[关键词]
[摘要]
目的 分析阿昔替尼致不良反应(ADR)的临床表现和特点,为其临床安全用药提供参考。方法 检索PubMed、Web of Science、中国知网数据库和万方数据库关于阿昔替尼的不良反应文献并进行分析。结果 阿昔替尼致ADR的个案报道18例;年龄分布以50~70岁居多(11例,61.11%);ADR多发生在用药后180 d内(13例,72.22%);阿昔替尼致ADR累及器官/系统主要以消化系统(6例,33.33%)和血液系统(6例,33.33%)为主。结论 阿昔替尼引起的不良反应可累及全身多个系统,临床使用时需加强用药监测,警惕不良反应的发生。
[Key word]
[Abstract]
Objective To analyze the clinical manifestations and characteristics of adverse drug reaction (ADR) induced by Axitinib in order to provide references for rational drug use. Methods PubMed, Web of Science, CNKI and Wan-fang databases were searched for ADR induced by Axitinib, and the collected literatures were further analyzed statistically. Results Eighteen ADR were indentified and included. Patients of 50 to 70 years showed the highest incidence (n =11, 61.11%). ADR of axitinib frequently occurred within 180 days after medication (n=13, 72.22%). Axitinib induced ADR were mainly digestive system (n =6, 33.33%) and hematological system (n =6, 33.33%). Conclusion The ADR induced by axitinib may involve multiple systems. Physicians and pharmacists should pay more attentions to the safety monitoring of axitinib during medication, be alert to the occurrence of ADR.
[中图分类号]
R979.1
[基金项目]
天津市教委科研计划项目(2019KJ187)