levels of chemerin, HIF-1α, and DAO in the treatment group were lower than those in the control group after treatment (P < 0.05). Conclusion The combination of Shenling Baizhu Granules and Olsalazine Sodium Capsules can improve the therapeutic effect of ulcerative colitis, enhance patients' quality of life, reduce disease activity and intestinal barrier damage.

R972

国家重点研发计划项目（2017YFC1703400）