目的 探讨祛风止痛胶囊联合塞来昔布胶囊治疗膝骨性关节炎的临床疗效。方法 选取2018年6月—2020年10月郑州市第七人民医院收治的80例膝骨性关节炎患者作为研究对象，按照随机数字表法将80例患者分为对照组和治疗组，每组各有40例。对照组口服塞来昔布胶囊，100 mg/次，2次/d。治疗组患者在对照组基础上口服祛风止痛胶囊，1.8 g/次，2次/d。两组患者连续治疗8周。观察两组的总有效率，比较两组的步态特征、膝关节功能和血清炎症因子水平。结果 治疗后，治疗组患者总有效率为92.50%，对照组为75.00%，组间比较差异有统计学意义（P<0.05）。治疗后，两组的步速、步长显著提高（P<0.05），以治疗组步速、步长提高的更明显（P<0.05）。治疗后，两组的Lysholm评分显著升高，差异有统计学意义（P<0.05）；治疗后，治疗组的Lysholm评分比对照组高，差异有统计学意义（P<0.05）。治疗后，两组的前列腺素E₂（PGE₂）、白细胞介素-1β（IL-1β）、基质金属蛋白酶-3（MMP-3）水平显著降低（P<0.05）；治疗后，治疗组的PGE₂、IL-1β、MMP-3水平低于对照组，差异有统计学意义（P<0.05）。结论 祛风止痛胶囊联合塞来昔布胶囊可提高膝骨性关节炎的疗效，改善步态情况和关节功能，降低炎症反应，安全性良好。

Objective To investigate the efficacy of Qufeng Zhitong Capsules combined with Celecoxib Capsules in treatment of knee osteoarthritis. Methods Patients (80 cases) with knee osteoarthritis in the 7 th People’s Hospital of Zhengzhou from June 2018 to October 2020 were divided into control and treatment groups according to the method of random number table, and each group had 40 cases. Patients in the control group were po administered with Celecoxib Capsules, 100 mg/time, twice daily. Patients in the treatment group were po administered with Qufeng Zhitong Capsules on the basis of the control group, 1.8 g/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacies were evaluated, and gait characteristics; joint function, and inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 92.50%, and that of the control group was 75.00%, and the difference between the groups was statistically significant (P < 0.05). After treatment, the walking speed and step length of two groups were significantly improved (P < 0.05), and the walking speed and step length of the treatment group were significantly higher than those of the control group (P < 0.05). After treatment, the Lysholm scores of two groups was significantly increased, the difference was statistically significant (P < 0.05). After treatment, the Lysholm scores of treatment group were higher than those of control group, and the difference was statistically significant (P < 0.05). After treatment, the levels of PGE₂, IL-1β, and MMP-3 in two groups were significantly decreased (P < 0.05). After treatment, the levels of PGE₂, IL-1β, and MMP-3 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Qufeng Zhitong Capsules combined with Celecoxib Capsules can improve the curative effect of knee osteoarthritis, improve gait characteristics and joint function, reduce inflammatory reaction, with good safety.

R977

河南省医学科技攻关计划项目（2018020856）