目的 探讨槐杞黄颗粒联合甘露聚糖肽胶囊治疗小儿反复呼吸道感染的临床疗效。方法 选取2017年6月-2018年6月在空军军医大学西京医院治疗的反复呼吸道感染患儿86例，根据用药的不同分为对照组（43例）和治疗组（43例）。对照组口服甘露聚糖肽胶囊，2~3周岁2.5 mg/次，3次/d，3~12周岁5 mg/次，3次/d；治疗组在对照组基础上口服槐杞黄颗粒，2~3周岁5 g/次，2次/d，3~12周岁10 g/次，2次/d。两组患者均经4周治疗。观察两组患者临床疗效，同时比较治疗前后两组患者症候积分、症状改善时间、血清白细胞介素-1β（IL-1β）、IL-6、半胱氨酰白三烯（CysLTs）、降钙素原（PCT）、胰岛素样生长因子（IGF1）和IL-2水平以及T淋巴细胞亚群和体液免疫情况。结果 治疗后，对照组和治疗组临床有效率分别为81.40%和97.67%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者症候积分均显著降低（P<0.05），且治疗组患者这些症候积分明显低于对照组（P<0.05）。治疗后，治疗组患者咳嗽、发热、喘息及肺部啰音消失时间均明显早于对照组（P<0.05）。治疗后，两组患者血清IL-1β、IL-6、Cysl Ts、PCT水平均显著降低（P<0.05），IGF-1、IL-2水平均升高（P<0.05），且治疗组患者这些指标明显好于对照组（P<0.05）。治疗后，两组患者CD3⁺、CD4⁺、CD4⁺/CD8⁺、IgA、IgG水平均明显升高（P<0.05），而CD8⁺、IgE水平均降低（P<0.05），且治疗组患者这些指标水平明显好于对照组（P<0.05）。结论 槐杞黄颗粒联合甘露聚糖肽胶囊治疗小儿反复呼吸道感染有利于患儿临床症状的改善，促进机体体液免疫和细胞免疫的提高，降低机体炎症反应。

Objective To explore the clinical efficacy of Huaiqi Huang Granules combined with Mannatide Capsules in treatment of recurrent respiratory infection in children. Methods Children (86 cases) with recurrent respiratory infection in Xijing Hospital of Air Force Medical University from June 2017 to June 2018 were divided into control (43 cases) and treatment (43 cases) groups based on different treatments. Children in the control group were po administered with Mannatide Capsules, 2.5 mg/time for 2-3 years old children, 5 mg/time for 3-12 years old children, three times daily. Children in the treatment group were po administered with Huaiqihuang Granules on the basis of the control group, 5 g/time for 2-3 years old children, 10 g/time for 3-12 years old children, twice daily. Children in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the symptom scores, the disappearance time of symptoms, the serum levels of IL-1β, IL-6, CysLTs, PCT IGF1 and IL-2, and the level of T lymphocyte subsets, humoral immunity indicators in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 81.40% and 97.67% respectively, and there were differences between two groups (P<0.05). After treatment, the symptom scores in two groups were significantly decreased (P<0.05), which in the treatment group were significantly lower than that in the control group (P<0.05). After treatment, the disappearance time of cough, fever, wheezing and lung rales in the treatment group was significantly earlier than that in the control group (P<0.05). After treatment, the serum levels of IL-1β, IL-6, CyslTs and PCT in two groups were significantly decreased (P<0.05), but the IGF-1 and IL-2 levels were significantly increased (P<0.05), and these cytokine levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the CD3⁺, CD4⁺, CD4⁺/CD8⁺, IgA, and IgG levels in two groups were significantly increased (P<0.05), the CD8⁺ and IgE levels were significantly decreased (P<0.05), and these indexes levels in the treatment group were significantly better than those in the control group (P<0.05). Conclusion Huaiqihuang Granules combined with Mannatide Capsules in treatment of recurrent respiratory infection in children is conducive to the improvement of clinical symptoms, the promotion of humoral immunity and cellular immunity, and the reduction of inflammation.