目的 探讨生血宝合剂联合蔗糖铁注射液治疗小儿缺铁性贫血的临床疗效。方法 选取2014年6月-2018年6月在驻马店市第一人民医院治疗的缺铁性贫血患儿80例，根据用药的不同分为对照组（40例）和治疗组（40例）。对照组静脉滴注蔗糖铁注射液，根据体质量将适量药物用生理盐水稀释成1：20，3次/周；治疗组在对照组基础上口服生血宝合剂，5 mL/次，3次/d。两组患者均治疗3月。观察两组患者临床疗效，同时比较治疗前后两组患者红细胞（RBC）、血红蛋白（Hb）、血清铁（S）、铁蛋白（SF）水平，血清γ干扰素（INF-γ）、白细胞介素-2（IL-2）、IL-6和IL-10水平以及QOL量表评分。结果 治疗后，对照组临床有效率为80.0%，显著低于治疗组的97.5%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者RBC、Hb、SF、SI、INF-γ、IL-2水平均显著升高（P<0.05），而IL-6和IL-10水平明显降低（P<0.05），且治疗组这些指标变化明显好于对照组（P<0.05）。治疗后，两组患者QOL评分均显著降低（P<0.05），且治疗组患者QOL评分明显低于对照组（P<0.05）。结论 生血宝合剂联合蔗糖铁注射液治疗小儿缺铁性贫血效果显著，可有效增加机体RBC、Hb、SF、SI水平，改善INF-γ、IL-2、IL-6、IL-10水平，促进患儿生活质量提高。

Objective To explore the clinical effect of Shengxuebao Mixture combined with Iron Sucrose Injection in treatment of iron deficiency anemia in children. Methods Children (80 cases) with iron deficiency anemia in the First People's Hospital of Zhumadian from June 2014 to June 2018 were divided into control (40 cases) and treatment (40 cases) groups according to different treatments. Children in the control group were iv administered with Iron Sucrose Injection, according to body weight, diluted the right amount of medicine with normal saline to 1:20, three times weekly. Children in the treatment group were po administered with Shengxuebao Mixture on the basis of the control group, 5 mL/time, three times daily. Children in two groups were treated for 3 months. After treatment, the clinical efficacy was evaluated, and the RBC, Hb, S, SF, INF-γ, IL-2, IL-6 and IL-10 levels, and QOL scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 80.0%, which was significantly lower than 97.5% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the RBC, Hb, S, SF, INF-γ, and IL-2 levels in two groups were significantly increased (P<0.05), but IL-6 and IL-10 levels were significantly decreased (P<0.05), and the change of these indexes in the treatment group was significantly better than those in the control group (P<0.05). After treatment, the QOL scores in two groups were significantly reduced (P<0.05), and which in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Shengxuebao Mixture combined with Iron Sucrose Injection has remarkable effect on iron deficiency anemia in children, can effectively increase the levels of RBC, Hb, SF, and SI, improve the levels of INF-γ, IL-2, IL-6 and IL-10, and promote the quality of life.