[关键词]
[摘要]
目的 探讨口炎清颗粒联合替硝唑片治疗慢性牙周炎的临床疗效。方法 选取2017年7月-2018年11月河南科技大学第一附属医院收治的96例慢性牙周炎患者作为研究对象,按照随机数字表法将全部患者分为对照组和治疗组,每组各48例。对照组口服替硝唑片,1 g/次,3次/d。治疗组在对照组基础上开水冲服口炎清颗粒,10 g/次,2次/d。两组患者均连续治疗4周。观察两组的临床疗效,比较两组的牙周指标、龈沟液炎症因子。结果 治疗后,对照组和治疗组的总有效率分别为66.67%、85.42%,两组比较差异有统计学意义(P<0.05)。治疗后,两组的菌斑指数(PLI)、龈沟出血指数(SBI)、牙周探诊深度(PD)、附着丧失(AL)均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后治疗组的牙周指标均明显低于对照组,差异有统计学意义(P<0.05)。治疗后,两组龈沟液单核细胞趋化蛋白-1(MCP-1)、白细胞介素-6(IL-6)、前列腺素E2(PGE2)、白细胞介素-1β(IL-1β)水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗后,治疗组的龈沟液炎症因子水平明显低于对照组,差异有统计学意义(P<0.05)。结论 口炎清颗粒联合替硝唑片治疗慢性牙周炎具有较好的临床疗效,可改善牙周组织症状,降低龈沟液炎症因子的水平,安全性较好,具有一定的临床推广应用价值。
[Key word]
[Abstract]
Objective To investigate the clinical efficacy of Kouyanqing Granules combined with Tinidazole Tablets in treatment of chronic periodontitis. Methods Patients (96 cases) with chronic periodontitis in the First Affiliated Hospital of Henan University of Science and Technology from July 2017 to November 2018 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were po administered with Tinidazole Tablets, 1 g/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 10 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and periodontal indexes and inflammatory factors of gingival crevicular fluid in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 66.67% and 85.42%, respectively, and there was difference between two groups (P<0.05). After treatment, PLI, SBI, PD, and AL in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the periodontal indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of MCP-1, IL-6, PGE2, and IL-1β in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the inflammatory factors of gingival crevicular fluid in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Kouyanqing Granules combined with Tinidazole Tablets has clinical curative effect in treatment of chronic periodontitis, can improve the symptoms of periodontal tissue, reduce the level of inflammatory factors in gingival crevicular fluid, with good safety, which has a certain clinical application value.
[中图分类号]
[基金项目]