近年来，肺部疾病的发病率和死亡率呈逐年上升的趋势，寻找积极有效的治疗药物对减轻肺损伤具有积极意义。桔梗皂苷D是从桔梗中分离出的五环三萜皂苷，具有多种活性。桔梗皂苷D通过降低肺部炎症反应、减轻肺部氧化应激反应、抑制肺组织纤维化、阻止肺组织细胞凋亡、阻止病原菌黏附、诱导肺癌肿瘤细胞凋亡、降低肺癌肿瘤细胞的侵袭力发挥防治肺部疾病作用。总结了桔梗皂苷D防治肺部疾病的研究进展，并归纳其作用机制，为桔梗皂苷D的临床应用提供支持。

In recent years, the incidence rate and mortality of lung diseases are increasing year by year. It is of positive significance to find active and effective drugs to prevent and treat lung injury. Platycoside D is a pentacyclic triterpenoid saponin isolated from Platycodonis Radix, which has various activities. Platycoside D plays a prevention and treatment role in lung diseases by reducing lung inflammation, alleviating lung oxidative stress, inhibiting lung tissue fibrosis, preventing lung tissue cell apoptosis, inhibiting pathogen adhesion, inducing apoptosis of lung cancer tumor cells, and reducing the invasiveness of lung cancer tumor cells. This article summarizes the research progress on platycoside D in prevention and treatment of lung diseases, summarizes its mechanism of action, and provides support for the clinical application of platycoside D.

R285;R286.4