目的 观察口炎清冲剂与氨来呫诺口腔贴片联合治疗复发性口疮的临床疗效及其安全性。方法 选取乐山市人民医院复发性口疮患者90例，随机分为对照组和治疗组。对照组患者口服口炎清冲剂，20 g/次，2 次/d，连续服用2个月。治疗组患者开始治疗时，加用氨来呫诺口腔贴片，每日餐后和临睡前口腔清洁后，将其在口腔溃疡部位，轻压10 s，连续用药5 d，口炎清冲剂的用法、用量、治疗时间同对照组。治疗结束后询问患者主观感觉，症状改善情况，治疗前、后口疮疼痛评分，口疮大小、数目等，同时判定两组的临床疗效及不良反应。结果 治疗组和对照组总有效率分别为97.78%、71.11%，两组差异有统计学意义（P＜0.05）；治疗后，两组患者临床症状均有所改善，所有患者较治疗前口疮疼痛评分降低，口疮大小、数目均较治疗前减少，差异有显著性（P＜0.05），且治疗组较对照组临床症状改善更明显（P＜0.05）；治疗组患者不良反应发生率明显低于对照组（P＜0.05）。结论 口炎清冲剂联合氨来呫诺口腔贴片治疗复发性口疮疗效明显，不良反应发生率较低，可以在临床上推广应用。

Objective To observe the clinical efficacy and the safety of Kouyanqing Electuary combined with amlexanox oral patch in the treatment of recurrent aphtha. Methods The patients (90 cases) diagnosed with recurrent aphtha in the People’s Hospital of Leshan were randomly divided into treatment (45 cases) and control (45 cases) groups. The patients in the control group were po administered with Kouyanqing Granule, 20 g/once, twice daily, and they were treated for two months. The patients in the treatment group made ammonia to presence of oral patch on the ulcer site, and then gently pressed 10 s after meals and before bed after patients’ oral cavity cleaned for 5 d, and other treatment was the same as the control group. After the treatment, the subject feeling, improvement of symptoms, pain scores before and after treatment, ulcer size and number were observed. At the same time, the adverse drug reactions were observed. Results The efficiency for the patients in both the treatment and control groups was 97.78% and 71.11% with significant difference (P < 0.05). After the treatment, the clinical symptoms of the two groups were improved, and pain scores, ulcer size and number were decreased. Clinical symptoms in the treatment group were improved more obviously than those in the control group (P < 0.05), and the incidence of adverse drug reactions was lower than those of the control group. Conclusion Kouyanqing Electuary combined with amlexanox oral patch has a accurate curative effect on the recurrent ulcers with low incidence of adverse drug reactions, which could be used in clinic.