目的 探讨桉柠蒎肠溶软胶囊联合注射用拉氧头孢钠治疗社区获得性肺炎的临床疗效。方法 选取2018年2月-2020年2月天津市泰达医院收治的社区获得性肺炎患者230例，随机分为对照组和治疗组，每组各115例。对照组患者静脉滴注注射用拉氧头孢钠，每次1~2 g加入生理盐水100 mL，2~6 g/d。治疗组在对照组的基础上口服桉柠蒎肠溶软胶囊，1粒/次，3次/d。两组患者均治疗14 d。观察两组患者临床疗效，同时比较治疗前后两组患者血氧饱和度、血氧分压指标、二氧化碳分压指标、症状变化、中性粒细胞与淋巴细胞比值比，及丙二醛（MDA）、醛固酮（ALD）、肿瘤坏死因子-α（TNF-α）和肺表面活性蛋白A（SP-A）水平。结果 治疗后，对照组和治疗组临床总有效率分别为78.26%、93.91%，两组比较差异具有统计学意义（P<0.05）。治疗后，两组患者血氧饱和度和有氧分压明显高于治疗前（P<0.05），二氧化碳分压明显低于治疗前（P<0.05）；且治疗组动脉血气指标明显好于对照组（P<0.05）。治疗后，两组患者体温明显好于治疗前（P<0.05），咳嗽时间、白细胞计数（WBC）和中性粒细胞与淋巴细胞比值（NLR）均明显降低（P<0.05）；且治疗组患者体温好于对照组，咳嗽时间、WBC和NLR明显低于对照组（P<0.05）。治疗后，两组患者MDA、ALD、TNF-α和SP-A水平均明显降低（P<0.05），且治疗组显著低于对照组（P<0.05）。结论 桉柠蒎肠溶软胶囊联合注射用拉氧头孢钠治疗社区获得性肺炎安全、有效，具有一定的临床推广应用价值。

Objective To explore the clinical study of Limonene and Pinene Enteric Soft Capsules combined with latamoxef sodium in treatment of community-acquired pneumonia. Methods Patients (230 cases) with community-acquired pneumonia in Tianjin TEDA Hospital from February 2018 to February 2019 were randomly divided into control and treatment groups, and each group had 115 cases. Patients in the control group were iv administered with Latamoxef Sodium for injection, 1-2 g added into normal saline 100 mL, 2-6 g/d. Patients in the treatment group were po administered with Limonene and Pinene Enteric Soft Capsules on the basis of the control group, 1 grain/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the saturation of blood oxygen, partial pressure of oxygen, partial pressure of carbon dioxide, symptom, the ratio of neutrophils to lymphocytes, and the levels of MDA, ALD, TNF-α, and SP-A in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 78.26% and 93.91%, respectively, and there were differences between two groups (P<0.05). After treatment, the saturation of blood oxygen, partial pressure of oxygen in two groups were significantly increased (P<0.05), but the partial pressure of carbon dioxide in two groups was significantly decreased (P<0.05), and the arterial blood gas levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the body temperature in two groups was significantly improved (P<0.05), the time of cough, WBC, and NLR were significantly decreased (P<0.05), and which in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the levels of MDA, ALD, TNF-α and SP-A in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusions Limonene and Pinene Enteric Soft Capsules combined with latamoxef sodium is safe, effect on community-acquired pneumonia, which has a certain clinical application value.

R974