[关键词]
[摘要]
目的 研究芪血通络片联合依达拉奉注射液治疗急性脑梗死的临床疗效。方法 选取2019年1月—2020年1月广元市第三人民医院收治的100例急性脑梗死患者,将所有患者随机分为对照组和治疗组,每组各50例。对照组患者静脉滴注依达拉奉注射液,30 mL/次,2次/d。治疗组在对照组基础上口服芪血通络片,4片/次,3次/d。两组患者持续治疗14 d。观察两组患者临床疗效,比较两组的日常生活能力、美国国立卫生研究院卒中量表(NIHSS)评分、血流动力学指标、血清炎性因子水平。结果 治疗后,对照组总有效率为78.00%,治疗组总有效率为96.00%,治疗组显著较高(P<0.05)。治疗后,两组Barthel指数评分显著升高,NIHSS评分显著降低(P<0.05),且治疗组Barthel指数评分明显高于对照组,NIHSS评分明显低于对照组(P<0.05)。治疗后,两组患者全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原水平显著降低(P<0.05);并且治疗组全血高切黏度、全血低切黏度、血细胞比容、纤维蛋白原水平明显低于对照组(P<0.05)。治疗后,两组血清丙二醛(MDA)、高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平明显降低(P<0.05);并且治疗组血清MDA、hs-CRP、IL-6水平明显低于对照组(P<0.05)。结论 芪血通络片联合依达拉奉注射液治疗急性脑梗死具有较好的疗效,可以提高患者生活能力,改善血液流变学指标,降低血清炎性因子水平。
[Key word]
[Abstract]
Objective To study the efficacy of Qixue Tongluo Tablets combined with Edaravone Injection in treatment of acute cerebral infarction. Methods Patients (100 cases) with acute cerebral infarction in Guangyuan Third People's Hospital from January 2019 to January 2020 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were iv administered with Edaravone Injection, 30 mL/time, once daily. Patients in the treatment group were po administered with Qixue Tongluo Tablets on the basis of the control group, 4 tablets/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the ability of daily living, NIHSS score, hemodynamic indexes, and the serum inflammatory factors in two groups were compared. Results After treatment, the total effective rates in the control group and the treatment group were 78.00% and 96.00%, respectively, which was significantly higher than that in the control group (P<0.05). After treatment, Barthel Index score of two groups was significantly increased, but NIHSS score was significantly decreased (P<0.05), and the Barthel Index score of the treatment group was significantly higher than that of the control group, and NIHSS score was significantly lower than that of the control group (P<0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, and fibrinogen levels of two groups were significantly decreased (P<0.05), and the whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, fibrinogen levels in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, serum levels of MDA, hs-CRP, and IL-6 in two groups were significantly decreased (P<0.05), and the serum levels of MDA, hs-CRP and IL-6 in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Qixue Tongluo Tablets combined with Edaravone Injection has clinical curative effect in treatment of acute cerebral infarction, can improve the living ability, improve hemorheology indexes, and reduce the serum level of inflammatory factors.
[中图分类号]
R971
[基金项目]