目的 观察固肠止泻丸联合复方谷氨酰胺肠溶胶囊治疗溃疡性结肠炎的临床疗效。方法 选取2014年1月—2015年1月鄂州市中医医院消化科收治的溃疡性结肠炎患者140例,随机分为对照组和治疗组,每组各70例。对照组患者饭前口服复方谷氨酰胺肠溶胶囊,3粒/次,3次/d。治疗组在对照组治疗基础上口服固肠止泻丸,4 g/次,3次/d。两组均连续治疗6周。观察两组的临床疗效,同时比较两组疾病活动指数(DAI)、治愈时间和不良反应发生情况。结果 治疗后,两组症状疗效总有效率分别为74.29%、92.86%,两组比较差异具有统计学意义(P<0.05)。两组内镜疗效总有效率分别为70.0%、90.0%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组DAI评分均显著降低,同组治疗前后差异具有统计学意义(P<0.05),且治疗后治疗组DAI评分的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗组的治愈时间显著短于对照组;对照组和治疗组的不良反应发生率分别为18.57%、7.14%,两组比较差异有统计学意义(P<0.05)。结论 固肠止泻丸联合复方谷氨酰胺肠溶胶囊治疗溃疡性结肠炎具有较好的临床效果,且不良反应发生率较低,治愈时间短,具有一定的临床推广应用价值。

Objective To observe clinical curative effect of Guchang Zhixie Pills combined with Compound Glutamin Entersoluble Capsules in treatment of ulcerative colitis. Methods Patients (140 cases) with ulcerative colitis in Department of Internal Medicine of Ezhou Hospital of Traditional Chinese Medicine from January 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 70 cases. The patients in the control group were po administered with Compound Glutamin Entersoluble Capsules, 3 grains/time, three times daily. The patients in the treatment group were po administered with Guchang Zhixie Pills on the basis of control group, 4 g/time, three times daily. The patients in two groups were treated for 6 weeks. After treatment, the clinical efficacies were evaluated, and disease activity index (DAI), the cure time and adverse reactions in two groups were compared. Results After treatment, the efficacy of clinical symptoms in the control and treatment groups were 74.29% and 92.86%, respectively, and there were differences between two groups (P< 0.05). The endoscopic efficacy in the control and treatment groups were 70.0% and 90.0%, respectively, and there were differences between two groups (P< 0.05). After treatment, DAI score in two groups were significantly decreased, and the difference was statistically significant in the same group (P< 0.05). After treatment, lower degree of DAI score in the treatment group was significantly better than that in the control group, with significant difference between two groups (P< 0.05). The cure time in the treatment group was significantly shorter than that in the control group, and the incidence of adverse reactions in control and treatment groups were 18.57% and 7.14%, respectively, and there were differences between two groups (P< 0.05). Conclusion Guchang Zhixie Pills combined with Compound Glutamin Entersoluble Capsules has clinical curative effect in treatment of ulcerative colitis, and has a lower incidence of adverse reactions, also can shorten the cure time, which has a certain clinical application value.