[关键词]
[摘要]
目的 探讨珠芽蓼止泻颗粒联合布拉氏酵母菌散治疗小儿功能性腹泻的临床疗效。方法 选取2018年1月—2020年1月在郑州颐和医院治疗的小儿功能性腹泻患儿264例,随机分为对照组(132例)和治疗组(132例)。对照组口服布拉氏酵母菌散,1袋/次,2次/d。治疗组在对照组基础上口服珠芽蓼止泻颗粒,1袋/次,3次/d。两组患者均连续服用14 d。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状缓解时间、大便性状、大便次数、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、二胺氧化酶(DAO)、IgA和IgG水平。结果 治疗后,对照组临床有效率为84.09%,显著低于治疗组的96.97%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患儿腹胀、呕吐、腹泻、腹痛症状缓解时间均明显短于对照组患儿(P<0.05)。治疗后,两组大便性状评分明显好转(P<0.05),大便次数明显降低(P<0.05),且治疗组患儿大便性状评分和大便次数显著好于对照组(P<0.05)。治疗后,两组血清TNF-α、IL-6、hs-CRP、DAO明显低于治疗前,而IgA和IgG水平均明显高于治疗前(P<0.05),且治疗组患者显著好于对照组同期水平(P<0.05)。结论 珠芽蓼止泻颗粒联合布拉氏酵母菌散治疗小儿功能性腹泻的疗效显著,可明显改善患儿大便次数及大便性状,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the curative effect of Zhuyaliao Zhixie Granules combined with Saccharomyces boulardii sachets in treatment of children with functional diarrhea. Methods Children (264 cases) with functional diarrhea in Zhengzhou Yihe Hospital from January 2018 to January 2020 were randomly divided into control (132 cases) and treatment (132 cases) groups. Children in the control group were po administered with Saccharomyces boulardii sachets, 1 bag/time, twice daily. Children in the treatment group were po administered with Zhuyaliao Zhixie Granules on the basis of the control group, 1 bag/time, three times daily. Children in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the relief time of clinical symptom, stool traits and frequency, and the serum level of TNF-α, IL-6, hs-CRP, DAO, IgA and IgG in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 84.09%, which was significantly lower than 96.97% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the relief time of abdominal distension, vomiting, diarrhea, abdominal pain in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, stool traits in two groups was significantly improved, stool frequency was significantly decreased (P<0.05), and the stool traits and frequency in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the serum levels of TNF-α, IL-6, hs-CRP, DAO in two groups were significantly decreased, but the levels of IgA and IgG were significantly increased (P<0.05), and these indexes levels in the treatment group were significantly higher than those in the control group (P<0.05). Conclusion Zhuyaliao Zhixie Granules combined with Saccharomyces boulardii sachets in treatment of children with functional diarrhea is significant, and the improvement of stool frequency and stool characteristics in children is obvious, which has a certain clinical application value.
[中图分类号]
R985
[基金项目]
河南省医学科技攻关项目(201602351)