目的 对西京医院2015-2018年抗肿瘤药物不良反应报告进行统计分析，了解临床抗肿瘤药不良反应的特点及规律，为指导临床合理用药提供参考。方法 对154份抗肿瘤药不良反应报告进行统计，按患者性别、年龄、不良反应分级、发生时间、给药途径、药品种类、剂量频次、累及器官系统等进行回顾分析。结果 154份抗肿瘤药不良反应报告中男性患者多于女性患者；不良反应多发生于46~60岁（55例，35.71%）；静脉滴注发生不良反应的比例最高（142例，92.21%）；注射用顺铂（28例，18.18%）、注射用奥沙利铂（21例，13.64%）和注射用奈达铂（12例，7.79%）的不良反应发生率最高；累及消化系统损害的不良反应发生比例最高（72例，46.75%）。结论 收集整理医院抗肿瘤药物不良反应报告，归纳总结其特点规律，有助于促进抗肿瘤药的临床合理应用，保障患者临床用药安全。

Objective Adverse drug reactions of antineoplastic drugs in Xijing Hospital from 2015 to 2018 were analyzed statistically, so as to investigate the characteristics and regularities and provide reference for rational drug use in clinic. Methods 154 Cases of ADR reports were analyzed statistically including patients gender and age, reaction grading, occurrence time, route of administration, types of drugs, dose frequency, and main clinical manifestations. Results Among 154 ADR reports, the number of ADR reports in males was slightly higher than that in females. The highest proportion of ADR occurred in 45-60 years old patients (55 cases, 35.71%). The most ADR reports were caused by intravenous drip administration (142 cases, 92.21%). Cisplatin (28 cases, 18.18%), oxaliplatin (21 cases, 13.64%), and nedaplatin (12 cases, 7.79%) caused the highest proportion of ADR. The main system involved in ADR was the gastrointestinal system (72 cases, 46.75%). Conclusion The reports of adverse reactions of antineoplastic drugs were collected, and their characteristics and regularities were summarized, in order to promote the rational clinical application of anti-tumor drugs and ensure the safety of patients.

国家自然科学基金资助项目（81603385）；西京医院助推计划项目（XJZT18MJ71）