目的 探讨地奥心血康胶囊联合酒石酸美托洛尔片治疗无症状性心肌缺血的疗效。方法 选择94例石家庄市人民医院2023年2月—2024年11月收治无症状性心肌缺血患者，按随机数字表法分为对照组和治疗组，每组各47例。对照组患者服用酒石酸美托洛尔片，2次/d，1片/次。治疗组在对照组基础上服用地奥心血康胶囊，3次/d，2粒/次。患者持续治疗8周。对比两组的治疗疗效、心动图监测、心功能指标、血清指标。结果 治疗组总有效率89.36%，对照组总有效率72.34%，组间差异有统计学意义（P＜0.05）。两组治疗后的ST段压低的频次和持续时间、无症状心肌缺血频次均低于治疗前（P＜0.05）；治疗组的ST段压低的频次和持续时间、无症状心肌缺血频次低于对照组（P＜0.05）。两组治疗后的左心射血分数（LVEF）、左心室整体长轴应变（GLS）高于治疗前，心肌做功指数（PW-Tei）低于治疗前（P＜0.05）；治疗组治疗后的LVEF、GLS高于对照组，PW-Tei低于对照组（P＜0.05）。两组治疗后的血清单核细胞趋化蛋白-1（MCP-1）、脂蛋白相关磷脂酶（Lp-PLA2）、氨基末端B型利钠肽前体（NT-proBNP）水平均比治疗前低（P＜0.05）；治疗组治疗后的血清MCP-1、Lp-PLA2、NT-proBNP水平比对照组低（P＜0.05）。结论 地奥心血康胶囊联合酒石酸美托洛尔片有助于提高无症状性心肌缺血的疗效，减轻心肌缺血症状，改善心功能，减轻心肌损伤。

Objective To investigate the efficacy of Di'ao Xinxuekang Capsules combined with Metoprolol Tartrate Tablets in treatment of asymptomatic myocardial ischemia. Methods 94 Patients with asymptomatic myocardial ischemia admitted to Shijiazhuang People's Hospital from February 2023 to November 2024 were divided into control group and treatment group using a random number table method, with 47 cases in each group. The control group patients took Metoprolol Tartrate Tablets, one tablet per time, twice daily. On the basis of the control group, the treatment group patients took Di'ao Xinxuekang Capsules, 2 capsules each time, 3 times daily. The patient received continuous treatment for 8 weeks. Therapeutic efficacy, cardiac monitoring, cardiac function indicators, and serum indicators between the two groups were compared. Results The total effective rate of the treatment group was 89.36%, while the total effective rate of the control group was 72.34%, and the difference between the groups was statistically significant (P < 0.05). The frequency and duration of ST segment depression and the frequency of asymptomatic myocardial ischemia in both groups after treatment were lower than those before treatment (P < 0.05). The frequency and duration of ST segment depression and the frequency of asymptomatic myocardial ischemia in the treatment group were lower than those in the control group (P < 0.05). The LVEF and GLS of both groups after treatment were higher than before treatment, but the PW-Tei was lower than before treatment (P < 0.05). The LVEF and GLS of the treatment group were higher than those of the control group after treatment, but PW-Tei was lower than that of the control group (P < 0.05). The serum levels of MCP-1, Lp-PLA2, and NT-proBNP in both groups after treatment were lower than those before treatment (P < 0.05), and the serum levels of MCP-1, Lp-PLA2, and NT-proBNP in the treatment group were lower than those in the control group after treatment (P < 0.05). Conclusion The combination of Di'ao Xinxuekang Capsules and Metoprolol Tartrate Tablets can improve the efficacy of asymptomatic myocardial ischemia, alleviate myocardial ischemia symptoms, improve heart function, and alleviate myocardial injury.

R972

河北省卫生健康委医学科学研究课题计划（20210198）