目的 探讨维生素B₂片联合双歧杆菌乳杆菌三联活菌片、蒙脱石散治疗小儿轮状病毒性肠炎的临床疗效。方法 选取2017年6月-2018年9月焦作煤业（集团）有限责任公司中央医院收治的168例患有轮状病毒性肠炎的小儿作为研究对象，将纳入的患儿采用随机数字表分为对照组和治疗组，每组各84例。对照组口服双歧杆菌乳杆菌三联活菌片，4片/次，2次/d，同时口服蒙脱石散，1袋/次，1次/d。治疗组在对照组治疗的基础上口服维生素B₂片，1片/次，3次/d。两组患儿治疗时间均为7 d。观察两组患儿的临床疗效，并比较治疗前后两组患儿临床症状改善情况和血清炎症因子水平。结果 治疗后，治疗组总有效率（98.81%）显著高于对照组（89.29%）（P<0.05）。治疗后，治疗组的止吐时间、止泻时间、退热时间均显著短于对照组（P<0.05）。治疗后，两组的血清白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）水平显著降低（P<0.05），且治疗组血清IL-6、hs-CRP、TNF-α水平显著低于对照组（P<0.05）。结论 维生素B₂片联合双歧杆菌乳杆菌三联活菌片、蒙脱石散治疗小儿轮状病毒性肠炎可改善小儿临床症状，提高临床疗效，降低血清炎症因子水平，安全性较好。

Objective To explore the effect of Vitamin B₂ Tablets combined with Live Combined Bifidobacterium and Lactobacillus Tablets and Montmorillonite Powder in treatment of rotavirus enteritis in children. Methods Children (168 cases) with rotavirus enteritis in Central Hospital of Jiaozuo Coal Industry (Group) Co., Ltd., from June 2017 to September 2018 were randomly divided into control and treatment groups, and each group had 84 cases. Children in the control group were po administered with Live Combined Bifidobacterium and Lactobacillus Tablets, 4 tablets/time, twice daily. And children in the control group were also po administered with Montmorillonite Powder, 1 bag/time, once daily. Children in the treatment group were po administered with Vitamin B₂ Tablets on the basis of the control group, 1 tablet/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the improvement of clinical symptoms and the levels of serum inflammatory factors in two groups were compared. Results After treatment, the total effective rate of the treatment group (98.81%) was significantly higher than that of the control group (89.29%) (P<0.05). After treatment, the antiemetic time, antidiarrheal time, and antipyretic time of the treatment group were significantly shorter than those of the control group (P<0.05). After treatment, the serum levels of IL-6, hs-CRP, and TNF-α in two groups were significantly decreased (P<0.05), and the serum levels of IL-6, hs-CRP, and TNF-α in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Vitamin B₂ Tablets combined with Live Combined Bifidobacterium and Lactobacillus Tablets and Montmorillonite Powder has clinical curative effect in treatment of rotavirus enteritis in children, can improve the clinical symptoms, improve the clinical efficacy, reduce the level serum of inflammatory factors, with good safety.

R985