目的 分析脑安滴丸联合佐米曲普坦治疗偏头痛的临床效果。方法 选取2017年1月-2019年2月天津市宝坻区人民医院治疗的偏头痛患者137例，随机分为对照组（68例）和治疗组（69例）。对照组患者口服佐米曲普坦片，1片/次，1次/d；治疗组在对照组的基础上口服脑安滴丸，20粒/次，2次/d。两组患者均治疗一个月。观察两组的临床疗效，比较两组治疗前后临床症状和血清活性物质的变化情况。结果 治疗后，对照组和治疗组的总有效率分别是72.06%、94.20%，两组比较差异具有统计学意义（P<0.05）。治疗后两组头痛发作频率、头痛持续时间和VAS评分均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且治疗后治疗组头痛发作频率、头痛持续时间和VAS评分明显低于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后两组内皮素-1（ET-1）、降钙素基因相关肽（CGRP）均显著降低，但5-羟色胺（5-HT）显著升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，治疗组ET-1、CGRP均显著低于对照组，而5-HT高于对照组，两组比较差异具有统计学意义（P<0.05）。结论 脑安滴丸联合佐米曲普坦治疗偏头痛临床效果显著，可降低头痛发作频率和持续时间，明显缓解疼痛程度，同时可调节相应血清活性物水平，具有一定的临床推广应用价值。

Objective To analyze the clinical effect of Naoan Dropping Pills combined with zomitriptan in treatment of migraine. Methods 137 Patients with migraine in Baodi District People's Hospital of Tianjin from January 2017 to February 2019 were randomly divided into control (68 cases) and treatment group (69 cases). Patients in the control group were po administered with Zolmitriptan Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Naoan Dropping Pills, 20 grains/time, twice daily. Patients in two groups were treated for 1 month. After treatment, the clinical efficacy was evaluated, and the changes of clinical symptoms and serum active substances before and after treatment were compared between the two groups. Results After treatment, the clinical efficacy in the control and treatment groups were 72.06% and 94.20%, respectively, and there were differences between two groups (P<0.05). After treatment, headache attack frequency, headache duration and VAS score in two groups were significantly decreased, and there were differences in the same group (P<0.05). After treatment, headache attack frequency, headache duration and VAS score in the treatment group were lower than those in the control group, and there were differences between two groups (P<0.05). After treatment, ET-1 and CGRP in two groups were significantly decreased, but 5-HT was significantly increased, and there were differences in the same group (P<0.05). After treatment, ET-1 and CGRP in the treatment group were lower than those in the control group, but 5-HT was higher than that in the control group, and there were differences between two groups (P<0.05). Conclusion Naoan Dropping Pills combined with zomitriptan has significant clinical effect in treatment of migraine, and can reduce the frequency and duration of headache attack, and also can significantly relieve the pain degree, and adjust the corresponding serum activity level, which has a certain clinical application value.