目的 探讨稳心颗粒联合瑞舒伐他汀治疗不稳定型心绞痛的临床疗效。方法 收集2012年1月—2014年2月新疆维吾尔自治区胸科医院收治的不稳定型心绞痛患者280例,随机分为对照组和治疗组,每组各140例。对照组在常规治疗基础上口服瑞舒伐他汀钙片,10 mg/次,1次/d。治疗组在对照组基础上口服稳心颗粒9 g/次,3次/d。两组均连续治疗24周。观察两组的临床疗效,比较两组红细胞压积、全血黏度、纤维蛋白原及C反应蛋白(CRP)等血液流变学指标的变化,同时比较两组不稳定型心绞痛的发生频率及持续时间。结果 治疗后,对照组和治疗组的总有效率分别为82.14%、92.86%,两组比较差异有统计学意义(P <0.05)。治疗后,两组患者红细胞压积、全血黏度、纤维蛋白原及CRP均显著降低,同组治疗前后差异有统计学意义(P <0.05);治疗后治疗组这些观察指标的下降程度优于对照组,两组比较差异具有统计学意义(P <0.05)。两组患者治疗后发作频率与持续时间均显著降低,同组治疗前后差异有统计学意义(P <0.05);治疗后治疗组这些观察指标的下降程度优于对照组,两组比较差异有统计学意义(P <0.05)。结论 稳心颗粒联合瑞舒伐他汀治疗不稳定型心绞痛具有较好的临床疗效,可显著降低患者血液流变学指标,明显改善患者不稳定型心绞痛发作频率与持续时间,具有一定的临床应用价值。

Objective To investigate the clinical effect of Wenxin Granule combined with rosuvastatin in treatment of unstableangina.Methods Patients (280 cases) with unstable angina in Chest Hospital of Xinjiang Uygur Autonomous Region from January 2012 to February 2014 were randomly divided into control and treatment groups, and each group had 140 cases. The patients in the control group were po administered with Rosuvastatin Calcium Tablets on the basis of conventional treatment, 10 mg/time, once daily. The patients in the treatment group were po administered with Wenxin Granule on the basis of the control group, 9 g/time, three times daily. Two groups were treated for 24 weeks. After treatment, the efficacy was evaluated, and the changes of blood rheology indexes such as red blood cells deposited, whole blood viscosity, fibrinogen and C-reactive protein (CRP) in two groups were compared. At the same time, unstable angina frequency and duration in the two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 82.14% and 92.86%, respectively, and there was difference between two groups (P < 0.05). After treatment, red blood cells deposited, whole blood viscosity, fibrinogen, and CRP in two groups were significantly reduced, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Unstable angina frequency and duration in two groups were significantly lower, and the difference was statistically significant in the same group (P < 0.05). And these indicators in treatment group improved better than those in the control group, with significant differences between two groups (P < 0.05). Conclusion Wenxin Granule combined with rosuvastatin has good clinical efficacy in treatment of unstable angina, and can significantly reduce blood rheology indexes, also can significantly improve unstable angina attack frequency and duration, which has certain clinical application value.