[关键词]
[摘要]
目的 研究茶黄素对高尿酸血症模型小鼠的降尿酸作用。方法 采用氧嗪酸钾诱导高尿酸血症小鼠模型,茶黄素低、中、高剂量(6、20、60 mg/kg)和别嘌呤(10 mg/kg)连续ig给药7 d,检测高尿酸血症小鼠血清尿酸(UA)、尿素氮(BUN)、肌酐(CRE)、天冬氨酸氨基转氨酶(AST)、丙氨酸氨基转氨酶(ALT)水平,评价茶黄素的降尿酸作用。结果 与对照组比较,模型组小鼠血清CRE、BUN、AST和ALT水平显著升高;与模型组相比,茶黄素中、高剂量组小鼠血清UA、CRE、BUN、AST、ALT水平显著降低(P<0.01)。结论 茶黄素对于氧嗪酸钾诱导的高尿酸血症模型小鼠有良好的降尿酸作用。
[Key word]
[Abstract]
Objective To study the reducing uric acid effect of theaflavins on hyperuricemia mice. Methods Hyperuricemia mice model was induced by potassium oxazinate. Theaflavins were fed to rats for 7 d with theaflavins at low, medium, and high doses (6, 20, and 60 mg/kg) and allopurinol (10 mg/kg) continuously. The serum uric acid (UA), urea nitrogen (BUN), creatinine (CRE), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels in mice were determined to evaluate the uric acid-lowering effect of theaflavins. Results Compared with the control group, the serum UA, BUN, CRE, AST, and ALT levels in mice of model group were significantly increased. Compared with the model group, the serum UA, BUN, CRE, AST, and ALT levels in mice of medium and high dose of theaflavins groups were significantly decreased (P<0.01). Conclusion Theaflavins have uric acid lowering effect on hyperoxalemia mice induced by potassium oxazinate.
[中图分类号]
R285.5
[基金项目]