目的 建立复方对乙酰氨基酚片中阿司匹林、咖啡因和对乙酰氨基酚测定的氢核磁共振波谱方法。方法 采用氘代甲醇为溶剂，马来酸为内标。采用zg30脉冲序列获取¹H-NMR谱图。测试温度：300 K；谱宽：8 012 Hz；采集时间：4.01 s：弛豫时间：20 s，样品扫描次数：64次；空扫次数：2次。并采用HPLC法测定进行比较。结果 阿司匹林、对乙酰氨基酚和咖啡因平均回收率分别为101.29%、101.68%、99.13%，RSD值分别为1.15%、1.73%、1.92%。qNMR法测定结果与HPLC法测定结果基本一致。结论 氢核磁共振波谱法操作简便、快速，能准确测定复方对乙酰氨基酚片中阿司匹林、咖啡因和对乙酰氨基酚。

Objective To establish a proton nuclear magnetic resonance (qNMR) method for simultaneous determination of of acetaminophen, aspirin, and caffeine in Compound Paracetamol Tablets. Methods CD₃OD was employed as solvent and maleic acid was used as an internal standard. The ¹H-NMR spectra were obtained by using zg30 pulse sequence. The parameters were following as test temperature:300 K, spectral width:8 012 Hz, acquisition time:4.01 s, relaxation time:20 s, sample scanning times:64 times, and air scanning times:2 times. The determination results were compared with those of determined by HPLC. Results The average recoveries were 101.29%, 101.68%, and 99.13%, with RSD of 1.15%, 1.73%, and 1.92%, respectively. The determination result of qNMR was basically in line with that of HPLC. Conclusion It is a simple, rapid and accurate method for the determination of aspirin, caffeine, and paracetamol in Compound Paracetamol Tablets by qNMR method.

R914;R966