目的 探讨热毒宁注射液联合注射用比阿培南治疗重症肺炎的临床疗效。方法 选取2018年2月-2019年1月在南阳市第一人民医院就诊的84例重症肺炎患者作为研究对象，按照随机数字表法将全部患者分为对照组和治疗组，每组各42例。对照组静脉滴注注射用比阿培南，0.3 g加入到生理盐水100 mL中，2次/d。治疗组在对照组基础上静脉滴注热毒宁注射液，20 mL/次，1次/d。两组患者连续治疗7 d。观察两组的临床疗效，比较两组的临床症状改善时间、血气指标、肺功能、血清因子水平。结果 治疗后，对照组和治疗组患者的总有效率分别为76.19%、92.86%，两组比较差异具有统计学意义（P<0.05）。治疗后，治疗组的退热时间、止咳时间、肺啰音消失时间、住院时间均明显短于对照组，差异有统计学意义（P<0.05）。治疗后，两组的动脉血氧分压（pO₂）、氧合指数（pO₂/FiO₂）、酸碱度（pH值）明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的血气指标明显高于对照组，差异有统计学意义（P<0.05）。治疗后，两组的一秒用力呼气容积（FEV1）、FEV1/用力肺活量（FVC）、最大呼气流量（PEF）均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的肺功能指标明显高于对照组，差异有统计学意义（P<0.05）。治疗后，两组的白细胞（WBC）、C反应蛋白（CRP）、降钙素原（PCT）水平均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组的WBC、CRP、PCT水平均明显低于对照组，差异有统计学意义（P<0.05）。结论 热毒宁注射液联合注射用比阿培南治疗重症肺炎具有较好的临床疗效，可改善临床症状，提升血气指标和肺功能，降低血清因子水平，具有一定的临床推广应用价值。

Objective To investigate the clinical efficacy of Reduning Injection combined with Biapenem for injection in treatment of severe pneumonia. Methods Patients (84 cases) with severe pneumonia in Nanyang First People's Hospital from February 2018 to January 2019 were randomly divided into control and treatment groups, and each group had 42 cases. Patients in the control group were iv administered with Biapenem for injection, 0.3 g added into normal saline 100 mL, twice daily. Patients in the treatment group were iv administered with Reduning Injection on the basis of the control group, 20 mL/time, once daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and clinical symptom improvement time, blood gas indexes, lung function, and serum factor levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.19% and 92.86%, respectively, and there was difference between two groups (P<0.05). After treatment, Antipyretic time, cough relief time, lung rale disappearance time, and hospitalization time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, pO₂, pO₂/FiO₂ and pH value in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the blood gas indexes in the treatment group were significantly higher than those in the control group, with significant difference between two groups (P<0.05). After treatment, FEV1, FEV1/FVC, and PEF in two groups were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the lung function indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of WBC, CRP, and PCT in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Reduning Injection combined with Biapenem for injection has clinical curative effect in treatment of severe pneumonia, can improve clinical symptoms, improve blood gas index and lung function, and reduce serum factor level, which has a certain clinical application value.