摘 要：目的 研究酒石酸美托洛尔脉冲微丸的制备和体外释放度。方法 采用碱诱导原理制备酒石酸美托洛尔脉冲微丸，考察制备工艺中不同因素对脉冲微丸体外释放度的影响。结果 碱性层增加质量不同、迟滞层增加质量不同、迟滞层组成不同、增塑剂用量不同和不同粒径的丸芯均会影响脉冲微丸的体外释放。结论 碱诱导原理制备脉冲微丸的方法操作简便，条件可控，制得微丸的脉冲效果理想。

Abstract: Objective To study the preparation of metoprolol tartrate pulsatile pellets and its in vitro dissolution．Methods The metoprolol tartrate pulsatile pellets were prepared by evocation of alkaline layer．The effects of different factors on dissolution in vitro during the preparation of pulsatile pellets were studied．Results The dissolution of metoprolol tartrate pulsatile pellets in vitro was influenced in varying degrees by increased weight of alkaline layer，increased weight and composition of out-layer coating level，dosage of plasticizer，and particle size of pellets．Conclusion The preparation of metoprolol tartrate pulsatile pellets by evocation of alkaline layer is practical and controllable，and the pulse effect of metoprolol tartrate pulsatile pellets is good．

国家科技支撑计划项目子项目（2007BAI41B05）