目的 探讨通窍鼻炎片联合克拉霉素治疗慢性鼻窦炎的临床疗效。方法 选取2016年1月-2019年1月西宁市第二人民医院于收治的慢性鼻窦炎患者120例，随机分为对照组和治疗组，每组各60例。对照组口服克拉霉素片，1片/次，2次/d。治疗组在对照组治疗的基础上口服通窍鼻炎片，5片/次，3次/d。两组患者连续治疗1个月。观察两组患者临床疗效，同时比较治疗前后两组患者临床症状评分及血清白细胞介素-5（IL-5）、IL-1β及肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，对照组临床有效率为81.67%，显著低于治疗组的96.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者临床症状评分均明显低于治疗前（P<0.05），且治疗组患者临床症状评分明显低于对照组（P<0.05）。治疗后，两组血清IL-5、IL-1β及TNF-α水平均明显低于治疗前（P<0.05），且治疗组患者IL-5、IL-1β和TNF-α水平明显低于对照组（P<0.05）。结论 通窍鼻炎片联合克拉霉素治疗慢性鼻窦炎的临床疗效显著，临床症状改善明显，且安全性较好。

Objective To investigate the clinical efficacy of Tongqiao Biyan Tablets combined with clarithromycin in treatment of chronic sinusitis. Methods Patients (120 cases) with chronic sinusitis in Xining Second People's Hospital from January 2016 to January 2019 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Clarithromycin Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Tongqiao Biyan Tablets on the basis of the control group, 5 tablets/time, three times daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, the serum levels of IL-5, IL-1β and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.67%, which was significantly lower than 96.67% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the serum levels of IL-5, IL-1β and TNF-α in two groups were significantly decreased (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Tongqiao Biyan Tablets combined with clarithromycin is effective and safe in treatment of chronic sinusitis, can improve clinical symptoms.