目的 探讨金芪降糖片联合二甲双胍治疗2型糖尿病的临床疗效和对血管内皮功能的影响。方法 选取2012年12月-2013年10月就诊于吉林油田总医院的2型糖尿病患者68例，随机分为治疗组（34例）和对照组（34例）。两组患者均进行糖尿病教育，均在糖尿病饮食、适当运动的基础上口服盐酸二甲双胍片，0.5 g/次，根据血糖水平调整每日剂量，最大剂量<2 g，3次/d；治疗组口服金芪降糖片，7片/次，3次/d，餐前0.5 h口服，其他同对照组。4周为1个疗程，两组患者均治疗2个疗程。观察两组患者的临床疗效，同时测定两组患者治疗前后糖代谢指标、血脂指标、血管内皮功能指标的变化。结果 治疗后，治疗组和对照组的总有效率分别为97.06%、91.18%，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的空腹血糖（FPG）、餐后2 h血糖（2h PG）、糖基化血红蛋白（HbAlc）均较治疗前明显降低，同组治疗前后差异有统计学意义（P<0.05、0.01），治疗后，治疗组糖代谢指标较对照组改善更加明显，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者的总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）均较治疗前明显降低，同组治疗前后差异有统计学意义（P<0.05、0.01）；治疗后，治疗组血脂指标较对照组改善更加明显，两组比较差异有统计学意义（P<0.05）。治疗后，两组患者血清一氧化氮（NO）、内皮素（ET）、血栓素B₂（TXB₂）水平均较治疗前明显下降，6-酮-前列腺素1α（6-keto-PGF1α）与治疗前比较显著升高，同组治疗前后差异有统计学意义（P<0.05、0.01）；治疗后，治疗组指标较对照组改善更加明显，两组比较差异有统计学意义（P<0.01）。结论 金芪降糖片联合二甲双胍治疗2型糖尿病有较好的临床疗效，能较好的控制血糖水平，并可改善患者的血脂代谢和血管内皮功能，适合临床推广应用。

Objective To study the clinical efficacy of Jinqi Jiangtang Tablets combined with metformin in the treatment of type 2 diabetes and the effect on vascular endothelial function. Methods Type 2 diabetic patients (68 cases) in Jilin Oil Fields General Hospital from December 2012 to October 2013 were randomly divided into treatment (34 cases) and control (34 cases) groups. The patients in two groups were given health education on diabetes and oral administration of Metformin Tablets (0.5 g/time) based on diabetes diet and proper exercise, and the daily dose was adjusted according to blood glucose levels, maximum dosage < 2 g, 3 times daily. The patients in the treatment group were po administered with Jinqi Jiangtang Tablets before meals 0.5 h, 7 tablets/time, 3 times daily, and other treatment was the same as the control group. Four weeks was as one period, and two groups were treated for two periods. Before and after the treatment, the clinical effect of the two groups were visualized, and the index changes of sugar metabolism, blood lipid, and vascular endothelial function were detected. Results After treatment, the effective rates in the treatment and control groups were 97.06% and 91.18%, respectively. There was significant difference between two groups (P < 0.05). FPG, 2 h PG, and HbAlc levels were significantly decreased in two groups (P < 0.05), and treatment group was decreased more than control group (P < 0.05 or 0.01). The improvement of TC, TG, and LDL-C in the treatment group was much better than those in the control group (P < 0.05). The levels of ET, NO, and TXB₂ were decreased after treatment in treatment group, and it had significant difference with control group (P< 0.05 or 0.01). The levels of 6-keto-PGF1α in both groups were apparently increased, and the increase of 6-keto-PGF1α in treatment group also had significant difference with control group (P < 0.01). Conclusion Jinqi Jiangtang Tablets combined with metformin has good clinical effect in the treatment of type 2 diabetes, and can better control blood sugar and improve blood lipid metabolism and vascular endothelial function, which is worthy of clinical application.