目的 探讨胃得安胶囊联合兰索拉唑治疗胃溃疡的临床效果。方法 选取2016年7月-2018年7月天津市第五中心医院收治的胃溃疡患者96例，随机分成对照组（48例）和治疗组（48例）。对照组早餐前30 min口服兰索拉唑肠溶胶囊，30 mg/次，1次/d。治疗组在对照组基础上口服胃得安胶囊，2粒/次，3次/d。两组患者均连续治疗6周。观察两组患者临床疗效，同时比较治疗前后两组患者上腹痛评分、反酸评分、前列腺素（PG）E2、C反应蛋白（CRP）、白介素-17（IL-17）、超氧化物歧化酶（SOD）和脂质过氧化物（LPO）水平以及幽门螺杆菌根除率、溃疡愈合率及复发率。结果 治疗后，对照组临床有效率为87.5%，显著低于治疗组的100.0%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者中上腹痛评分和反酸评分均显著降低（P<0.05），且治疗组患者中上腹痛评分和反酸评分明显低于对照组（P<0.05）。治疗后，两组患者胃液中PGE2浓度及血清SOD水平均显著升高（P<0.05），血清CRP、IL-17、LPO浓度则均显著降低（P<0.05），且治疗组患者这些指标水平明显好于对照组（P<0.05）。治疗后，治疗组幽门螺杆菌根除率、溃疡愈合率分别为93.8%、75.0%，均显著高于对照组（P<0.05）。随访6个月，治疗组复发率为8.3%，比对照组的25%明显显著降低（P<0.05）。结论 胃得安胶囊联合兰索拉唑治疗胃溃疡的整体疗效切实，促进溃疡愈合，增强胃黏膜的防御功能及机体的抗氧化能力。

Objective To investigate the clinical effect of Weidan Capsules combined with lansoprazole in treatment of gastric ulcer. Methods Patients (96 cases) with gastric ulcer in Tianjin Fifth Central Hospital from July 2016 to July 2018 were randomly divided into control (48 cases) and treatment (48 cases) groups. Patients in the control group were po administered with Lansoprazole Enteric-coated Capsules, 30 mg/time, once daily. Patients in the treatment group were po administered with Weidan Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 6 weeks. After treatment, the clinical efficacy was evaluated, and the upper abdominal pain score, acid regurgitation score, PGE2, CRP, IL-17, SOD, LPO, and Hp eradication rate, ulcer healing rate and recurrence rate in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 87.5%, which was significantly lower than 100.0% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the upper abdominal pain scores, acid regurgitation scores in two groups were significantly reduced (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the concentration of PGE2 in gastric juice and serum SOD levels in two groups were significantly increased (P<0.05), serum CRP, IL-17, LPO levels were significantly decreased (P<0.05), and these indexes in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the Hp eradication rate, ulcer healing rate in the treatment group were 93.8% and 75.0%, which were significantly lower than that in the control group, respectively, and there were differences between two groups (P<0.05). After treatment, the recurrence rate in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Weidan Capsules combined with lansoprazole is accurate in treatment of gastric ulcer, can promote ulcer healing, enhance the defense function of gastric mucosa and the antioxidant capacity.