目的 研究蒲地蓝消炎口服液联合磷酸奥司他韦胶囊治疗小儿病毒性肺炎的临床疗效。方法 选取2018年12月—2019年12月在河南科技大学第一附属医院治疗的100例病毒性肺炎患儿为研究对象，将所有患儿随机分为对照组和治疗组，每组各50例。对照组口服磷酸奥司他韦胶囊，体质量≤15 kg，30 mg/次，体质量15～23 kg，45 mg/次，体质量23～40 kg，60 mg/次，体质量>40 kg，75 mg/次，2次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液，10 mL/次，3次/d。两组患儿持续治疗10 d。观察两组患儿临床疗效，比较两组的临床症状缓解时间、血清炎性细胞因子水平。结果 治疗后，治疗组总有效率（94.00%）显著高于对照组（82.00%）（P<0.05）。治疗后，治疗组退热时间、肺部啰音消失时间、咳嗽停止时间明显短于对照组（P<0.05）。治疗后，两组血清C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平明显降低（P<0.05）；且治疗组血清CRP、IL-6、TNF-α水平降低较明显（P<0.05）。结论 蒲地蓝消炎口服液联合磷酸奥司他韦胶囊治疗小儿病毒性肺炎具有较好的疗效，可以缩短临床症状消失时间，降低血清炎性因子水平。

Objective To study the efficacy of Pudilan Xiaoyan Oral Liquid combined with Oseltamivir Phosphate Capsules in treatment of viral pneumonia in children. Methods Children (100 cases) with viral pneumonia in the First Affiliated Hospital of Henan University of Science and Technology from December 2018 to December 2019 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Oseltamivir Phosphate Capsules, body weight ≤ 15 kg, 30 mg/time, body weight 15-23 kg, 45 mg/time, body weight 23-40 kg, 60 mg/time, body weight > 40 kg, 75 mg/time, twice daily. Patients in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 10 d. After treatment, the clinical efficacies were evaluated, and the remission time of clinical symptoms and the serum levels of inflammatory cytokines in two groups were compared. Results After treatment, the total effective rate of the treatment group (94.00%) was significantly higher than that of the control group (82.00%) (P<0.05). After treatment, the antipyretic time, pulmonary rales disappearance time, and cough stop time in the treatment group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of CRP, IL-6 and TNF-α in two groups were significantly decreased (P<0.05), and the levels of CRP, IL-6, and TNF-α in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Oseltamivir Phosphate Capsules has clinical curative effect in treatment of viral pneumonia in children, can shorten the disappearance time of clinical symptoms, and reduce the serum level of inflammatory factors.

R974