[关键词]
[摘要]
目的 探讨蜂胶牙泰联合米诺环素治疗急性牙周炎的临床效果。方法 选取2018年6月-2020年6月上海市嘉定区安亭医院收治的90例急性牙周炎患者(121颗患牙),随机分成对照组(45例,62颗患牙)和治疗组(45例,59颗患牙)。对照组口服盐酸米诺环素片,50 mg/次,2次/d。治疗组在对照组的基础上给予蜂胶牙泰,1次/d。两组患者均连续治疗3 d。观察两组临床疗效,比较治疗前后两组患者牙周袋深度、菌斑指数,龈沟液前列腺素E2(PGE2)、基质金属蛋白酶-9(MMP-9)和血管内皮生长因子(VEGF)水平,疼痛视觉模拟量表(VAS)评分和血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平。结果 治疗后,治疗组总有效率为95.16%,较对照组的79.66%显著提高(P<0.05)。治疗后,两组牙周袋深度均较治疗前显著变浅,菌斑指数则均显著降低(P<0.05);且与对照组比较,治疗组牙周袋水平显著更浅,菌斑指数显著更低(P<0.05)。治疗后,两组龈沟液PGE2、MMP-9、VEGF水平均较本组治疗前显著降低(P<0.05),但治疗组下降更显著(P<0.05)。治疗后,两组疼痛VAS评分和血清CRP、TNF-α、IL-1β浓度均显著降低(P<0.05),但治疗组比对照组降低作用更显著(P<0.05)。结论 蜂胶牙泰联合米诺环素治疗急性牙周炎的总体疗效满意,可安全有效地改善患者临床症状及牙周组织状况,明显减轻患者牙周组织局部及全身炎症反应,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical effect of Fengjiao Yatai combined with minocycline in treatment of acute periodontitis. Methods Patients (121) with acute periodontitis in Anting Hospital of Jiading District in Shanghai from June 2018 to June 2020 were randomly divided into control (45 cases, 62 teeth) and treatment (45 cases, 59 teeth) groups. Patients in the control group were po administered with Minocycline Hydrochloride Tablets, 50 mg/time, twice daily. Patients in the treatment group were administered with Fengjiao Yatai on the basis of the control group, once daily. Patients in two groups were treated for 3 d. After treatment, the clinical efficacy was evaluated, and the periodontal pocket depth, plaque index, PGE2, MMP-9, and VEGF levels in gingival crevicular fluid, VAS scores, the serum levels of CRP, TNF-α, and IL-1β in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 95.16%, which was significantly higher than that of the control group (79.66%) (P<0.05). After treatment, the depth of periodontal pocket in both groups was significantly shallower than that before treatment, but the plaque index was significantly decreased (P<0.05), and the periodontal pocket depth in the treatment group was significantly shallower than that in the control group, Plaque index was significantly lower (P<0.05). After treatment, the contents of PGE2, MMP-9 and VEGF in gingival crevicular fluid of the two groups were significantly lower than those before treatment (P<0.05), but the decrease was more significant in the treatment group (P<0.05). After treatment, the VAS score of pain and the concentration of serum CRP, TNF-α and IL-1β in both groups decreased significantly (P<0.05), but the effect in the treatment group was more significant than that in the control group (P<0.05). Conclusion The overall curative effect of Fengjiao Yatai combined with minocycline in treatment of acute periodontitis is satisfactory, which can safely and effectively improve the clinical symptoms and periodontal tissue condition, and significantly reduce the local and systemic inflammatory reaction of periodontal tissue, which has a certain clinical application value.
[中图分类号]
R988.2
[基金项目]
上海市卫生健康委员会卫生行业临床研究课题(20184Y0189)