目的 观察维生素AD滴剂联合孟鲁司特钠咀嚼片治疗毛细支气管炎的临床疗效。方法 选择衡水市桃城区妇幼保健院2015年1月—2015年6月确诊的毛细支气管炎患儿80例,随机分为对照组(40例)和治疗组(40例)。对照组口服孟鲁司特钠咀嚼片,6个月以下患儿2 mg/次,6个月以上患儿4 mg/次,每晚1次。治疗组在对照组的基础上加用维生素AD滴剂,1粒/次,1次/d。两组患儿均连续用药7 d。观察两组患儿治疗后的临床疗效和临床症状,比较γ-干扰素(IFN-γ)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平。结果 治疗后,对照组和治疗组的总有效率分别为87.5%、95.0%,两组患儿总有效率比较差异具有统计学意义(P<0.05)。治疗后治疗组患儿气促、咳嗽、喘憋、肺部体征消失时间和呼吸、心率恢复正常时间与对照组比较差异具有统计学意义(P<0.05)。治疗后,两组IFN-γ水平显著升高,同组治疗前后差异有统计学意义(P<0.05);且治疗组的上升程度优于对照组,两组比较差异有统计学意义(P<0.05)。结论 维生素AD滴剂联合孟鲁司特钠治疗毛细支气管炎具有较好的临床疗效,可明显减轻临床症状和体征,不良反应较少,具有一定的临床推广应用价值。

Objective To observe the clinical efficacy of Vitamin A and D Drops combined with Montelukast Sodium Chewable Tablets in treatment of capillary bronchitis. Methods Children (80 cases) with capillary bronchitis in Maternity and Child Health Hospital of Hengshui City Taocheng District from January 2015 to June 2015 were randomly divided into control and treatment groups, and each group had 40 cases. Children in control group were po administered with Montelukast Sodium Chewable Tablets, once daily at night. The amounts of drugs were corresponding with ages of children, such as below six months children had 2 mg/ time, but above six months children had 4 mg/ time. Children in treatment group were added Vitamin A and D Drops on the basis of control group, 1 grain/time, once daily. The children in two groups were treated for 7 d. The clinical efficacies and symptoms of the two groups were observed, and the levels of γ-interferon (IFN-γ), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were compared between two groups. Results After treatment, the efficacies in the control and treatment groups were 87.5% and 95.0%, respectively, and there were significant differences between two groups (P < 0.05). After treatment, disappear time of breath, cough, wheezing, and pulmonary symptoms, and returned to normal time of respiration and heart rate in treatment group were significantly shorter than those in the control group, with significant difference between two groups (P < 0.05). After treatment, level of IFN-γ was obviously increased, and the difference was statistically significant in the same group (P < 0.05). The observational index in the treatment group was better than that in the control group, with significant difference between two groups (P < 0.05). Conclusion Vitamin A and D Drops combined with Montelukast Sodium Chewable Tablets has clinical curative effect in treatment of capillary bronchitis, can significantly reduce the clinical symptoms and signs, and less adverse reactions, which has a certain clinical application value.