目的 采用多指标成分定量结合化学计量学评价小儿感冒颗粒的质量。方法 采用UPLC法测定15批小儿感冒颗粒中告伊春、木犀草苷、绿原酸、3,5-O-二咖啡酰基奎宁酸、对羟基苯乙酮、迷迭香酸、靛玉红、连翘苷，结合聚类分析、主成分分析评价不同厂家、不同批次小儿感冒颗粒的质量差异。结果 15批小儿感冒颗粒样品分为3类，同厂家样品间差异性不明显，不同厂家样品存在差异性。3个主成分的累计方差贡献率达到91.050%。结论 方法高效、科学合理，结果较准确，可用于小儿感冒颗粒质量综合评价。

Objective To evaluate quality of Xiaoer Ganmao Granules by multi-index component determination combined with chemometrics. Methods UPLC method was used to determine contents of goitrin, luteolin, chlorogenic acid, p-hydroxyacetophenone, 3,5-O-dicaffeoylquinic acid, rosmarinic acid, forsythin, and indigo in 15 batches of Xiaoer Ganmao Granules, and cluster analysis and principal component analysis were combined to evaluate the quality differences of Xiaoer Ganmao Granules from different manufacturers and batches. Results Fifteen batches of Xiao’er Ganmao Granules were divided into three categories, and there were no obvious differences between samples from the same manufacturer, but there were differences between samples from different manufacturers. The cumulative variance contribution rate of the three principal components reached 91.050%. Conclusion The method is efficient, scientific, and reasonable, and the results are accurate, which can be used for comprehensive quality evaluation of Xiaoer Ganmao Granules.

R286.02

河北省药品监督管理局科技项目（2022ZC1004）