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<title cf:type="text"><![CDATA[Chinese Herbal Medicines -->Reviews]]></title>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Challenges in Research and Development of Traditional Chinese Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1020E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new “-omics” techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LIU Chang-xiao,XIAO Pei-gen,PENG Yong and SONG Nai-ning]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LIU Chang-xiao,XIAO Pei-gen,PENG Yong and SONG Nai-ning</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1020E]]></guid><cfi:id>289</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Safety Issues of Chinese Medicine: A Review of Intoxication Cases in Hong Kong]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1031E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese medicine (CM) has been widely used in Hong Kong for centuries. In fact, CM practitioners currently provide over 20% of the medical consultations in Hong Kong and about 60% of the population has previously used CM. In 1999, the Legislative Council passed the Chinese Medicine Ordinance with aims to govern practice, use, trading, and manufacturing of CM in Hong Kong. While it is usually safe to use CM under proper application and guidance, there have been frequent reports on intoxication and fatalities. The misuse of potent/toxic CM, because of misidentification or overdose, can cause severe aconite, aristolochic acid, anticholinergic, podophyllin, grayanotoxin, pyrrolizidine alkaloids, matrine, gelsemine, teucvin, and strychnine poisoning. In this review, we summarized CM intoxication cases in Hong Kong, concentrating on the discussion of toxic and adverse effects as well as the quality control of CM. By increasing the awareness of CM toxicity, we hope to enhance the regulatory process and stimulate further research on their toxic dose, toxic ingredients, intoxication mechanisms, and quality control.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[NG Kit-ying,CHENG Chuen-lung and XU Hong-xi]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>NG Kit-ying,CHENG Chuen-lung and XU Hong-xi</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1031E]]></guid><cfi:id>288</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Highlight of Publications on Chinese Traditional and Herbal Drugs in 2008]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM2008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[《中草药》自1970年创刊以来出版了包括增刊在内的近500期刊物。2008年，《中草药》共刊登了535篇文章，其中化学成分132篇，制剂与质量143篇，药理与临床134篇，药材与资源126篇。综述刊登了包括化学成分，制剂质量、分析方法等方面的75篇文章。]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LIU Yan-ze]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LIU Yan-ze</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM2008]]></guid><cfi:id>287</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Authentication of Medicinal Plants by DNA Based Markers and Genomics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1076E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[For the protection of consumers and developments of relevant industry, authentication of medicinal plants is a critical issue. This review covers various aspects of authentication methods and techniques based on molecular biology and genomics with special emphasis on molecular biology techniques including genome-based authentication, microchip-based authentication, DNA barcoding, and their applications.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[HAO Da-cheng,CHEN Shi-lin,XIAO Pei-gen and PENG Yong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HAO Da-cheng,CHEN Shi-lin,XIAO Pei-gen and PENG Yong</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1076E]]></guid><cfi:id>286</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[The Genus Gentianella Moench: A Phytochemical and Ethno- pharmacological Review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1077E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The plants in genus Gentianella Moench (Gentianaceae) which comprised approximately 250 species, are mainly distributed in temperate regions of the world. Many Gentianella plants are intensely bitter and employed in traditional medicine to stimulate appetite, treat disorders of the gallbladder, and treat fever like the other bitter gentians in various regions of the world. Some species exhibit other remarkable therapeutic effects in the treatments of obesity, diabetes, and heart diseases. Eleven iridoids, twenty-eight xanthones, three C-glucoflavonoids, and eight other compounds have been isolated from the genus. Most of these compounds are associated with antimicrobial, anti-inflammatory, anti-oxidant, hypoglycemic, and antitumor activities, which provide an empirical base for the traditional utilization of the plants in genus Gentinella Moench.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LI Min-hui,LI Li,YANG Yu-mei,ZHANG Na,SONG Xiao-ling and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Min-hui,LI Li,YANG Yu-mei,ZHANG Na,SONG Xiao-ling and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1077E]]></guid><cfi:id>285</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 I. Callicarpa Linn. and Related Items]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/zcy005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Callicarpa Linn. (beautyberry) is one of the major genera in Verbenaceous, about 20 of which are medicinal plants. Beautyberry, called Zizhu in China, is a generic name of those species and largely used as hemostatic medicine. The Chinese Pharmacopoeia 2010 has admitted three new crude drugs from the genus of Callicarpa Linn. including Callicarpae Macrophyllae Folium, Callicarpae Caulis et Folium, and Callicarpae Formosanae Folium for the first time since the 1977 version of the Chinese Pharmacopoeia. In order to better understand these new crude drugs, we systematically described their bibliography, admission reasons, botanical identification, chemistry, and pharmacology. Several other species, out of national regulations but intensively studied and widely used, are also covered in this review.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[DAN Yang,QIAN Zhong-zhi,LIU Yan-ze,ZHOU Guo-ping,PENG Yong and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>DAN Yang,QIAN Zhong-zhi,LIU Yan-ze,ZHOU Guo-ping,PENG Yong and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/zcy005]]></guid><cfi:id>284</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Application of Bioinformatics and Systems Biology in Medicinal Plant Studies]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1074E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[One important purpose to investigate medicinal plants is to understand genes and enzymes that govern the biological metabolic process to produce bioactive compounds. Genome wide high throughput technologies such as genomics, transcriptomics, proteomics and metabolomics can help reach that goal. Such technologies can produce a vast amount of data which desperately need bioinformatics and systems biology to process, manage, distribute and understand these data. By dealing with the “omics” data, bioinformatics and systems biology can also help improve the quality of traditional medicinal materials, develop new approaches for the classification and authentication of medicinal plants, identify new active compounds, and cultivate medicinal plant species that tolerate harsh environmental conditions. In this review, the application of bioinformatics and systems biology in medicinal plants is briefly introduced.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[DENG You-ping,AI Jun-mei and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>DENG You-ping,AI Jun-mei and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1074E]]></guid><cfi:id>283</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Reflecting the Steps of Modernization of Chinese Materia Medica from the Papers in Chinese Traditional and Herbal Drugs in 2009]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100628001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The publications on the journal of Chinese Traditional and Herbal Drugs in Vol.40, 2009 are briefly reviewed in the categories of chemical constituents, preparations and technologies, analysis and quality control, pharmacological and clinical studies, reviews, and finally healthy principles. Some comments, especially for hot topics have been personally provided.]]></description>
<pubDate>2010/11/2 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LIU Yan-ze,DAN Yang,PENG Yong and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LIU Yan-ze,DAN Yang,PENG Yong and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100628001]]></guid><cfi:id>282</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Bioactivities and Pharmaceutical Effects of 1-Aminocyclopro- panecarboxylic Acid]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1046C]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective  The 1-aminocyclopropanecarboxylic acid (ACPC) is a natural micromolecule non-protein amino acid  that exists only in plants. Despite the determination of its regulating effects on plants, several bioactivities and effects on animals or humans are still unclear. This review focuses the pharmaceutical effects，above all, the neuroprotective effects of ACPC on the cerebro- and cardiovascular system. Methods  Two hundred and seventy nine studies were selected and identified from a total of 2457 references in Medline and Chemical Abstracts from 1957 to 2008. Only 38 articles on neuroprotective effects of ACPC from seven different countries qualified to be included in the analysis. Results  ACPC has altogether following six general neuroprotective effects on the brain and nervous system: anti-neurotoxicity induced by NMDA, dynorphin-A, glutamate, and morphine; protection from cerebral neurological injury induced by ischemia; antidepressant and anxiolytic effects; anti-convulsion and -seizures and control of epilepsy; facilitation of spatial learning and memory; and the effect of reducing alcohol consumption. Conclusion  ACPC has shown a variety of effects on plants and animals. The bioactivities and pharmaceutical effects on animals are of great significance to medical research and public health. Further clinical trials or epidemiological studies are needed to determine its effect in humans. Food intervention with ACPC-rich vegetables and fruits may be a suitable therapy for cerebro- and cardiovascular system diseases. Administration of trace exogenous ACPC could produce vegetables and fruits of rich endogenous ACPC.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[ZHU Qin-wei,KRAEMER Alexander and ZHU Xu-xiang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZHU Qin-wei,KRAEMER Alexander and ZHU Xu-xiang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1046C]]></guid><cfi:id>281</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical Constituents and Biological Activities of Plants from Ehretia Linn.]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1065E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The plants of the genus Ehretia Linn. composed of about 50 species mainly distributed in tropical Asia and Africa. They have been used as folk medicines or traditional tea to treat various ailments in China for a long time. This contribution reviews the chemical constituents isolated from the plants of the genus Ehretia Linn. and related biological activities of these species in the past few decades. The compounds in the genus mainly belong to the classes of phenolic acids, flavonoids, benzoquinones, cyanogenetic glycosides, and fatty acids. The main biological activities include antioxidant, anti-inflammatory, antisnake venom, and anti-allergic activities.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LI Li,PENG Yong,YAO Xia,XU Li-jia,WULAN Ta-na,LIU Yong,SHI Ren-bing and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Li,PENG Yong,YAO Xia,XU Li-jia,WULAN Ta-na,LIU Yong,SHI Ren-bing and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1065E]]></guid><cfi:id>280</cfi:id><cfi:read>true</cfi:read></item>
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<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Strategies for Revitalization of Traditional Medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1034E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional medicine (TM) plays an inevitable role in drug discovery and development. Most of the therapeutically useful molecules used in the present day are inspired from TM. Herbal drugs are the oldest forms of medicines used for the treatment of various ailments and the TM of every country has a long history of their usage. To develop more data on their quality, safety, and efficacy, so also to improve the consumer’s need of modern days several thrust areas of research are to be focused on the development of TM. Based on the above concept, a paradigm shift is required for the revitalization of TM. These facts along with the modern scientific approaches, molecular tools, and strategies make it necessary for TM to be revitalized. Confluencing several strategies with the technological and scientific developments including pharmacogenomics, nutrigenomics, system biology, and related approaches, the scientific potential of TM can be explored further with international coordination and collaborations.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[MUKHERJEE Pulok K,PITCHAIRAJAN Venkatesh,MURUGAN Venkatesh,SIVASANKARAN Ponnusankar and KHAN Yaseen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>MUKHERJEE Pulok K,PITCHAIRAJAN Venkatesh,MURUGAN Venkatesh,SIVASANKARAN Ponnusankar and KHAN Yaseen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1034E]]></guid><cfi:id>279</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Ensuring Compliance of Raw Herbal Materials Stemmed from China with European Good Agricultural and Collection Practice]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110329002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[A “simplified” European procedure now allows the registration of traditional herbal medicines as medicinal products even without the support of clinical data. This procedure entails the requirement that those products comply with European Good Manufacturing Practice for medicinal products, which in turn implies that the raw herbal materials comply with the European Guidelines for Good Agricultural and Collection Practice. On the basis of a comparison between European Good Agricultural and Collection Practice and China Good Agricultural Practice, as well as direct observation made at sites in China, we issue some recommendations to facilitate good communication between the Chinese producer and European pharmaceutical customer, with a view to ensure full compliance with European expectations.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[ANDRE Philippe,SU Hao-bo and GAO Wen-yuan]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ANDRE Philippe,SU Hao-bo and GAO Wen-yuan</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110329002]]></guid><cfi:id>278</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New Progress in Modern Research on Chinese Herbal Medicines Published in Chinese Traditional and Herbal Drugs in 2010: Annual Highlights and Comments]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110727001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[As a series of and continuous publication, the papers published on Chinese Traditional and Herbal Drugs in 2010 were selectively and briefly highlighted to reflect the new progress on modern research of Chinese herbal medicines. Within 617 articles, chemical constituents (127), pharmaceutics and technology (149), pharmacological studies and clinical observation, and medicinal materials are still major categories. Some comments have also been personally provided.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[HE Chun-nian,LIU Yan-ze and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HE Chun-nian,LIU Yan-ze and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110727001]]></guid><cfi:id>277</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacological Effects of Mangiferin]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100801001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Mango leaves have been widely used in the clinical practice for thousands of years in traditional Chinese medicine. Mangiferin, an effective constituent in the mango leaves, has multiple pharmacological actions involved in some basic pathological processes, such as inflammation, oxidative injury, tumor growth, micro-organism infections, metabolic regulations, and immunological regulations. The pharmacological effects of mangiferin from some published data are reviewed in this article.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[WEI Zhi-quan,DENG Jia-gang and YAN Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>WEI Zhi-quan,DENG Jia-gang and YAN Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100801001]]></guid><cfi:id>276</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 II. Sankezhen (Berberis spp.)]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110607002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Sankezhen (Berberidis Radix) is a traditional Chinese materia medica, cold in nature and bitter in taste, for treating syndromes of liver, stomach, and large intestinal meridians, in which berberine and berbamine are the major pharmacological components. Sankezhen has been readmitted in Chinese Pharmacopoeia 2010 following the 1977 version as the roots of Berberis spp. e.g. B. soulieana, B. wilsonae, B. poiretii, B. vernae, etc. Recent studies showed that Berberis spp. were potential phytomedicines with multiple spectrums therapeutic effects and various pharmaceutical parts. Here we reviewed Sankezhen in traditional use and phytochemistry, and its major active components berberine and berbamine with potential bioactivities recently discovered, such as antitumor, antidiabetic, antihyperlipidemic, anti-arrhythmic, and neuro-protective activities. It is necessary to mature the quality assessment of Sankezhen as a new admission of Chinese Pharmacopoeia 2010. Other parts of Berberis spp. should be investigated to better develop this herb in medicinal usage.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[DAN Yang,LIU Yan-ze,PENG Yong,QIAN Zhong-zhi and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>DAN Yang,LIU Yan-ze,PENG Yong,QIAN Zhong-zhi and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110607002]]></guid><cfi:id>275</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Delineation on Therapeutic Significance of Transporters as Molecular Targets of Drugs]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201101]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Transporters are membrane proteins mediating permeation of organic and inorganic solutes through the plasma membrane and membranes of intracellular organella. They play essential roles in the epithelial absorption and cellular uptake of nutrients as well as absorption, distribution, metabolism, and excretion of drugs. Because transporters contribute to determining the distribution of compounds in the body in concert with metabolic/synthetic enzymes, the drugs that affect the functions of transporters are expected to alter the distribution of compounds in the body and to ameliorate disrupted homeostasis. In this context, drugs targeting transporters have been used clinically. Such drugs include antidepressants targeting monoamine transporters, diuretics targeting inorganic ion transporters of renal tubules, and uricosuric agents targeting renal urate transporters. Now new transporter-targeting drugs designed based on post-genome drug development strategy have been in the process of clinical trials or basic/clinical researches. For example, the inhibitors of renal Na+/glucose cotransporter SGLT2 have been proved for their efficacy in the treatment of diabetes mellitus. The cancer L-type amino acid transporter 1 (LAT1) has been considered as a target of cancer diagnosis and therapeutics. The transporter-targeting drugs are expected to provide new rationale in the therapeutics of various diseases.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[KANAI Yoshikatsu,HE Xin and LIU Chang-xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>KANAI Yoshikatsu,HE Xin and LIU Chang-xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201101]]></guid><cfi:id>274</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in Studies on Chemistry, Pharmacological Effect, and Pharmacokinetics of Eurycoma longifolia]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201102]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Eurycoma longifolia, also known as Tongkat Ali in Malaysia, as one of traditional herbal medicines, is used for centuries in South-East Asia. With the discovery of anticancer and anti-HIV properties, this herbal medicine has attracted great attention recently. In this review, the following information on E. longifolia, including chemistry, bioactivities, pharmacokinetics, clinical studies, and side effects and safety, was introduced. Our results, to a certain extent, will provide scientific base for commercial utilization and clearance of the Tongkat Ali products with regard to consumers’ safety.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[HOU Wen-bin,XIAO Xue-feng,GUO Wei and ZHANG Tie-jun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HOU Wen-bin,XIAO Xue-feng,GUO Wei and ZHANG Tie-jun</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201102]]></guid><cfi:id>273</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Review of Astragali Radix]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1090E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Astragali Radix (AR), known as Huangqi in China, is one of the most popular herbal medicines learnt worldwide to reinforce Qi (the vital energy). AR is traditionally prepared from the dried roots of Astragalus membranaceus or A. membranaceus var. mongholicus. It has been reported to have cardiotonic, hepatoprotective, hypotensive, immunostimulant, anti-aging, anti-oxidative, antidiabetic, and anti-inflammatory activities. The bioactive compounds were found to be flavonoids, saponins, polysaccharides, amino acids, and some trace elements. The present paper reviews the studies on AR including history, phytochemistry studies, pharmacological functions, and clinical application in recent years.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LIU Jing,ZHAO Zhong-zhen and CHEN Hu-biao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LIU Jing,ZHAO Zhong-zhen and CHEN Hu-biao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1090E]]></guid><cfi:id>272</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Key Techniques and Application Progress of Molecular Pharmacognosy]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1087E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[At the boundary between pharmacognosy and molecular biology, molecular pharmacognosy has developed as a new borderline discipline. This paper reviews the methods, application, and prospect of molecular pharmacognosy. DNA marker is one of genetic markers and some molecular marker methods which have been successfully used for genetic diversity identification and new medicinal resources development. Recombinant DNA technology provides a powerful tool that enables scientists to engineer DNA sequences. Gene chip technique could be used in determination of gene expression profiles, analyses of polymorphisms, construction of genomic library, analysis of mapping, and sequencing by hybridization. Using the methods and theory of molecular biology and pharmacognosy, molecular pharmacognosy represents an extremely prospective branch of pharmacognosy and focuses on the study of systemic growth of medicinal plants, identification and evaluation of germplasm resources, plant metabolomics and production of active compounds. Furthermore, the great breakthrough of molecular pharmacognosy could be anticipated on DNA fingerprint analysis, cultivar improvement, DNA identification, and a global DNA barcoding system in the future.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[XIAO Xue-feng,HU Jing,XU Hai-yu,GAO Wen-yuan,ZHANG Tie-jun and LIU Chang-xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>XIAO Xue-feng,HU Jing,XU Hai-yu,GAO Wen-yuan,ZHANG Tie-jun and LIU Chang-xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1087E]]></guid><cfi:id>271</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical and Pharmacological Researches on Hyoscyamus niger]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100513001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The reports on chemical constituents of Hyoscyamus niger were summarized. The compounds include alkaloids, saponins, lignans, coumarinolignans, flavonoids, and some other nonalkaloidal compounds. TLC, HPLC, and GC were used for the qualitative and quantitative analyses of some chemical constituents in H. niger. Modern pharmacological experiments showed that H. niger had the analgesic, anti-inflammatory, antipyretic, anticonvulsant, spasmolytic, antidiarrhoeal, antisecretory, bronchodilatory, urinary bladder relaxant, hypotensive, cardiosuppressant, vasodilator, antitumor, and feeding deterrent properties. In addition, the toxicities of this medicinal plant were also described.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LI Jun,SHI Ji,YU Xin-wen,SUN Jing-kuan,MEN Qi-ming and KANG Ting-guo]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Jun,SHI Ji,YU Xin-wen,SUN Jing-kuan,MEN Qi-ming and KANG Ting-guo</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100513001]]></guid><cfi:id>270</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[An Overview on the Progress of Chemical Constituents and Bioactivities of Plants in Urticaceae during 2000－2010]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100602001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Urticaceae includes about 1300 species in 47 genera which largely spread in wet tropical regions, and 341 species in 25 genera are in China. Some species are used in Chinese folk medicine. So far, studies on chemistry and pharmacology of Urticaceous plants are mainly focused on nettle of Urtica L. In this review, the chemical researches on 35 new compounds and related pharmacological effects of the plants in Urticaceae reported during 2000－2010 are described. The 35 new compounds belong to the classes of lignan, secolignan, norlignan, flavonoid, alkaloid, sesquiterpenoid, triterpenoid, sterol, and sphingolipid. The main bioactivities include cytotoxic, antitumor, antimicrobial, antifungal, anti-BPH, anti-HIV, antidiabetic, hypolipidemic, 5α-reductase inhibitory, hair regrowth promotion, and anti-oxidative activities.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[WANG Jian,YANG Hong-xing,TENG Yong-zhen,YUAN Pei,TIAN Rui and LIAO Chun-bi]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>WANG Jian,YANG Hong-xing,TENG Yong-zhen,YUAN Pei,TIAN Rui and LIAO Chun-bi</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20100602001]]></guid><cfi:id>269</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Quality Control Approaches for Chinese Herbal Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1061E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The current official quality control approaches meet the challenges from the complexity of herbal medicines. In fact, any herbal medicines containing numerous unknown components, its curative effect usually depends on the whole of herbal medicines, so it is impossible and unnecessary to qualitatively and quantitatively study every component. By investigating the limitations of current quality control approaches for herbal medicines and the difference and similarity in the chemical substantial style as well as quality control pattern of herbal medicines, a new quality control approach for Chinese herbal medicines should be explored and designed. The combination approach of chemical analysis with bioassay is promising to be developed and employed in order to ensure the safety and efficacy of Chinese herbal medicines.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[YUAN Hai-long,ZHANG Tian-tian and XIAO Xiao-he]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>YUAN Hai-long,ZHANG Tian-tian and XIAO Xiao-he</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1061E]]></guid><cfi:id>268</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Prevention and Treatment of Osteoporosis with Chinese Herbal Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110902001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In this paper, laboratory reports, medication rules, formulating principles, and research methods are summarized and analyzed, including single herb, compound herbs, and the problems in the prevention and treatment of osteoporosis (OP) within the past decade. With widely recognized efficacy, satisfying achievements have been achieved in preventing and treating OP with Chinese herbal medicines (CHM). However, due to the complex of constituents, the pharmacological activities and mechanism of CHM are not clear yet, and there is no unified standard on the diagnosis and syndrome differentiation of OP and the efficacy evaluation of CHM in the treatment. Accordingly, the research in the future should focus on the pharmacology and standardization of CHM in treating OP.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[ZHAO Xiao-ling,FENG Yu-xiong and PENG Yong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZHAO Xiao-ling,FENG Yu-xiong and PENG Yong</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110902001]]></guid><cfi:id>267</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research Status of Astragali Radix on Nerve Cells and Nerve System Diseases]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110329001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Astragali Radix has a wide application in the nerve system diseases because of its obvious nerve cell protection and recovery effects. Astragali Radix has good clinical effects both in acute and chronic cerebrovascular diseases and neurological degenerative diseases. This paper reviews the experimental and clinical research status of Astragali Radix on nerve system and nerve system diseases, which may promote its experimental research and clinical application.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LUAN Zeng-qiang,ZHAO Ping-li and CAO Wen-fu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LUAN Zeng-qiang,ZHAO Ping-li and CAO Wen-fu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110329001]]></guid><cfi:id>266</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New Collection of Crude Drugs in Chinese Pharmacopoeia 2010 III. Kadsurae Caulis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110722001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The dried cane of Kadsura interior (Kadsurae Caulis) is recorded in Chinese Pharmacopoeia 2010 as Dian Jixueteng for the treatment of rheumatism, irregular menstruation, and deficiency of Qi and blood. In this paper, morphological characteristics, chemical constituents, and pharmacological activities in the cane of K. interior were summarized. Moreover, some suggestions about application and quality control of Kadsurae Caulis were proposed in order to provide a theoretical basis for further scientific use.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[XU Li-jia,MA Pei,LI Li,WANG Wan-ying,XIAO Wei,PENG Yong and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>XU Li-jia,MA Pei,LI Li,WANG Wan-ying,XIAO Wei,PENG Yong and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110722001]]></guid><cfi:id>265</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in Isolation and Synthesis of Xanthone Derivatives]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110607001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Xanthone and its derivatives occupy a large part of the family of natural polyphenolic compounds with various biological and pharmacological activities. In recent years (from 2006 to 2011), it was reported that 127 xanthones were discovered from plants and fungi using various modern separation methods including silica gel/polyamide column chromatography, HPLC, high-speed counter-current chromatography, high-performance centrifugal partition chromatography, etc. Since total synthesis and structure modification for xanthone and its derivatives have been given attention worldwide, we introduced the synthetic methods of xanthone skeletons as well. Unfortunately, to date, there are still weaknesses in current methods of separation and synthesis, which need to be improved. This review, to a certain extent, provides necessary foundation for the further research and development of medicines containing xanthone and its derivatives.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[YANG Chun-hui,MA Li,WEI Zhen-ping,HAN Feng and GAO Jing]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>YANG Chun-hui,MA Li,WEI Zhen-ping,HAN Feng and GAO Jing</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110607001]]></guid><cfi:id>264</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemicals and Their Biological Activities of Plants in Tagetes L.]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110701001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Tagetes L., the genus in the family Asteraceae, consists of about 30 species spread in South and Middle America as well as Mexico. More than one hundred secondary metabolites have been obtained in phytochemical investigation on the species, some of which have potent biological activities. The advances in phytochemical studies and biological activities of the plants in Tagetes L. from 1925 to 2011 are summarized in this paper.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[XU Li-wei,CHEN Juan,QI Huan-yang and SHI Yan-ping]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>XU Li-wei,CHEN Juan,QI Huan-yang and SHI Yan-ping</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110701001]]></guid><cfi:id>263</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Recent Advance in Studies on Angelica sinensis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/2011112-5]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Angelicae Sinensis Radix (ASR) is the root of Angelica sinensis which is a fragrant and perennial herb native to China, Japan, and Korea. In traditional Chinese medicine (TCM), the plant is useful for replenishing and invigorating blood, relieving pain, and moistening the intestines, resulting in its application for the treatment of menstrual disorders, and as an emollient and laxative for chronic constipation of the aged and debilitated. An in-depth review of the literature brings to light a great number of chemical constituents that have been isolated from ASR as well as both preclinical (in vivo and in vitro) and clinical studies, which over the years, have sought to investigate the medicinal relevance of some of these phytoconstituents and/or extract(s) prepared from ASR. The purpose of this review is therefore to present some major pharmacological and pharmacokinetic research findings on some selected phytoconstituents of ASR with emphasis on the current trends in terms of research techniques or design. This review would also provide a wealth of information for users/practitioners of TCM regarding the use of ASR or its products for maximum efficiency and minimal toxicity or side effects.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[FANG Ling,XIAO Xue-feng,LIU Chang-xiao and HE Xin]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>FANG Ling,XIAO Xue-feng,LIU Chang-xiao and HE Xin</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/2011112-5]]></guid><cfi:id>262</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in Studies on Pharmacological Functions of Ligustilide and their Mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110610002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The article reviewed the research progress of ligustilide in recent years and elaborated its pharmacological functions and mechanisms in detail, especially in ischemic brain injury. Its mechanism includes reducing cerebral infarct volumes and improving neurobehavioral deficits, anti-oxidant and anti-apoptosis, antithrombotic activity, calcium channel blockers function, and effect on erythropoietin. Other pharmacological effects of ligustilide including inhibiting vascular smooth muscle cell proliferation, anti-inflammatory and analgesic effects, effects on LPS-induced endotoxic shock, inhibiting constriction effect, suppression of the central nervous system, and ameliorating the memory impairment induced by scopolamine and so on, are also introduced. Ligustilide has potential pharmacological value, which provides a reference for its further research and development.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[YANG Jin-ying,CHEN Hu-hu,WU Jiang,GONG Su-xiao,CHEN Chang-qing,ZHANG Tie-jun and WANG Min-jie]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>YANG Jin-ying,CHEN Hu-hu,WU Jiang,GONG Su-xiao,CHEN Chang-qing,ZHANG Tie-jun and WANG Min-jie</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20110610002]]></guid><cfi:id>261</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Status and Trends of GAP Base Construction of Chinese Materia Medica in Guangdong Province]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1067E]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[It is one of the key points for modernization and internationalization of traditional Chinese medicines to construct the Good Agricultural Practice (GAP) base of Chinese materia medica (CMM). GAP helps to minimize contamination and improve the quality of CMM during the plantation and the production of Chinese crude drugs. In this article, the status and development of CMM production bases of GAP in Guangdong Province, China, are presented. The suggestions upon the problems during the development of GAP for Chinese crude drugs are also provided.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[DING Ping,LAI Xiao-ping,XU Hong-hua,DU Qin,WANG Jian-gang,YING Ge,LIAO Hui-jun,DAI Lei and SHAO Yan-hua]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>DING Ping,LAI Xiao-ping,XU Hong-hua,DU Qin,WANG Jian-gang,YING Ge,LIAO Hui-jun,DAI Lei and SHAO Yan-hua</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM1067E]]></guid><cfi:id>260</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Use, Pharmacology, Toxicology, and Quality Control of Species in Genus Bupleurum L.]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201304001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Many species of genus Bupleurum L. have been pharmaceutically used mainly in Asia and Europe for thousand years. Their roots are the most popular ingredients in Chinese materia medica prescriptions for the treatment of inflammatory diseases and auto-immune diseases. A plenty of chemical constituents have been isolated and identified from the species in Bupleurum L., such as saikosaponins, polysaccharides, volatile oils, flavonoids, polyacetylenes, lignins, and coumarins, most of which possess a variety of biological activities, especially for the hepatoprotective effect, antitumor activity, immunoregulation, and febrifuge efficacy. Therefore, the species in genus Bupleurum L. could be potential herbs of immunomodulator, antineoplastic, anti-oxidant, etc. Meanwhile, as potential toxicities have been discovered in some constituents, it is urgent to establish a comprehensive quality evaluation system to ensure the safety and efficiency of herbs. This paper reviews on the phytochemical and pharmacological studies, especially for the toxicology and quality control of the species in Bupleurum L., which is a reference for the species in this genus for safe usage and further development.]]></description>
<pubDate>2013/11/15 10:48:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[YAO Ru-yu,ZOU Yuan-feng and CHEN Xing-fu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>YAO Ru-yu,ZOU Yuan-feng and CHEN Xing-fu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201304001]]></guid><cfi:id>259</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacophylogenetic Study on Plants of Genus Salvia L. from China]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201303001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In China, many species of genus Salvia L. (Lamiaceae) are important medicinal plants with a long history. Due to their marked ethnopharmacological uses in folk medicine and a large number of active constituents with therapeutic potential found recently, they have become a rich source for new drug discovery, mechanism research, and biological experiment. All medicinal plants of Salvia L. could be divided into three groups (Groups 1, 2, and 3). The plants in Group 1 were used as “Danshen” and are rich in diterpenoids and caffeic acid derivatives. Few introduced plants in Group 2 from America or Europe have been used to clear body-heat and toxins. Abietane diterpenes of medicinal species in Group 3 (the species are from Subg. Allagospadonopsis Briq., Sect. Plethiosphace, or Sect. Notiosphace) are absent, and the contents of caffeic acid derivatives are considerably lower than those in plants of Group 1.]]></description>
<pubDate>2013/8/17 18:57:33</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[LI Min-hui,LI Qian-quan,LIU Yan-ze,CUI Zhan-hu,ZHANG Na,HUANG Lu-qi and XIAO Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>LI Min-hui,LI Qian-quan,LIU Yan-ze,CUI Zhan-hu,ZHANG Na,HUANG Lu-qi and XIAO Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201303001]]></guid><cfi:id>258</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Recent Advance in Chemical and Biological Studies on Cimicifugeae Pharmaceutical Resources]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20121010001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cimicifugeae is one of the rich sources for various active components and the health promoting and therapeutic values of the components have been corroborated by long-term use in folk medicine and traditional Chinese medicine. Increasing interest in Cimicifugeae pharmaceutical resources has led to the further discoveries of triterpenoid saponins, phenolic compounds, chromones, and many other compounds in various species of Cimicifugeae, and to the investigations on their chemotaxonomy, molecular phylogeny, and bioactivities. Based on our pharmacophylogenetic studies, the progress in phytochemistry, chemotaxonomy, molecular biology, and phylogeny of Cimicifugeae had been summarized since 2007, especially Cimicifuga L. ex Wernisch. and Actaea L., and their relevance to therapeutic efficacy. An exhaustive literature survey is used to characterize the global scientific effort in the phytochemical and biological studies of Cimicifugeae. More triterpenoid saponins have been found in various species, among which the cimigenol type (type A) is predominant. The versatile bioactivities of saponins and extracts, as well as those of phenolics and other ingredients, were summarized and discussed. The morphology-based five-genus classification of Cimicifugeae is not supported by molecular phylogeny. Molecular phylogeny based on nuclear and chloroplast DNA sequences tends to merge Cimicifuga Wernisch., Souliea Franch., and Actaea L. into a single genus. It is indispensable to integrate the emerging technologies into Cimicifugeae research for both the sustainable utilization of Cimicifugeae pharmaceutical resources and finding novel compounds with potential clinical utility and less adverse effects. Systems biology and omics technologies would play an increasingly important role in booming pharmaceutical research involving bioactive compounds of Cimicifugeae.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[HAO Da-cheng,GU Xiao-jie,XIAO Pei-gen,LIANG Zhan-guo,XU Li-jia and PENG Yong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>HAO Da-cheng,GU Xiao-jie,XIAO Pei-gen,LIANG Zhan-guo,XU Li-jia and PENG Yong</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20121010001]]></guid><cfi:id>257</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Review of Rhubarbs: Chemistry and Pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201301]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Rhubarb is a perennial herb belonging to the genus Rheum L. (Polygonaceae). Rhei Radix et Rhizoma (rhubarb roots and rhizomes) is one of the most popular Chinese materia medica and has been widely used for strong laxative function. About 200 compounds with six different types of skeletons (anthraquinone, anthrone, stilbene, flavonoids, acylglucoside, and pyrone) have so far been isolated from eighteen species of the genus Rheum L. These constituents showed extensive pharmacological activities including cathartic, diuretic, anticancer, hepatoprotective, anti-inflammatory, and analgesic effects, as well as toxicological effects. Chemical fingerprint, LC-MS, and other analytical techniques have been used for the quality control of rhubarb. This comprehensive review summarizes the researches into the isolation, pharmacological activities, and phytochemical analysis reported since investigations began in the late 1940s. In addition, pharmacokinetic studies and clinical application of rhubarb are also discussed in present paper.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[ZHENG Qing-xia,WU Hai-feng,GUO Jian,NAN Hai-jiang,CHEN Shi-lin,YANG Jun-shan and XU Xu-dong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>ZHENG Qing-xia,WU Hai-feng,GUO Jian,NAN Hai-jiang,CHEN Shi-lin,YANG Jun-shan and XU Xu-dong</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201301]]></guid><cfi:id>256</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemistry, Pharmacology, Toxicology, and Structure-Cytotoxicity Relationship of Paridis Rhizome Saponin]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20120717001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The rhizomes of Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis are used as traditional herbal medicines in many parts of China. The Paridis Rhizome saponin (PRS), as the active ingredient, has played an important role in hemostasis, antibacterial action, and inflammation counteraction, bearing some analogy to Gongxuening and Yunnanbaiyao in efficacy. Modern pharmacological experiments have proved that PRS possesses two main sapogenins: diosgenin and pennogenin, which could provide a lot of clinical treatment effects (anti-oxidation, anti-inflammation, anti-apoptosis, anti-metastasis, and immunostimulant, etc.). In the past, several main steroid saponins have been studied in a number of randomized controlled trials for their effects and mechanisms mainly on antitumor performance. The extensive results have demonstrated that PRS was an effective group of active components to antitumor clinical trials. In this article, we reviewed the reported phytochemical, pharmacological, and toxicological properties of PRS and compared the structure-cytotoxicity relationship of PRS in antitumor effects.]]></description>
<pubDate></pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[MAN Shu-li,WANG Yan-li,LI Yuan-yuan,GAO Wen-yuan,HUANG Xian-xiao and MA Chao-yi]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>MAN Shu-li,WANG Yan-li,LI Yuan-yuan,GAO Wen-yuan,HUANG Xian-xiao and MA Chao-yi</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM20120717001]]></guid><cfi:id>255</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biopotency Assays, a Model with Integration Feature for Quality Control Research of CMM]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2014/11/12 16:19:17</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404001]]></guid><cfi:id>254</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biopotency Assays: an Integrated Application to Quality Control of Chinese Materia Medica]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The current quality control (QC) pattern for Chinese materia medica (CMM) lacks suitable methods and indicators to evaluate their safety and efficacy effectively, which impedes the smooth development of CMM. In this review, main problems of the current QC pattern for CMM, principally focused on the content determination of constituents, were summarized and the inspiration from the QC of biological products was introduced. With the aim at introducing a suitable tool to the QC of CMM, biopotency assay and its feasibility in the QC pattern for CMM were analyzed and confirmed by relevant researches with years of practice. From the applications of biopotency assays in the QC of CMM in the last 10 years, we propose that biopotency assays should be an integral part of the QC pattern for CMM, for these assays can make the QC indicators related to the clinical safety and efficacy, supplementing the existed QC system of CMM.]]></description>
<pubDate>2014/11/12 16:19:17</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yin Xiong,Dan Yan,Jia-bo Wang and Xiao-he Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yin Xiong,Dan Yan,Jia-bo Wang and Xiao-he Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404002]]></guid><cfi:id>253</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Use of Sargassum fusiforme Extract and its Bioactive Molecules to inhibit HIV Infection: Bridging Two Paradigms between Eastern and Western Medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[AIDS is a global pandemic that has seen the development of novel and effective treatments to improve the quality of life of those infected and reduction in the spread of the disease. While great advancements have been made in HIV/AIDS therapeutics, there is still no cure or viable vaccine in development. The high rate of HIV-1 mutation contributing to virus immune escape, combined with increase in sexual transmission and the significant clinical therapeutics side effects of the currently available treatments highlights the need for novel therapeutics with broad anti-viral activity against both CXCR4 (X4) and CCR5 (R5)-tropic viruses. In our search for novel modalities against HIV infection, we investigated several aqueous extracts from Traditional Chinese Medicine (TCM) collection and identified Sargassum fusiforme (S. fusiforme) as a potent inhibitor of HIV infection. Following the Western approach of drug discovery and development, we isolated several bioactive molecules from S. fusiforme and determined their mechanism of action. TCM and Western approaches to disease treatment and drug development have been shown to be complementary to each other. The former provides a rich medicinal history for natural compounds that can have clinical impact on a variety of illnesses, while the latter enables the application of chemical informatics with rational drug design approach coupled to mechanistic underpinnings of such therapeutics. This multistep paradigm is demonstrated in the example of S. fusiforme as a treatment to prevent HIV infection, as described in this review.]]></description>
<pubDate>2014/11/12 16:19:17</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hui-jun Guo,Yan-ze Liu,Elena E. Paskaleva,Manoj Arra,Jeffrey S. Kennedy,Alexander Shekhtman and Mario Canki]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hui-jun Guo,Yan-ze Liu,Elena E. Paskaleva,Manoj Arra,Jeffrey S. Kennedy,Alexander Shekhtman and Mario Canki</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404003]]></guid><cfi:id>252</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Antitumor Activities of Widely-used Chinese Herb—Licorice]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Licorice (the roots of Glycyrrhiza uralensis) is widely-used in Chinese herbal compound prescriptions for its functions of nourishing qi, alleviating pain, tonifying spleen and stomach, eliminating phlegm, relieving coughing, and harmonizing prescriptions. It contains more than 20 triterpenoids and approximately 300 flavonoids. In recent years, many studies have reported that it possesses various pharmacological activities, such as antitumor, antimicrobial, and antivirus effects. In this paper, the antitumor activity of licorice is deeply summarized. The antitumor active components and the possible antitumor mechanism are analyzed.]]></description>
<pubDate>2014/11/12 16:19:17</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Rui Yang,Li-qiang Wang and Ying Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Rui Yang,Li-qiang Wang and Ying Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201404004]]></guid><cfi:id>251</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Scientific and Practical Bio-analysis Method is Basic for TCM Pharmacokinetic Study]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201403001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2014/8/28 9:46:22</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201403001]]></guid><cfi:id>250</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical Constituents in Plants of Genus Kadsura Kaempf. ex Juss.]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201403002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Genus Kadsura Kaempf. ex Juss. includes important medicinal plants widely used in the south and southwest of China. The stems and roots are effective in activating blood and resolving stasis, promoting qi circulation to relieve pain, dispelling wind and eliminating dampness, in which lignans and triterpenoids are the major bioactive constituents. Here we summarized the chemical constituents isolated from genus Kadsura Kaempf. ex Juss., which would provide a primary and strategic platform for further exploiting the medicinal value and resources of genus Kadsura Kaempf. ex Juss.]]></description>
<pubDate>2014/8/28 9:46:22</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hai-tao Liu,Jiu-shi Liu,Jin Zhang,Yao-jie Guo,Yao-dong Qi,Xiao-guang Jia,Ben-gang Zhang and Pei-gen Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hai-tao Liu,Jiu-shi Liu,Jin Zhang,Yao-jie Guo,Yao-dong Qi,Xiao-guang Jia,Ben-gang Zhang and Pei-gen Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201403002]]></guid><cfi:id>249</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Correlation Analysis between Visceral Manifestation Theories on Xuanfa and Effect of Adrenergic Receptors]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201402001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese visceral manifestation theory states that lung dominates qi, regulates breathing, and governs Xuanfa (dispersing) and Sujiang (descending). Clarifying this theory with modern physiological and pathological knowledge has been considered as an important part of complementary and alternative medicine therapy. Previous studies found that most Xuanfa drugs contained pharmacodynamic ingredients related to adrenergic receptors (ARs) signal transduction. The association of Xuanfa, with the control of breath movement, nutrient transfer, spreading heat to regulate temperature, and helping the heart control blood circulation, coincides with the physiological function of organs dominated by ARs-regulated sympathetic postganglionic fibers. Therefore, we hypothesize that Xuanfa is closely related to ARs-regulated signal transduction. By modern biological knowledge, we tried to evaluate and expound the correlation between the molecular mechanisms of modern physiology or pathology and Xuanfa or Sujiang theory. Ultimately, the research and development of modern drugs should fully expect the guidance from Chinese visceral manifestation theory, and the application of this principle will guide the prevention and clinical treatment of a variety of refractory diseases caused by a change in environment, climate, or lifestyle.]]></description>
<pubDate>2014/5/12 9:56:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Gang Bai,Yuan-yuan Hou,Min Jiang and Jie Gao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Gang Bai,Yuan-yuan Hou,Min Jiang and Jie Gao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201402001]]></guid><cfi:id>248</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Chinese Medicine for Diminished Ovarian Reserve: A Systematic Review and Meta-analysis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201402002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective  To assess the effectiveness and safety of traditional Chinese medicine (TCM) for women with diminished ovarian reserve (DOR). Methods  A literature search was conducted in eight electronic databases for randomized controlled trials. Results  Seventeen randomized controlled trials involving 1174 patients were included. Meta-analysis indicated that TCM was superior to Western medicine (WM) in reducing basal serum FSH level [MD = -1.70, 95% CI (-2.63, -0.77); P = 0.0004] and FSH/LH  (MD = -0.43, 95% CI [-0.56, -0.30]; P = 0.0001), and the effect was more obvious two months after the last treatment (MD = -4.60, 95% CI [-6.26, -2.90], P < 0.000 01 and MD = -0.56, 95% CI [-0.85, -0.28], P = 0.0001), and increasing antral follicle count (AFC) (MD = 0.44, 95% CI [0.04-0.83]; P = 0.03). The review also revealed the positive role of CMM as an adjuvant to IVF-ET in improving pregnancy rate (PR = 1.75, 95% CI [1.25, 2.46]; P = 0.001). Conclusion  TCM, with its unique way of replenishing the kidney, may provide an effective and safe alternative therapy to patients with DOR.]]></description>
<pubDate>2014/5/12 9:56:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Tian Xia,Rui-hong Ma,Wei Mu,Meng-di Hu,Sai-hua Ma,Shu-wen Mao and Yu Fu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Tian Xia,Rui-hong Ma,Wei Mu,Meng-di Hu,Sai-hua Ma,Shu-wen Mao and Yu Fu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201402002]]></guid><cfi:id>247</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical Constituents of Plants from Tribe Chelidonieae and their Bioactivities]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201401001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The tribe Chelidonieae comprises 23 species of eight genera with an extensive distribution and a long medicinal usage history both in China and Western countries. A large number of chemical constituents have been isolated and identified from the species in tribe Chelidonieae, such as alkaloids, organic acids, and their derivatives, aromatics, triterpenoids, sterols, essential oils, and proteins, most of which possess a variety of bioactivities, especially for the antibacterial, anti-inflammation, antitumor, analgesia, anti-oxidation, and antiparasitic activity. Meanwhile, potential toxicities have been discovered in some constituents. Therefore, the species in tribe Chelidonieae have become a rich source for new drug discovery, biologic study, and mechanism research. This paper presents comprehensive information of the chemical constituents, pharmacological and toxicological research on the plants in tribe Chelidoieae, which is a reference for the plants in this tribe for further development.]]></description>
<pubDate>2014/2/14 13:48:49</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Qi-fang Lei,Xiao-ling Zhao,Li-jia Xu,Yong Peng and Pei-gen Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Qi-fang Lei,Xiao-ling Zhao,Li-jia Xu,Yong Peng and Pei-gen Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201401001]]></guid><cfi:id>246</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research Progress on Novel Carrier-modified Methods and Evaluation of Active Targeting Antitumor Preparation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201401002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[This article mainly introduced novel carrier-modified methods for active targeting antitumor preparation as well as their evaluation methodology in recent years. By reviewing related domestic and overseas literatures, the up-to-date scientific researches concerning active targeting antitumor preparation were elaborated and the problems existing in present studies were discussed. Numerous valid vector- embellished methods had been discovered with excellent targeting effects, and the significant progress was acquired for the evaluation tools in vitro and in vivo. The active targeting agent would be a major direction in prospective tumor or cancer therapeutic regimen.]]></description>
<pubDate>2014/2/14 13:48:49</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jun-jun Wang and Sheng-wu Huang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jun-jun Wang and Sheng-wu Huang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201401002]]></guid><cfi:id>245</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[<i>HMGR, SQS, β-AS</i>, and Cytochrome P450 Monooxygenase Genes in <i>Glycyrrhiza uralensis</i>]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150402]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[<i>Glycyrrhiza uralensis</i> is frequently used in traditional Chinese medicine. This plant contains a large amount of effective constituents, including triterpenoids and flavonoids. Among them, glycyrrhizin is believed to be the marker compound to evaluate the quality of <i>G. uralensis</i> based on <i>Chinese Pharmacopoeia</i>. Many studies showed that glycyrrhizin possesses various pharmacological activities, such as antibacterial, antiviral, antitumor, anti-inflammatory, and immune-stimulating activities. In this paper, we summarized the cloning, characterization, expression, and polymorphism analysis of several functional genes involved in glycyrrhizin biosynthesis in <i>G. uralensis</i>.]]></description>
<pubDate>2015/11/25 14:14:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Rui Yang,Bo-chuan Yuan,Yong-sheng Ma,Li-qiang Wang,Chun-sheng Liu and Ying Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Rui Yang,Bo-chuan Yuan,Yong-sheng Ma,Li-qiang Wang,Chun-sheng Liu and Ying Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150402]]></guid><cfi:id>244</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Systems Biology Application in Research on Sustainable Utilization of Chinese Materia Medica Resources]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150302]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[This paper reviews the progress of systems biology applied to researching on sustainable utilization of Chinese materia medica (CMM) resources in the following aspects: identification and evaluation of CMM resources, analysis of biosynthesis and their regulation of active ingredients in medicinal plants, metabolic engineering and synthetic biology research of medicinal plants, and molecular breeding of medicinal plants. Development of systems biology is currently leading to extremely broad applications in the field of CMM resources, and systems biology will become a significant approach for the sustainable utilization of CMM resources.]]></description>
<pubDate>2015/8/19 15:08:59</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Sheng Wang,Hai-yu Xu,Lan-ping Guo,Lu-qi Huang and Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Sheng Wang,Hai-yu Xu,Lan-ping Guo,Lu-qi Huang and Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150302]]></guid><cfi:id>243</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemistry and Ethnopharmacology of <i>Epimedium</i> L. Species]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150303]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[<i>Epimedii Folium</i>, a famous Chinese materia medica, is botanically originated from <i>Epimedium</i> L. species. Here<i> Epimedium </i>L. species were reviewed in phytochemistry, ethnopharmacology, ADME (absorption, distribution, metabolism, and excretion), and processing. They have been proven to possess the efficacy on anti-osteoporosis, antitumor, and treating sexual dysfunction in traditional Chinese medicines. More than 270 compounds have been isolated from the plants of <i>Epimedium</i> L., some of which could be metabolized into a series of metabolites after oral absorption by the active enzymes and intestinal microflora leading to various bioactivities. Polyglucosides (epimendins A-C) and the coresponding oligoglycosides (icariin and baohuoside I) play important roles in clinical application.]]></description>
<pubDate>2015/8/19 15:08:59</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jun Jiang,Jie Song and Xiao-bin Jia]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jun Jiang,Jie Song and Xiao-bin Jia</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/20150303]]></guid><cfi:id>242</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Correlation of Metabolism, Metabolomics, and Metabonomics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Li-da Tang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Li-da Tang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502001]]></guid><cfi:id>241</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemistry, Metabolism, and Metabolomics of Ginseng]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ginseng, as a medicinal plant, has been used for thousands of years in China, Korea, and Japan, and the study on ginseng is a hotspot in the research field as evidenced by about 7000 scientific papers in PUBMED. In recent decades, many ginseng studies focused on the metabolism and metabolomics of ginseng or its active ingredients using modern bioanalytical technologies. To date, more than 200 ginsenosides and non-saponin constituents have been isolated and identified. In the past decades, rapid development of analytical technologies has facilitated the advancement of ginseng research in many ways. In this review, we focus on the advances of ginseng research in chemistry, pharmacology, and metabolomics. We also provide the comments on the significance as well as challenges of metabolomics-based ginseng studies.]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiao-peng Chen1,2,Yan-ping Lin1,Yao-zhong Hu3,4,Chang-xiao Liu5,Ke Lan6 and Wei Jia6]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiao-peng Chen1,2,Yan-ping Lin1,Yao-zhong Hu3,4,Chang-xiao Liu5,Ke Lan6 and Wei Jia6</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502002]]></guid><cfi:id>240</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Metabolism of Chinese Materia Medica in Gut Microbiota and Its Biological Effects]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The drug metabolism in gut microbiota draws increasing attentions. After interacting with the gut bacteria, the biological effects of drugs might be altered, leading to toxicity or detoxification, production of potential bioactivities, regulating intestinal absorption, etc. In this review, we will focus on the metabolism of Chinese materia medica (CMM) in mammal gut microbiota and its biological effects to learn the interaction between gut bacteria and drugs through oral route in CMM.]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yan Wang,Jia-wen Shou and Jian-dong Jiang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yan Wang,Jia-wen Shou and Jian-dong Jiang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502003]]></guid><cfi:id>239</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in Transcriptomic Studies and Ginsenoside Biosynthesis of American Ginseng]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[American ginseng (Panax quinquefolius L.), belonging to the Araliaceae family, is one of the most widely used traditional herbs in the world. Its major bioactive constituents are triterpene saponins known as ginsenosides. Up to date, it is still a big challenge to sequence and assemble the large and repeat-enriched genome of tetraploid American ginseng, using whole genome shotgun (WGS) sequencing strategy. The lack of American ginseng genome information has significantly impeded its genetic and functional genomic studies. With the development of next-generation sequencing (NGS) technologies, sequencing and analysis of transcriptomes have become powerful tools for the discovery of novel genes and elucidation of specific biosynthetic pathways of secondary metabolites. Here we summarized the recent advances in the transcriptomic studies of American ginseng, including high-throughput transcriptome sequencing, assembly, and functional gene annotation and classification. Based on the results of transcriptomic data mining and co-expression analyses, many candidate genes possibly involved in the biosynthetic pathway of ginsenosides have been found, thereby providing an unparalleled opportunity to fully understand the mechanism of ginsenoside biosynthesis and its regulations in American ginseng. Advances in transcriptomic studies will contribute to the molecular breeding and planting management of American ginseng and to the development of novel ginsenoside-type drugs.]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Li-qiu Zou,Xue-jun Kuang and Chao Sun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Li-qiu Zou,Xue-jun Kuang and Chao Sun</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502004]]></guid><cfi:id>238</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Microsatellite Development and Potential Application in Authentication, Conservation, and Genetic Improvement of Chinese Medicinal Plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants are popular and widely used as a major source of herbal drugs and pharmaceutical compounds. Ever-growing demands make medicinal plants faced to several problems including efficacy and safety to meet business requirements, conservation, and artificially assisted breeding. As a powerful molecular tool, microsatellites offer the great potentials for various purposes in plants. This review provides a scenario of microsatellites in medicinal plants including development from genomic or expressed sequence tag libraries, cross-species transferability, genotyping, and potential applications. We emphasized on the authentication of medicinal plants by microsatellite markers.]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jian-jun Chen 1 and Ying Wang 1, 2, 3*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jian-jun Chen 1 and Ying Wang 1, 2, 3*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502005]]></guid><cfi:id>237</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Cistanches Herba : Chemical Constituents and Pharmacological Effects]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cistanches Herba, known as ‘‘Ginseng of the desert’’, is authenticated from the dried succulent stems of Cistanche deserticola and Cistanche tubulosa. As a famous remedy in China for tonic the kidney, it is used to treat “kidney-deficiency syndrome”-induced diseases such as infertility, forgetfulness, hearing lost, chronic constipation, etc.. As various biological activities, including anti-aging, antioxidant, estrogenic, anti-osteoporotic, and anti- inflammation effects, have been discovered, here we reviewed Cistanches Herba in biological characteristics, chemical constituents, and pharmacological activities.]]></description>
<pubDate>2015/5/25 11:22:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lin–lin Wang,Hui Ding,He–shui Yu,Li-Feng han,Qing-hai Lai,Li-juan Zhang and Xin-bo Song]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lin–lin Wang,Hui Ding,He–shui Yu,Li-Feng han,Qing-hai Lai,Li-juan Zhang and Xin-bo Song</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201502006]]></guid><cfi:id>236</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Integrated Network Research will Advance Traditional Chinese Medicine Innovating Development]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2015/2/26 17:16:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liang Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liang Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501001]]></guid><cfi:id>235</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network Pharmacology Bridges Traditional Application and Modern Development of Traditional Chinese Medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicine (TCM) has developed over thousands of years and has accumulated abundant clinical experience, forming a comprehensive and unique medical system. Emerging evidence has begun to illustrate TCM as an area of important medical rediscoveries. This review article briefly introduced the concept, significance, and technology of network pharmacology based on network biology and systems biology. It focused on the theoretical system and potential prospect of TCM network applied in TCM research and development including predicting new drug targets, action mechanism, new drug discovery; evaluating pharmacodynamics, pharmacokinetics, safety, toxicology, quality control, and bioinformatics of drugs. We also discussed the opportunities and challenges in the development and application of network pharmacology in the modernization of TCM research.]]></description>
<pubDate>2015/2/26 17:16:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu,Rui Liu,Hui-rong Fan,Xue-feng Xiao,Xiao-peng Chen,Hai-yu Xu and Yan-ping Lin]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu,Rui Liu,Hui-rong Fan,Xue-feng Xiao,Xiao-peng Chen,Hai-yu Xu and Yan-ping Lin</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501002]]></guid><cfi:id>234</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network Pharmacology for Traditional Chinese Medicine Research: Methodologies and Applications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The inception of network pharmacology comes from the advance in “multi-target, multi-drug” paradigm and opens up a new field for pharmaceutical science. Traditional Chinese medicine (TCM) is well-known for its use of medicinal herb combinations to treat the functional disorders induced by diseases through a holistic view, which naturally followed the principal of network pharmacology. In this review, the methodologies of network pharmacology in TCM studies were summarized. Specifically, the methodologies for network construction and network analysis were discussed in detail by following several TCM study cases. The perspectives for TCM network pharmacology were also provided.]]></description>
<pubDate>2015/2/26 17:16:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yu-feng Liu,Ni Ai,Anthony Keys,Xiao-hui Fan and Min-jun Chen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yu-feng Liu,Ni Ai,Anthony Keys,Xiao-hui Fan and Min-jun Chen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501003]]></guid><cfi:id>233</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Development and Application of Network Toxicology in Safety Research of Chinese Materia Medica]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Network toxicology that is an important branch of the network pharmacology emerges on the basis of network biology. It refers to study on the toxicological features of a constructed network model which is used to analyze toxic substances and their interaction and regulation in biological systems, particularly investigate the toxic effects of drugs and/or compatibility of medicines on body, and clarify the mechanism of toxicity. Network toxicology currently develops rapidly in safety prediction of Chinese materia medica (CMM). The application of network toxicology to safety and toxicology study on CMM is extremely beneficial to identify the toxic components and potential incompatibility of CMM. Since CMM is a complex system with multi-components, multi-targets, and multi-interactions, the network toxicology in safety prediction of CMM faces three great challenges, including integration studies of bioinformatics, innovation of methods, and tools and risk assessment in future development of the network toxicology in CMM research. In this paper, relevant database, approaches and tools that network toxicology utilized in the safety study of CMM were carefully reviewed. Based on the progress made, the scientific development and modernization of CMM will be greatly enhanced.]]></description>
<pubDate>2015/2/26 17:16:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xing Zhang,Hui-rong Fan,Ya-zhuo Li,Xue-feng Xiao,Rui Liu,Jing-wen Qi,Jie Wang,Zong-peng Zhang,Chang-xiao Liu and Xiu-ping Shen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xing Zhang,Hui-rong Fan,Ya-zhuo Li,Xue-feng Xiao,Rui Liu,Jing-wen Qi,Jie Wang,Zong-peng Zhang,Chang-xiao Liu and Xiu-ping Shen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201501004]]></guid><cfi:id>232</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinmedomics Builds a Bridge from Traditional to Modern Research of Traditional Chinese Medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective  Pinoresinol di-glucopyranoside (PDG) is one of the main active lignans ingredients of Eucommiae Cortex considered to be a high-quality antihypertensive drug. In this study the pharmacokinetic process of PDG and its primary in vivo metabolite PG in the portal and jugular vein were surveyed and evaluated simultaneously. Methods  A sensitive high-performance liquid chromatography coupled with tandem quadruple mass spectrometry (HPLC-MS/MS) method and sample preparation protocol were developed and validated in method of selectivity, sensitivity, precision, stability, and extraction recovery for the simultaneous determination of PDG and its primary metabolite pinoresinol glucoside (PG) in rat plasma.The double intubation technique was used to simultaneously collect blood from common jugular vein and hepatic portal vein after single ig administration of PDG. Results  Using this method, the quantification linearity ranges of PDG and PG in rat plasma were both 0.05-100 ng/mL.This method was successfully applied to the evaluation of the absolute oral bioavailability of PDG and determination of the pharmacokinetic properties of PDG and PG after ig administration of single dose in rats. The bioavailability of PDG at common jugular vein ws 51.3% compared to that of 91.6% at hepatic portal vein. Conclusion  We conclude that liver is the major conversion site of PDG to PG.]]></description>
<pubDate>2016/10/13 10:54:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604001]]></guid><cfi:id>231</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinmedomics: Newer Theory and Application]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The scientific interpretation of the effectiveness of traditional Chinese medicine (TCM) is a communication channel between Chinese medicine and modern medicine. The evaluation of TCM efficacy is an important prerequisite for discovering active constituents. Therefore, there is an urgent need to establish a biological language for scientific explanation of the effectiveness of TCM, and modern scientists can further accept the significant value of TCM theory and its clinical practice. The syndrome and corresponding formulation are two important parts in TCM, and they are directly related to the effectiveness of TCM. Our team has taken syndrome and formulation as the research objects, integrated serum pharm-chemistry of TCM with metabolomics technology, developed a new platform termed Chinmedomics, which is capable of evaluating effectiveness of TCM and discovering the syndrome biomarkers as well as the effective substances. The correlation between the endogenous biomarkers of syndrome and exogenous constituents of formulation is analyzed to find the highly associated compounds as the effective substances, and further clarifying their activities, and may discover lead compounds. This effective strategy could speed the drug discovery from natural resources. This article systematically introduced the establishment and application of Chinmedomics theory, in order to provide references for studies on TCM, and some characteristic examples are presented to highlight the application of this new strategy for discovering the potential active constituents of TCM.]]></description>
<pubDate>2016/10/13 10:54:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xi-jun Wang,Ai-hua Zhang,Hui Sun and Guang-li Yan]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xi-jun Wang,Ai-hua Zhang,Hui Sun and Guang-li Yan</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604002]]></guid><cfi:id>230</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Clinical Implementation of Arsenic Trioxide]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Introduction of arsenic trioxide (ATO, As2O3) to the treatment of acute promyelocytic leukemia in the 1970s enlightened an effective treatment approach for the disease. Decades later, knowledge on this agent’s further functions has rapidly advanced so that it has entered common use in hematology and oncology. In addition, As2O3 reportedly induces DNA and chromosomal damage, inhibits DNA repair, and alters DNA methylation in mammalian cells. The compound is becoming increasingly reasonable as a treatment modality to rectify genetic blood disorders and other cancer types. Nevertheless, limitations of As2O3 typically emerged from drug resistance, adverse effects and secondary tumors, which may result in a myriad of outcomes. Though prolonged exposure to As2O3 ensues poisons and genome alternations that do not permanently change the DNA sequence, other synergistic alterations should be considered as replacement. In this review, we recollect the discovery and clinical implementation of As2O3, describe its advantages and shortcomings for leukemia and solid cancer treatment, and consider future prospects for engendering useful impacts.]]></description>
<pubDate>2016/10/13 10:54:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lu-yao Sun1,Hong Wang1 and Jin Zhou1, 2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lu-yao Sun1,Hong Wang1 and Jin Zhou1, 2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201604003]]></guid><cfi:id>229</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Implementation of Pharmacopoeia Regulations]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2016/7/21 17:23:32</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-Xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-Xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603001]]></guid><cfi:id>228</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Revision and Improvement of Criterion on Traditional Chinese Medicines in Chinese Pharmacopoeia 2015]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese Pharmacopoeia is updated every five years, of which traditional Chinese medicine (TCM) is the most important part. The 2015 version completed by the 10th Pharmacopoeia Commission has come into operation since December 1, 2015. Here we introduced the revision and improvement of quality evaluation and control standards of TCMs in Chinese Pharmacopoeia 2015.]]></description>
<pubDate>2016/7/21 17:23:32</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yang Dan1,Zhong-zhi Qian2,Yong Peng1,Chang-qing Chen3,Yan-ze Liu1,Wen Tai3 and Jing-wen Qi3]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yang Dan1,Zhong-zhi Qian2,Yong Peng1,Chang-qing Chen3,Yan-ze Liu1,Wen Tai3 and Jing-wen Qi3</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603002]]></guid><cfi:id>227</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Genus Ilex L.: Phytochemistry, Ethnopharmacology, and Pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The genus Ilex L. has been used as remedies in traditional Chinese medicine in Aquifoliaceae and beverages for thousands of years due to abundant pharmaceutical bioactivities. There are 600 species in genus Ilex L. containing various compounds such as terpenoids, saponins, glycosides, etc. Three species, I. cornuta, I. chinensis, and I. rotunda have been admitted in Chinese Pharmacopoeia 2015 to treat dyspepsia, stomatitis, and hyperactivity cough and protect the liver and kidney. Recent studies showed that several species have been daily drunk to promote human health and prevent cardiovascular diseases in the folk. Here we reviewed the genus Ilex L. in phytochemistry, ethnopharmacology, and pharmacology.]]></description>
<pubDate>2016/7/21 17:23:33</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fan Yi,Xiao-ling Zhao,Yong Peng and Pei-gen Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fan Yi,Xiao-ling Zhao,Yong Peng and Pei-gen Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201603003]]></guid><cfi:id>226</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Systems Biology Strategy in Chinese Materia Medica Research]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2016/4/28 14:29:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wei-dong Zhang and Chang-Xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wei-dong Zhang and Chang-Xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602001]]></guid><cfi:id>225</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Integrated Systems Biology and Chemical Biology Approach to Exploring Mechanisms of Traditional Chinese Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[After thousands of years of development, traditional Chinese medicines (TCMs) have evolved into a complete scientific system characterized by multiple components, targets, and pathways, which mediates numerous pharmacological activities and efficacies. The development of “-omics” technology, including systems biology and network pharmacology, has enabled the illustration of TCMs from a more systematic view. Although the network adequately reflects the overall philosophy of TCMs, its complexity hinders the relevant research to a hover. In addition, the strategies involved appear to be in contrast to the original concise and efficacious disease therapy oriented focus on classic Chinese material medica (CMM). Based on the established holistic view and reductionism, in this review, we discuss an integrated systems biology and chemical biology research approach that will facilitate and accelerate the understanding of the mechanisms of TCMs. Furthermore, we are optimistic that it will elucidate the associated interactions between active natural products and their targets, and ultimately improve the strategies for complex disease therapies.]]></description>
<pubDate>2016/4/28 14:29:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Gang Bai,Yuan-yuan Hou,Min Jiang and Jie Gao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Gang Bai,Yuan-yuan Hou,Min Jiang and Jie Gao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602002]]></guid><cfi:id>224</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network Pharmacology-based Approaches Capture Essence of Chinese Herbal Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese Medicine (TCM), a crucial component of the current medical system, has been extensively used in clinical practice due to its valuable therapeutic efficacy, and its potentials as an important source of new pharmacophores. TCM is characterized by holistic theory, which emphasizes maintaining the balance of the patient’s whole body using herbal formulae (fangji in Chinese) composed of mixtures of herbs with multiple bioactive ingredients. Because of the complex nature of these formulae, it is necessary to develop systematic methods to identify their bioactive ingredients and to clarify their mechanisms of action. With the rapid progress in bioinformatics, systems biology, and polypharmacology, “network pharmacology”, which shifts the “one target, one drug” paradigm to the “network target, multi-component” strategy, has attracted the attention because it can not only reveal the underlying complex interactions between a herbal formula and cellular proteins but detect the influence of their interactions on the function and behavior of the system. Growing evidence shows that the network pharmacology strategy can be a powerful approach to modern research on TCM. The present paper focuses on the basis of network pharmacology and the recent progress in its methodology, illustrates its utility in screening bioactive ingredients and elucidating the mechanisms of action of TCM herbal formulae, analyzes its limitations and problems, and discusses its development direction and application prospects.]]></description>
<pubDate>2016/4/28 14:29:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yan-qiong Zhang1,Xia Mao1,Qiu-yan Guo1,Na Lin1 and Shao Li2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yan-qiong Zhang1,Xia Mao1,Qiu-yan Guo1,Na Lin1 and Shao Li2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602003]]></guid><cfi:id>223</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Application of Connectivity Map Database to Research on Chinese Materia Medica]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The connectivity map (CMAP) database is established initially to connect biology, chemistry, and clinical conditions, which helps to discover the connection of disease-gene-drug. The CMAP approach has been applied in the field of drug discovery and development, which is widely recognized. In recently years, CMAP analysis has been applied in the research on Chinese materia medica (CMM). The study of CMM is facing a wide range of challenges, such as complicated ingredients, multiple targets, multiple pathways of action and complex functioning mechanism. The idea of employing CMAP in the CMM research has brought a new perspective for researchers and provides a systematic method for elucidating the mechanism of CMM.]]></description>
<pubDate>2016/4/28 14:29:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chao Lv1, 2,Yu-chong Wang1,Run-hui Liu1 and Wei-dong Zhang1]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chao Lv1, 2,Yu-chong Wang1,Run-hui Liu1 and Wei-dong Zhang1</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602004]]></guid><cfi:id>222</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in Study on Three-dimensional Printing in Pharmaceutics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Three dimensional printing (3DP) is a solid freeform fabrication technology which employs powder processing and a liquid binder material in the construction of parts in a layer-wise manner. 3DP can accommodate much geometric outline and be made with many materials due to its unprecedented flexibility. The technology can control over the material composition, microstructure and surface texture so it attracts great attentions in the pharmaceutics field. 3DP can offer many novel strategies and approaches for the research and is widely focused in the field of the controlled-release drug delivery systems. Through consulting a large number of documents the current development and the technical characteristics of 3DP in pharmaceutics field are discussed and reviewed. It is expected that 3DP technique may play a tremendous role in pharmaceutics field in the future.]]></description>
<pubDate>2016/4/28 14:29:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fang Zheng and Sheng-wu Huang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fang Zheng and Sheng-wu Huang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201602005]]></guid><cfi:id>221</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Medicinal Model Plants: Breaking the Traditional Medicine Research Methods]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2016/1/28 16:54:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601001]]></guid><cfi:id>220</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biosynthesis and Regulation of Active Compounds in Medicinal Model Plant Salvia miltiorrhiza]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Natural products from plant secondary metabolits are a major source of clinical drugs and industrial chemicals. Salvia miltiorrhiza is one of the most important plants in traditional Chinese medicine. Its dried roots and rhizomes are highly valued for use in the treatment of vascular diseases and for their anti-oxidative activities. Furthermore, S. miltiorrhiza is described as a medicinal model plant mainly due to its biosynthesis of active compounds. Here, we reviewed the research on S. miltiorrhiza in genomics, transcriptomics, biosynthesis of tanshinones and phenolic acids, biotic and abiotic elicitors, and regulation of transcription factors. This will provide a solid foundation for new breeding and synthetic biology approaches to produce and study natural products.]]></description>
<pubDate>2016/1/28 16:54:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zhi-chao Xu,Ai-jia Ji,Xin Zhang,Jing-yuan Song and Shi-lin Chen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zhi-chao Xu,Ai-jia Ji,Xin Zhang,Jing-yuan Song and Shi-lin Chen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601002]]></guid><cfi:id>219</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacology and Clinical Application of Plants in Epimedium L.]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Herba Epimedii is widely used as a traditional Chinese medicine for “strengthening the kidney” and “reinforcing bone” for a long time in China and other Asian countries. In this study, based on the large number of domestic and international references and research results, the authors reviewed pharmacological effects and the clinical application of species in genus Epimedium L. Meanwhile, chemical conversion and biotransformation of the major active compounds during the processing of the plants in Epimedium L. and their metabolism in vivo were summarized. This provides a guidance for the application and development in clinical therapy in the future.]]></description>
<pubDate>2016/1/28 16:54:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jun Jiang,Bing-jie Zhao,Jie Song and Xiao-bin Jia]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jun Jiang,Bing-jie Zhao,Jie Song and Xiao-bin Jia</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601003]]></guid><cfi:id>218</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytopharmacological Review on Vitex agnus-castus:  A Potential Medicinal Plant]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Vitex agnus-castus is a small tree or shrub, belonging to the family Verbenaceae. It is a deciduous shrub native to European, Mediterranean, and Central Asian countries. V. agnus castus has a long tradition as a herbal remedy and was used in ancient times not only as an anaphrodisiac but also against diverse disturbances of the female genital system. The major constituents in V. agnus-castus are flavonoids, essential oils, diterpenes, and glycosides. The flavonoids (casticin, quercetagetin, and isovitexin) have been shown in vitro to affect estrogen receptors. V. agnus-castus could be used to treat acne, digestive complaints, menstrual irregularities, premen-strual syndrome (PMS), mastalgia, and infertility, and also for lactation support. Although V. agnus-castus has been used for centuries and enjoys wide support from practitioners and the general public for many gynecological com-plaints, few clinical studies support its documented uses. The presence of phytochemical and pharmacological activities has proved that the plant has a leading capacity for the development of new good efficacy drug in future.]]></description>
<pubDate>2016/1/28 16:54:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hina Zahid,Ghazala H. Rizwani and Sumaira Ishaqe]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hina Zahid,Ghazala H. Rizwani and Sumaira Ishaqe</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201601004]]></guid><cfi:id>217</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Determination of Quality Markers is Basis for Establishing Quality Standard and Control of Chinese Herbal Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201704001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2017/10/17 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201704001]]></guid><cfi:id>216</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Gut Microbiota Brings a Novel Way to Illuminate Mechanisms of Natural Products in vivo]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201704002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Poor bioavailability and undefined major/direct targets are two major obstacles for herbal medicines and natural products (NPs) to elucidate their precise mechanisms in vivo. Gut microbiota is an important bridge between eukayotic body and environment, which can interact with a majority of medicines with poor bioavailability and mediate their in vivo pharmacological activities. There are two main modes through which gut microbiota may mediate the pharmacological effects of NPs. First, gut microbiota catabolizes the NPs in herbal medicines into secondary metabolites with higher bioavialability and/or higher activity, facilitating the NPs enter circulation and exert beneficial impact at the pathological spot. Second, herbal medicines and NPs can favorably shift the compositional structure of gut microbiota, thereby performing remote functions to diseased organs/tissues via the systemic impaction of gut microbiota. In this review, the potential pathways were summarized through which gut microbes facilitate the pharmacological functions of herbal medicines and NPs and highlight the significance of gut microbiota in clarifying the in vivo mechanisms of herbal medicines and NPs.]]></description>
<pubDate>2017/10/17 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Peng Guo and Chong-ming Wu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Peng Guo and Chong-ming Wu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201704002]]></guid><cfi:id>215</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Looking forward to the Future to Meet the Challenge: Research for Rhizosphere Microbes and Mocrobiome of Medicinal Plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201703001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2017/8/9 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201703001]]></guid><cfi:id>214</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Rhizosphere Microbiota and Microbiome of Medicinal Plants: From Molecular Biology to Omics Approaches]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201703002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The rhizosphere is a narrow region of soil that is directly influenced by roots and associated soil microorganisms. Research on rhizosphere microbes of various medicinal plants is essential for microbial ecology, applied microbiology and industrial biotechnology with regard to the sustainable utilization of Chinese medicinal resources. However, the inability of culturing most rhizosphere microorganisms (around 99%) in the laboratory obviates the research progress. In recent years, there is enormous advances in applying non-culturing techniques based on molecular biology and omics to the study of rhizosphere microbial diversity and plant-microbe interactions. DGGE, T-RFLP, ARDRA, DNA cloning and Sanger sequencing are still useful in the rhizosphere studies, while various omics tools, such as FISH, SIP, microarray, next generation sequencing (NGS), etc., evolve quickly to provide more comprehensive understanding of the rhizosphere microbiota and microbiome. Flexible applications of NGS technologies are here exemplified, e.g., amplicon sequencing, metagenomic sequencing, whole genome sequencing, and transcriptome sequencing, which address the biology and biotechnology potentials of the rhizosphere microbiome of medicinal plants. This review discusses recent findings and future challenges in the study of rhizosphere microbes, highlighting medicinal plant rhizosphere study, evolution of research methods, and innovative combinations of novel high-throughput techniques. The top-down approaches such as metagenomics and bottom-up approaches targeting individual species or strains should be integrated and combined with modeling approaches to afford a wide-ranging understanding of the microbial community as a whole.]]></description>
<pubDate>2017/8/9 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Da-cheng Hao1 and Pei-gen Xiao2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Da-cheng Hao1 and Pei-gen Xiao2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201703002]]></guid><cfi:id>213</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Plant Tissue Culture and Biosynthesis Provide a Fast Way to Produce Active Constituents of Traditional Chinese Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2017/5/2 17:04:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702001]]></guid><cfi:id>212</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Discovery and Development of Artemisinin and Related Compounds]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Artemisinin is isolated from the plant Artemisia annua, sweet wormwood, an herb employed in traditional Chinese medicine. Prof. You-you Tu discovered artemisinin in the 1960s, so she was awarded the 2015 Nobel Prize in Physiology or Medicine. Artemisinin and its semi-synthetic derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria. In this review, the author investigated history on discovery of artemisinin, ethnopharmacology of Artemisia plants, chemistry and pharmacological activities of the relative compounds, and introduced Tu and other Chinese and world scientists’ contribution, development of artemisinin and the related compounds and registered and marketed artemisinin drugs in China, UK, and USA. The author also recalled the studies on the mechanism of action of artemisinins and artemisinin combination therapies and summed up the resistance issues. In Current Recommendations and the Global Plan for Insecticide Resistance Management in Malaria Vectors (GPIRM), that the WHO prevents the development and manages the spread of insecticide resistance is summarized in the technical basis for coordinated action against insecticide resistance: preserving the effectiveness of modern malaria vector control. Prof. Tu re-emphasized the artemisinin resistant on five principles to the WHO. She called on the world's scientists to pay attention to the study of drug resistance, and hopes scientists to contribute to break resistance of artemisinins.]]></description>
<pubDate>2017/5/2 17:04:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702002]]></guid><cfi:id>211</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Production of Active Compounds in Medicinal Plants: From Plant Tissue Culture to Biosynthesis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Over past decades plant tissue culture has emerged as an alternative of whole plant cultivation in the production of valuable secondary metabolites. Adventitious roots culture of Panax ginseng and Echinacea purpure has reached the scale of 1?10 kL. Some molecular biological techniques, such as transgenic technology and genetic stability are increasingly used in the studies on plant tissue cultures. The studies on elicitors have deepened into the induction mechanism, including signal molecules, functional genes, and so on. More and more biological elicitors, such as A. niger and yeast are used to increase the active compounds in plant tissue cultures. We also discussed the application of synthetic biology in the studies on biosynthesis of artemisinin, paclitaxel, and tanshinon. The studies on active ingredients biosynthesis of medicinal plants provide unprecedented possibilities to achieve mass production of active ingredients. Plant tissue cultures can not only produce active ingredients but also as experimental materials for biosynthesis. In order to improve the contents of active compounds in medicinal plants, following aspects could be carried out gene interference or gene silencing, gene overexpression, combination with chemical synthesis, application of elicitors, and site-directed mutagenesis of the key enzymes.]]></description>
<pubDate>2017/5/2 17:04:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Juan Wang1,Jian-li Li2,Jing Li1,Jin-xin Li1,Shu-jie Liu2,Lu-qi Huang3 and Wen-yuan Gao1]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Juan Wang1,Jian-li Li2,Jing Li1,Jin-xin Li1,Shu-jie Liu2,Lu-qi Huang3 and Wen-yuan Gao1</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702003]]></guid><cfi:id>210</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and Application of Adlay in Medicinal Field]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The traditional Chinese medicine (TCM) adlay has been used as a dietary supplement to promote health and treat various ailments for thousands of years. The effective and safe ingredients of TCM could be used as sources for developing new drugs. This paper reviews the main research and application of adlay seed in medicinal field in the following aspects: botanical resource, ethnopharmacological function, chemical constituents, pharmacology and pharmacokinetics, safety evaluation and toxicity, and clinical application. We hope that the review could help researchers mine the scientific values of adlay seed, innovative drug design, provide the guidance for the application in clinical therapy, and enhance the academic level and clinical efficacy of adlay seed.]]></description>
<pubDate>2017/5/2 17:04:13</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fei Yu1, 2,Jun Zhang1, 2,Ya-zhuo Li2, 3,Zhen-ying Zhao4 and Chang-xiao Liu2, 3]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fei Yu1, 2,Jun Zhang1, 2,Ya-zhuo Li2, 3,Zhen-ying Zhao4 and Chang-xiao Liu2, 3</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201702004]]></guid><cfi:id>209</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Quality Marker Concept Inspires the Quality Research of Traditional Chinese Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2017/1/23 9:58:31</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[De-an Guo]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>De-an Guo</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701001]]></guid><cfi:id>208</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A New Concept on Quality Marker for Quality Assessment and Process Control of Chinese Medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese medicine (CM) is the most typical conventional therapy compared with any other traditional or alternative medicine systems. The active components of CMs are either primary or secondary metabolites generated by metabolic and biosynthetic enzymes in plants, protecting the plants from environmental stress. The characteristics of these metabolites are diverse, complicated and unique. In this paper, current approaches for quality assessment were extensively reviewed, a new concept of quality marker (Q-marker) was then proposed for CM quality assessment. Additionally, definition of the Q-marker, as well as the relevant methods, were discussed, on the basis of the biosynthetic pathways of secondary metabolites and source of biological active components. Study design of Q-marker is complex system for quality assessment and production process control of CM products with transitivity and traceability. Therefore, the system with characteristics of transmission and traceability is expected to be established for regulation of quality. Upon the concept which the transitivity and traceability in the quality assessment and production process control covered the entire process, such as raw materials, decoction slices, processing, extraction and production can be further enhanced. The transitivity and traceability will inevitably require close attention to “who, what, where, when, and why” details at each stage of Q-markers of CM production form raw materials to patent product. The establishing quality standards are enablers of many and various transitivity and traceability solutions, not a solution in them. It means that the transitivity and traceability system is readily link between products and across borders in quality. According to the thinking mode and methods of investigation on quality assessment of CM product, we focus on the entire process, in terms of safety and effectiveness and quality control. The standard preparation of CM or CM decoction is not only the basis for study of Q-marker, but also the basis for transmission and traceability of the quality of CM product.]]></description>
<pubDate>2017/1/23 9:58:31</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu1,Yi-yu Cheng2,De-an Guo3,Tie-jun Zhang4,Ya-zhuo Li1,Wen-bin Hou4,Lu-qi Huang5 and Hai-yu Xu5]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu1,Yi-yu Cheng2,De-an Guo3,Tie-jun Zhang4,Ya-zhuo Li1,Wen-bin Hou4,Lu-qi Huang5 and Hai-yu Xu5</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701002]]></guid><cfi:id>207</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[LC-MS-based Metabolomics in Traditional Chinese Medicines Research: Personal Experiences]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[LC-MS-based metabolomics has being widely used in traditional Chinese medicines (TCMs) research due to the great coverage of mass ranges, high sensitivity to detect metabolites, and no need of sample derivatization. Herein, we reviewed our research on the applications of LC-MS-based metabolomics in TCMs research over the past decade in the following aspects: herbal authentication, determination of herb harvest time, chemical transformation of herbs during post-harvest handlings (sulfur- fumigation and drying), discrimination of raw and processed herbs, chemical transformation of TCMs during preparation, screening endogenous toxic compounds in TCMs, unveiling synergistic mechanisms between small molecules (such as saponins) and polysaccharides in TCMs, revealing synergistic actions of TCMs with chemical drugs, which demonstrated that metabolomics is a superior strategy in TCMs research concerning the holistic perspectives.]]></description>
<pubDate>2017/1/23 9:58:31</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Qian Mao1,Jin-di Xu1,Ming Kong1,Hong Shen1,He Zhu1,Shan-shan Zhou1 and Song-lin Li1, 2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Qian Mao1,Jin-di Xu1,Ming Kong1,Hong Shen1,He Zhu1,Shan-shan Zhou1 and Song-lin Li1, 2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701003]]></guid><cfi:id>206</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A Review of Quality Assessment and Grading for Agarwood]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Agarwood is an important non-timber forest product widely used in religious and cultural activities as perfume and fragrance and as traditional medicine in Asia. The high value of agarwood and the inflated consuming market have led to constant rising of the prices. In general, the price of the agarwood is determined according to its quality, which can be divided into different grades. But up to now, there is not any standard quality grading system which could be used overwhelmingly throughout the agarwood producing, commerce and consumption. Therefore, we reviewed agarwood in diversified grading indexes, systems and methods.]]></description>
<pubDate>2017/1/23 9:58:31</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yang-yang Liu1, 2,Jian-he Wei1, 2,Zhi-hui Gao1,Zheng Zhang1, 2 and Jun-chen Lyu2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yang-yang Liu1, 2,Jian-he Wei1, 2,Zhi-hui Gao1,Zheng Zhang1, 2 and Jun-chen Lyu2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201701004]]></guid><cfi:id>205</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Understanding "medicine and food homology", developing utilization in medicine functions]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese medicine is a very big concept of medicine. In Shen-nong era, medicine and food do not divide. "Medicine and food homology", which is called “Chinese medicine and dietary application”, refers to that many foods are drugs, and there is no absolute demarcation line between them. At that time, seventy poisons were encountered in a day for experimental accusations, herbal medicines are divided into upper, middle and lower categories, the safe and non-toxic Chinese medicines are the upper product, which can be consumed, but is just a difference in dosage. Ancient medical scientists applied the theory of "four natures" and "five tastes" of traditional Chinese medicine (TCM) into food, believing that each food also has "four natures" and "five tastes". "Medicine and food homology" means that Chinese medicine and food are of the same origin. 
The theory of "medicine and food homology" based on practice has existed in Chinese traditional medicine since ancient times. In ancient primitive society, people discovered the sexual taste and efficacy of various foods and medicines in the process of searching for food, realizing that many foods can be used medicinally and many medicinal materials can be used as dietary supplement. The theory holds that many foods are both food and medicine, and that they are just as effective in preventing disease as drugs. Therefore, this theory of "medicine and food homology" is also the basis of food therapy. Strictly speaking, in the TCM, drugs and food are indiscriminate. Food has fewer side effects, but drugs have more. This is another meaning of medicine and food homology. Hence, the source of Chinese medicine and food is the same. Some things can only be used to treat diseases, known as drugs, some things can only be used for diet, known as foods. The line between medicine and food is not very clear because they all have healing powers. Such as orange, hawthorn, black plum, walnuts, almonds, fennel, cinnamon, pumpkin seeds and so on, they are not only Chinese medicine with a good curative effect, but also nutritious delicious food that people often eat.
The common point of TCM and food is to have a healthy function to prevent and control diseases. The difference between them is that the TCM has strong therapeutic effect, which is often called "strong drug". When the medicine is used correctly, the effect is prominent. However, the therapeutic effect of food is not as prominent and rapid as that of TCM. The important issue cannot be ignored is that medicaments will not be often taken commonly though their action is strong, and food we eat every day though food action is weak. Our daily diet, in addition to the supply of essential nutrients, will also be more or less due to the performance of the food on the balance and physiological function of the adverse or favorable impact, accumulation, from quantitative change to qualitative change, the impact becomes very obvious. In this sense, they are no less effective than TCM. Accordingly, adjusting food correctly and reasonably, with long-term adherence, can have the effect that medicaments cannot achieve.
In this issue of CHM journal, we organized four articles on Lycium barbarum, Gardenia jasminoides, Taraxacum mongolicum, and Moringa oleifera (Gouqizi, Zhizi, Pugongying, and Lamu in Chinese, respectively) with medicine and food functions, focusing on the analysis and discussion of the current research status and put forward the views or opinions of authors on the development of these four Chinese medicines.
The present paper on Lycium barbarum focuses on the legal plant resource and reviews the main research in medicinal field including botanical identification, ethnopharmacological functions, phytochemistry, pharmacological effects, clinic usages, and safety issues. Fruits of Gardenia jasminoides haves been used as dietary supplement and traditional Chinese medicine for thousands of years. Recent studies of Gardenia jasminoides reveal that the extracts or the active components play an essential role in oxidative stress, inflammation, hepatoprotection, neuroprotection, anti-diabetes, antitumor and so on. Here, we reviewed Gardenia jasminoides in the botanical identity, chemical ingredients, pharmacology, and pharmacokinetics, safety and toxicity evaluation, clinical application, etc. Taraxacum mongolicum has been used in TCM and dietary application, and T. officinale has been applied in medicinal and food use in other regions and cultures around the globe. Authors summarized the phytochemical constituents of dandelion (particularly from T. mongolicum and T. officinale). Recent published health benefits of dandelion, such as anti-oxidant activity, anti-inflammatory activity, blood sugar and lipids regulation and hepatoprotective activity, as well as its safety data were highlighted. The limited human clinical study and pharmacokinetics information lead to the thought that well-designed human clinical study should be the focus and opportunity for the future research area to truly understand efficacy function and health benefit of dandelion for its application in medicine and health food area. Moringa oleifera is one of the most widespread species belonging to family Moringaceae. Almost each part of this tree has enormous properties in nutrition, medicine or other industrial purposes. This review mainly introduces nutritional ingredients, bioactive compounds, applications, and potentials of this tree including leaves, seeds, pods, flowers, root barks, and gum in order to bring convenience to industries and researchers all over the world focusing on each part of this amazing plant. Moreover, the review also analyzes the current application situation of M. oleifera in China. Authors concluded that most current researches focus on the leaves and seeds of this plant, and the most concerned property of M. oleifera is the antioxidant ability.
Medicine and food dual-use plants of China have a long history of application, and the medicine-food dual-use plants have both certain physiological effects and long-term edible safety. For people with potential risk of onset, healthy products developed by edible and edible dual-use plants can prevent disease occurrence and maintain health, and are more scientific and rational than drug treatment after disease occurrence. The development and utilization has broad market prospects.
According to the research and development status of Chinese plant resources, the development and utilization of medicine-food dual-use plants is facing challenges. Evaluation and selection of efficacy in research and development, study of functional substance basis and mechanism of action, functional product positioning and composition design, and plant resource germplasm evaluation, planting process management, post-harvest storage, etc. involved in functional food quality control process. A series of key technical issues, such as intensive processing and comprehensive utilization of resources, require efforts to carry out research in order to provide certain theoretical guidance and practice for the development and utilization of dual-use plant resources in China.
]]></description>
<pubDate>2018/10/8 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liu Chang-xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liu Chang-xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804001]]></guid><cfi:id>204</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and application of Lycii Fructus in medicinal field]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Lycii Fructus (Lycium barbarum, Gouqizi in Chinese name) is one of the most popular Chinese material medica and a common ingredient in tonic food. This fruit has been paid rapidly growing attention for its nutrient value and noticeable pharmacological properties. The present paper focuses on the legal resource of Gouqizi and reviews the main research in medicinal field including botanical identification, ethnopharmacological functions, phytochemistry, pharmacological effects, clinic usages, and safety issues. In addition, some issues needed address will be also discussed. We strongly believe that further investigation will deepen our knowledge of Gouqizi and promote the industrial development in the world.]]></description>
<pubDate>2018/10/8 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jin Yang, Yu-qing   Wei, Jian-Bao   Ding, Yan-long   Li, Jian-long   Ma and Jian-li   Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jin Yang, Yu-qing   Wei, Jian-Bao   Ding, Yan-long   Li, Jian-long   Ma and Jian-li   Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804002]]></guid><cfi:id>203</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Taraxacum: Phytochemistry and health benefits]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Taraxaci Herba (Taraxacum mongolicum and other species) has been used in traditional Chinese medicine and dietary application for a long history in China, and Taraxacum officinale has been applied in medicinal and food use in other regions and cultures around the globe. In this review, the phytochemical constituents of dandelion (particularly from T. mongolicum and T. officinale) were summarized. Recent published health benefits of dandelion, such as anti-oxidant activity, anti-inflammatory activity, blood sugar and lipids regulation and hepatoprotective activity, as well as its safety data were highlighted. The limited human clinical study and pharmacokinetics information lead to the thought that well-designed human clinical study should be the focus and opportunity for the future research area to truly understand efficacy function and health benefit of dandelion for its application in medicine and health food area.]]></description>
<pubDate>2018/10/8 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chun Hu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chun Hu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804003]]></guid><cfi:id>202</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and application progress of Gardenia jasminoides]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Fruits of Gardenia jasminoides (Zhizi in Chinese) have been used as dietary supplement and traditional Chinese medicine for thousands of years. Recent studies on Gardenia jasminoides reveal that the extracts or the active components play an essential role in oxidative stress, inflammation, hepatoprotection, neuroprotection, anti-diabetes, antitumor and so on. Here, we reviewed G. jasminoides in the aspects of botanical identity, chemical ingredients, pharmacology and pharmacokinetics, safety and toxicity evaluation, clinical application, etc.]]></description>
<pubDate>2018/10/8 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fei Yin and Jian-hui   Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fei Yin and Jian-hui   Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804004]]></guid><cfi:id>201</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Values, properties and utility of different parts of Moringa oleifera: an overview]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Moringa oleifera is one of the most widespread species belonging to family Moringaceae. Almost each part of this tree has enormous properties in nutrition, medicine, or other industrial purposes. This review mainly introduces nutritional ingredients, bioactive compounds, applications and potentials of this tree, including leaves, seeds, pods, flowers, root barks and gum, in order to bring convenience to industries and researchers all over the world focusing on each part of this amazing plant. Moreover, the review also analyzes the current application situation of M. oleifera in China. After summarizing the recent researches of M. oleifera, we conclude that most current researches focus on the leaves and seeds of this plant, and the most concerned property of M. oleifera is the antioxidant ability. However, the molecular mechanisms under its multiple properties need further studies.]]></description>
<pubDate>2018/10/8 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yang Liu, Xiao-yue   Wang, Xue-min   Wei, Zi-tong   Gao and Jian-ping   Han]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yang Liu, Xiao-yue   Wang, Xue-min   Wei, Zi-tong   Gao and Jian-ping   Han</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201804005]]></guid><cfi:id>200</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Recognizing importance of epigenetic and epigenomic regulations of medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetics most often denotes changes in a chromosome that affect gene activity and expression, and also can be used to describe any heritable phenotypic change. Such effects on cellar and physiological phenotypic traits may result from external or exvironmental factors, or be part of normal developmental program. The standard definition of epigenetics requires these alterations to be heritable, either in the progeny of cells or of organisms. Epigenomics is the study based on the comprehensive analyses of the epigenome using high-throughput technologies. Many fundamental discoveries concerning epigenetics and the elucidation of mechanisms of epigenetic regulation have developed from studies performed in medicinal plants. Many techniques now allow genome-wide analyses of epigenetic regulation and help to understand how epigenetic regulatory mechanisms affect cellular and genome function with a particular focus on the epigenetics of medicinal plants. 
It is considered what has been historically understood by the “epigenetics” before turning to the advances in biochemistry, molecular biology, and genetics. It is given to know how advances in molecular techniques for more comprehensive understanding of epigenetic phenomena in medicinal plants. Some opportunities, challenges, and techniques for epigenetic research in both model and non-model medicinal plants, in particular for advancing understanding of the regulation of genome function by epigenetic mechanisms.
In this issue of CHM journal, the article titled “Deep in shadows: Epigenetic and epigenomic regulations of medicinal plants” (CHM, 2018, 10(3):xxx-xxx) is written by Professors Hao and Xiao. After reading it happily, the editor felt that there are three points worth mentioning to the readers: Firstly, recognizing the importance of epigenetic and epigenetic mechanisms of genuine medicinal materials; Secondly, the study of epigenetic processes opens up a new field of post-transcriptional gene regulation; Finally, the epigenome layer is critical in the age of multi-omics.

Recognizing importance of epigenetic and epigenetic mechanisms of genuine medicinal materials 
Genuine medicinal material (geoherb) is produced in particular geographic regions. The special medicinal features of a plant are determined by its genome, while the proper ecological conditions have major effects on the formation of a geoherb, which is at least partially mediated by the epigenetics. By epigenetics/epigenomics, researchers uncover the complexities of the influence of the environment on the expression of genes that control medicinal plant growth, development, stress responses, and medicinal phytometabolite yield, and put the other "omics layers" in a meaningful biological context. The unique phenotypes of geoherb are closely related to the growth, development, and stress responses of medicinal plants. In addition to the commonly known genetic control, epigenetic machineries, active at the population level, play an essential role in the formation of geoherbs. This contribution gives a comprehensive overview of the epigenetic regulation of medicinal plants and the associated microbes, and the role of DNA methylation, small non-coding RNA, transposable elements, and histone modifications in the gene expression regulation of geoherbs and relevant microbiota. The epigenetic and epigenomic mechanisms should be highlighted in the study of specific phenotype and indigenousness of geoherbalism. Revealing the correlation between epigenetics and geoherbs could shed light on the quality assessment, authentication, molecular breeding, and sustainable utilization of medicinal plants and the associated microbes.

Study of epigenetic processes opens up a new field of post-transcriptional gene regulation
Various epigenetic processes affect the transcriptome of medicinal plant cells: (1) cytosine methylation influences gene expression by altering transcription and chromatin structure; (2) histone modifications have a profound impact on the structure of chromatin and can make DNA relatively accessible for transcription; (3) sRNAs, like miRNA and siRNAs, influence gene expression through targeted degradation of mRNA (PTGS) or induction of methylation at complementary DNA sequences (transcriptional gene silencing). Moreover, reversible mRNA methylation and other novel modifications, i.e., epitranscriptome, open a new realm of post-transcriptional gene regulation in plants. The regulation of mRNA metabolism is particularly crucial under stress conditions. With over 100 known RNA modifications, understanding the repertoire of RNA modifications in medicinal plant development and phytometabolite production is a huge enterprise.

Epigenome layer is critical in age of multi-omics
In epigenetic/epigenomic studies of medicinal plants, it becomes highly possible that large-scale epigenetic reprogramming to the establishment of transcriptionally permissive epigenetic landscapes that put the medicinal compound production onto a fast track. In the age of multi-omics, the numerous layers of biological systems to progressively understand cellular functions and interactions. From studying the genome and epigenome, one understands the complexities of the environmental interactions. Genome is based on study for the simplicity of understanding DNA sequences and the high level detection of genes. Progressive layers uncover further details: transcriptomics to understand mRNAs, proteomics to reveal protein expression and characterization, and metabolomics to study metabolites. Therefore, the epigenome layer is critical. Firstly, epigenomics aims to discover the complexities of the influence of the environment on the expression of genes and the other “omics layers” in a meaningful and pertinent biological context. Secondly, Epigenetic/epigenomic techniques could be alternative strategies for large scale in vitro or even in vivo production of high value phytochemicals, the deeper understanding of the molecular mechanisms underlying genotype-environment interactions is beneficial for long-term improvement of medicinal plant development. ?]]></description>
<pubDate>2018/8/3 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803001]]></guid><cfi:id>199</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Deep in shadows: Epigenetic and epigenomic regulations of medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Around 60% of the extant plants have medicinal and health-promoting values. genuine medicinal material (geoherb) is produced in particular geographic regions, that is defined ecological environment and cultivation pipeline. The clinical efficacy of a geoherb is superior to that of the same medicinal plant growing in other regions. The special medicinal features of a plant are determined by its genome, while the proper ecological conditions have major effects on the formation of a geoherb, which is at least partially mediated by the epigenetics. By epigenetics/epigenomics, researchers uncover the complexities of the influence of the environment on the expression of genes that control medicinal plant growth, development, stress responses, and medicinal phytometabolite yield, and put the other "omics layers" in a meaningful biological context. The unique phenotypes of geoherb are closely related to the growth, development, and stress responses of medicinal plants. In addition to the commonly known genetic control, epigenetic machineries, active at the population level, play an essential role in the formation of geoherbs. This contribution gives a comprehensive overview of the epigenetic regulation of medicinal plants and the associated microbes, and the role of DNA methylation, small non-coding RNA, transposable elements and histone modifications in the gene expression regulation of geoherbs and relevant microbiota. The epigenetic and epigenomic mechanisms should be highlighted in the study of specific phenotype and indigenousness of geoherbalism. Revealing the correlation between epigenetics and geoherbs could shed light on the quality assessment, authentication, molecular breeding, and sustainable utilization of medicinal plants and the associated microbes.]]></description>
<pubDate>2018/8/3 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Da-Cheng Hao1 and Pei-Gen Xiao2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Da-Cheng Hao1 and Pei-Gen Xiao2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803002]]></guid><cfi:id>198</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Identification and classification of medicinal plants in Epimedium]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Epimedium (Berberidaceae) has been used as Chinese medicines for a long time in China due to the efficiency of enhancing kidney function, strengthening sinew and bone, and dispelling wind-dampness. However, it is difficult to identify them because of the morphological similarity which has focused extensive attention. Here the advances in identification and classification of medicinal plants in the genus were summarized.]]></description>
<pubDate>2018/8/3 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Li Ren, Meng-yue Guo and Xiao-hui Pang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Li Ren, Meng-yue Guo and Xiao-hui Pang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201803003]]></guid><cfi:id>197</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Scientific understanding of toxicity and safety of Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Scientific understanding of toxicity and safety of Chinese medicines


Traditional Chinese medicine is a treasure of traditional culture and medicine which should be inherited and developed. How to correctly understand the toxicity of Chinese materia medica (CMM) is an important guarantee for safe drug use. The history of the application and research of the toxicity of CMM has been long, and the Chinese medicine community has never stopped exploring the issues related to the safety of CMM. As early as in the ancient time, the meaning of poison and medicine was the same, and poisons were commonly used as the term for "drug bait". During the pre-Qin period, a book on medicine and doctor “Zhou-Li: Tian-Guan Zai-Zhai” had recorded the words of "a physician's order of a doctor's prescription and a poison medicine". Although the words of the ancients may not be entirely correct, it reflects an unignorable aspect of the medicine world.
With the development of society and science, the understanding of Chinese medicine has been continuously deepened, and the concept has gradually changed. The safety issue has also been paid attention to by the world's medical and pharmaceutical circles. We know that toxicity is a serious adverse effect of drugs on the body, which reflects the safety of a drug performance.
Drug toxicity and adverse reactions can cause visceral tissue damage and dysfunction, and cause the body to undergo pathological changes or even death. The concept of complete toxicity of modern Chinese medicines should also include acute and sub-acute toxicity, chronic toxicity, and special toxicity such as carcinogenesis, mutagenesis, gene-toxicity, and addiction. Based on the above toxicological studies, in-depth toxicological mechanisms and health hazards can be beneficial to enhance the understanding of traditional medicines. Some research results published in domestic and foreign scientific journals are sufficient to illustrate the contribution of Chinese and foreign scientists to traditional medicine research.
This special issue has published four articles on the toxicity and safety of Chinese medicine. From one aspect, we see the achievements of authors in this field.
In a topic on "Application and prospect of toxicity quality markers (Q-markers) of Chinese materia medica based on metabolomics" (CHM 2018, 10(2): 108-116), authors reviewed that the toxicity Q-markers of CMM were explained from the following four aspects: 1) The establishment of toxicity prediction model of CMM based on metabolomics, recognition, and relative techniques; 2) The discovery of toxicity Q-markers of CMM based on metabolomic and toxicity mechanism research; 3) The research on the formation of toxicity Q-markers based on metabolomics from biosynthetic pathway and the secondary metabolites analysis of toxicity Q-markers; and 4) The susceptibility study of toxicity Q-markers based on metabolomics, key targets, and metabolic pathways of toxicity Q-markers to explain the target organ toxicity. Therefore, authors suggested that the application of metabolomics helped to systematically and comprehensively discover the quality control indicators related to the CMM safety, and it can provide rational evidences for the clinical toxicity of CMM.
We know that the concept of Q-marker is possible to monitor the quality of Chinese Herbal medicines (CHMs) in the whole process, and control final products. However, as the complexity of CHM components and the great varieties of the extrinsic harmful residues, such as mycotoxins, pesticides, heavy metals, and sulfites, it is difficult to ensure the quality of CHMs. In the review paper "Extrinsic harmful residues in Chinese herbal medicines: types, detection and safety evaluation" (CHM 2018, 10(2): 117-136), authors summarized the potential harm, limit standards, detection methods of the harmful residues, and provided reference for the formulation or amendment of relative regulations to promote the healthy and stable development of CHMs, the information is value to establish a complete system with Q-marker evaluating the safety and quality of CHMs.
In order to determine the toxic potential of Realgar-Indigo naturalis formula (RIF), Prof. Gao’s team performed a research titled "Synergistic effect and different toxicities of adjuvant components of Realgar-Indigo naturalis Formula" (CHM 2018, 10(2): 137-144). The assays acute toxicity and sub chronic toxicity were to evaluate the toxic potential of Realgar and the adjuvant components of RIF in addition to Realgar's synergy with these adjuvant components. Based on these experimental results presented, researchers found that the RIF toxicity was the result of the soluble arsenic in Realgar, and Indigo naturalis, and Salvia miltiorrhiza in the RIF exert completely opposite effects on the toxicity. Therefore, the intelligent explanation is not only a possible for the compatibility of the formula, but also the RIF study may be viewed as a classic case of CMM research on compatibility.
The research paper of Prof. Zhang’s team titled “Toxicity-efficacy converting of ginseng combined with Fuzi Banxia incompatibility in heart failure stage of Cor pulmonale” (CHM 2018, 10(2): 145-151) used a heart failure model to evaluate the toxicity-efficacy and explore mechanism of ginseng combined with Fuzi Banxia. The study result exhibited that ginseng compatible environment could attenuate cardiac toxicity of Fuzi Banxia incompatibility intervening in the heart failure stage of Cor pulmonale, and improve cardiac function, which may be related to the expression of hypertrophy and apoptosis associated genes in the occurrence and development of heart failure.
From the limited information and research results in these four articles, it can be understood the some safety issues of CMM from different perspectives, it can be seen that compatibility will affect their safety and effectiveness, and also affect the quality of medicines. Also, the effects are far more complex than those of single ingredient. Although the modern biology technology, such as genomics, proteomics and metabolomics technology, has been widely used in the study of mechanism of drug action, its mechanism research far fail to be elucidated and has a long way to go due to the complex components in CMM.]]></description>
<pubDate>2018/5/16 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802001]]></guid><cfi:id>196</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Application and Prospect of Toxicity Quality Markers of Traditional Chinese Medicine based on Metabolomics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In view of the problem that the quality evaluation indicators divorced from effectiveness and safety in Chinese
materia medica (CMM), Prof. Chang-xiao Liu et al have put forward a concept of quality markers (Q-markers)
of CMM, which provided a new thought for improving the CMM quality control method. The toxicity
Q-markers of CMM are described as follows, the early toxicity prediction of CMM, the discovery, formation
and susceptibility research of toxicity Q-markers of CMM. Metabolomics is a systematic biology approach,
closely related to the toxicity phenotype of organism, has unique advantages in toxicity Q-markers research.
The toxicity Q-markers of CMM are explained from the following four aspects in this review: 1) the establishment
of toxicity prediction model of CMM, which is based on metabolomics, pattern recognition, and other
techniques; 2) the discovery of toxicity Q-markers of CMM based on metabolomic, which is meaning that
the toxicity Q-markers are interpreted regarding to the chemical composition analysis of CMM, preliminary
screening and verification of the toxicity Q-markers and toxicity mechanism research; 3) the research on the
formation of toxicity Q-markers based on metabolomics, which is described from biosynthetic pathway analysis
and the secondary metabolites analysis of toxicity Q-markers; and 4) the susceptibility study of toxicity
Q-markers based on metabolomics, namely, the key targets, and metabolic pathways of toxicity Q-markers are
explained according to the target organ toxicity susceptibility caused by CMM, and then the toxicity susceptibility
mechanism of CMM is clarified. Therefore, the application of metabolomics helps to systematically and
comprehensively discover the quality control indicators related to the CMM safety, which further provides a
rational evidence for the clinical application of toxicity of CMM.]]></description>
<pubDate>2018/5/16 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Peng-jie Zhang a, Ya-mei Li a, Ya-ni Zhang a, Wei Huang a, Yu-bo Li a, Yan-jun Zhang a and Chang-xiao Liu b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Peng-jie Zhang a, Ya-mei Li a, Ya-ni Zhang a, Wei Huang a, Yu-bo Li a, Yan-jun Zhang a and Chang-xiao Liu b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802002]]></guid><cfi:id>195</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Extrinsic harmful residues in Chinese herbal medicines: types, detection and safety evaluation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese herbal medicines (CHMs) are playing important roles in the treatment of diseases and human health care throughout the world. However the extrinsic harmful residues have been threatening the therapies by destroying CHMs qualtiy which hinders the international trades of CHMs. This review summarized the extrinsic harmful residues contaminating CHMs in types, detection methods, national and international regulations, and made safety evaluations according to their contaminated levels, aiming to establish understanding among nations or organizations and provide references for the formulation or amendment of relative regulations.]]></description>
<pubDate>2018/5/16 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Cong-min Liu, Jia-an Qin, Xiao-wen Dou, Mei-hua Yang and Xiao-bo Sun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Cong-min Liu, Jia-an Qin, Xiao-wen Dou, Mei-hua Yang and Xiao-bo Sun</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201802003]]></guid><cfi:id>194</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Worth to Know and Explore Medicinal Value of Genus Engelhardia]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Engelhardia is a genus of seven species of trees in the family Juglandaceae, native to southeast Asia. In China, the genus is mainly distributed in Guangdong, Hainan, Guangxi, Guizhou, Yunnan and other places. The genus name is commonly misspelled “Engelhardtia”, a “correction” made by the original author Carl Ludwig Blume in 1829 was used until today, as it was thus entered in the Index Kewensis; the original spelling is Engelhardia. According to the literature, the Genus of: Engelhardia include 26 Species: Engelhardtia aceriflora, E. apoensis, E. aurifolia, E. danumensis, E. hainanensis, E. kinabaluensis, E. lepidota, E. mendalomensis, E. mersingensis, E. mollis, E. nicaraguensis, E. nudiflora, E. boreomunnea, E. palembanica, E. parvifolia, E. permicrophylla, E. philippinensis, E. polystachya, E. pterococca, E. rigida, E. selanica, E. serrata, E. spicata, E. subsimplicifolia, E. villosa, and E. zambalensis.
Ethnopharmacologically, The herb has detoxification effects on spleen and stomach stagnation, chest and abdomen bloating, cold fever, diarrhea, hernia abdominal pain and so on. Its root, bark, leaves and flowers can be used as medicine, the medicinal bark is slightly bitter, pungent and calm. The leaf medicine is slightly bitter and cool. Folk said the leaves of the herbal medicine called sweet tea since ancient times as a heat, detoxification for weight loss health care.
Modern pharmacologically, the studies have shown that the herb has main pharmacological activities for hypoglycemic action, hypolipidemic effects, anticoagulant, anti-platelet aggregation, anti-thrombosis, anti-inflammatory, anti-cancer, enhancing immunity, inhibition of cardiovascular and cerebrovascular diseases and so on.
From a large number of documents, many researchers found that the chemical constituents, pharmacology and toxicology of Fructus genus were studied. It mainly contains flavonoids, polyphenols and saponins.
The review article entitled “Chemical Constituents and Pharmacological Effects of Genus Engelhardia” (CHM 2018, 10(1):xx-xx) provides a wealth of informatics on chemical constituents and pharmacological researches of genus Engelhardia Leschen. ex Blume. The constituents of this genus were introduced and classified according to their structures. Based on the large amount of constituents, this genus plants exhibited various biological activities such as antioxidant, protective effects on ischemia/reperfusion injury, anticancer, anti-inflammatory, immunosuppression activities, antidiabetic and antitubercular activities and so on. Authers compared with some common species, current research of genus Engelhardia is not quite enough to elucidate the relationship between chemical constituents, pharmacological data and traditional medical usage. Most studies focused on E. roxburghiana possibly due to its broader distribution and wider usage than other species in the past. Later, parts of the genus plants were further studied, and more pharmacological activities were found. As national medicine and health tea, the usage parts of Engelhardia plants is not extensive, which cause not much attention. With various biological activities, genus Engelhardia might have considerable potential value for the development of new drugs. For example, dihydroflavonoids show immunosuppressive activity due to its lower cytotoxicity. E. roxburghiana is rich in these constituents, which means it will take good therapeutic effects on autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. In this paper, authors suggested that genus Engelhardia has a good development prospects. Researchers look forward that the genus Engelhardia plants not only E. roxburghiana, but also other species can attract more attention.
A total of over 100 compounds have been isolated from the genus Engelhardia, in which phenolic derivatives are dominant compounds including flavonoids, triterpenes, diarylheptanoids, aromatic acids, esters, and naphthalenones. From a development perspective, there are many issues in discovery and development that need to be made in how to combine modern pharmacological research with valuable new drugs for discovery. Additionally, biological activity of most natural chemical composition is not strong, and pharmacokinetic characteristic is not prominent (such as low bioavailability), which could be modified for improving the biological activity of the potential.
]]></description>
<pubDate>2018/2/5 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801001]]></guid><cfi:id>193</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical Constituents and Pharmacological Effects of Genus Engelhardia]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Engelhardia Leschen. ex Blume (Juglandaceae) is native to southern and southeastern Asia and used to be traditional medicines and health tea. Hitherto, a large amount of chemical constituents had been isolated from genus Engelhardia and more pharmacological effects were found due to the presence of the second metabolites. There have been few comprehensive reports about Engelhardia plants especially the chemical constituents by now. The traditional usage of Engelhardia plants were for treating cold fever, detoxication, rheumatism, diarrhea, obesity, gastrointestinal problem and so on. While the modern pharmacological activities showed antioxidant activity, anti-ischemia/reperfusion injury, anticancer activity, anti-inflammatory activity, immunosuppression activity, antidiabetic activity, antitubercular activity and so on. In this review, constituents of this genus would be introduced and classified by structures, the pharmacological effects of which would be described as well.]]></description>
<pubDate>2018/2/5 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yan-Mei Pang a, b, Qi Shanb, Fu-Jun Zhoub, Jie Huab and Wen-Bin Houa, b, c]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yan-Mei Pang a, b, Qi Shanb, Fu-Jun Zhoub, Jie Huab and Wen-Bin Houa, b, c</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801002]]></guid><cfi:id>192</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Methods for Determination of Absolute Configuration of Monosaccharides]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Monosaccharides are one of the most important structural components of biomolecules, such as polysaccharides, nucleic acids, glycolipids and glycoproteins. In structural analysis of polysaccharides and glycoconjugates, the absolute configurations (d or l) of the constituent monosaccharides are usually determined by measurement of the optical rotation, CD spectra or characteristic chromatographic retention behavior. However, each method has its unique advantages and limitations which should be considered while using them. In this review, an overview of the different methods for the determination of absolute configuration of monosaccharides and their underlying principles are summarized to serve as a reference for researchers.]]></description>
<pubDate>2018/2/5 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Nan Zhang a, b, Wei-xing Huang a, b, Gui-yang Xia a, b, Mahmood Brobbey Oppong a, b, Li-qing Ding a, b, Pan Li a, b and Feng Qiu a, b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Nan Zhang a, b, Wei-xing Huang a, b, Gui-yang Xia a, b, Mahmood Brobbey Oppong a, b, Li-qing Ding a, b, Pan Li a, b and Feng Qiu a, b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801003]]></guid><cfi:id>191</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Progress on Research of Tissue Culture of Bletilla striata]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Rhizoma Bletillae is in high demand as a traditional Chinese medicine, which natural resources have been severely damaged due to excessive exploitation. Because Bletilla striata seeds are small and have no en- dosperm, the seed germination rate is low in natural conditions. Traditional division propagation could not meet the demands of large-scale cultivation. But tissue culture can provide many seedlings in a short time and is more effective and convenient than other methods. Most studies on tissue culture of B. striata selected seeds as explants. This review summarized the processes of the aseptic seed germination path- way. It included such stages as seed germination, proliferation of clusters of buds, induction of rooting and transplanting of seedlings. Influential factors as well as optimum combination and concentration of the plant growth regulators of each stage were also summarized. The further research on tissue culture of B. striata was also prospected.]]></description>
<pubDate>2018/2/5 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xue-Min Wei a, Yang Liu a, Xiao-Yue Wang a, Zi-Tong Gao a, Shu-Ming Yao b and Jian-Ping Han a]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xue-Min Wei a, Yang Liu a, Xiao-Yue Wang a, Zi-Tong Gao a, Shu-Ming Yao b and Jian-Ping Han a</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201801004]]></guid><cfi:id>190</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New progress of interdisciplinary research between network toxicology, quality markers and TCM network pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese Mmedicine (TCM) has been applied in treating various complex diseases for thousands of years, and has been widely known for its distinguished holistic therapeutic strategy. How to ensure the safety and lower the risk of toxic effects of TCM herbal formulae are of critical importance during the process of the modernization of TCM industry. Due to the complex composition of TCM herbal formulae and its sophisticated interaction between the biomolecules inside the body, there is an urgent need for systematic methodology in the in-depth investigation on TCM herbal formulae regarding its mechanism of action (MoA), which is the basis for its toxicology assessment (Y. B. Li et al., 2019; S. Liu et al., 2017) and quality control (C. X. Liu et al., 2017). 
    As a new research paradigm for drug discovery and development, network pharmacology has aroused interests among researchers in the area of TCM since its emergence about 10 years ago (Hopkins, 2007; Li, 2007; Li et al., 2007). In particular, we proposed the new concept of “network target” (Li, 2011; Li, et al, 2011), an elementary entity for the development of TCM Network Pharmacology (TCM-NP), which offer the opportunity to describe and measure the emergence of an ON or OFF effect on the level of network modules, revealing the biological basis of both diseases and drugs by integrating multi-level omics data and temporal-spatial biomedical data with network analysis (Guo et al., 2017; Li, 2015). The network target may offer a powerful computable measurement for evaluating the complex MoA underlying the TCM compounds, herbs and formulae and thus help shift the classical “one target, one drug” research paradigm towards the new “network target, multicomponent therapeutics” strategy. It is suitable for exploring the mysteries of TCM from both the conceptual and the applicable perspective (Li & Zhang, 2013), including toxicology assessment and quality control of the TCM herbal formulae. 
To answer the urgent needs in the field of TCM toxicology and quality control, new concepts are continuing to be put forwards, showing compatibility with the strategy of “network target, multicomponent therapeutics”, while forming the hot research field together with network pharmacology. In this issue, two reviews (X. Y. Li et al., 2019; Wang et al., 2019) on quality marker and network toxicology will be published, discussing the new progress on these two booming research fields, and their integration potential with network pharmacology.
    The new concept of the quality marker (Q-marker) was first proposed by Liu et al. in 2016 (C. X. Liu et al., 2017; Liu, Guo, & Liu, 2018), establishing a valuable framework for the rational quality control of TCM. The framework emphasizes both the transitivity and traceability along the intact life-cycle of the TCM herbs, decoction-prieces and formulae. In the recent review (Wang et al., 2019), the role of network pharmacology is further demonstrated and integrated into the strategy for Q-marker prediction and application. The “effect-ingredient-target-fingerprint” is developed as the basis for network pharmacology analysis, and the predicted Q-markers based on the fingerprint are further validated both on the theoretical level of TCM compatibility rules, and also on the experimental level of pharmacokinetics, pharmacodynamics and toxicology.
    Network toxicology is another important concept, characterizing the interaction and regulation of potential poisonous materials through network models (Liu et al., 2015), which may lead to precise prediction of the toxic components, indication of the biomarkers, and a deeper understanding of the MoA related to the side effect. As reviewed in the recent work (X. Y. Li et al., 2019), metabolomics with the help of liquid chromatography- – mass spectrometry (LC-MS), which provide big data on endogenous metabolites, serve as a powerful method facilitating the network building and analysis. The “toxicity-target-drugs” network is built for network pharmacology analysis, while metabolomics help withcan be useful in the in-depth interrogation of the network and more accurate infer of the toxic components.
    There are still many theoretical, methodological, and practical challenges that need to be addressed for future developments of the current research area. With the integration of more cutting-edge assays and artificial intelligence, as well as the evolvement of the interdisciplinary research fields of TCM-NP, especially with network toxicology and Q-markers, we are expecting the fast extending of the research area, more and more successful application cases, and eventually innovative breakthroughs for both traditional and conventional medicines.]]></description>
<pubDate>2019/11/12 9:40:23</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shao Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shao Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904001]]></guid><cfi:id>189</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Prediction of quality markers of traditional Chinese medicines based on network pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Network pharmacology is a powerful tool to reflect the pharmacologically active effects, mechanism of action and toxic activity of traditional Chinese medicines (TCMs). The ingredients of TCMs, associated with quality control of TCM products, are those fundamental chemicals that exhibit biological activities. A great amount of effort has been made by scientists in that field in order to improve the quality of TCMs, though the approaches to determine their quality and the TCM theory and compatibility rules remain ambiguous. Now some methods and technologies must be applied to predict and explore the quality marker (Q-marker) for quality control, as well as to clarify the factors affecting the quality of TCM, which may give new insight into rational ground of establishment of appropriate quality control and assessment system. In this review paper, authors focus on the prediction of quality markers of TCMs by network pharmacology based on three aspects: (1) from network medicine to network pharmacology, (2) complex network system of traditional Chinese medicine, and (3) predicting TCM quality markers based on network pharmacology. Authors proposed the research pattern on network pharmacology based on biological and medical networks, and further TCM network pharmacology based on substantial basis of TCM formulae, and the idea of “effect-ingredient-target-fingerprint” to predict and recognize the TCM Q-marker was the ultimate goal. In addition, authors yet noted how to make full use of the advantages of network toxicology to provide new ideas for the toxicity study of complex TCM systems and the prediction of TCM toxicity markers.]]></description>
<pubDate>2019/11/12 9:40:23</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yu-li Wang, Tao Cui, Ya-zhuo Li, Mao-liang Liao, Hong-bing Zhang, Wen-bin Hou, Tie-jun Zhang, Liang Liu, He Huang and Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yu-li Wang, Tao Cui, Ya-zhuo Li, Mao-liang Liao, Hong-bing Zhang, Wen-bin Hou, Tie-jun Zhang, Liang Liu, He Huang and Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904002]]></guid><cfi:id>188</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network tocicolgy and LC-MS-based metabolomics: New approaches for mechnanism of action of toxic components in traditional Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Network toxicology combined with metabonomics is of great significance for the study of the toxic mechanism and prediction of toxicity of traditional Chinese medicines (TCMs). In this study, we reviewed the application of network toxicology based on LC-MS metabolomics, mainly in the study of toxic components and the toxicity mechanism of TCMs, which provides new ideas and methods for the further study of the toxicity mechanism of TCMs.]]></description>
<pubDate>2019/11/12 9:40:23</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xin-yu Li, Xin Jin, Ya-zhuo Li, Dan-dan Gao, Rui Liu and Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xin-yu Li, Xin Jin, Ya-zhuo Li, Dan-dan Gao, Rui Liu and Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201904003]]></guid><cfi:id>187</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Building a bridge between ecology and Chinese herbal medicined]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201903001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2019/7/31 15:54:06</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fang Rui]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fang Rui</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201903001]]></guid><cfi:id>186</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201903002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Reactive metabolites (RMs) generated by hepatic metabolism are thought to play an important role in the pathogenesis of drug-induced liver injury (DILI). Like many synthetic drugs undergoing metabolic activation to form RMs which are often associated with drug toxicity, it is recognized that some herbal components may be also converted to toxic, or even mutagenetic and carcinogenic metabolites by cytochrome P450s (CYP450s). This review focuses on the metabolic activation of herbal components and its liver toxicological implications. By summarizing references, we found that hepatotoxic herbal components via producing RMs have some certain structural dependence. There is a correlation between the generation of RMs and the structures, which provides a good chance for the early discovery of toxic ingredients in Traditional Chinese medicines (TCMs): i) A potential hepatotoxic component information database based on active functional groups can be built, which might provide an early information for the basic research of hepatotoxic substances in TCMs; ii) RMs can combine with CYP450s to form a complete antigen, which eventually leads to an antigen-specific immune response. RMs-CYP450 protein complete antigen can be set up, and the potential idiosyncratic liver toxicity might be predicted by testing RMs-CYP450 protein antibody in plasma.]]></description>
<pubDate>2019/7/31 15:54:06</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zi-jun?Wua, Li-li?Wang?a, b, Xue?Gaoa, Yue?Hai?a, Wen-li?Liua, Le-mei?Dua, Lei?Zhanga, Ai-hong?Yang?a, b and Nan-nan?Huanga]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zi-jun?Wua, Li-li?Wang?a, b, Xue?Gaoa, Yue?Hai?a, Wen-li?Liua, Le-mei?Dua, Lei?Zhanga, Ai-hong?Yang?a, b and Nan-nan?Huanga</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201903002]]></guid><cfi:id>185</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Award-winning projects and experts are role models for learning]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The 2018 national science and technology award conference was held at the Great Hall of the People in Beijing on Jan. 8, 2019. The winning projects of the national science and technology award once a year reflect the outstanding achievements in the national science and technology field. From the published winning projects, we can see that there are three winning projects in the field of TCM research. On behalf of the CHM editorial board, I would like to extend our sincere congratulations to the award winners.
1. Key Technology and Application of Invention and Preparation of Ginkgo diterpene lactones Strong Effect Composition won the second prize of National Science and Technology Invention Award jointly contributed by Wei Xiao, Feng-chang Lou, Ya Ling, Ji-ye Aa, Gang Hu, and Shu-wei Ma.
Ginkgo biloba extract has a variety of pharmacological activities, and has been extensively studied in China and abroad. Dozens of ginkgo preparations have already been commercially available, with the primary components containing flavonoids, lactones, etc. Ginkgo diterpene lactones is a naturally potent PAF receptor antagonist of pharmacological activities in anticoagulation and prevention of stroke. Before this dosage form of Injection of two terpene lactones from Ginkgo biloba was approved for marketing, no product with ginkgolides diterpenoid as the primary components has been approved and commercially available worldwide. The main innovations of this project are as follows: (1) The specific efficacy of each lactone component and the optimal combination of the components was not clear, and the preparation of the diterpene lactone was not so effective to remove the main toxic component of ginkgolic acid contained in diterpene lactone. To go through the puzzles above, the research team underwent a systematic study and finally completed a series of technological innovations and inventions, so that the extract of two terpene lactones from Ginkgo biloba achieved a rather high purity of ginkgo diterpene lactone more than 98%, with the content of toxic ginkgolic acid much lower than the international standard. For the first time, Ginkgolide two ginkgolide Injection was successfully developed and approved for the market. (2) The injection has obtained 11 Chinese invention patents authorization, and finally acquired new drug certificates and production approvals in 2012, which provided an innovative drug with antiplatelet and neuroprotective effects for the treatment of ischemic stroke without the risk of bleeding. It entered the national medical insurance catalogue for the treatment of stroke.   
2. “The establishment and application of key technology of the modern research on Traditional Chinese Medicine based on a holistic view” won the second prize of National Science and Technology advance Award jointly contributed by Wei-dong Zhang, Jun-jie Zhou, Hai-ming Shi, Run-hui Liu, Chang-sen Zhan, Yong Li, Peng Jiang, Xin-ping Luo, Ning Xie and Yan-he Lin.
Researchers established the identification method and technology of the active ingredients of TCM formulas to clarify the pharmacodynamic substances; They established a technical analytical method combining system biology and network biology to solve the problem of unclear mechanism of action, and established the whole process of production chain automation technology to ensure the quality of TCM formulas; The carried out the international standards of evidence-based medical research to clear clinical positioning. The main innovations of this project are as follows: (1) For the first time, based on the holistic view, it constructed a modern research system of TCM formulas and published the first Chinese and English monograph on the modern study of TCM formulas and first proposed the overall research strategy of TCM formulas. (2) The method of rapid identification of active ingredients of TCM formulas was established to solve the problems of many kinds of chemical components in TCM formulas and large differences in physical and chemical properties. (3) Aiming at the characteristics of the overall pharmacodynamic effect of TCM formulas, the association technology of metabolomics, network biology, chemical biology and connectivity map was established. (4) An overall quality control system was established to ensure the product quality of modern TCM formulas to be uniform and stable. (5) A large-scale evidence-based medicine study of TCM formulas was carried out, which provided full and accurate evidence for excavating the clinical characteristics and application of TCM formulas.
Shexiang Baoxin Pill has achieved an annual growth of more than 30% through technological innovation. The industrial scale ranks first in the national TCM microparticle industry. It has a good demonstration effect on improving the development of TCM industry and promoting the development of large variety of TCM. This project was first time to propose the research strategy of TCM formulas based on the holistic view. It also developed a number of core technologies for the study of TCM formulas and comprehensively explained the scientific connotations of TCM formulas. It promoted the development of the TCM industry and innovated a modern research model of TCM formulas.
3. “Establishment of the mode and technical system for resource recycling utilization during industrialization process of Chinese Medicinal Materials and their applications” won the second prize of National Science and Technology advance Award jointly contributed by Jin-ao Duan, Zhi-shu Tang, Ming-geng Wang, Qin-an Wu, Wen-jie Quan, Shu-lan Su, Qi-ming Liu, Sheng Guo, Hao Ji and Peng Xiong.
The project belongs to the basic and applied research field of traditional Chinese medicine. This project focuses on the CMM recycling utilization, developing the key technologies and promoting their transformation application, which has made a pioneering contribution to the quality and efficiency, the resource conservation, and the green development of the whole industrial chain of the traditional Chinese medicine. The main innovations are described as follows: (1) The theoretical foundation of recycling utilization of CMM resources is put forward and constructed innovatively to lead the green development of CMM. Five kinds of recycling patterns of CMM resources have been established based on the characteristics of the waste and by-products of traditional Chinese medicine. The comprehensive benefits of their popularization and application have been significantly increased. The "one increase and one decrease" green development model, which has significantly reduced the waste of resources and environmental pressure, has explored a replicable model easy to popularize the effective way for promoting the improvement of quality and efficiency, the sustainable development of Chinese traditional medicine industry, and the transformation of production mode and development mode. (2) Three sets of recycling technology systems suitable for biotransformation, chemical transformation, and physical transformation of CMM wastes and by-products have been constructed innovatively. A biotransformation system and equipment based on bioengineering and enzyme engineering technology was established, which was used to screen resistant microorganism, construct engineering bacteria, produce enzyme fermentation-enzymatic hydrolysis and saccharification, and realize industrialization. The establishment, popularization, and application of the technical system of recycling utilization of CMM resources have provided strong support for the green development of Chinese traditional medicine industry. (3) As practices, some non-medicinal parts, wastes and by-products have been innovatively transformed into new pharmaceutical and health products, new resource of medicinal materials, cellulase, oligosaccharides, bioethanol, biochar, and carbon-based compound fertilizer, etc. The circular economy concept of "being from and returning to farmland, improving the quality and efficiency, and green development" has been realized. These research results have been popularized and applied in more than 20 medicinal materials production and deep processing enterprises in more than 10 provinces of China. The project leads to the improvement of quality and green development of the industrialization of CMM resources, and possesses unique advantages and important influence in related fields nationally and even internationally.

As premier Ke-qiang Li pointed out in his speech at the awards conference, "in the past year, faced with the complex and severe international situation and arduous tasks of reform, development and stability, China's economy and society maintained sound development, actively promoted the strategy of innovation-driven development, and made new achievements in scientific and technological innovation. A number of major achievements have been made in basic research, cutting-edge technology, high-end equipment, and major projects”. 
At present, we must seize the new round of scientific and technological revolution and industrial transformation in the world. These achievements of modern research on traditional Chinese medicine will also strongly encourage scientists and technicians across the country to carry out more extensive research and development, create more safe, effective and quality-controllable new traditional Chinese medicine drugs, and make more new products serving the cause of people's health.]]></description>
<pubDate>2019/5/7 15:22:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liu Chang-xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liu Chang-xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902001]]></guid><cfi:id>184</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Non-Camellia Tea in China: traditional usage, phytochemistry, and pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Non-Camellia Tea, as an integral part of Chinese tea culture for several centuries, is important to prevent chronic metabolic diseases. However, it was not systematically studied until Xiao defined it. Hereby, Non-Camellia Tea was reviewed  systematically in definition, classification, traditional functions, chemical compositions, and pharmacology.]]></description>
<pubDate>2019/5/7 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Kai Ren1, Bi-qun Han3, Li-juan Lv4, Guo-jun Zhang1, Lu-jing Lei5, Xiao-rong Bai1, Pei-gen Xiao3* and Min-hui Li1,2,5*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Kai Ren1, Bi-qun Han3, Li-juan Lv4, Guo-jun Zhang1, Lu-jing Lei5, Xiao-rong Bai1, Pei-gen Xiao3* and Min-hui Li1,2,5*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902002]]></guid><cfi:id>183</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and application of Alpinia officinarum in medicinal field]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Alpinia officinarum is a medicinal plant and food. Its dried rhizome has been widely used for the relief of symptoms such as stomach aches, colds, ulcer and diarrhea for hundreds of years. Recent pharmacological studies showed it has anti-inflammatory, anti-oxidative, antidiabetic, anti-ulcer, anti-diarrhea, antiemetic, analgesia, anticoagulation, antitumor and antivitiligo effects. In this study, we summarized the current knowledge about its botanical resources, ethanopharmacological function, chemical constituents, pharmacologies and pharmacokinetics, safety and toxicity, and clinical application.]]></description>
<pubDate>2019/5/7 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ping Ding1, Li Yang1, Chong Feng1 and Jian-chun Xian2]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ping Ding1, Li Yang1, Chong Feng1 and Jian-chun Xian2</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902003]]></guid><cfi:id>182</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Applications of Pueraria lobata in treating diabetics and reducing alcohol drinking]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Pueraria lobata is one of the most important medicinal herbs used traditionally in China. According to Shanghan Lun (Treatise on Exogenous Febrile Disease), it has been used traditionally to relieve body heat, eye soring, dry mouth, headache associated with high blood pressure, and stiff neck problems. Modern studies in the 1970s revealed that isoflavonoids extracted from P. lobata were the bioactive components of an herbal remedy namely Yufeng Ningxin Tablets for the treatment of patients after stroke. This article reviews recent application of P. lobota in the treatment of diabetics and in reducing alcohol drinking. In view of its low toxicity profile, P. lobota stands an excellent chance to be developed as a phytomedicine for treating human diseases.]]></description>
<pubDate>2019/5/7 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jing Liu a, Yeu-Ching Shi b and David Yue-Wei Lee a, *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jing Liu a, Yeu-Ching Shi b and David Yue-Wei Lee a, *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902004]]></guid><cfi:id>181</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and application of Portulaca oleracea in pharmaceutical area]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Purslane, a plant species used as medicine and food, is widely spread in most areas of China. It is also a popular food in some Europe and Mediterranean countries. Purslane contains a variety of chemical constituents with pharmacological activities, such as antitumor, hypoglycemic, antioxidant, antibacterial, anti-inflammatory activities. It is also full of plenty of nutrients serving as a diet food or healthy food. Here, we reviewed purslane in the following aspects: botanical resources, ethnopharmacological function, chemical constituents, pharmacology and pharmacokinetics, safety evaluation and toxicity, and clinical applications.]]></description>
<pubDate>2019/5/7 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Di Chen1, Jun-na Yao1,2, Ting Liu1, Hai-yan Zhang1, Rao-rao Li1*, Zhi-jie Zhang1* and Xue-zhu Gu1]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Di Chen1, Jun-na Yao1,2, Ting Liu1, Hai-yan Zhang1, Rao-rao Li1*, Zhi-jie Zhang1* and Xue-zhu Gu1</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201902005]]></guid><cfi:id>180</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[After a decade of persistent endeavor, Chinese Herbal Medicine is on the rise]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Founded in 2009, Chinese Herbal Medicines (CHM) has experienced an initial stagnant period and recent soaring growth as reflected in an array of publication statistics. The citation reports from 2015 to 2018 performed by Elsevier indicated that CHM possessed the sum of 213 citations for the 210 papers published in this duration with the average citations per item of 1.01, which doubled the number of 0.5 in 2017 within merely one year. Another important indicator for a journal impact is the sum of downloads for the recent published articles. As for CHM, the number of top ten most downloaded articles ranged from 409 to 1126 in 2018, while the highest lifetime downloads reached 2328 for one of the review articles entitled “Production of Active Compounds in Medicinal Plants: From Plant Tissue Culture to Biosynthesis”. This rapid development and growth in the quality of articles published and journal impact should vastly attribute to the joint efforts of authors, entire editorial staff and board members, which is greatly acknowledged and appreciated by the editors and host organizations.
This quarterly peer-reviewed journal is co-hosted by Tianjin Institute of Pharmaceutical Research and Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, which dedicated their great efforts and financial resources to have promoted the journal for a decade to the current stage. When CHM arrives at today’s status, we can’t fail to mention the two celebrated editors in chief, the founding editor professor Pei-gen Xiao and his successor Professor Chang-xiao Liu, both being members of Chinese Academy of Engineering, who have devoted their painstaking efforts and passion to foster the journal. From its founding, CHM was established to aim at providing an international communication platform for the up-to-date research achievements in the field of Chinese herbal medicines, traditional medicines, and natural products including research in bioactive principles, pharmacological actions, toxicity, pharmacokinetics, therapeutic efficacy of single herbs and/or their compound formulas. Article types published by CHM include research articles, reviews, short communications, etc. After arduous attempt, CHM is now indexed in an array of journal data bases such as China Academic Journals Integrated Online Database, Chemical Abstracts Service (CAS), Index Copernicus (IC), Ulrich's Periodicals Directory (UPD), Global Health and ESCI, EMBASE, CAB Abstracts, ProQuestetc, CNKI, etc.
Contrast to the achievements, CHM is still having a lot to improve. The proportion of contributed papers from international authors is still at the low level as evidenced that in 2016, only nine papers out of 104 were submitted by non-Chinese authors, while this number reduced to eight out of 126 in 2017 and enhanced to 30 out of 152 in 2018, which showed the trend for improvement. In addition, the number of papers published each year in four issues remained to be about 60, which clearly showed that authors are unseal us to submit their quality manuscripts either due to unawareness to the journal or to nonexistent impact factor in the Web of Science. There is still a high ratio of published papers receiving no attention from readers without any citations either due to low research quality or out of date topics. Apparently, these aforementioned deficient aspects with the journal are the targeted focus for improvement by the team in the future. 
Looking forward to the next ten years of CHM, we have the full confidence in CHM reaching to the new height after a steady development period. Quality of the submitted papers is essential and pivotal to the journal. Hence, soliciting and/or attracting high quality manuscripts from the established scientists worldwide in herbal field will be the top priority. Enhancing the exposure of the journal in the global herbal community is equally paramount, as well. The imbalance between papers contributed from domestic and ones from should be adjusted by alluring more international contributors. Special issues on the recent hot topics as systems biology, chemical biology, synthetic biology, network pharmacology, high-content screening of herbal medicines and natural products should be organized by inviting prominent guest editors to reflect the most recent research progress in the field. It is anticipated that the CHM will be rising to a new level that all editorial board members desire with their continuous improvement on the quality of the journal.   
2019 marks the beginning of CHM's second decade. Although the specific answers about how to improve journal quality take time and thought to uncover, the best way to approach the second decade and all of the changes it will bring can be summed up in one word—“Confidence”. As Robert Stuberg say in “Increasing Confidence”: “With confidence, all things are within the realm of possibility. Without confidence, even the smallest challenges seem insurmountable. While the problems or challenges seem too big to be overcome, the person with confidence always finds a way to win regardless of the circumstances”.
Confidence is the guarantee of success. Cooperation is the strength of success. We believe that in the first year of the second decade, with the cooperation of the publishers, editors, authors and reviewers, CHM will certainly move to a new level.
In the 2019 New Year, CHM's publishers sincerely thank the experts of editorial board and thank authors, reviewers and readers for yours loving and supporting to CHM over the past decade.
]]></description>
<pubDate>2019/1/14 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[De-An Guo and Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>De-An Guo and Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901001]]></guid><cfi:id>179</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Chinese medicines treating macrophage: A particular strategy for atherosclerosis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Atherosclerosis is a major cause of cardiovascular disease and one of the most deadly diseases in the world. Macrophages are the main contributors in the development of atherosclerosis, a target that drugs inhibit the inflammation and regulate lipid metabolism. In this review, we summarized the effects and mechanisms of traditional Chinese medicines and their bioactive compounds on atherosclerosis.]]></description>
<pubDate>2019/1/14 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shan?Lu, Yun Luo, Gui-bo Sun and Xiao-bo Sun]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shan?Lu, Yun Luo, Gui-bo Sun and Xiao-bo Sun</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901002]]></guid><cfi:id>178</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Therapeutic effects of traditional Chinese herbal prescriptions for primary dysmenorrhea]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Primary dysmenorrhea is a common disease among females in their reproductive age and adolescents. The main complaint is lower abdominal pain during menstruation. Females, who suffer from dysmenorrhea, widely use nonsteroidal anti-inflammatory drugs that reduce muscle spasm by inhibiting prostaglandin synthesis and vasopressin secretion. However, there are side effects when patients take them for a long time. It is therefore against this backdrop that herbal medicines are suggested as an alternative source of treatment for primary dysmenorrhea. In this paper, a review of studies demonstrating the relieving of uterine contraction and reduction in prostaglandin synthesis by alternative sources such as traditional Chinese medicines (TCM) is spelt out. TCM conceptualizes that, menstrual pain resulting from qi is due to stagnated and retained blood. Blood deficiency and coldness in the whole human body are two additional causes of dysmenorrhea. Therefore, based on these, the main focus of treatment is directed at relieving the above symptoms. Chinese herbal prescriptions exert their effects through these mechanisms: prostaglandin reduction, inhibition of cyclooxygenase, intracellular Ca2+, and nitric oxide, declining malondialdehyde, and reverse increasing superoxide dismutase. Hence, Chinese herbal prescriptions, present perhaps a more beneficial efficacious alternative in the treatment of primary dysmenorrhea, more especially in the confines of complementary and alternative medicine.]]></description>
<pubDate>2019/1/14 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Dorjbat Sosorburama, Zeng-guang Wua,, Si-chao Zhanga, Peng Hua, Hai-yan Zhanga, Tong Jianga, Joshua Ahiasi-Mensaha and Xin Hea, b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Dorjbat Sosorburama, Zeng-guang Wua,, Si-chao Zhanga, Peng Hua, Hai-yan Zhanga, Tong Jianga, Joshua Ahiasi-Mensaha and Xin Hea, b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM201901003]]></guid><cfi:id>177</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Rudolf Bauer: China anti-COVID-19 success is closely related with the role TCM played]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2020/11/9 13:45:56</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[De-an Guo, Chang-xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>De-an Guo, Chang-xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004001]]></guid><cfi:id>176</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Lung diseases and their related complications represent a critical source of morbidity and mortality globally and have become a research focus in recent years. There are plenty of hazards that threaten the health of lung by exposure to external environmental stimuli, such as dust, cigarette smoke, PM2.5, air pollution and pathogen infection. These risks lead to the impairment of lung function and subsequent lung diseases including pneumonia, chronic obstructive pulmonary disease (COPD), asthma and idiopathic pulmonary fibrosis (IPF). Compared with antibiotics and corticosteroids therapies, traditional Chinese medicine prescriptions are more effective with fewer side effects. A considerable variety of bioactive ingredients have been extracted and identified from Chinese herbal medicines and are used for the treatment of different lung diseases, including resveratrol. Increasing studies have reported promising therapeutic effects of resveratrol against lung diseases by inhibiting oxidative stress, inflammation, aging, fibrosis and cancer both in vitro and in vivo. In this review, the recent progress in the studies of lung-protective effects and underlying mechanisms of resveratrol and also highlight the potency of resveratrol and traditional Chinese prescriptions containing resveratrol as promising therapeutic options were summarized for the treatment of lung and respiratory diseases.]]></description>
<pubDate>2020/11/9 13:45:56</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Bo-ning Ma, Xiao-jiaoyang Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Bo-ning Ma, Xiao-jiaoyang Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004002]]></guid><cfi:id>175</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Brusatol: A potential anti-tumor quassinoid from Brucea javanica]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo. This review also covers pharmacokinetics studies, modification of dosages forms of brusatol. Increasing evidences have validated the value of brusatol as a chemotherapeutic agent in cancers, which may contribute to drug development and clinical application.]]></description>
<pubDate>2020/11/9 13:45:56</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiao-qi Yua, Xin-yue Shanga, Xiao-xiao Huanga, Guo-dong Yaoa,b, Shao-jiang Songa]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiao-qi Yua, Xin-yue Shanga, Xiao-xiao Huanga, Guo-dong Yaoa,b, Shao-jiang Songa</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202004003]]></guid><cfi:id>174</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Chinese medicine contributes to the treatment of COVID-19 patients]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Since December 2019, the SARS-CoV-2 infection has worldwide affected thousands of people and is life-threatening to patients who progress to the severe/critical condition, especially in the elderly. Governments and scientists all over the world are urging for new treatment measures to combat this world epidemic. Ever since the start, most agreements on the measures against COVID-19 rely on early RT-PCR diagnosis, proper quarantine, and vaccination; while treatment strategies rely on the use of multiple anti-viral drugs and cytokine inhibitors. However, when facing of this pandemic, it takes time to develop specific drugs and vaccines. To save life, it is indeed necessary to use the existing experience and knowledge of traditional Chinese medicine (TCM).
      Historically, there have been not less documents recorded in the classical TCM literatures about the use of TCM to treat epidemics. In ancient times, there was no Western medicine, while TCM was used on the main historical infectious disease battlefields. Many TCM formulas and products have been widely application in treating infectious and non-infectious diseases. The accumulated clinical experiences and effective prescriptions are believed to be used effectively today. In this urgent period, TCM should be taken into reference as a treatment option because most patients are still suffering. Importantly, there are also academically skilled TCM experts in China who have rich clinical experiences and can properly treat the novel coronavirus pneumonia to achieve curative outcomes. 
       In this issue of Chinese Herbal Medicines, Professor Chang-xiao Liu, the academician of Chinese Academy of Engineering and Editor-in-Chief of this journal, provides his wonderful insights on the outbreak and characteristics of COVID-19 to us, as well as particularly highlights all advantages of the therapeutic TCM principles and formulas for treating this new coronavirus epidemic. His insightful views are able to guide us to use TCM properly to fight this century virus.
      Since the outbreak of SARS-CoV-2 infection, Chinese Government initiated a policy that the COVID-19 patients should be treated with integrated Chinese and Western medicine because it is believed that such integrative approach would achieve better objective curative effects than that of using any one mono medicine alone. According to the news reports in China, TCM treatment has been applied in over 90% of COVID-19 patients, and some Chinese herbal formulas showed significant potencies of relieving patients’ symptoms, shorting the time of fiver and reducing the cases being conversed from the mild cases into the severe and even the critical ill.
      The drug action mechanisms of TCM are basically both similar and different from the conventional medicine. For the similarity, although COVID-19 is a new infectious disease, there have been reports to show that certain chemical components contained in a Chinese herbal formula are actually targeting on the pathological and molecular targets of COVID-19 to produce therapeutic effects, such as 3CL Pro, ACE2 and IL6 etc. On the contrary, the curative effects of Chinese herbal formula sometimes are not necessarily by directly inhibiting or killing the virus, but through the integration of various aspects such as relieving cytokines storm syndrome, protecting human tissues and organs, relieving immunological injury and enhancing the body's ability. With quick development of research programs on this new infection, we believe that solid scientific data would be provided to support widely application of TCM against this epidemic. 
      For further implantation of TCM treatment on the novel coronavirus pneumonia worldwide, we would suggest that "full coverage" and "full process" should be ensured in treating COVID-19 patients, together with highly quality assurance of TCM intervention throughout the process. Especially, TCM must be prescribed early, and the sooner the better, so as to prevent the disease from progressing to a serious condition. However, for the severe and critical cases, incorporating TCM into conventional treatment methods are also recommended so as to generate synergistic effect by the combinational therapy of Chinese and Western medicine.
      Moreover, TCM is able to play very important roles in rehabilitation of COVID-19 patients. Although some patients have reached discharge standard such as negative viral load and relief of observable syndromes, the patients are usually still suffered from the syndrome of qi and yin deficiency or other clinical symptoms and pathological alterations like pulmonary fibrosis and multiple organ functional destruction after immunological injury, which may not be completely resolved during their hospitalization. All these above manifestations, we may call them as a “Post-COVID-19 Syndrome” which is indeed needed for further treatment after discharge; while TCM is an indispensable method that should be promoted to use in such a stage of COVID-19 patients. 
      In the near future, we should further perform comprehensive drug screening based on the reported anti-viral molecular targets with our existing TCM chemical database, as well as the existing marketed drugs. Because scientific data of TCM treatment have not yet been solicited enough, more efforts should be made to expand deeply research on TCM for treating COVID-19 patients. And, we hope that we can enforce the contribution of the TCM treasure box together with modern technological investigation to combat the SARS-CoV-2 infection powerfully, together with internationals.]]></description>
<pubDate>2020/5/18 17:53:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liang Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liang Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002001]]></guid><cfi:id>173</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pay attention to situation of SARS-CoV-2 and TCM advantages in treatment of novel coronavirus infection]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Since the outbreak of the new coronavirus epidemic, novel coronavirus has infected nearly 100,000 people in more than 110 countries. How to face this new coronavirus epidemic outbreak is an important issue. Basic reproduction number (R0) is an important parameter in epidemiology; The basic reproduction number of an infection can be thought of as the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection. Epidemiology dynamics is a mathematical model based on a susceptibility-infection-recovery epidemic model. Researchers analyzed the epidemiological benefits of different transmission rates for the establishment of effective strategy in prevention and control strategies for epidemic infectious diseases. In this review, the early use of TCM for light and ordinary patients, can rapidly improve symptoms, shorten hospitalization days and reduce severe cases transformed from light and normal. Many TCM formulas and products have wide application in treating infectious and non-infectious diseases. The TCM theoretical system of treating epidemic diseases with TCM and the treatment scheme of integrated Chinese and Western medicine have proved their effectiveness in clinical practice. TCM can cure COVID-19 pneumonia, and also shows that the role of TCM in blocking the progress of COVID-19 pneumonia.]]></description>
<pubDate>2020/5/18 17:53:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liua,b,c]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liua,b,c</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002002]]></guid><cfi:id>172</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmaceutical resource discovery from traditional medicinal plants: Pharmacophylogeny and pharmacophylogenomics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The worldwide botanical and medicinal culture diversity are astonishing and constitute a Pierian spring for innovative drug R&D. Here, the latest awareness and the perspectives of pharmacophylogeny and pharmacophylogenomics, as well as their expanding utility in botanical drug R&D, are systematically summarized and highlighted. Chemotaxonomy is based on the fact that closely related plants contain the same or similar chemical profiles. Correspondingly, it is better to combine morphological characters, DNA markers and chemical markers in the inference of medicinal plant phylogeny. Medicinal plants within the same phylogenetic groups may have the same or similar therapeutic effects, thus forming the core of pharmacophylogeny. Here we systematically review and comment on the versatile applications of pharmacophylogeny in 1) looking for domestic resources of imported drugs, 2) expanding medicinal plant resources, 3) quality control, identification and expansion of herbal medicines, 4) predicting the chemical constituents or active ingredients of herbal medicine and assisting in the identification and determination of chemical constituents, 5) the search for new drugs sorting out, and 6) summarizing and improving herbal medicine experiences, etc. Such studies should be enhanced within the context of deeper investigations of molecular biology and genomics of traditional medicinal plants, phytometabolites and metabolomics, and ethnomedicine-based pharmacological activity, thus enabling the sustainable conservation and utilization of traditional?medicinal resources.]]></description>
<pubDate>2020/5/18 17:53:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Da-cheng Hao, Pei-gen Xiao b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Da-cheng Hao, Pei-gen Xiao b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002003]]></guid><cfi:id>171</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Immunomodulatory effects and structure-activity relationship of botanical pentacyclic triterpenes: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Botanical pentacyclic triterpenes possessed a broad range of pharmacological activities such as anti-oxidant, anti-tumor, anti-microbial and anti-in?ammatory. It is believed that the mechanisms involved in these bioactivities are due to the modulation of immune system. Recently, the pharmacological validation on immunomodulatory of pentacyclic triterpenes derived from higher plants is very limited and several existence review papers related for this group of compound have not been focused for this activity. In this review, we have highlighted several studies on immunomodulatory potential of botanical pentacyclic triterpenes isolated from wide array of different species of medicinal plants and herbs based on various preclinical in vitro and animal models. This review also attempts to discuss on bioactivities of this compound related with their structure-activity relationship. Hence, the evaluation of this botanical pentacyclic triterpenes offers a great opportunity to discover adjuvants and novel therapeutic agents that presented beneficial immunomodulatory properties.]]></description>
<pubDate>2020/5/18 17:53:42</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Nurul Hikmah Haruna,b, Abdi Wira Septamac, Wan Amir Nizam Wan Ahmada, Rapeah Suppiana]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Nurul Hikmah Haruna,b, Abdi Wira Septamac, Wan Amir Nizam Wan Ahmada, Rapeah Suppiana</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202002004]]></guid><cfi:id>170</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Inheriting Essence, Keeping Integrity and Innovation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In China, traditional Chinese medicine (TCM) is a complicated scientific system formulated by the health philosophy and practice in China’s thousands of years of history. It is a treasure of the Chinese civilization and embodies the great wisdom of the Chinese people and nation. Since the founding of the People’s Republic of China in 1949, remarkable achievements have been made in the field of TCM, which has made important contributions to the improvement of people’s health. Today, during the process of advancing the construction of healthy China, Chinese herbal medicine (CHM) must abide by “The Thought of Socialism with Chinese Characteristics for a New Era”, and give full play to the advantages of TCM in an attempt to make a historic contribution to realize the healthy China dream. In addition, one should vigorously push forward with the scientific and technological innovation of Chinese medicine and new drug research & development and make full use of the TCM unique advantage in disease prevention, treatment and rehabilitation, and finally realize high quality development of TCMs amid the inheritance and innovation of TCMs. President Xi Jin-ping called for the importance of "following the development rules of TCM, inheriting the essence and keeping the integrity and innovation", which is the significant and guiding thought to give play to the unique advantages of TCM in the disease prevention and treatment, modernization and industrialization of CHM products, complement each other between traditional and west medicine, promote the coordinated and high quality development of Chinese medicine cause and industry. It is a pivotal strategic guiding thought to build a healthier China system, and to realize the great rejuvenation of the Chinese nation. Following the law of development of Chinese medicine, understanding the thought of "Inheriting essence, keeping integrity and innovation", insisting on cultural confidence, deepening the reform and innovation are the core messages passed by "Central Committee of Chinese Communist Party and State Council Opinion on Preservation and Innovative Development of TCM” (Opinion) with 20 articles containing 125 items released in October 2019. Under the guidance of the “Opinion”, actions should be urgently taken on implementing the ground work in accordance with development road of the characteristics of TCM. It is an imperative historical
mission and responsibility to follow President Xi’s philosophy of "Inheriting essence, keeping integrity and innovation" and develop TCM with the historical view and development vision. After thousands of years of development, TCM embodies the profound theory, great wisdom, cognitive mode, development law and exuberant vitality of the Chinese people and nation. In today’s great rejuvenation of the Chinese nation, "carrying forward,inheriting and innovating" has always been the key to promote TCM sticking to its own development. During the development and transformation of TCM industry, we gradually lost ourselves due to the existing problems in TCM research & development and industry supervision, theory, methods and standards for TCM evaluation,as well as lack of culture confidence.
The newly released historic "Opinion” by Central Committee of CPC and States Council of China has clearly stated that the spirit of following the development law of TCM should run throughout.
That is to say, only by following the development law of TCM could we understand how to inherit the “essence”, keep the “right” and create the “new”. As the document pointed out, it is essential to give play to the unique role of TCM in maintaining and promoting people’s health.
We should follow the development rules of TCM, establish and improve the modern management system reflecting the characteristics of TCM, establish the safety and efficacy evaluation methods and technical standards of TCM products with the characteristics of TCM. However, if it deviates from its own law and "right" is not observed, it will be impossible to address the characteristic advantages of TCM. If it does not create "new", it will inevitably deviate from the goal with great clinical demand. Of course, to follow its own development rules does not mean self-isolation. Openness and inclusiveness also need to be followed. It is an important
part of the development to accelerate the construction of TCM theory and the establishment of a multidisciplinary scientific research platform in the coordinated development.
The "integrity" of TCM innovation lies in the practical significance of strengthening the confidence of TCM culture and theory, keeping an open and inclusive mind and focusing on the innovation goal. For TCM research & development and industry sustainable development, ranging from industry development,medicinal herbs cultivation and breeding, research and development of new products, the recourse of the quality management system, to the medical and health need, to the product safety and effectiveness, must conform to the trend of the new era, social demand and social contribution to the economic development of practical significance. The development of TCM has always been the root of TCM discipline innovation, but also the soul of TCM innovation.
Therefore, looking back on the unforgettable 2019 and ushering in the 2020s, we should "inherit essence and keep integrity and innovation", carry forward the innovative development, and blaze a trail with the characteristics of TCM development for a healthier China. Cultivating TCM acclaimed doctors, famous hospitals and classic prescriptions, forming well-known factories, celebrated medicines and branded shops in CHM industry,will be the inevitable trend for the development of TCM in the world.
Our international academic journal, Chinese Herbal Medicines (CHM), with the support of colleagues home and abroad, has gone through its full 10 years of history and has made an international impact on published quality articles. With the ushering of 2020s, we would like to convey our sincere gratitude to all who contributed CHM. TCMs from different nationalities are the targeted sources of the research and development, and CHM is a great platform for scientists to promote academic discoveries and carry forward innovative research results.]]></description>
<pubDate>2020/2/18 16:22:09</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-xiao Liu, De-an Guo]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-xiao Liu, De-an Guo</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001001]]></guid><cfi:id>169</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinese herbal medicine resources: Where we stand]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In recent years, the development of Chinese herbal medicine (CHM) has been challenged by shortages
of CHM resources and drug safety concerns related to end products. There have been significant efforts
by Chinese scholars to tackle these challenges, which are revealed by analyzing the research trend of
CHM resources via surveying Chinese Traditional and Herbal Drugs (Zhong Cao Yao), a representative jour-
nal in CHM. Our study focused on 781 articles in CHM resources from 2013 to 2018 and included four
subject areas: germplasm resources, quality analysis and evaluation, cultivation, and bioengineering of
CHM. Discussion and prospective for future investigations were also presented, including: construct the
core germplasm of medicinal plants and expand germplasms; combine molecular research with field ex-
periments and promote the deeper study of cultivation of CHM plants; improve the quality evaluation
method of CHM and strengthen the identification of Chinese patented medicines; promote the sustain-
able development of CHM resources by utilizing bioengineering and synthetic biology. This study helps
international scholars understand the status quo of CHM research and provides theoretical support for
the healthy, modern, and international development of CHM, and it will facilitate the sustainable devel-
opment of the traditional Chinese medicine industry]]></description>
<pubDate>2020/2/18 16:22:09</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ran-ran Gao a,c, Ya-ting Hu b, Yang Dan a, Li-jun Hao a,c, Xia Liu b, Jing-yuan Song a,c,d,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ran-ran Gao a,c, Ya-ting Hu b, Yang Dan a, Li-jun Hao a,c, Xia Liu b, Jing-yuan Song a,c,d,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001002]]></guid><cfi:id>168</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New insights into roles of basophils in initiating T helper type 2 immunity]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Allergic diseases, mainly mediated by T helper type 2 (Th2) immunity, have become a worldwide public health problem. Traditional Chinese medicine (TCM) has long been used in treating and preventing allergic symptoms. As the new target of anti-allergy TCM, basophils, after approximately 140 years since their discovery, are just now gaining respect as important contributors in the pathogenesis underlying allergic inflammation and disease. In addition to their role as effector cells, basophils can release early IL-4, migrate from circulatory system into draining lymph nodes, present antigen to naive CD4 + T cells,and promote the differentiation of Th2 cells. Herein, we briefly summarized the recent research advances of the essential contributions of basophils in the initiation of Th2 immune responses.]]></description>
<pubDate>2020/2/18 16:22:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Tian-xiang Ma a, Yuan Gao b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Tian-xiang Ma a, Yuan Gao b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202001003]]></guid><cfi:id>167</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Surging cooperation with ASEAN countries on traditional medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In November 4th, 2002, China has signed the landmark agreement with Association of South East Asian Countries (ASEAN), dubbed “Framework Agreement on Comprehensive Economic Cooperation between The Peoples’ Republic of China and the Association of South East Asian Countries”, which signaled the economic and trade cooperation ushering in a brand new historic stage. In the wake of the Framework Agreement, the two sides initiated ensuing pivotal measure to hold the China ASEAN EXPO series which had been practicing for consecutive 18 years as the pragmatic step in a bid to further promote and strengthen the economic and trade development between the two parties. The corresponding effect is obviously remarkable. According to the statistics, the two sides have witnessed bilateral trade rocketing from 8.36 billion U.S. dollars in 1991, the year that China and ASEAN established dialogue relations, to 685.28 billion U.S. dollars in 2020, an increase of over 80 times. Just recently the 18th China-ASEAN Expo and China-ASEAN Business and Investment Summit opened in Nanning, the permanent venue of Expo and capital city of south China's Guangxi Zhuang Autonomous Region with Chinese President Xi Jinping’s congratulatory letter, which indicated the great success from series of operations in enhancing the bilateral ties. Along with the skyrocketing economic and trade development, one has also seen the booming in two sides’ cooperation on traditional medicine and herbal medicine, the area that China and ASEAN have communicated and exchanged with a long history and also reckoned as the significant part in traditional culture exchange between China and ASEAN countries. On top of the increasing concrete project collaborations, China ASEAN Forum on Traditional Medicine has also been annually hosted by the Guangxi local government as important sector of the Expo. Great progress in bilateral operation in the field of traditional and herbal medicines has been reached including the bilateral and multi-lateral collaborative centers of traditional medicine established between China and each member of ASEAN countries. Recently, both sides devoted the cooperation in traditional Chinese medicine (TCM) fighting against Covid-19 by donating TCM products to ASEAN countries and collaborating in screening of traditional medicines and compounds therefrom to fight against Covid-19 infections, which has yielded remarkable research progress from these close collaborations. 
RCEP is an organization initiated by 10 ASEAN countries in 2012, in which China, Japan, South Korea, Australia, New Zealand and India were invited to participate. There are 16 countries (10 ASEAN+6) for establishing a free trade agreement with a unified market of 16 countries by reducing tariff and non-tariff barriers. RCEP covers about 3.5 billion people, with a total GDP of US$ 23 trillion, accounting for one third of the global total. Because of its special geographical location and climatic conditions, its medicinal plant resources are abundant, and its traditional medicine has obvious advantages. Therefore, it is of far-reaching significance to analyze and study its traditional medicine resources and applications for the benefit of 16 countries. 
The Editorial Department of CHM organized this special issue according to the "Solvent Contributions Plan of Special Issue RCEP Traditional Medicine Research". Authors from RCEP countries and regions contributed the articles. In this special issue of RCEP Traditional Medicine Research dedicated to unearth the overall picture and progress made related to traditional medicine, 14 review or original research articles were collected to unleash the advancement in the traditional medicine research progress among the countries with same-rooted traditional medicine systems. These articles on basic research and applied development research provided useful information to readers and also will benefit the health of the people in the region and produce beneficial social and economic effects.
In his review article, Prof. Chang-xiao Liu, the academician of Chinese Academy of Engineering and the honorary president of Tianjin Pharmaceutical Research Institutes, expounded in detail from five aspects to outline the general situation in traditional medicine development between China and ASEAN countries, including i) development basis of China ASEAN traditional medicine and herbal medicine, ii) development and efficacy of traditional medicine theory system, iii) industry development and regulation management of traditional medicine and herbal medicine products, iv) China-ASEAN traditional medicine exchanges and cooperation to promote traditional medicine cooperation and medicine trade, and v) strengthening academic and industrial cooperation and promoting the healthy development of traditional medicine and herbal medicine, respectively. From the points of geographical adjacency and cultural resemblance between China and ASEAN countries, Prof. Liu indicated that commonly shared culture and similar traditional medical systems formulated the basis for further development in the rising cooperation of traditional medicines. In addition, he also described the formation of each country’s traditional medicine theory system and the traditional and herbal medicine industry development plus the regulatory framework in China and each individual ASEAN country. The similarity, differences and even the restrictions among the theory systems and industrial developments were compared and highlighted. The research and cooperation progress in traditional and herbal medicines were individually summarized from each country’s perspective and some of the significant research achievements were exemplified with concrete case studies. He calls for strengthening the academic and industrial cooperation and promoting the healthy development in traditional medicine between China and ASEAN countries from the following respects. Firstly, research and development of traditional medicine products for treatment of Covid-19 should be highly addressed; secondly, research on the resources, medicinal values and application of traditional medicines ought be strengthened; thirdly, scientific research of traditional and herbal medicines should be reinforced and cooperation and sharing system should be established by taking advantage of modern technology like big data and artificial intelligence; fourthly, training of personnel in the areas of new methods and technology, new tools for probing medicinal value of traditional and herbal medicines is also the indispensable aspect. This review article will certainly facilitate the readers to navigate the current situation and future prospect in traditional medicine research between China and ASEAN countries.
Other contributions to this special issue cover reviews or original research in the following areas including immuno-metabolism for treatment of rheumatoid arthritis, future development of good agricultural practice, comprehensive analysis of traditional Chinese medicine for treatment and prevention of Covid-19 infections, chemical and pharmacological research progress of some important southeast Asian important medicinal or edible plants, phytochemical analysis and efficacy study of medicinal herbs, and the like, which were contributed by quite diversified authors from Mainland China, Macau China, Japan, Korea, Malaysia, Thailand, Singapore, and Germany. Prof. Liang Liu, also a academician of Chinese Academy of Engineering and former president of Macau University of Science and Technology, together with his team, reviewed the pathological mechanism of rheumatoid arthritis (RA) and strategies to treat RA by applying traditional Chinese medicine and its natural compounds through targeting metabolic reprogramming of immune cells, and project them as a rich resource for providing the new potential paradigm for the treatment of RA. Prof. Jia-gang Deng and his team contributed three review articles with two focusing on the use of traditional Chinese medicine to prevent and treat Covid-19 diseases. In the article entitled “Analysis on Oral Medication Rules of Traditional Chinese Medicine Prescription for the Prevention of COVID-19”, they selected 157 commonly used anti-Covid-19 TCM prescriptions involving a total of 130 TCM herbs for manual screening through Excel and TCM inheritance assistant platform and summarized that the top five TCM herbs with the highest use frequency are Glycyrrhizae Radix et Rhizoma, Astragali Radix, Lonicerae Japonicae Flos, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix respectively. Based the above analysis, they concluded that the anti-Covid-19 TCMs mainly play the role by invigorating and tonifying qi (vital enegy), strengthening spleen, and eliminating dampness and heat according to Chinese medical terms. The contributors to this special issue from Malaysia, Thailand, Singapore, Japan and Korea mainly represented their research outcome dealing with antihypertensive, antioxidant and antiviral activity, anti-allergic contact dermatitis, signaling pathway regulation of local herbal medicines or edible fruit products.
It is firmly believed that this special issue will provide valuable information to the readers and related parties on the recent research progress of traditional and herbal medicines among China, and ASEAN and RCEP countries. Due to the inseparable geographic relation and similarly-rooted culture in traditional medicines in the region, there is a nature-endowed advantage to closely cooperate on the research of traditional medicines under the established frameworks of China with ASEAN and RCEP countries. During the process, modern science and technology should be widely embraced to advance the scientific understanding of the theory and action mechanism of traditional medicine. It is anticipated that traditional medicine and herbal medicine would play much more significant role with more scientific understanding of its safety, efficacy, quality and mechanism to maintain and assuring the health of people in the geographical region and even entire mankind at large.]]></description>
<pubDate>2021/11/17 13:46:21</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Guo De-an]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Guo De-an</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104001]]></guid><cfi:id>166</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Overview on development of ASEAN traditional and herbal medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional medicine is an important and often underestimated part of health services. In some countries, it has a long history of use in health maintenance and in disease prevention and treatment, particularly for disease. WHO has always emphasized the important role of traditional, complementary and alternative medicine in human healthcare. In this review article, author provided some information from the following five aspects: (1) Development basis of China ASEAN traditional medicine and herbal medicine; (2) The development and afficacy of traditional medicine theory system; (3) Industry development and regulation management of traditional medicine and herbal medicine products; (4) China-ASEAN traditional medicine exchanges and cooperation to promote traditional medicine cooperation and medicine trade, and (5) Strengthening academic and industrial cooperation and promoting the healthy development of traditional medicine and herbal medicine. It is believed that the information will have certain reference value for readers in studies on traditional and herbal medicines.]]></description>
<pubDate>2021/11/17 13:46:21</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chang-Xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chang-Xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104002]]></guid><cfi:id>165</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Targeting immunometabolism by active ingredients derived from traditional Chinese medicines for treatment of rheumatoid arthritis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Rheumatoid arthritis (RA), the most common inflammatory arthropathy word wild, is a systemic autoimmune disease that mainly affects the synovium of joints with a high disability rate. Metabolic mis-regulation has emerged as a fundamental pathogenesis of RA linked to immune cell dysfunction, while targeting immunometabolism provides a new and effective approach to regulate the immune responses and thus alleviate the symptom of RA. Recently, natural active compounds from traditional Chinese medicines (TCMs) have potential therapeutic effects on RA and regulating immunometabolism. In this review, in addition to updating the connection between cellular metabolism and cell function in immune cells of RA, we summarized that the anti-inflammatory mechanisms of the potential natural compounds from TCM by targeting metabolic reprogramming of immune cells, and discusses them as a rich resource for providing the new potential paradigm for the treatment of RA.]]></description>
<pubDate>2021/11/17 13:46:21</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yu-fei He, Chu-tian Mai, Hu-dan Pan, Liang Liu, Hua Zhou, Ying Xie]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yu-fei He, Chu-tian Mai, Hu-dan Pan, Liang Liu, Hua Zhou, Ying Xie</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104003]]></guid><cfi:id>164</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical constituents and pharmacological effects of durian shell in ASEAN countries: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Durio zibethnus is mainly distributed in Southeast Asia. Traditional Chinese medicine believes that durian shells have the effects of clearing heat and purging fire, nourishing yin and moisturizing dryness. Therefore, it is often used as a pharmaceutic food in the Chinese folk to assist treating diseases. At present, the chemical constituents isolated in durian shell include phenolic acids, phenolic glycosides, flavonoids, coumarins, triterpenes, simple glycosides and other compounds. Modern pharmacological studies show that durian shell has many pharmacological activities, such as antioxidant, anti-inflammatory, regulation of glucose and lipid metabolism. The chemical composition and pharmacological effects of durian shells are summarized in order to provide references for the further research and application of durian shell.]]></description>
<pubDate>2021/11/17 13:46:21</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yuan-fei Zhana,b,c,d, Xiao-tao Houa,b,c,d,e, Li-li Fan a,b,c, Zheng-cai Dub,c,d,e, Ch'ng Soo Eed,f, Ng Siok Mengg, Khamphanh Thepkaysoned,h, Er-wei Hao b,c,d,e, Jia-gang Dengb,c,d,e]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yuan-fei Zhana,b,c,d, Xiao-tao Houa,b,c,d,e, Li-li Fan a,b,c, Zheng-cai Dub,c,d,e, Ch'ng Soo Eed,f, Ng Siok Mengg, Khamphanh Thepkaysoned,h, Er-wei Hao b,c,d,e, Jia-gang Dengb,c,d,e</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104004]]></guid><cfi:id>163</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Future development of Good Agricultural Practice in China under globalization of traditional herbal medicine trade]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional herbal medicine (THM) is an important part of the traditional Chinese medicine culture. Due to its high medicinal potential, it should not only serve for the Chinese people's medical use, but also contribute to the world medicine, THM for the international market must be standardized and large-scale, and produced according to the “Good Agriculture Practice” (GAP). The quality of THM directly affects the patient's treatment status and safety of use. Therefore, the quality assurance of THM runs through the entire process of research and development, production and clinical practice. The standardized production and cultivation of THM is the starting point of the THM industry chain and plays a decisive role in the economic development of the THM industry. This article summarizes the development history, limitations and future development of GAP, and clarifies the opportunities for THM in the rapid development of the international and domestic Chinese medicine industry. In addition, analyzing the deficiencies that were existing in the former GAP implementation process and by suggesting science-based quality measures, it is hoped to stipulate improved GAP guidelines in the future and to lay the foundation for a modern THM international trade.]]></description>
<pubDate>2021/11/17 13:46:22</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ru Zhanga, Ming-xu Zhanga, Yuan Chenf, Cong-cong Wanga, Chun-hong Zhanga,c,d, Heidi Heubergerb, Huan-ting Lia, Min-hui Lia,c,d,e,f]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ru Zhanga, Ming-xu Zhanga, Yuan Chenf, Cong-cong Wanga, Chun-hong Zhanga,c,d, Heidi Heubergerb, Huan-ting Lia, Min-hui Lia,c,d,e,f</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104005]]></guid><cfi:id>162</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Dihydrophenanthrenes from medicinal plants of Orchidaceae: A Review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The plants of Orchidaceae are widely distributed in the world, 47 species of which have been used as folk medicines with a long history. The tubers and stems of them exhibit diverse efficacy, including clearing heat and resolving toxin, moistening lung and relieving cough and promoting blood circulation. Since dihydrophenanthrenes were responsible for the medical purposes, the characteristic skeletons, pharmacological effects and clinical applications of dihydrophenanthrenes were summarized in this review, so as to provide a theoretical basis for the comprehensive study, development and application of DPs from medicinal plants of Orchidaceae.]]></description>
<pubDate>2021/11/17 13:46:22</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jia-xin Qia, Di Zhoua, Wan-ru Jianga, Gang Chena, Wei Li b, Ning Li a]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jia-xin Qia, Di Zhoua, Wan-ru Jianga, Gang Chena, Wei Li b, Ning Li a</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104006]]></guid><cfi:id>161</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Antiviral medicinal plants found in Lanna traditional medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional medicine uses a multitude of plants to create medicinal formulations, some of which show antiviral properties that may be of benefit in treating emerging viral diseases, including Covid-19. Lanna, an ancient Kingdom in northern Thailand, with a thriving culture that continues to this day and has a rich history of traditional medicine using local plants that is still practiced today. To find potential antiviral medicinal candidates, we examined ancient manuscripts, interviewed traditional healers practicing today, and inventoried current traditional medicines to catalogue 1400 medicinal formulations used in Lanna traditional medicine. We then narrowed this list to find those traditionally used to treat diseases that in their original use and descriptions most likely map to those we know today to be viral diseases. We identified the plants used in these formulations to create a list of 64 potential antiviral herbal candidates drawn from this ancient Lanna wisdom and matched these to the scientific literature to see which of these plants had already been shown to possess antiviral properties, generating a list of 64 potential antiviral medicinal candidates from Lanna traditional medicine worth further investigation for treating emerging viral diseases.]]></description>
<pubDate>2021/11/17 13:46:22</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jakaphun Julsrigivala,b,c, Panee Sirisa-ardc, Sarinya Julsrigivald, Nararat Akarchariyac]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jakaphun Julsrigivala,b,c, Panee Sirisa-ardc, Sarinya Julsrigivald, Nararat Akarchariyac</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202104007]]></guid><cfi:id>160</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Back to beginning: Searching for Rosetta Stone of enhancing herbal medicine quality]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202103001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese herbal medicines (CHMs) are an integral part of ecosystem service for humankind and represent one of most important bioresources in our planet, in which nature's ability is fully unlocked to prevent/treat human diseases. From the world-wide research and practice in recent years, we can feel that the process of globalization of traditional Chinese medicine (TCM) is accelerating; especially since the outbreak and spread of COVID-19 since December 2019, the world has gained more recognition of its important/unique values. Nowadays, considerable studies have focused on the quality evaluation of CHMs (Liu, 2021), which, however, cannot meet the growing demand for drug safety, if the problem of pesticide residues and heavy metals in CHMs cannot be effectively tackled. Hence, the eligible medicinal plant cultivation pattern should be actively explored, so as to solve the quality problems of CHMs from the source and provide quality CHMs sustainably. In the review “How to improve CHMs quality: Enlighten from CHMs ecological cultivation” (Cao et al., 2021), the situation and characteristics of medicinal plant resources, including wild-harvested and cultivated ones, in different historical periods are scrutinized. In Dream Creek Talk (梦溪笔谈) of Song Dynasty, the scholar Shen Kuo thought that “In ancient times, herbs are mostly collected in February or August, which is very inappropriate. It's just that the February grass has sprouted and the August seedling hasn't dried up, so it's easy for the picker to recognize it, but it's not a good time for medicine picking”. Shen sagaciously realized the influence of ecological/environmental factors on the quality of phytomedicine; he said that “the peach and plum trees in ZhuYue of southern China bear fruit in winter, while those in the northern desert only bloom in summer. This is the difference of telluric effluvium (i.e., soil/climate conditions). The crops in the same Mu germinate first with good water and fertilizer conditions…... How can the collection of herbs be limited to a fixed month”. The growth stage, season and phenological factors should be paid attention to when harvesting TCM plants. Based on ancient experiences, the ecological cultivation is recommended in developing medicinal plant cultivation to obtain quality CHMs.
The rhizosphere, a slender region of soil, is unswervingly influenced by roots and associated soil microbes. Studies on rhizosphere microbes of TCM plants are critical for applied microbiology, microbial ecology, and industrial biotechnology with regard to ecological cultivation and CHM quality (Hao & Xiao, 2017). In contrast to the inability of culturing most rhizosphere microbes (around 99%) in the laboratory, currently there are enormous advances in applying culture-independent techniques based on molecular biology and omics to the study of rhizosphere microbial community structure/composition and plant-microbe interactions. The various omics tools, such as FISH, stable isotope probing (SIP), next/third generation sequencing, etc., evolve quickly to provide more comprehensive understanding of the rhizosphere microbiota and microbiome. The flexible applications of high-throughput sequencing technologies, e.g., amplicon sequencing, shotgun metagenomic sequencing, whole genome sequencing, and transcriptome sequencing, continuously address the biology and biotechnology potentials of the rhizosphere microbiome of medicinal plants. The review “How to improve CHMs quality: Enlighten from CHMs ecological cultivation” (Cao et al., 2021) discusses recent findings and future challenges in the study of rhizosphere microbes, highlighting multi-faceted roles of microbial inoculants. Moreover, the evolution of research methods and innovative combinations of different techniques should also be encouraged. The top-down approaches such as metagenomics and bottom-up approaches targeting individual species or strains should be integrated and combined with modeling approaches to afford a wide-ranging understanding of the microbial community as a whole.
Searching for Rosetta Stone of enhancing herbal medicine quality is never an easy task. Green technologies, e.g., bioaugmentation and biostimulation, are cost effective and eco-friendly, and are becoming Rosetta Stone for the remediation of soil heavy metal and pesticides. The bacteria, fungi and their consortia can be combined with physical and chemical techniques for the targeted remediation of soil organic pollution, heavy metal contamination or both. The review of Cao et al. (2021) exemplifies the representative studies, summarizes the potentials of microbial strains in transforming/degrading pollutants, and highlights the roles of biochar and mineral elements in laboratory，greenhouse and field conditions. The complexity of microbial remediation is ascribed to not only the variations of physiological and metabolic traits, but also numerous environmental factors, including abiotic factors, e.g., pH, temperature, type of soil, pollutant concentration, content of water and organic matter, additional carbon and nitrogen sources, and biotic factors, e.g., inoculum size, interactions between the introduced strains and autochthonous microbes, and survival of inoculants, etc. The ingeniously combined remediation and rational applications of molecular methods will maximize the soil remediation without much cost.
Microbes in arable soil participate in the biogeochemical cycling of nitrogen, which profoundly impact on the fertility and greenhouse gas emission. As the effects of environmental factors on the structure and functions of microbial communities have not been thoroughly elucidated, it is necessary to perform the microcosm/mesocosm study to collect the soil samples under different moisture (e.g., constant and wetting)/pH/gas (air, 10% acetylene, oxygen and argon) regimes and investigate the alterations of microbial community structure, gene abundance and nitrogen metabolic functions under different conditions by high-throughput sequencing, quantitative PCR and RT-PCR, SIP, physicochemical analyses and bioinformatics. The impact of moisture/gas regimes, processing time and interaction item on NH4+-N and NO3--N would be conspicuous. The water/gas regime could significantly affect the microbial community diversity. The key responsive microbial classes under different moisture/pH/gas conditions would be disclosed in such a study. Novel microbial species that are positively correlated with moisture and N2O emission will be found; the dominant processes of nitrogen cycle, e.g., denitrification, nitrate reduction to ammonium, nitrification, nitrogen mineralization/fixation, in different types of soil will be determined, which, along with the co-occurring network and gene-species correlation heatmap, are invaluable information in improving medicinal plant growth and production of medicinal compounds. Medicinal plant scholars should communicate and cooperate with soil researchers more. The findings therefrom shed light on the prevention and control of soil fertility decline and global warming, as well as heavy metals and pesticide residues exceeding the standard in CHM products.]]></description>
<pubDate>2021/8/2 9:37:07</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Da-Cheng Hao, Chang-Xiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Da-Cheng Hao, Chang-Xiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202103001]]></guid><cfi:id>159</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[How to improve CHMs quality: enlighten from CHMs ecological cultivation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202103002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chinese herbal medicines (CHMs) are one of the important bioresources of medicine, which works by unlocking nature's ability to prevent diseases and recover from illnesses. Recently, it has ascended to the world stage and become a global icon. Nowadays, a considerable of researches have focused on the quality evaluation of CHMs. However, it is difficult to meet the reasonable needs of human beings for safe drug use to evaluate the quality of a huge number of inferior goods for the CHMs contaminated by pesticides and heavy metals. Hence to explore an eligible medicinal plant cultivation pattern, which can provide high quality CHMs sustainably, is most promising. This review analyzed the situation and characteristics of medicinal plant resources in different periods, including wild-harvested resources and domestic cultivation during different stages, putting forward that ecological cultivation must be the way to develop medicinal plant cultivation and to obtain high quality CHMs.]]></description>
<pubDate>2021/8/2 9:37:07</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Pei Caoa, Gang Wanga, Xue-Min Weia, Shi-Lin Chenb, Jian-Ping Hana,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Pei Caoa, Gang Wanga, Xue-Min Weia, Shi-Lin Chenb, Jian-Ping Hana,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202103002]]></guid><cfi:id>158</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Daphne-type diterpenes from genus Daphne and their anti-tumor activity]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Daphne-type diterpenenoids is the major biologically active constituents in the genus Daphne. We find that there are about 101 Daphne-type diterpenes in this genus, most of these compounds show different degrees of inhibitory effect on various cancer cell. Some of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling pathways. In addition, some compounds of this type also can inhibit the synthesis of protein and DNA. Absolutely, the anti-tumor activity of Daphne-type diterpenes is worthy of attention. Unfortunately, most of the current research on the activity of these compounds is focused on simple drug efficacy, and its in-depth mechanism research is far from enough. On the other point of view, there still exists wide growing space on the depth of these compounds.]]></description>
<pubDate>2021/6/10 15:43:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zi-lin Hou, Guo-dong Yao, Shao-jiang Song]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zi-lin Hou, Guo-dong Yao, Shao-jiang Song</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102001]]></guid><cfi:id>157</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A review of lignans from genus Kadsura and their spectrum characteristics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae. Plants from genus Kadsura are widely distributed in the South and Southwest of China. The plants of the genus are widely used as folk medicine for a long time in history, with the functions of relieving pain, promoting 'qi' circulation, activating blood resolve stasis, and applications in the treatment of rheumatoid arthritis and gastroenteric disorders. Lignans are the primary characteristic constituents with various biological activities of plants from genus Kadsura. This paper summarized 81 lignans isolated from the plants of genus Kadsura over the past eight years (from 2014 to 2021)，which belong to five types: dibenzocyclooctadienes, spirobenzofuranoid dibenzocyclooctadienes, aryltetralins, diarylbutanes and tetrahydrofurans. Each type of these lignans possess typical characteristics in proton magnetic resonance (1H-NMR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectra, the NMR regularities of these types of lingans were summarized, which provided a useful reference for the structural analysis of lignans. The relationships between lignans and pharmacodynamics were also systematically analyzed, the lignans were predicted to be the quality markers (Q-marker) of Kadsura genus.]]></description>
<pubDate>2021/6/10 15:43:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liu Zhanga, Yan-zhe Jiaa, Bin Lia, Cai-yun Penga, Yu-pei Yanga, Wei Wanga, Chang-xiao Liub]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liu Zhanga, Yan-zhe Jiaa, Bin Lia, Cai-yun Penga, Yu-pei Yanga, Wei Wanga, Chang-xiao Liub</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102002]]></guid><cfi:id>156</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Sesquiterpene lactones of Aucklandia lappa: Pharmacology, pharmacokinetics, toxicity, and structure-activity relationship]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The medicinal part of Aucklandia lappa (Asteraceae) is its dried root, which is one of the commonly used Chinese medicinal materials. Here we reviewed sesquiterpene lactones isolated from A. lappa over the past ten years in the following aspects of pharmacological activities, pharmacokinetics, toxicology, structure-activity relationship. Pharmacological activities consist of anti-cancer, anti-inflammatory activity, anti-immunity activity, anti-oxidant activity, antimicrobial activity, spasmolytic activity and so on. The extractive, showing similar pharmacokinetics parameters, may exert their various biological activities by the interaction of their α-methylene-γ-butyrolactone moiety with the thiol groups of biomacromolecules through Michael-addition. However, the poor aqueous solubility, non-selective binding as a Michael acceptor at undesired targets limited clinical translation of this class. In order to evaluate the potential effect of the extractive applied in clinical trial, the present review outlines information on pharmacological activities, pharmacokinetics, toxicology, and structure-activity relationship, as well as the future research directions of the extractive for further development and utilization of A. lappa.]]></description>
<pubDate>2021/6/10 15:43:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xin-nan Liua, b, Hui-min Lib, Shu-ping Wangc, Jing-ze Zhangb, Dai-lin Liu b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xin-nan Liua, b, Hui-min Lib, Shu-ping Wangc, Jing-ze Zhangb, Dai-lin Liu b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202102003]]></guid><cfi:id>155</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Flavonoids in myocardial ischemiaâ€“reperfusion injury: Therapeutic effects and mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties; They also have other benefits that may be relevant for ameliorating myocardial ischemia–reperfusion injury (MIRI). In this review, we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e) myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.]]></description>
<pubDate>2021/1/18 13:59:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jun-ying Jiaa, Er-huan Zangb, Li-juan Lvc, Qin-yu Lib, Chun-hua Zhangb, Ying Xiad, Lei Zhange, Lian-sheng Dangf, Min-hui Lib,d,e,g]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jun-ying Jiaa, Er-huan Zangb, Li-juan Lvc, Qin-yu Lib, Chun-hua Zhangb, Ying Xiad, Lei Zhange, Lian-sheng Dangf, Min-hui Lib,d,e,g</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101006]]></guid><cfi:id>154</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Panax japonicus and chikusetsusaponins: A review of diverse biological acivities and pharmacology mechanism]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Panax japonicus, which in the Tujia dialect is known as “Baisan Qi” and “Zhujieshen”, is a classic “qi” drug of Tujia ethnomedicine and it has unique effects on disease caused by “qi” stagnation and blood stasis. This paper serves as the basis of further scientific research and development of Panax japonicus. The pharmacology effects of molecular pharmacology were discussed and summarized. P. japonicus plays an important role on several diseases, such as rheumatic arthritis, cancer, cardiovascular agents, and this review provides new insights into P. japonicus as promising agents to substitute ginseng and notoginseng.]]></description>
<pubDate>2021/1/18 13:59:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiao-Juan Wanga, Qian Xie b, Yang Liub, Sai Jiangb, Wei Lib, Bin Lib, Wei Wangb, Chang-Xiao Liuc]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiao-Juan Wanga, Qian Xie b, Yang Liub, Sai Jiangb, Wei Lib, Bin Lib, Wei Wangb, Chang-Xiao Liuc</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101007]]></guid><cfi:id>153</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Challenges and strategies in progress of drug delivery system for traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen)]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicines (TCMs), with a history of thousands of years, are widely used clinically with effective treatment. However, the drug delivery systems (DDSs) for TCMs remains major challenges due to the characteristics of multi-components including alkaloids, flavones, anthraquinones, glycosides, proteins, volatile oils and other types. Therefore, the novel preparations and technology of modern pharmaceutics is introduced to improve TCM therapeutic effects due to instability and low bioavailability of active ingredients. Salviae Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza Bunge (Danshen in Chinese), is a well known Chinese herbal medicine for protecting the cardiovascular system, with active ingredients mainly including lipophilic tanshinones and hydrophilic salvianolic acids. In this review, this drug is taken as an example to present challenges and strategies in progress of DDSs for TCMs. This review would also summary the characteristics of active ingredients in it including physicochemical properties and pharmacological effects. The purpose of this review is to provide inspirations and ideas for the DDSs designed from TCMs by summarizing the advances on DDSs for both single- and multi-component from Danshen.]]></description>
<pubDate>2021/1/18 13:59:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ruo-ning Wanga,b, Hua-cong Zhao a,b, Jian-yu Huang a,b, Hong-lan Wang a,, Jun-song Li a,b, Yin Lua, c, Liu-qing Di a,b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ruo-ning Wanga,b, Hua-cong Zhao a,b, Jian-yu Huang a,b, Hong-lan Wang a,, Jun-song Li a,b, Yin Lua, c, Liu-qing Di a,b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101008]]></guid><cfi:id>152</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in biotechnological production of santalenes and santalols]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101009]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Sandalwood essential oil has been widely used not only as natural medicines but also in perfumery and food industries, with sesquiterpenoids as its major components including (Z)- α-santalol and (Z)-β-santalol and so on. The mature heartwoods of Santalum album, Santalum austrocaledonicum and Santalum spicatum are the major plant resources for extracting sandalwood essential oil, which have been overexploited. Synthetic biology approaches have been successfully applied to produce natural products on large scale. In this review, we summarize biosynthetic enzymes of santalenes and santalols, including various santalene synthases (STSs) and cytochrome P450 monooxygenases (CYPs), and then highlight the advances of biotechnological production of santalenes and santalols in heterologous hosts, especially metabolic engineering strategies for constructing santalene- and santalol-producing Saccharomyces cerevisiae.]]></description>
<pubDate>2021/1/18 13:59:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wen-long Zhaa,b, Jia-chen Zia,b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wen-long Zhaa,b, Jia-chen Zia,b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202101009]]></guid><cfi:id>151</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network pharmacology in quality control of traditional Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicine (TCM) has been widely used to treat and prevent diseases for thousands of years in China and is generally recognized for its unique holistic view and remarkable therapeutic effect on complex diseases. The worldwide interest to TCM has been increasing in recent years, especially since TCM has shown inspiring efficacy in the treatment of COVID-19. These attentions include both recognition of the important role of TCM and doubts about its efficacy and safety. At present, the internationalization and modernization of TCM are facing many challenges, such as unclear biological mechanism of herbs and formulae, and the difficulty of ensuring the quality and safety of TCM. Given the multi-component and multi-target characteristics of TCM, how to systematically describe the interaction between TCM and complex diseases, evaluate the efficacy and toxicity of TCM and carry out quality control has become the focus and difficulty of research.
Network pharmacology, as a systematic and holistic medical research paradigm, can help to systematically reveal the biological basis of TCM, and has been widely used in the research of TCM bioactive ingredients, syndromes, formulae, and other topics. The concept of "network target" based on TCM research (Li et al., 2011) has been used to explore new methods and applications since its inception, leading to a new discipline of TCM network pharmacology (Li and Zhang, 2013). On the one hand, TCM network pharmacology research shows the tendency of combining computational, experimental and clinical approaches (Wang et al., 2021), and the research paradigm is improving continuously. On the other hand, the application of network pharmacology is expanding to a variety of aspects in TCM research. It has been applied in fields such as exploring the biological basic of disease and syndrome, uncovering the mechanism of TCM formulae, identifying toxic components and quality markers (Q-Marker) of traditional Chinese medicine and so on.
The concept of Q-Marker which was proposed by Prof. Liu to standardize the quality research of TCM has established an effective research framework for the quality control of traditional Chinese medicine (Liu et al., 2017). Since it was proposed, Q-Marker has been utilized by researchers to analyze many TCM herbs and formulae, making an important contribution to the TCM quality control system. A previous research strategy of predicting and determining Q-Marker based on network pharmacology method (Wang et al, 2019) shows the potential of network pharmacology combined with Q-Marker in the application of quality control of TCM. The effectiveness and safety of TCM are taken into consideration when determining Q-Marker. There have been many successful application cases of network pharmacology in studying the effective ingredients and mechanism of TCM, and network pharmacology is also being used more and more frequently in the study of TCM toxicity.
This issue will publish a research paper titled “Integrating systematic pharmacology-based strategy and experimental validation to explore mechanism of Tripterygium glycoside on cholangiocyte-related liver injury” on the use of network pharmacology to explore the toxic components of TCM and their underlying mechanisms. Tripterygium glycoside (TG) extracted from Tripterygium wilfordii have been used in clinical treatment of rheumatoid arthritis and other diseases, and there are several new indications under study. However, hepatotoxicity, the main adverse effect of TG in clinical practice, is an urgent problem to be solved. By combining network pharmacological analysis with in vivo and in vitro experimental verification, the authors discovered that triptolide, the primary toxic component of TG, could inhibit proliferation and promoted apoptosis of cholangiocytes by inhibiting the phosphorylation of ERK1/2 and AKT and activating Bax and cleaved-Caspase 3 signaling. This study is a typical example of using network pharmacology to predict the toxic components and mechanisms of TCM. At the same time, it also shows that network pharmacology can be combined with Q-Marker strategy to identify the toxicity Q-Marker of TCM, and aids in the quality control and standardization of traditional Chinese medicine.
As a discipline that has been developed for a short period of time, there are still many challenges in the theory, methodology and application of network pharmacology. The quality control research of TCM using network pharmacology also needs more investigation and exploration. The publication of Network Pharmacology Evaluation Method Guidance in 2021 has positive implications for the standardization of network pharmacology research and promotes the healthy development of the discipline (Li, 2021). However, as the fields of network pharmacology research continues to expand, the guidance cannot cover all kinds of research and need to be updated and revised in time. With the combination with new technologies such as artificial intelligence high-throughput technologies, network pharmacology will undoubtedly develop at a high speed. We look forward to a wider application of network pharmacology in TCM research, which will provide new scientific evidence for deciphering the mysteries of TCM and thus promote the inheritance, innovation and development of TCM.]]></description>
<pubDate>2022/11/18 8:20:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ziyi Wang, Shao Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ziyi Wang, Shao Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204001]]></guid><cfi:id>150</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Zedoary tumeric (Curcumae Rhizoma, Ezhu in Chinese) has a long history of application and has great potential in the treatment of liver cancer. The anti liver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances. In order to clarify the specific mechanism of zedoary tumeric against liver cancer, this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer, and then verifies the joint anti liver cancer mechanism of its "pharmacodynamic group". By searching the research on the anti hepatoma effect of active components of zedoary tumeric in recent years, we found that pharmacodynamic substances, including curcumol, zedoarondiol, curcumenol, curzerenone, curdione, curcumin, germacrone, β-elemene, can act on multi-target and multi-channel to play an anti hepatoma role. For example, curcumin can regulate miR, GLO1, CD133, VEGF, YAP, LIN28B, GPR81, HCAR-1, P53 and PI3K/Akt/mTOR, HSP70/TLR4 and NF-κB. Wnt/TGF/EMT, Nrf2/Keap1, JAK/STAT and other pathways play an anti hepatoma role. Network pharmacological analysis showed that the core targets of the "pharmacodynamic group" for anti-life cancer are AKT1, EGFR, MAPK8, etc, and the core pathways are neuroactive live receiver interaction, nitrogen metabolism, HIF-1 signaling pathway, etc. At the same time, by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and "pharmacodynamic group", it is found that they have great reference significance in target, pathway, biological function, determination of core pharmacodynamic components, formation of core target protein interaction, in-depth research of single pharmacodynamic substance, increasing curative effect and so on. By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and "pharmacodynamic group" in the treatment of liver cancer, this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and "pharmacodynamic group".]]></description>
<pubDate>2022/11/18 8:20:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zeyu Li a,b,c, Erwei Hao a,b,c, Rui Cao a,b,c, Si Lin a,b,c, Linghui Zou a,b,c, Tianyan Huang a,b,c, Zhengcai Du a,b,c, Xiaotao Hou a,b,c, Jiagang Deng a,b,c]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zeyu Li a,b,c, Erwei Hao a,b,c, Rui Cao a,b,c, Si Lin a,b,c, Linghui Zou a,b,c, Tianyan Huang a,b,c, Zhengcai Du a,b,c, Xiaotao Hou a,b,c, Jiagang Deng a,b,c</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204002]]></guid><cfi:id>149</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Post-infectious cough of different syndromes treated by traditional Chinese medicines: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The application of traditional Chinese medicines (TCMs) has a history of more than 2000 years, which have the characteristics of multi-component, multi-target, and high safety. Post-infectious cough (PIC) is a respiratory disease with high incidence. It belongs to subacute cough and accounts for as much as 40%?50%. Cough is the main clinical manifestation of PIC. PIC seriously affects people's life quality because of complex etiology, long-term course of disease, treatment difficulties and other characteristics. Western medicines are based on the principle of symptomatic treatment, so they are often difficult to control PIC fundamentally. These factors could due to that PIC is prolonged and unable to heal repeatedly. TCMs have obvious advantages in treating PIC, with accurate curative effects, less side effects and adverse reactions and are effective in improving PIC-related symptoms and indicators, enhancing patients' life quality and reducing pain. TCMs, guided by holistic concept and syndrome differentiation, advocate determine treatment on the basis of pattern types, and have remarkable clinical treatment effects. As for TCMs etiology, pathogenesis and syndrome types of PIC, TCM scholars have not yet reached a unified standard. However, most of them think that wind pathogen can cause PIC alone, or it can be combined with other evils, which might be the main mechanism of PIC. This paper discusses the advantages and limitations of TCMs in PIC treatment from etiology, pathogenesis, distribution of syndrome types and treatment of TCMs. This article focuses on the treatment methods and pharmacodynamic material basis of wind pathogen, providing ideas in treating PIC of TCMs clinically and innovative drug development.]]></description>
<pubDate>2022/11/18 8:20:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wanru Jianga, Jiaxin Qia, Xu Lib, Gang Chena, Di Zhoua,b, Wei Xiaoa,b,c, Ning Lia]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wanru Jianga, Jiaxin Qia, Xu Lib, Gang Chena, Di Zhoua,b, Wei Xiaoa,b,c, Ning Lia</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204003]]></guid><cfi:id>148</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacological and analytical aspects of alkannin/shikonin and their derivatives: An update from 2008 to 2022]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Alkannin/shikonin (A/S) and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants. They are integral constituents of traditional Chinese medicine Zicao (roots of Lithospermum erythrorhizon). In last two decades significant increase in pharmacological investigations on alkannin/shikonin and their derivatives has been reported that resulted in discovery of their novel mechanisms in various diseases and disorders. This review throws light on recently conducted pharmacological investigations on alkannin/shikonin and their derivatives and their outputs. Various analytical aspects are also discussed and brief summary of patent applications on inventions containing alkannin/shikonin and its derivatives is also provided.]]></description>
<pubDate>2022/11/18 8:20:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Kirandeep Kaura, Rashi Sharmaa, Atamjit Singha, Shivani Attrib, Saroj Arorab, Sarabjit Kaura, Neena Bedia]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Kirandeep Kaura, Rashi Sharmaa, Atamjit Singha, Shivani Attrib, Saroj Arorab, Sarabjit Kaura, Neena Bedia</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204004]]></guid><cfi:id>147</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Molecular mechanisms of anti-cancer bioactivities of seaweed polysaccharides]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Seaweed is a traditional Chinese medicine homologous to food, in which polysaccharides are responsible for anti-cancer by enhancing immunity, inducing cancer cell apoptosis, inhibiting cancer cell invasion and metastasis or directly scavenging oxidative free radicals that induce cancer cell changes. Among them, regulating immunity and promoting cancer cell apoptosis are intensively studied due to the important role in preventing cancer. Here we reviewed seaweed in the apoptosis-inducing signaling pathways including PI3K/AKT, ROS and JNK and discussed challenges in studying seaweed.]]></description>
<pubDate>2022/11/18 8:20:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Tingting Liu a, Qing Lib,c, Xu xu b,c, Guoxia Li a, Chengwang Tian b,c,d, Tiejun Zhang b,c,d]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Tingting Liu a, Qing Lib,c, Xu xu b,c, Guoxia Li a, Chengwang Tian b,c,d, Tiejun Zhang b,c,d</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202204005]]></guid><cfi:id>146</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Mongolian medicine: Past, present and future]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Mongolian medicine (TMM) forms an essential part of traditional Chinese medicine (TCM) with its own unique and profound theoretical system, drug resources, processing technologies, and drug usage procedures. TMM has the characteristics of being "raw, simple, inexpensive, and green". It has unique advantages and remarkable efficacy in treating common diseases, frequently-occurring diseases, and certain rare diseases. TMM has been increasingly recognized in recent years, together with an increased understanding and appreciation of its advantages. The development of the TMM industry can not only meet the health needs of local people but also had great significance for the economic and social development of ethnic minority areas.    ?
Mongolian ancestors not only accumulated healthcare experience compatible with the geographical environment, climate conditions, and way of life but also developed distinctive diets, medicines, and other treatments. According to historical records, the Mongolians had a proficient knowledge of medicine at least 2000 years ago. The Secret History of Mongolia is a literary masterpiece, containing information on medicinal herbs, such as Pyrus betulaefolia, cypress, red artemisia, Sanguisorba?officinalis, Tephroseris kirilowii, mountain leek, and wild onion, amongst many others. In addition, Mongolians make good use of animal medicines, which is inseparable from the production and lifestyle of hunting and husbandry. For example, wild boar dung, fox lung, wolf stomach, bear bile, musk, vulture dung, bat meat, and deer antlers have been used as valuable medicinal materials up to the present day. The TCM theoretical system significantly influenced and promoted the development of TMM medical theory. In addition, with the spread of Buddhism, ancient Indian and Tibetan medical works were also introduced into Mongolia, including the Astanga Hrdaya Samhitd (Eight Branches of Medical Classics) and the Four Medical Tantra, which had a significant influence on the TMM theoretical system during the 16th century. Furthermore, since the founding of the People’s Republic of China, nearly 100 ancient Mongolian medical books have been re-edited and published, and around 2200 Mongolian medicinal herbs and prescriptions have been summarized. This indicates an unprecedented development in TMM under the support of the government.    
At present, there are increasing numbers of evidence-based investigations into TMM. A variety of studies have been conducted to improve the quality and safety of TMM by optimizing the harvesting time, processing, preparation, and storage of Mongolian medicinal materials. With the development of modern pharmaceutical science, researchers are putting their efforts into the extraction and isolation of active compounds, pharmacology research, the formulation of quality standards, and dosages. Research on the chemical components of the TMM has developed rapidly. Modern chromatographic separation techniques, spectral analysis, and other technologies have been used to isolate and identify the chemical components of the TMM. The quality standard of Guanxin Shutong Capsule, a Mongolian medicine-based new drug was included in Chinese Pharmacopoeia. The application of the internet and big data-mining technology has been used for further improving the quality standards of TMM medicinal materials, using controlled conditions and processing, together with accurate descriptions of the functions and indications.
However, there are still many challenges in the TMM field. First, the basic research into TMM has often been relatively weak, with less emphasis on innovative research and the development of new products. This affects the standardization, modernization, and industrialization of TMM significantly. For example, research into the formation of a complete set of quality standards and specifications, including the standardization, material basis, mechanisms of action, and compound preparations is still insufficient. Second, enterprises dealing in Mongolian medicine tend to have low production levels with weak innovation and development capacities. The cooperation between enterprises and universities and research institutions is relatively poor, and scientific research and production cannot be effectively combined. The production process of Mongolian medicine tends to be primitive, using mostly traditional forms of dosage, and many of the preparations lack the attributes of modern pharmaceutical products, such as quick-acting, long-lasting, and sustained-release properties. Last but not least, Mongolian medicine is deficient in wild resources and artificial planting technology has tended to lag. For a long time, Mongolian medicinal materials were largely obtained from the wild, with few planted artificially. With the increasing demand for the raw materials of Mongolian medicine, the output and reserves of wild medicinal materials are declining rapidly, and many medicinal plants are on the verge of extinction. However, there is little research into the artificial cultivation of Mongolian medicinal materials, and the present limited cultivation cannot meet the needs of TMM production, thus threatening the sustainable development of the TMM industry.
It is thus important to focus on the combination of modern medicine and traditional Mongolian theory, giving full play to the advantages of the unique characteristics of TMM, and using modern science and technology for Mongolian pharmaceutical industry production and process standardization, quality control, drug standardization, standardization of clinical evaluation, accelerate the realization of the process of transforming TMM research achievements into productivity. At the same time, we should aim to develop a new generation of high-efficiency and low-toxicity pharmaceutical products that are in line with international standards, improve the level of Mongolian medicine research and the development of engineering technology to ensure the quality of TMM preparations, and cultivate more senior engineering and technical personnel. We firmly believe that with the implementation of the “Healthy China” strategy, the advantages of TMM will be further demonstrated and will make greater contributions to human health.]]></description>
<pubDate>2022/9/1 15:43:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Laxinamujila Bai, Minghai Fu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Laxinamujila Bai, Minghai Fu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203001]]></guid><cfi:id>145</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Mongolian medicine: History, development and existing problems]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Mongolian medicine (MM) is an important part of Mongolian culture. Exploration of MM can play a crucial role in the prevention and treatment of various diseases and can help provide better health care globally. In this article, we gave a brief introduction to the origin and development of MM, the theoretical system of MM, the principles of Mongolian materia medica formula, the modern research on Mongolian materia medica and the quality control of Mongolian materia medica. The present situation and outlook of MM were also discussed.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Songbo Qua,1, Jinshan Baob,1, Wuliji Aob, Laxinamujila Baib,*, Almaz Borjigidaia,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Songbo Qua,1, Jinshan Baob,1, Wuliji Aob, Laxinamujila Baib,*, Almaz Borjigidaia,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203002]]></guid><cfi:id>144</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Connotation and scientific research points of processing of Mongolian medicinal materials]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Mongolian medicine (TMM) is an important part of Chinese traditional culture, which plays an important role within the medical system of China. The processing of Mongolian medicinal materials is a pharmaceutical technology, which is the unique characteristics of Mongolian medicine. In this paper, the basic concepts related to the processing of Mongolian medicinal materials were introduced, and its scientific research points were put forward, in order to deeply excavate the connotation of Mongolian pharmacy and further study the processing mechanism of Mongolian medicinal materials, so as to provide important basis for the development of Chinese traditional medicine. The essence of Mongolian medicinal materials processing is to use drugs safely and dialectically to ensure the quality of Mongolian medicinal materials. The scientific research sites of Mongolian medicinal materials processing have two categories: reducing toxicity (increasing) effect and synergistic effect of excipients and processing factors. Because of the not perfect research platform of Mongolian medicinal materials and the weak processing power, the development of research of Mongolian medicinal materials is relatively slow. Therefore, there are many research breakthroughs in the interdisciplinary research on the processing of Mongolian medicinal materials, and it is expected to become a research hotspot.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lin Song1,*, Chula Sa1, Li Mei, Lina Du, Sarula Wu, Rigugaqiqige Su, Ligema Dao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lin Song1,*, Chula Sa1, Li Mei, Lina Du, Sarula Wu, Rigugaqiqige Su, Ligema Dao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203003]]></guid><cfi:id>143</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Discussion on evolution of Mongolian medicinal material names and countermeasures for standardization]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Mongolian pharmacy is an important part of traditional medicine for the Chinese nation, with a long history and a complete theoretical system. The Mongolian people have accumulated and summarized the types and usage of Mongolian medicines in the practice of fighting against diseases over a long history. Mongolian medicinal resources are rich and diverse, the processing is self-contained, and the methods of medication are scientific and reasonable. Mongolian pharmacy not only has a deep historical relationship with traditional Chinese medicine but has also absorbed the essence of ancient Tibetan and Indian Ayurvedic medicine in the process of its development. We can identify the historical traces of the continuous exchange, communication, and integration of various ethnic medicinal cultures from the names of Mongolian medicinal materials. Because of the differences in languages and cultures of the various ethnic groups, the names of Mongolian medicinal materials have undergone a long historical period of evolution. These need to be further standardized owing to complications caused by the existence of synonyms and homonyms.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Bao Longa, Aodungerilea, b, Laxinamujila Baia,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Bao Longa, Aodungerilea, b, Laxinamujila Baia,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203004]]></guid><cfi:id>142</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-??B pathway activation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are the most problematic metabolic diseases in the world. NAFLD encompasses a spectrum of severity, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis and hepatocellular carcinoma. Importantly, NAFLD is closely linked to obesity and tightly interrelated with insulin resistance and T2DM. T2DM and NAFLD (T2DM-NAFLD) are called as the Xike Rixijing Disease and Tonglaga Indigestion Disease respectively, in Mongolian medicine. Xike Rixijing Disease maybe develop into Tonglaga Indigestion Disease. Forturnately many Mongolian medicines show efficient treatment of T2DM-NAFLD, such as Agriophyllum squarrosum, Haliyasu (dried powder of camel placenta), Digeda-4 (herbs of Lomatogonium carinthiacum, rhizomata of Coptis chinensis, ripe fruits of Gardenia jasminoides, herbs of Dianthus superbus), Guangmingyan Siwei Decoction Powder (Halite, ripe fruits of Terminalia chebula, rhizomata of Zingiber officinale, fruit clusters of Piper longum), Tonglaga-5 (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piperlonguml., flowers of Carthamus tinctorius), Tegexidegeqi (rhizomata of Inula helenium, ripe fruits of Gardenia jasminoides, rhizomata of Platycodon grandiflorum, rhizomata of Coptis chinensis, heartwood of Caesalpinia sappan), Ligan Shiliu Bawei San (ripe fruits of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, fruit clusters of Piperlonguml., flowers of Carthamus tinctorius, ripe fruits of Amomum tsao-ko, rhizomata of Zingiber officinale), etc. Principles of Mongolian medicine in treating diseases： by balancing “three essences or roots” and “seven elements”, strengthening liver and kidney function, transporting nutrients to enhance physical strength and disease resistance, and combined with drugs for comprehensive conditioning treatment. However, their molecular mechanisms remain unclear. In this review, we prospect that Mongolian medicines might be a promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-κB inflammatory pathway via lipid-sensitive nuclear receptors (i.e., FXR and LXR).]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shuyin Baoa, b, d, Xiuzhi Wang c, Qianqian Ma a, b, Chengxi Weia, b, *, Jixing Nan d, *, Wuliji Ao e, f, *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shuyin Baoa, b, d, Xiuzhi Wang c, Qianqian Ma a, b, Chengxi Weia, b, *, Jixing Nan d, *, Wuliji Ao e, f, *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203005]]></guid><cfi:id>141</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Sugemule-10: Source of prescription and modern clinical application]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Sugemule-10, one of the traditional Mongolian medicine (TMM) formulae, is derived from Four Medical Classics (Vol. 4) and composed of 10 Mongolian medicines. It is used to treat kidney cold, low back pain, urinary obstruction, kidney/bladder stones, and is the main prescription for kidney cold. The current research on Sugemule-10 is mostly focused on its clinical efficacy, and few papers are available upon its historical changes. Therefore, we systematically reviewed Sugemule-10 from the aspects of prescription source, prescription interpretation, efficacy evolution, and modern clinical applications.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiangmei Chen d, e, Liangliang a, b,*, Hadanbaoligao Zhang a, Buriebao b, c, Xiulan Wang e, WurihanTai b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiangmei Chen d, e, Liangliang a, b,*, Hadanbaoligao Zhang a, Buriebao b, c, Xiulan Wang e, WurihanTai b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203006]]></guid><cfi:id>140</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Famous traditional Mongolian medicine Xieriga?€?4 (Turmeric-4) Decoction: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Xieriga-4 Decoction, composed of dried rhizomes of Curcumae longae rhizoma, barks of Phellodendron chinense or Phellodendron amurense, fruits of Cardenia jasminoides, and fruits of Tribulus terrestris, is a famous prescription of traditional Mongolian medicine for the treatment of urinary system diseases such as frequent urination, urgent urination, urine occlusion, hematuria, bladder irritation and pain. This work reviewed Xieriga-4 Decoction from the aspects of historical description, prescription principle, chemical components, pharmacology, clinical application and quality control.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Dulan, Bagenna, Huan Wang*, Yuanyuan Wu, Ling Ling, Anggelima]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Dulan, Bagenna, Huan Wang*, Yuanyuan Wu, Ling Ling, Anggelima</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203007]]></guid><cfi:id>139</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemical and pharmacological progress on Syringa oblata, a traditional Mongolian medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Syringa oblata is a traditional Mongolian medicine mainly distributed in the Helan Mountains (the boundaries of Inner Mongolia and Ningxia, China) and the north of Yan Mountains (Aohan Qi, Inner Mongolia, China). It is clinically used to treat diseases caused by Heyi, such as heartache and heat pathogen in the heart. Phytochemical studies on S. oblata revealed the presence of iridoids, lignans, triterpenes, phenylpropanoids, phenylethanoids, and volatile components. Pharmacological investigations revealed a broad spectrum of bioactivities, such as antimicrobial, antioxidant, antiproliferative, and hepatoprotective effects. This article summarized the chemical components and pharmacological activities of S. oblata, providing a scientific rationale for its bioactive constituents, quality control, and utilization as an important medicine.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Badalahu Taia,b, Laxinamujila Baib, Ruifeng Jic, Muyao Yuc, NAlab, Luqi Huanga,c, Han Zhengc,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Badalahu Taia,b, Laxinamujila Baib, Ruifeng Jic, Muyao Yuc, NAlab, Luqi Huanga,c, Han Zhengc,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203008]]></guid><cfi:id>138</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Emerging therapeutic role of Prunella vulgaris in thyroid disease]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203009]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Thyroid disease is characterized by unusual levels of thyroid hormones, which results in either hyperthyroidism or hypothyroidism. The pathology of a particular type or stage of thyroid disease is very complicated, and always linked to a variety of biological functions. Although the mortality rate is not high, thyroid dysfunction could leads to metabolic and immunological disorders that can subsequently cause discomfort. To date, many medical drugs are suggested to have curative effects on thyroid disease, however, drug toxicity and long treatment periods encourage the search for more promising drugs. Prunella vulgaris L. (Labiatae) is a popular herb that has shown great potential for improving human immunity and organ protection. It has been extensively used in the treatment of many diseases but its ability to treat specific diseases has not been fully reported. In this review, a literature search regarding herbs and herbal recipes for treating thyroid disease were carried out, organized, and summarized. In addition, this study conducted a literature search on the current situation and progress of P. vulgaris treatment for various diseases. Finally, this study discussed studies regarding P. vulgaris treatment of goiter, and the mechanism of treatment through the regulation of apoptosis. Accordingly, a combination therapy of herbs and Western medicine can provide significant therapeutic effects in the clinical treatment of thyroid disease. Furthermore, the association between P. vulgaris and various diseases suggests that P. vulgaris is rich in a variety of active substances that can fight oxidation and participate in the regulation of apoptosis, thus having a protective effect on the thyroid. Here, a comprehensive literature review regarding the application of herbs or herbal recipes in the treatment of thyroid disease was presented. It is concluded that there is strong evidence for further research regarding the use of P. vulgaris in the treatment of thyroid diseases.]]></description>
<pubDate>2022/9/1 15:43:52</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wen Zhang a,c,1, Qimuge Wuhan c,1, Meiri Na b, Riba Hu b, Qier Mu b, Xilinqiqige Bao b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wen Zhang a,c,1, Qimuge Wuhan c,1, Meiri Na b, Riba Hu b, Qier Mu b, Xilinqiqige Bao b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202203009]]></guid><cfi:id>137</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinese herbal medicines will illuminate the post-epidemic era]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In less than 20 years since the beginning of 21th century, there have been many major outbreaks of SARS, avian influenza, H1N1 flu, Ebola virus, and COVID-19 in the world one after another. These epidemics have caused huge losses of human life and property. Meanwhile, tumors, diabetes, cardiovascular and cerebrovascular diseases, mental diseases and diseases with unknown etiology that were rare in the past have now become common diseases in society. Coupled with the outbreak of major epidemics, they have posed a huge threat to human health and even survival. How to minimize and/or eliminate these threats? The traditional application and modern research of traditional Chinese medicine (TCM) give us a lot of inspiration.
 This issue has ushered in several excellent papers to continuously spotlight the exciting progress of Chinese herbal medicines in human health and diseases. Both Rosa and Tetrastigma belong to the Eudicots clade Rosids, which possess astounding biodiversity and chemodiversity, followed by highly diverse bioactivities. Their traditional uses and pharmacological activities have been elaborated in two comprehensive reviews (Wang et al., 2022; Zhang et al., 2022a); extracts and compounds of both genera showed the following activities: Antineoplastic and anti-cancer, anti-inflammatory, antioxidant, hepatoprotective, blood sugar regulatory/antidiabetic, antibacterial, antiviral, and cardiovascular protection, and others. Possibly due to the distinct chemical composition, these genera also have some differences in bioactivities, e.g., flavonoids of Rosa displayed the nervous system protection, Rosa also had the anti-aging and hypolipidemic properties, while Tetrastigma showed the analgesic activity. The studies of these pharmacological activities are booming (Gu et al., 2022; Zhang et al., 2022b), as they are aimed at the current common and frequently occurring diseases, including epidemic and pandemic diseases.
Promisingly, both Rosa and Tetrastigma had no toxic effect in human subjects, which is especially validated by their long-term uses in folk medicine. Notwithstanding, the drug metabolism and pharmacokinetic studies of both genera, as well as other taxonomic groups with abundant medicinal phytometabolites, should be strengthened to further expound the absorption, distribution, metabolism, excretion and toxicity attributes of botanical extracts and phytometabolites; Q-markers of herbal products (Liu, 2021; Liu et al., 2018) derived from them should also be developed to maximize their health-promoting and therapeutic effects.
The specialized metabolites of medicinal plants induced by ecological/environmental factors vary greatly, but meanwhile the specific biosynthetic pathways and related phytometabolites, and even therapeutic efficacy, may have some phylogenetic signals, which is suggested by pharmacophylogeny investigations (Hao et al., 2022). The metabolomic studies of medicinal genera should be further expanded to collect compound information as completely as possible, so as to analyze the correlation between specialized metabolites and molecular phylogeny qualitatively and quantitatively. After superimposing phylogenetic background, the dominance of a specific type of phytometabolites could be found in the specific part of phylogenetic tree, and the evolutionary trajectory of chemodiversity could be revealed, which has important guiding significance for the discovery and development of new/alternative phytomedicine resources. Many phytometabolites are phylogenetically conserved, and their abundance in different taxonomic groups is highly variable; e.g., indole alkaloids are reported in Tetrastigma instead of Rosa (Wang et al., 2022; Zhang et al., 2022a), the ursane-type triterpenoids are abundant in the latter rather than the former, while diterpenoids are trivial in both genera. In addition, the correlation between geographical distributions and therapeutic compounds should also be taken into account to assess the resource value of any taxonomic groups. We could find that some local species which were lately diverged have more diverse specialized metabolites as compared with widespread species firstly diverged, or vice versa. The genetic background and environmental pressure jointly shape the unique metabolome of each taxonomic group. With the explosive increase of the identified compounds in recent years (Gu et al., 2022), we are more confident in the systematic study of variation pattern of chemodiversity in the taxonomic group of interest in the light of evolution. These studies will promote the vitality of TCM supply chain and the sustainable development of Chinese herbal medicine industry.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Dacheng Hao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Dacheng Hao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202001]]></guid><cfi:id>136</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research progress of Chinese herbal medicine compounds and their bioactivities: Fruitful 2020]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicines (TCMs) have continued to be a treasure trove. The study of chemodiversity and versatility of bioactivities has always been an important content of pharmacophylogeny. There is amazing progress in the discovery and research of natural components with novel structures and significant bioactivities in 2020. In this paper we review 271 valuable natural products, including terpenoids, steroids, flavonoids, phenylpropanoids, phenolics, nitrogen containing compounds and essential oil, etc., isolated and identified from TCMs published in journals of Chinese Traditional and Herbal Drugs (Zhong Cao Yao) and Chinese Herbal Medicines (CHMs), and focus on their structures, source organisms, and relevant bioactivities, paying special attention to structural characteristics of novel compounds and newly revealed pharmacological properties of known compounds. It is worth noting that natural products with antitumor activity still constitute the primary object of research. Among the reported compounds, two new triterpenoids, i.e., ursolic acid 3-O-β-cis-caffeate and mollugoside E, display remarkable cytotoxicity against PC-9 and HL-60 cell lines, respectively. Three known phenolic compounds, i.e., pyoluteorin, 4-hydroxy-3-methoxy cinnamaldehyde and 3,7-dimethoxy-5-hydroxy-1,4-phenanthrenequinone, exhibit significant cytotoxicity against multiple cell lines. Numerous studies on the free radical scavenging activity of reported compounds are currently underway. In vitro, three known phenolic compounds, i.e., 3,4-O-dicaffeoylquinic acid methyl ester, 3,4,5-O-tricaffeoylquinic acid methyl ester and arbutin, had more considerable antioxidant activities than vitamin C. The anti-inflammatory, anti-diabetic, hypolipidemic, neuroprotective and antimicrobial activities of isolated compounds are also encouraging. The structural characteristics and bioactivities of TCM compounds highlighted here reflect the enormous progress of CHM research in 2020 and will play a positive role in the future drug discovery and development. According to pharmacophylogeny, the phylogenetic distribution of compounds with different natures and flavors can be explored, with view to better mining TCM resources.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiaojie Gu, Dacheng Hao, Peigen Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiaojie Gu, Dacheng Hao, Peigen Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202002]]></guid><cfi:id>135</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical constituents and pharmacological activities of medicinal plants from Rosa genus]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The genus Rosa (Rosaceae family) includes about 200 species spread in the world, and this genus shows unique advantages in medicine and food. To date, several scholars concentrated on compounds belonging to flavonoids, triterpenes, tannins, polysaccharide, phenolic acids, fatty acids, organic acids, carotenoids, vitamins. Pharmacological effects such as antineoplastic and anti-cancer properties, anti-inflammatory, antioxidant, liver protection, regulate blood sugar, antimicrobial activity, antiviral activity, as well as nervous system protection and cardiovascular protection were wildly reported. This article reviews the chemical constituents, pharmacological effects, applications and safety evaluations of Rosa plants, which provides a reference for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of the genus Rosa.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yansheng Wang a,b, Yanmin Zhao c, Xinnan Liu a, Jingyang Li c, Jingze Zhang b,*, Dailin Liu a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yansheng Wang a,b, Yanmin Zhao c, Xinnan Liu a, Jingyang Li c, Jingze Zhang b,*, Dailin Liu a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202003]]></guid><cfi:id>134</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Genus Tetrastigma: A review of its folk uses, phytochemistry and pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The genus Tetrastigma belongs to the Vitaceae family and contains over 100 species. This paper reviewed folk uses, chemical constituents, pharmacological activities, and clinical applications of the medicinal plants in the genus Tetrastigma. In addition, the paper also discussed the current problems for the further studies. Up to now, more than 240 compounds were reported from the genus Tetrastigma, covering 74 flavonoids, 14 terpenoids, 19 steroids, 21 phenylpropanoids, 14 alkaloids and others constituents. Among them, flavonoids are the major and the characteristic chemical constituents in this genus. Modern pharmacological studies and clinical practice showed that the extracts and chemical constituents of Tetrastigma species possessed wide pharmacological activities including antitumor, antioxidative, hepatoprotective, antiviral, anti-inflammatory, and analgesic activities. The information summarized in this paper provided valuable clues for discovering new drug for further research and an incentive to expand the research of genus Tetrastigma.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lizhi Zhanga, 1, Bin Lia, 1, Mengyun Wanga, Haotian Lina, Yilin Penga, Xudong Zhoua, Caiyun Penga, Jixun Zhana, b,*, Wei Wanga, *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lizhi Zhanga, 1, Bin Lia, 1, Mengyun Wanga, Haotian Lina, Yilin Penga, Xudong Zhoua, Caiyun Penga, Jixun Zhana, b,*, Wei Wanga, *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202004]]></guid><cfi:id>133</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Molecular mechanisms of isoflavone puerarin against cardiovascular diseases: What we know and where we go]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Puerarin (Pue), known as a phytoestrogen, has salient bioactivities and is promising against cardiovascular diseases. This article summarizes the underlying molecular mechanisms of Pue in treating cardiovascular diseases, especially regulating the intracellular signal transduction, influencing ion channels, modulating the expression of microRNA, and impacting on the autophagy, which are mainly involved in the inflammatory signaling pathways, fatty acid/lipid metabolism, oxidative stress, apoptosis, and the like. The protective effect of Pue against cardiovascular diseases mainly involves attenuating the myocardial injury and decreasing the myocardial fibrosis, improving the myocardial ischemia/reperfusion injury, as well as inhibiting the myocardial hypertrophy and atherosclerosis. The molecular mechanisms of Pue’s cardiovascular protective effects for the first time and comment on the state-of-the-art research methods and principles of Pue’s regulation of small molecules were reviewed, so as to provide the rationale for its basic research and clinical applications.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Weida Qina,b, Jianghong Guoa, Wenfeng Goua, Shaohua Wua,b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Weida Qina,b, Jianghong Guoa, Wenfeng Goua, Shaohua Wua,b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202005]]></guid><cfi:id>132</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Curcumin's prevention of inflammation-driven early gastric cancer and its molecular mechanism]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Worldwide, gastric cancer is the second leading cause of cancer deaths and the fifth most common malignant tumor. Gastric cancer is believed to be caused by a variety of factors, such as genetics, epigenetics, and environmental influences. Among the pathogenic factors, inflammation has been considered as one of the main risk factors for gastric cancer. There are currently limited ways to prevent gastric cancer. Although the combined application of aspirin and non-steroidal anti-inflammatory drugs can reduce the risk, it has great side effects and can easily cause gastric perforation or gastric bleeding. Therefore, an alternative plan is urgently needed. Curcumin is the yellow pigment in the rhizome of the plant turmeric. Current studies have found that curcumin has a protective effect on gastric mucosal damage caused by non-steroidal anti-inflammatory drugs, gastric mucosal damage in rats, and gastric mucosal damage caused by stress bleeding and Helicobacter pylori infection. Curcumin shows significant anti-inflammatory and anti-cancer activities by regulating DNA methylation, histone modification, nuclear factor erythrocyte 2 related factor 2 and other related signal pathways. In this article, the latest evidence of curcumin for epigenetic changes in gastric cancer and its potential contribution to gastric cancer were discussed.]]></description>
<pubDate>2022/4/21 13:15:46</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wensen Zhang, Na Cui, Jin Ye, Bingyou Yang, Yanping Sun, Haixue Kuang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wensen Zhang, Na Cui, Jin Ye, Bingyou Yang, Yanping Sun, Haixue Kuang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202202006]]></guid><cfi:id>131</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2022/2/21 14:11:40</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiao Pei-gen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiao Pei-gen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201001]]></guid><cfi:id>130</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chronic atrophic gastritis (CAG), a common disease of digestive system, is an extremely important cause of gastric cancer (GC). The occurrence and development of CAG involves the abnormality of multiple signaling pathways. Traditional Chinese medicines (TCMs) has the advantages of mild action, multi-target and small adverse reaction, etc., which broadens the way for the treatment of the disease, and TCMs can play a therapeutic role by regulating multiple signaling pathways. In this review, based on the related experiments of TCMs and Chinese herbal compounds in recent years, the related literatures were searched and 10 kinds of signaling pathways involved were summarized, in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer.]]></description>
<pubDate>2022/2/21 14:11:40</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xin-nan Liua,b, Shu-ping Wangc, Jing-yang Li d, Jing-ze Zhanga, Dai-lin Liua]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xin-nan Liua,b, Shu-ping Wangc, Jing-yang Li d, Jing-ze Zhanga, Dai-lin Liua</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201002]]></guid><cfi:id>129</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Taxonomy of Epimedium (Berberidaceae) with special reference to Chinese species]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Epimedii Herba is a commonly used traditional Chinese herbal medicine. Five Epimedium species are included in Chinese Pharmacopoeia and most species of Epimedium are used as Epimedii Herba in practical application. However, as the largest herbaceous genus of the Berberidaceae, Epimedium has many taxonomic controversies which hinder the effective use of Epimedii Herba. This paper reviewed the taxonomic research related to Epimedium, including taxonomic history, taxonomic values of morphological characters, species and distribution, infra-genera taxonomic system and the taxonomic research of Chinese Epimedium. For instance, we recognized Epimedium wushanense and clarified that the species, as described in Flora Reipublicae Popularis Sinicae and Flora of China, actually includes four Epimedium species similar in leaflet shape. In general, it was recognized here that Epimedium comprises 62 species, of which 52 species are distributed in China. For Chinese Epimedium species with the most taxonomic problems, the taxonomic research on the taxa was reviewed and the newest species key was proposed along with proposals for those taxonomic problems needing further resolution. This review is of great implication for the identification, exploration and utilization of Epimedii Herba.]]></description>
<pubDate>2022/2/21 14:11:40</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yan-jun Zhang1, Jian-qiang Li1, Ying Wang2, Qiong Liang1]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yan-jun Zhang1, Jian-qiang Li1, Ying Wang2, Qiong Liang1</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201003]]></guid><cfi:id>128</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Discussion on several statistical problems in establishing quality standards of standard decoctions]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Since 2016, a number of studies have been published on standard decoctions used in Chinese medicine. However, there is little research on statistical issues related to establishing the quality standards for standard decoctions. In view of the currently established quality standard methods for standard decoctions, an improvement scheme is proposed from a statistical perspective. This review explores the requirements for dry matter yield rate data and index component transfer data for the application of two methods specified in "Technical Requirements for Quality Control and Standard Establishment of Chinese Medicine Formula Granules," which include the average value plus or minus three times the standard deviation () or 70% to 130% of the average value (). The square-root arcsine transformation method is used as an approach to solve the problem of unreasonable standard ranges of standard decoctions. This review also proposes the use of merged data to establish a standard. A method to judge whether multiple sets of standard decoction data can be merged is also provided. When multiple sets of data have a similar central tendency and a similar discrete tendency, they can be merged to establish a more reliable quality standard. Assuming that the dry matter yield rate and transfer rate conform to a binomial distribution, the number of batches of prepared slices that are needed to establish the standard decoction quality standard is estimated. It is recommended that no less than 30 batches of prepared slices should be used for the establishment of standard decoction quality standards.]]></description>
<pubDate>2022/2/21 14:11:41</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shi-shi Gua, Pei-ying Lin a, Run-ling Ou a, Jun-lin Guob, Xing-chu Gonga,b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shi-shi Gua, Pei-ying Lin a, Run-ling Ou a, Jun-lin Guob, Xing-chu Gonga,b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202201004]]></guid><cfi:id>127</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Awareness and ability of paradigm shift are needed for research on dominant diseases of TCM]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yanjun Zhang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yanjun Zhang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304001]]></guid><cfi:id>126</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Clinical value-oriented research paradigm about inheritance and innovation development of TCM dominant diseases]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Modern medicine has made remarkable achievements in safeguarding  people’s life and health, however, it is increasingly found that in the face of complex diseases, selective targeting single target is often difficult to produce a comprehensive rehabilitation effect, and is prone to induce drug resistance, toxic side effects. Traditional Chinese medicine (TCM) has a long history of clinical application, and its clinical value in the treatment of complex diseases such as cardiovascular and cerebrovascular diseases, digestive diseases, skin diseases, rheumatism and immunity diseases, and adjuvant treatment of tumors has been proven to have obvious advantages. However, its modern research is relatively lagging behind, and in the face of the aging society and the characteristics of the modern disease spectrum, the traditional knowledge-driven research paradigm seems to be stuck in a bottleneck and difficult to make greater breakthroughs. Focusing on the key issues of TCM development in the new era, the clinical value-oriented strategy becomes to be a new research paradigm of TCM inheritance and innovation development, and dominant diseases would be the focus of the TCM inheritance and innovation development, which has been highly valued in recent years by the TCM academia and the relevant national management departments. Based on the clinical value, a series of policies are formulated for the selection and evaluation of the TCM dominant diseases (TCMDD), and exploratory researches about the clinical efficacy characteristics, the modern scientific connotation interpretation were carried out. The clinical value-oriented research paradigm of TCMDD inheritance and innovation development has been initially formed, which is characterized by strong policy support as the guarantee, systematic and standardized selection and evaluation methods as the driving force, scientific and effective research on internal mechanisms as the expansion, and effective clinical guidelines and principles as the transformation, which is of great value in promoting the high-quality development of the industries and undertaking of TCM. In this paper, the main policy support, selection and evaluation methods, therapeutic effect characterization, and modern scientific connotation research strategies of TCMDD in recent years have been comprehensively sorted out, with a view to providing the healthy and benign development of the research on TCMDD.]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Dongna Li a,b,1, Hong Guo a,b,1, Lin Niu a,b, Qingsheng Yin a,b, Yanjun Zhang c,d,*, Pengwei Zhuang a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Dongna Li a,b,1, Hong Guo a,b,1, Lin Niu a,b, Qingsheng Yin a,b, Yanjun Zhang c,d,*, Pengwei Zhuang a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304002]]></guid><cfi:id>125</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinese herbal medicines for prostate cancer therapy: From experimental research to clinical practice]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Prostate cancer remains the second most common malignancy in men worldwide, is a global health issue, and poses a huge health burden. Precision medicine provides more treatment options for prostate cancer patients, but its popularity, drug resistance, and adverse reactions still need to be focused on. Chinese herbal medicines (CHMs) have been widely accepted as an alternative therapy for cancer, with the advantages of multiple targets, multiple pathways, and low toxicity. We searched the experimental research and clinical practice of CHMs for prostate cancer treatment published in PubMed, Embase, and Web of Science in the last five years. We found five CHM formulas and six single CHM extracts as well as 12 CHM-derived compounds, which showed induction of apoptosis, autophagy, and cell cycle arrest, suppression of angiogenesis, proliferation, and migration of prostate cancer cells, reversal of drug resistance, and enhancement of anti-tumor immunity. The mechanisms of action include the PI3K/Akt/mTOR, AR, EGFR and Wnt/β-catenin signaling pathways, which are commonly implicated in the development of prostate cancer. We also summarized the advantages of CHMs in patients with hormone-sensitive and castration-resistant prostate cancer and provided ideas for their further experimental design and application.]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fanming Kong a,b,1, Chaoran Wang a,b,c,1, Jing Zhang a,b, Xiaoqun Wang a,b, Binxu Sun a,b, Xian Xiao a,b,c, Haojian Zhang a,b,c, Yanqi Song d, Yingjie Jia a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fanming Kong a,b,1, Chaoran Wang a,b,c,1, Jing Zhang a,b, Xiaoqun Wang a,b, Binxu Sun a,b, Xian Xiao a,b,c, Haojian Zhang a,b,c, Yanqi Song d, Yingjie Jia a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304003]]></guid><cfi:id>124</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ischemic stroke (IS) is a severe cerebrovascular disease with a high incidence, mortality, and disability rate. The first-line treatment for IS is the use of recombinant tissue plasminogen activator (r-tPA). Regrettably, numerous patients encounter delays in treatment due to the narrow therapeutic window and the associated risk of hemorrhage. Traditional Chinese medicine (TCM) has exhibited distinct advantages in preventing and treating IS. TCM enhances cerebral microcirculation, alleviates neurological disorders, regulates energy metabolism, mitigates inflammation, reduces oxidative stress injuries, and inhibits apoptosis, thereby mitigating brain damage and preventing IS recurrence. This article summarizes the etiology, pathogenesis, therapeutic strategies, and relationship with modern biology of IS from the perspective of TCM, describes the advantages of TCM in the treatment of IS, and further reviews the pharmacodynamic characteristics and advantages of TCM in the acute and recovery phases of IS as well as in post-stroke complications. Additionally, it offers valuable insights and references for the clinical application of TCM in IS prevention and treatment, as well as for the development of novel drugs.]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hanyu Zhang a,b, Bowen Jin a,b, Xinyu You a,b, Pengrong Yi a,b, Hong Guo a,b, Lin Niu a,b, Qingsheng Yin a,b, Jiangwei Shi c,d, Yanjun Zhang c,d,*, Pengwei Zhuang a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hanyu Zhang a,b, Bowen Jin a,b, Xinyu You a,b, Pengrong Yi a,b, Hong Guo a,b, Lin Niu a,b, Qingsheng Yin a,b, Jiangwei Shi c,d, Yanjun Zhang c,d,*, Pengwei Zhuang a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304004]]></guid><cfi:id>123</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Chinese medicines for non-small cell lung cancer: Therapies and mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The most common subtype of lung cancer is non-small cell lung cancer (NSCLC), which has a poor prognosis and seriously threatens the health of human beings. The multidisciplinary comprehensive treatment model has gradually become the mainstream of NSCLC treatment. Traditional Chinese medicine (TCM) can be used effectively either as an adjunctive therapy or alone throughout the NSCLC therapy, which has a significant impact on survival, quality of life, and reduction of toxicity. Therefore, this paper reviewed the theoretical basis, the latest clinical application, and combined treatment mechanisms in order to explore the advantage stage of TCM treatment and the synergistic therapeutic mechanisms.]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fanming Kong a,b,1, Chaoran Wang a,b,c,1, Linlin Zhao a,b, Dongying Liao a,b,c, Xiaoqun Wang a,b, Binxu Sun a,b, Peiying Yang a,b, Yingjie Jia a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fanming Kong a,b,1, Chaoran Wang a,b,c,1, Linlin Zhao a,b, Dongying Liao a,b,c, Xiaoqun Wang a,b, Binxu Sun a,b, Peiying Yang a,b, Yingjie Jia a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304005]]></guid><cfi:id>122</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Effects and mechanisms of traditional Chinese medicines on functional dyspepsia: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Functional dyspepsia (FD) is a common and frequently occurring disease in clinic. With the influence of environmental factors, social factors and dietary factors, the incidence rate of FD in the general population is yearly increasing. Traditional Chinese medicine has a long history and far-reaching influence in the treatment of FD. It can prevent and treat FD in the form of multiple-components, targets and channels, with obvious effect and prominent advantages. This article starts with the common syndrome types of FD, and discusses the research progress of single Chinese medicine, effective ingredients and the mechanism of traditional Chinese medicines in treating FD, in order to provide a theoretical basis for the treatment of FD with traditional Chinese medicines.]]></description>
<pubDate>2023/11/9 13:22:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Bo Liu a, Zixiang Kou b,*, Baogui Chen b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Bo Liu a, Zixiang Kou b,*, Baogui Chen b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304006]]></guid><cfi:id>121</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Therapeutic effects of Chinese herbal medicines for treatment of urolithiasis: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Urolithiasis is a common and complex disease of the urinary system, which can cause urinary tract blockage, urinary tract infection, and even damage to urinary system-related tissues. Although urolithiasis can be cured, its high recurrence rate and the development of chronic kidney disease in some patients have drawn the attention of nephrologists. Although the application of extracorporeal lithotripsy, percutaneous nephrolithotomy and other minimally invasive techniques have made the treatment of urolithiasis more efficient, pharmacotherapy plays an indispensable role in reducing their morbidity and recurrence rates. Traditional Chinese medicine (TCM) has been used for treatment and prevention of urolithiasis in developing countries for centuries, known for its unquestionable efficacy and safety. This article reviews the progress of clinical trials and pharmacological studies on the treatment of urolithiasis with Chinese herbal medicines (CHMs). The mechanism of CHMs in the treatment of urolithiasis mainly involve preventing further growth and aggregation of urolithiasis, reducing the PH of urine, promoting calculus dissolution. Furthermore, some CHMs can increase urine output, relax smooth muscles, and promote the removal of calculus. These findings provide new treatment strategies and options for urolithiasis and secondary kidney damage.]]></description>
<pubDate>2023/11/9 13:22:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chen Jiang a, Lingyun Wang b, Yang Wang a, Rongjia Xu a, Hongtao Yang a,*, Jibin Peng b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chen Jiang a, Lingyun Wang b, Yang Wang a, Rongjia Xu a, Hongtao Yang a,*, Jibin Peng b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202304007]]></guid><cfi:id>120</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Essential role of medicine and food homology in health and wellness]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicine (TCM) is an ancient healing system that has been practiced for thousands of years in China and other East Asian countries. According to the TCM theory, medicine and food share the same origin and may have the same functions in the prevention and treatment of various health conditions. This is how the concept of medicine and food homology is developed and popularized.
In China, an official list of medicine and food homology substances is promulgated by the China National Health Commission (formerly Ministry of Health) (NHC, 2002; NHC, 2020a; NHC, 2020b). All these substances are included in the Chinese Pharmacopoeia and safe to be used as food.]]></description>
<pubDate>2023/7/21 14:06:28</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Junshi Chen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Junshi Chen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303001]]></guid><cfi:id>119</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Natto: A medicinal and edible food with health function]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Natto is a soybean product fermented by natto bacteria. It is rich in a variety of amino acids, vitamins, proteins and active enzymes. It has a number of biological activities, such as thrombolysis, prevention of osteoporosis, antibacterial, anticancer, antioxidant and so on. It is widely used in medicine, healthcare food, biocatalysis and other fields. Natto is rich in many pharmacological active substances and has significant medicinal research value. This paper summarizes the pharmacological activities and applications of natto in and outside China, so as to provide references for further research and development of natto.]]></description>
<pubDate>2023/7/21 14:06:28</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chunfang Wang a,b, Jinpeng Chen b,c,d, Wenguo Tiana,b, Yanqi Han b,c,d, Xu Xu b,c,d, Tao Ren b,c,d, Chengwang Tian b,c,d,*, Changqing Chen b,c,d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chunfang Wang a,b, Jinpeng Chen b,c,d, Wenguo Tiana,b, Yanqi Han b,c,d, Xu Xu b,c,d, Tao Ren b,c,d, Chengwang Tian b,c,d,*, Changqing Chen b,c,d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303002]]></guid><cfi:id>118</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phyllanthi Fructus: A modal medicinal and food homologous item in quality evaluation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Phyllanthi Fructus is a highly unique medicine and food homologous item, which exhibits distinctive flavor, notable nutritional value, and abundant pharmacological activity. It has enormous potential in the creation of health products and pharmaceuticals. However, due to the unique laws of quality formation and transfer of Phyllanthi Fructus, its appearance, shape, chemical compositions, nutrients, and sensory flavors are frequently greatly influenced by botanical resources, the processing and storage conditions. As a result, the current quality evaluation model is difficult to meet the needs of Phyllanthi Fructus as a medicine and food homologous item in the development of diversified products. This paper constructs the hierarchical utilization mode of Phyllanthi Fructus based on its unique quality formation and transmission laws, explores the quality evaluation model for food-oriented use and medicinal-oriented use, respectively, and systematically describes the quality evaluation idea under diversified application scenarios. This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of Phyllanthi Fructus.]]></description>
<pubDate>2023/7/21 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Gefei Li a, Yurou Jiang a, Dingkun Zhang a, Li Han a, Taigang Mo b, Sanhu Fanb, Haozhou Huang c,*, Junzhi Lin d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Gefei Li a, Yurou Jiang a, Dingkun Zhang a, Li Han a, Taigang Mo b, Sanhu Fanb, Haozhou Huang c,*, Junzhi Lin d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303003]]></guid><cfi:id>117</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Perilla frutescens: A traditional medicine and food homologous plant]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Perilla frutescens, an annual herb of the Labiatae family, has been cultivated in China for more than 2000 years. P. frutescens is the one of the first medicinal and edible plant published by the Ministry of Health. Its leaves, stems and seeds can be used as medicine and edible food. Because of the abundant nutrients and bioactive components in this plant, P. frutescens has been studied extensively in medicine, food, health care and chemical fields with great prospects for development. This paper reviews the cultivation history, chemical compositions and pharmacological activities of P. frutescens, which provides a reference for the development and utilization of P. frutescens resources.]]></description>
<pubDate>2023/7/21 14:06:29</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xinling Wu a,b,c, Shuting Dong b,c, Hongyu Chen b,c, Miaoxian Guo b,c, Zhiying Sun a,*, Hongmei Luo b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xinling Wu a,b,c, Shuting Dong b,c, Hongyu Chen b,c, Miaoxian Guo b,c, Zhiying Sun a,*, Hongmei Luo b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303004]]></guid><cfi:id>116</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Germplasm resources and secondary metabolism regulation in Reishi mushroom (Ganoderma lucidum)]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites, in which triterpenoids are the major constituents. This paper introduced the germplasm resources of genus Ganoderma from textual research, its distribution and identification at the molecular level. Also we overviewed G. lucidum in the components, the biological activities and biosynthetic pathways of ganoderic acid, aiming to provide scientific evidence for the development and utilization of G. lucidum germplasm resources and the biosynthesis of ganoderic acid.]]></description>
<pubDate>2023/7/21 14:06:29</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xinyu He a, Yiwen Chen a, Zhenhao Li b, Ling Fang b, Haimin Chen a, Zongsuo Liang a, c, Ann Abozeid d, Zongqi Yang a,*, Dongfeng Yang a, c, *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xinyu He a, Yiwen Chen a, Zhenhao Li b, Ling Fang b, Haimin Chen a, Zongsuo Liang a, c, Ann Abozeid d, Zongqi Yang a,*, Dongfeng Yang a, c, *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303005]]></guid><cfi:id>115</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Proteins: Neglected active ingredients in edible bird's nest]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Edible bird’s nest (EBN) is a kind of natural invigorant with a long history of consumption in Asia, especially in China. EBN is formed by mixing the saliva of swiftlets (Aerodramus) with feathers and other components during the breeding season. Proteins are the most important nutrient in EBN. By studying proteins in EBN, we can not only elucidate their components at the molecular level, but also study their bioactivities. Therefore, it is of great significance to study the proteins in EBN. Previous research on the proteins in EBN was preliminary and cursory, and no one has summarized and analyzed the proteins in EBN and correlated the bioactivities of these proteins with the biological functions of EBN. This article focused on the proteins in EBN, listed the proteins identified in different proteomic studies, and introduced the sources, structures and bioactivities of the most frequently identified proteins, including acidic mammalian chitinase, lysyl oxidase homolog 3, mucin-5AC, ovoinhibitor, nucleobindin-2, calcium-binding protein (MW: 4.5 × 104) and glucose-regulated protein (MW: 7.8 × 104). The properties of these proteins are closely related to the bioactivities of EBN. Therefore, this article can provide inspiration for further research on the efficacy of EBN.]]></description>
<pubDate>2023/7/21 14:06:29</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Man Yuan a, Xiaoxian Lin a, Dongliang Wang a,b,*, Jianye Dai a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Man Yuan a, Xiaoxian Lin a, Dongliang Wang a,b,*, Jianye Dai a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303006]]></guid><cfi:id>114</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and application of leek roots in medicinal field]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Some Chinese herbs have been used to prevent and treat diseases, and are also used as common food ingredients. These Chinese herbs are potential resource for research and development of new drugs. Leek roots is a typical medicine of food and medicine continuum. It has a long history of medicinal applications and edible food in China. In this paper, the origin, biological active components, pharmacological action and clinical application of leek roots were introduced. We hope that this review will contribute to the development of leek roots for pharmaceutical research and clinical applications, as well as related health products.]]></description>
<pubDate>2023/7/21 14:06:29</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Huaijian Wang a,1, Ying Tian a,1, Hao Tan a, Mengru Zhou a, Miao Li a, Yuchen Zhi a, Yanbin Shib, Xuefeng Li a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Huaijian Wang a,1, Ying Tian a,1, Hao Tan a, Mengru Zhou a, Miao Li a, Yuchen Zhi a, Yanbin Shib, Xuefeng Li a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202303007]]></guid><cfi:id>113</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Contents and significance of secondary development of large varieties of traditional Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Large variety of traditional Chinese medicine (TCM) refers to the traditional Chinese medicines that have achieved large-scale production and undergone long-term clinical trials, proving to have ideal clinical value and market prospects. However, these medicines are limited by the technological capabilities at the time registration, always leading to the possible problems such as insufficient research into raw materials, unclear clinical mechanisms, backward manufacturing techniques and relatively low quality standards. Consequently, a more extensive and systematic research effort is needed, as well as a comprehensive improvement of the raw materials, manufacturing processes, and quality standards, in order to raise the quality of products and provide better service to the public. The research mentioned above is known as the secondary development of large variety of TCM, which specifically includes the following four parts of contents.
The initial research that should be conducted is the material basis research on the TCM, and subsequently identifying its Q-markers based on the findings. Specifically, the material basis of raw materials, extract intermediates, and final preparations are explored based on a combination of plant chemistry and modern analytical techniques to fully clarify their composition, and combining pharmacology, toxicology, pharmacokinetics, and other methods to determine Q-markers. Meanwhile, researches on safety indicators such as heavy metals, pesticide residues, and fungal toxins in medicines are carried out to lay the foundation for the studies of the raw materials, production processes and products quality.  
The second part of content is focused on the mechanism of clinical action of the TCM, which can provide a more scientific evaluation of its clinical therapeutic prospects. Through modern pharmacological research, the active ingredients and their related mechanisms of action are identified, and suitable animal models are constructed to conduct pharmacological studies. Subsequently, conducting evidence-based medicine research to obtain richer clinical data, and integrating traditional Chinese medicine theory with modern medical concepts from the chemical and biological levels in an organic manner, in order to achieve individualized treatment based on syndrome differentiation.
The third part of the research is to establish a comprehensive quality control system that involves the raw materials, preparation processes and final products. This system is designed to comprehensively improve the quality standards and level of quality control in the large varieties of TCM. Traditionally, the quality control of TCM often involves post-production testing of the final product, as known as quality by test (QbT), which ignores the fundamental reasons for the formation of TCM quality. Under the modern pharmaceutical manufacturing concepts, such as “quality formed in production” and “quality by design (QbD)”, it is crucial to establish a comprehensive quality control system that can be applied to the large varieties of TCM. This system should include an online monitoring system to visualize the entire production process of the medicine, thereby improving its controllability and quality.
The last part of content involves the continuous optimization of the existing pharmaceutical processes, pharmaceutical machines, dosage forms, and clinical administration routes. However, due to the limited technological capabilities during the research and registration of the large varieties of TCM, there is still considerable room for improvement in these areas. With the continuous advancement of science and technology, various efficient separation and purification technologies have emerged, represented by column chromatography, membrane separation, and supercritical fluid extraction. Similarly, modern pharmaceutical production technologies, including hot melt extrusion, fluidized bed, 3D printing, continuous manufacturing, and intelligent production, have also emerged. Moreover, novel high-end formulations, such as those with controlled release and targeting, and new administration routes, such as transdermal, inhalation, and microneedles, have provided ample technological options for the secondary development of large varieties of TCM. In summary, it is important to be bold in exploring and daring to try to apply these emerging techniques to the production process of TCM varieties.
Since the founding of the People's Republic of China, the government has prioritized the advancement of TCM by improving the quality and quantity of traditional Chinese patent medicines. During this process, a series of large varieties of TCM with significant therapeutic effects for specific diseases have been developed. Conducting research on the secondary development of large varieties of TCM in this background can expedite the standardization, modernization, and internationalization process of TCM, and better benefit the health of all mankind.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenlong Li a,b,c]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenlong Li a,b,c</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302001]]></guid><cfi:id>112</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New insights for infection mechanism and potential targets of COVID19: Three Chinese patent medicines and three Chinese medicine formulas as promising therapeutic approaches]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide. Currently, there is no accepted specific drug for COVID-19 treatment. Therefore, it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19. According to several reliable reports from China, traditional Chinese medicine (TCM), especially for three Chinese patent medicines and three Chinese medicine formulas, has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines. In this review, we systematically summarized and analyzed the pathogenesis of COVID-19, the detailed clinical practice, active ingredients investigation, network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat. Additionally, we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism, which provides guidance for the development of new drugs against COVID-19. Collectively, by addressing critical challenges, for example, unclear targets and complicated active ingredients of these medicines and formulas, we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Kexin Jia a, Yijie Li a, Tiegang Liu b,c, Xiaohong Gu b,c,*, Xiaojiaoyang Li a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Kexin Jia a, Yijie Li a, Tiegang Liu b,c, Xiaohong Gu b,c,*, Xiaojiaoyang Li a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302002]]></guid><cfi:id>111</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cancer still has elevated morbidity and mortality, which undoubtedly impacts the life quality of affected individuals. Remarkable advances have been made in cancer therapy, although the toxicities of traditional therapies remain an obvious challenge. Dahuang Zhechong Pill (DHZCP), developed by Zhongjing Zhang in the Synopsis of the Golden Chamber, represents an effective anticancer traditional Chinese medicine (TCM). In this review, it was found that DHZCP is therapeutically utilized in liver, lung, gastric, pancreatic and other cancers in clinic. Pharmacological evidence showed that its anti-tumor mechanisms mainly involve induced cell cycle arrest, apoptosis and autophagy, as well as suppressed tumor cell proliferation, obstructed angiogenesis and metastasis, enhanced immunity, and reversal of multidrug resistance. The present review provides a solid basis for the clinical application of DHZCP and may promote the wide use of TCM in clinical antitumor application.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yingying Tian a,1, Beibei Ma b,1, Shangyue Yu a, Yilin Li a, Hailuan Pei a, Shiqiu Tian a, Xinyue Zhao a, Chuang Liu a, Zeping Zuo b,*, Zhibin Wang a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yingying Tian a,1, Beibei Ma b,1, Shangyue Yu a, Yilin Li a, Hailuan Pei a, Shiqiu Tian a, Xinyue Zhao a, Chuang Liu a, Zeping Zuo b,*, Zhibin Wang a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302003]]></guid><cfi:id>110</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC. Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC. Many Chinese herbal medicines including some of single herb, herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity. Some clinical trials have shown promising results. This review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut immunity. The existing clinical trials are also summarized.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yifei Yang a,b,1, Yi Wang c,1, Long Zhao d,1, Fang Wang a,b, Mingxing Li a,b,e, Qin Wang a,b, Haoming Luo a,b, Qianyun Zhao a,b, Jiuping Zeng a,b, Yueshui Zhao a,b,e, Fukuan Du a,b,e, Yu Chen a,b,e, Jing Shen a,b,e, Shulin Wei a,b, Zhangang Xiao a,b,e,*, Xu Wu a,b,e,f,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yifei Yang a,b,1, Yi Wang c,1, Long Zhao d,1, Fang Wang a,b, Mingxing Li a,b,e, Qin Wang a,b, Haoming Luo a,b, Qianyun Zhao a,b, Jiuping Zeng a,b, Yueshui Zhao a,b,e, Fukuan Du a,b,e, Yu Chen a,b,e, Jing Shen a,b,e, Shulin Wei a,b, Zhangang Xiao a,b,e,*, Xu Wu a,b,e,f,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302004]]></guid><cfi:id>109</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Albizzia julibrissin is empirically used as an antidepressant in clinical practice. Preclinical studies have indicated that its total extracts or bioactive constituents exerted antidepressant-like responses in animal models, providing the molecular basis to reveal its underlying mechanism of action. While attempts have been made to understand the antidepressant effect of A. julibrissin, many fundamental questions regarding its mechanism of action remain to be addressed at the molecular and systems levels. In this review, we conclusively discussed the mechanism of action of A. julibrissin and A. julibrissin formulae by reviewing recent preclinical and clinical studies conducted by using depressive animal models and depressive patients. Several representative bioactive constituents and formulae were highlighted as examples, and their mechanisms of action were discussed. In addition, some representative A. julibrissin formulae that have been shown to be compatible with conventional antidepressants in clinical practice were also reviewed. Furthermore, we discussed the future research directions to reveal the underlying mechanism of A. julibrissin at the molecular and systems levels in depression treatment. The integrated study using both the molecular and systematic approaches is required not only for improving our understanding of its molecular basis and mechanisms of action, but also for providing a way to discover novel agents or approaches for the effective and systematic treatment of depression.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Bishan Huang a,1, Yingyao Wu a,1, Chan Li a, Qingfa Tang b, Yuanwei Zhang a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Bishan Huang a,1, Yingyao Wu a,1, Chan Li a, Qingfa Tang b, Yuanwei Zhang a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302005]]></guid><cfi:id>108</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Jiawei Xiaoyao San in treatment of anxiety disorder and anxiety：A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Jiawei Xiaoyao San (JWXYS) has shown excellent clinical efficacy in anxiety disorder, but has not yet attracted widespread attention. The animal experiments, clinical trials and mechanism studies of JWXYS were reviewed in this article, which may provide a reference for developing new anxiolytic drugs based on this prescription. The literature was searched in PubMed and CNKI and the documents written in English or with English abstracts were selected. JWXYS could reduce the anxiety symptoms of patients alone and reduce the adverse reactions when it is used in combination with other drugs in the clinic. In preclinical studies, JWXYS also showed therapeutic effects in reducing anxiety-like behavior. The mechanisms may include improving the hypothalamic–pituitaryadrenal (HPA) axis and hormone disorders, increasing neurotransmitter content, neurogenesis, and regulating the synthesis of related enzymes. This article shows that JWXYS could effectively treat anxiety disorders by regulating the central nervous system. In the future, with the participation of more researchers, it is expected to develop innovative drugs for the treatment of anxiety disorders based on JWXYS.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jiaqi Xie, Dandan Xu, Can Wang *, Jianmei Huang *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jiaqi Xie, Dandan Xu, Can Wang *, Jianmei Huang *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302006]]></guid><cfi:id>107</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Pharmacological importance of Kunxian Capsule in clinical applications and its adverse effects: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Kunxian Capsule (KX) is a popular Chinese patent medicine for the treatment of rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Sch?nlein purpura, ankylosing spondylitis, psoriatic arthritis and eczema. However, there is scarcity of comprehensive information on the significance of KX in the clinical application and its side effects. Hence, it is aimed to provide a review of the significance of KX, with a focus on the pharmacological effects, clinical applications, and its adverse reactions. This review was based on the published literatures in PubMed, China National Knowledge Infrastructure and WanFang database. The articles were collected by two independent authors with no time limits applied until November 30, 2022. The search term includes Kunxian Capsule and/or clinical effect, pharmacology, disease, therapy, adverse effects and quality control. KX has been shown to be effective in the treatment of autoimmune arthritis by inhibiting inflammatory responses and inducing apoptosis. Many studies suggest that KX has anti-inflammatory and analgesic properties that aid in the improvement of joint functions. KX dispels wind, removes dampness, invigorates the kidneys, and promotes blood circulation, thereby curing various diseases. However, studies also suggest KX-related adverse reactions in multiple systems. Overall, this review highlights the scientific basis of KX in curing or preventing various diseases and provides novel insights for further research and clinical applications.]]></description>
<pubDate>2023/5/12 15:22:51</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ruijiao Ma a,b,1, Maharajan Kannan a,b,1, Kaiyan Zhuang a,b, Qing Xia a,b, Dong Sun c, Pengfei Tu d, Taiping Fan e, Kechun Liu a,b, Yun Zhang a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ruijiao Ma a,b,1, Maharajan Kannan a,b,1, Kaiyan Zhuang a,b, Qing Xia a,b, Dong Sun c, Pengfei Tu d, Taiping Fan e, Kechun Liu a,b, Yun Zhang a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202302007]]></guid><cfi:id>106</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Deepening insights into food and medicine continuum within the context of pharmacophylogeny]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The concept of food and medicine continuum (FMC) is traced back to Shennong’s Classic of Materia Medica (Shénnóng Běncǎo Jīng in Chinese) of the 1st century (Heinrich et al., 2022), which recorded 120 herbal medicines of the ‘top grade’ with nourishing properties; they can be consumed for extended periods of time without obvious side effects, indicating their functional food and medicinal benefits (Xiao, 2023). In recent decades, the health-promoting actions of numerous edible herbal medicines and phytometabolites therein have been scrutinized. For instance, many FMC plants, such as ginseng, Camellia sinensis, Ganoderma lucidum, goji, etc., display effects of enhancing immunity (Pan et al., 2023; Yao et al., 2023). The benefits of dietary interventions and phytometabolites on improving cognitive functions in elderly population have been supported by accumulating evidence (Heinrich et al., 2022). Therefore, food and medicine dual-use products are important in the prevention and intervention of chronic diseases and senile illnesses. Due to the different historical and cultural backgrounds of the East and the West, as well as the huge differences in geographical environment, physique and resources, the eating/medication habits are also distinct between East and West, which have established unique standards and knowledge systems for FMC products, and have different ways, purposes and methods of using the same FMC species or phylogenetically related species (Xiao, 2023). The list for FMC substances of China includes 109 entities, which are from 151 species (Yao et al., 2023). However, in Europe only 37 of these species are very important in healthy food use, and 86 of them are not used for healthy food. Strengthening the research and knowledge dissemination of Oriental FMC within the phylogenetic framework, consistent with the oriental systematic thinking, will help to improve the regulatory standards for FMC items, reduce barriers to communication, and make FMC more effective for the benefit of all mankind.
Nature presents a wonderful scene of food and medicine dual use, which brings endless fun to human rational thinking, no matter macro or micro. This issue has several outstanding papers that demonstrate the unremitting pursuit of human beings in exploring FMC substances. For instance, the phytochemistry analysis displayed that the main components of Benincasae Exocarpium (the dried outer pericarp of Benincasa hispida (Thunb.) Cogn.) are flavonoids, alkaloids, tannins, trace elements and vitamins (Zhang et al., 2023), and 43 compounds have been reported at present. The tea polyphenols, e.g., flavan-3-ols, flavonol glycosides, theanine, caffeine, are the most important compounds for both bioactivities and flavors, which are abundant in both black tea/oolong tea and dark tea (Pan et al., 2023)/Kombucha (Selvaraj & Gurumurthy, 2023). Additionally, the enriched metabolites via microbial fermentation form the mellow, sweet, and smooth taste of dark tea. Such metabolites include but not limited to prenylated cyclic dipeptides, B-vitamins, anthraquinones, flavan-3-ol B-ring fission analogues, fatty acids, triterpenoids, guanidine derivatives, cholesterol, lipopeptides, acarbose, asperphenamate, prenylated benzaldehydes, among others. Similarly, Kombucha is made from black tea via microbial fermentation (Selvaraj & Gurumurthy, 2023), which contains abundant organic acids, amino acids, vitamins, probiotics, sugars, polyphenols, and antioxidants. It could be intriguing to compare the fermentation metabolome of dark tea and Kombucha, and reveal the underlying microbial mechanisms via multiple omics techniques. It is interesting to treat Benincasae Exocarpium with fermentation microbiota to see whether its metabolome, flavor and health-promoting bioactivities could be further improved, so as to enrich the value-added products derived from FMC materials. Based on experimental analyses of phytochemistry and bioactivity of FMC materials, the medicinal/edible compounds and properties of related plants can be predicted by virtue of phylogenetic methods (Hao et al., 2022a, c), which nevertheless has not been utilized to explore the regularity of most ethnomedicinal and edible species. It is promising to investigate the distribution of the specific compound type and/or efficacy of ethnomedicinal/edible plants on the species-level Tree of Life, so as to more effectively tap health food resources.
Tea has a deep history as the first Chinese herbal medicine used by the Chinese. Modern pharmacological studies and clinical practice showed that Benincasae Exocarpium has diuretic, hypolipidemic, hypoglycemic, antioxidant, antibacterial, and antiviral effects (Zhang et al., 2023), which has long been used as a material of tea. Kombucha, originated in northeast China and is popular abroad, possesses anti-inflammatory, anti-carcinogenic, antimicrobial, antioxidant, anti-proliferative activities (Selvaraj & Gurumurthy, 2023). The bioactivities of dark tea are also diverse, including antioxidation, anti-bacteria, anti-inflammation, anti-obesity, ant-diabetes, anti-diarrhea, anti-cancer, gastrointestinal regulation, cardiovascular protection, immune-regulation, hepatoprotection, neuroprotection, and photoprotection (Pan et al., 2023). In contrast to these advances, the pharmacokinetic/pharmacodynamic (PKPD) studies of these FMC materials are far less enough, and there is gap in the awareness of absorption, distribution, metabolism, excretion and toxicity (ADMET) attributes of many FMC products. Despite numerous reports about beneficial effects of FMC materials, it is difficult to determine the chemical basis of different therapeutic and health effects, for which studies of ADMET properties must be taken into account, including the elucidation of gut microbiota mediated transformation (Hao et al., 2022b). The phylogenetically closer species are more likely to have similar phytometabolome, but FMC chemicals with the same/similar structural type might have analogous or reverse ADMET properties, which warrant case-by-case elaborations in the context of pharmacophylogeny. Facing the competition of western medicine, the identity of herbal medicine is always in crisis, and it must constantly redefine itself in the landscape of evolving new theories and technologies. It is important to provide consumers with the recommended, minimum, and maximum daily doses of FMC products (Pan et al., 2023). The optimal duration of intake to achieve a significant preventive and ameliorating effects of diseases should also be carefully studied.
At the beginning of the birth of FMC, art, science and technology were interrelated. The overlapping and intertextuality of art, science and technology on FMC jointly defined FMC. In the contemporary era when western medicine has overwhelming advantages, most of the health benefits and non-toxicity of FMC materials have not been scientifically validated in human body. Clinical trials are yet to be done to manifest the claimed health benefits. Of note, most FMC studies focus on either in vitro screening in cell culture or network pharmacology speculations based on data from in silico and/or simple cell culture models (Hao et al., 2022b). In the future, the clinical trials of FMC products have to be conducted as open label with placebo, covering enough number of subjects, and should focus on symptomatic benefits. The clinical studies are expected to generate PKPD insights as well. With any luck, findings from such research could strengthen consumers' confidence and recognition of FMC, as legitimate prevention and treatment option. Actually, the recent COVID-19 outbreak in major cities could help generate real-world data on the use of TCM (including FMC), which provide appreciated insights on their utilities.
Last but not least, as the food and/or drink, the proper sensory evaluation should be performed to provide a vibrant view of the flavor profile, the consumer’s desire, and acceptance (Selvaraj & Gurumurthy, 2023). Many FMC substances are traditionally used as food and listed in the Chinese Pharmacopoeia, which have both the efficacy of TCM and the safety of traditional food, therefore they play a vital role in health care. However, people often overemphasize the safety of FMC products in the clinical application, but ignore their application principles, function characteristics, application forms and dietary taboos, thus resulting in ineffectiveness and even harm to health. Pharmaceutical researchers must master the concept and connotation of FMC, and also learn more about food science and engineering. Under the guidance of TCM theory, researchers and clinicians need to use the dialectical thinking, apply FMC materials based on syndrome differentiation, reasonably mix them, adjust measures to people and local conditions, and grasp the functions and characteristics of FMC products, which can not only demonstrate the effectiveness of TCM, but also further ensure the safety of FMC application as food, so as to benefit the healthy development of standardization, modernization and internationalization of FMC products.]]></description>
<pubDate>2023/1/30 8:18:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Dacheng Hao, Changxiao Liu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Dacheng Hao, Changxiao Liu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301001]]></guid><cfi:id>105</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Food-medicine can promote cross-culture communication between East and West]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Since the 18th National Congress of the Communist Party of China (CPC), the CPC Central Committee with Comrade Xi Jinping at its core has set an action plan for the Construction of a Healthy China Program, insisting on putting people’s health in the strategic position of prioritizing development. As an important part of traditional Chinese medicine (TCM) culture in China, food-medicines, the stuff consumed both as food and medicine, are one of the material foundations to prevent and treat chronic diseases and manage health ahead of sick, and an important carrier for China to promote the Belt and Road Initiative (BRI) and participate in global health governance. To enrich the knowledge system of food-medicine through cross-cultural exchanges between the East and the West, and to promote the research progress of food-medicine are of critical importance in the context of the current global pandemic of COVID-19, since it is a profound understanding of the spirit of General Secretary Xi Jinping’s important speech and a practice of giving priority to people’s health in the strategic position of development, which helps to provide strong support for the comprehensive promotion of the Healthy China strategy and human well-being (Huang et al., 2022).]]></description>
<pubDate>2023/1/30 8:18:45</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chunnian He, Xinning Zhao, Ruyu Yao, Peigen Xiao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chunnian He, Xinning Zhao, Ruyu Yao, Peigen Xiao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301002]]></guid><cfi:id>104</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[‘Food and medicine continuum’ in the East and West: Old tradition and current regulation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Food-medicine products are important materials for daily health management and are increasingly popular in the global healthy food market. However, because of the biocultural difference, food-medicine knowledge may differ among regions, which hinders the global sharing of such health strategies. Aim at bridging the food-medicine knowledge in the East and West, this study traced the historical roots of food and medicine continuum of the East and West, which was followed by a cross-cultural assessment on the importance of food-medicine products of China, thereafter, the current legislative terms for foodmedicine products were studied using an international survey. The results show that the food and medicine continuum in the East and West have their historical roots in the traditional medicines since antiquity, and the food-medicine knowledge in the East and West differs substantially; although the foodmedicine products have common properties, their legislative terms are diverse globally; with proofs of traditional uses and scientific evidence, food-medicine products are possible for cross-cultural communication. Finally, we recommend facilitating the cross-cultural communication of the food-medicine knowledge in the East and West, thus to make the best use of the traditional health wisdom in the globe.]]></description>
<pubDate>2023/1/30 8:18:45</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ruyu Yao, Chunnian He *, Peigen Xiao *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ruyu Yao, Chunnian He *, Peigen Xiao *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301003]]></guid><cfi:id>103</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Ethnopharmacology, phytochemistry and pharmacology of Benincasae Exocarpium: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Benincasae Exocarpium (BE, Dongguapi in Chinese), as the dried outer pericarp of Benincasa hispida (wax gourd) in Cucurbitaceae family, is one of traditional Chinese medicines with the same origin as medicine and food. Up to now, 43 compounds were isolated from BE, including flavonoids, alkaloids, tannins, phenolic acids, soluble fiber and carbohydrates. Modern pharmacological studies and clinical practice showed that BE has diuretic, hypolipidemic effects, hypoglycemic, antioxidant, antibacterial, and other effects. The folk uses, functional factors, pharmacological activities, patents and clinical applications of BE were reviewed in this paper. In addition, the paper also discussed the current problems for the further studies. The information summarized in this paper provides valuable clues for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of BE.]]></description>
<pubDate>2023/1/30 8:18:45</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Meng Zhang a,b,1, Jialong Lei a,b,1, Yansheng Wang a,b, Jingze Zhang a,b,*, Dailin Liu a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Meng Zhang a,b,1, Jialong Lei a,b,1, Yansheng Wang a,b, Jingze Zhang a,b,*, Dailin Liu a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301004]]></guid><cfi:id>102</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[An overview of probiotic health booster-kombucha tea]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional herbal medicine (THM) is a significant division of traditional Chinese medicine (TCM) that plays an important role in maintaining health and disease prevention. WHO has consistently highlighted the significance of traditional, complementary, and alternative medicine in human healthcare. Most people in Eastern Asia will start their day with a cup of tea. The tea provides a nourishing effect, and it has become an inevitable part of life. There are several types of tea, like black tea, green tea, oolong tea, white tea, and herbal tea. Besides the refreshments, it is important to consume beverages that benefit health. One such alternative is a healthy probiotic drink called kombucha, a fermented tea. Kombucha tea is aerobically fermented by infusing sweetened tea with a cellulose mat/ pellicle called SCOBY (symbiotic culture of bacteria and yeast). Kombucha is a source of bioactive compounds that include organic acids and amino acids, vitamins, probiotics, sugars, polyphenols, and antioxidants. Currently, studies on kombucha tea and SCOBY are gaining attention for their remarkable properties and applications in the food and health industries. The review gives an overview of the production, fermentation, microbial diversity, and metabolic products of kombucha. The possible implications for human health are also discussed.]]></description>
<pubDate>2023/1/30 8:18:45</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Suriyapriya Selvaraj, Kalaichelvan Gurumurthy *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Suriyapriya Selvaraj, Kalaichelvan Gurumurthy *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301005]]></guid><cfi:id>101</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Dark tea: A popular beverage with possible medicinal application]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Tea is a famous beverage that is produced from leaves of Camellia sinensis. Amongst the six major tea categories in China, dark tea is the only one that involves microbial fermentation in the manufacturing process, which contributes unique flavors and functions for the tea. In the recent decade, the reports about the biofunctions of dark teas have increased rapidly. Therefore it may be the proper time to consider dark tea as one potential homology of medicine and food. In this viewpoint, our current understanding of the chemical constituents, biological activities and possible health beneficial effects of dark teas were introduced. Some future directions and challenges to the development perspectives of dark teas were also discussed.]]></description>
<pubDate>2023/1/30 8:18:45</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hongjing Pan a, Miamoiao Le a, Chunnian He b, Chung S. Yang a,c,d, Tiejun Ling a,d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hongjing Pan a, Miamoiao Le a, Chunnian He b, Chung S. Yang a,c,d, Tiejun Ling a,d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202301006]]></guid><cfi:id>100</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Integrating tradition and innovation: Health industry opportunities for
ginseng with foods and medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wei Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wei Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404001]]></guid><cfi:id>99</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Ginsenoside Rb1 in cardiovascular and cerebrovascular diseases: A review of therapeutic potentials and molecular mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cardiovascular and cerebrovascular diseases (CCVDs), which are circulatory system diseases caused by heart defects and vascular diseases, are the major noncommunicable diseases affecting global public health. With the improvement of economic level and the change of human lifestyle, the prevalence of CCVDs continues to increase. Ginseng (Panax ginseng C. A. Mey.) was widely used in traditional diseases due to its supposed tonic properties. Ginsenoside Rb1 (G-Rb1) is the most abundant active ingredient with multiple pharmacological effects extracted from ginseng, which has been shown to have potential benefits on the cardiovascular system through a variety of mechanisms, including anti-oxidation, antiinflammatory, regulation of vasodilation, reduction of platelet adhesion, influence of calcium ion channels, improvement of lipid distribution, involving in glucose metabolism and controlling blood sugar. This review reviewed the protective effects of G-Rb1 on CCVDs and its potential mechanisms, such as atherosclerosis (AS), hypertension, coronary heart disease (CHD), ischemic stroke (IS) and periocular microvascular retinopathy. Finally, we reviewed and reported the results of in vivo and in vitro experiments using G-Rb1 to improve CCVDs, highlighted its efficacy, safety, and limitations.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yueqin Song a, Chen Chen b, Wei Li a,c,d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yueqin Song a, Chen Chen b, Wei Li a,c,d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404002]]></guid><cfi:id>98</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Phytochemistry, quality control and biosynthesis in ginseng research from 2021 to 2023: A state-of-the-art review concerning advances and challenges]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Panax L. (Araliaceae) has a long history of medicinal and edible use due to its significant tonifying effects, and ginseng research has been a hot topic in natural products research and food science. In continuation of our recent ginseng review, we highlighted the advances in ginseng research from 2021 to 2023 with 157 citations, which exhibited the increasingly systematic, collaborative, and intelligent characteristics. In this review, we firstly updated the progress in phytochemistry involving the ginsenosides and polysaccharides and summarized the researches on the active components. Then, some specific applications by feat of the multidimensional chromatography, mass spectrometry imaging, DNA barcoding, and metabolomics, were analyzed, which could provide rich information supporting the multi-component characterization, authentication, and quality control of ginseng and the versatile products. Finally, the recent biosynthesis studies concerning ginsenosides were retrospected. Additionally, the current challenges and future trends with respect to ginseng research were discussed.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mengxiang Ding 1, Huizhen Cheng 1, Xiaohang Li 1, Xue Li, Min Zhang, Dianxin Cui, Yijin Yang, Xiaojin Tian, Hongda Wang *, Wenzhi Yang *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mengxiang Ding 1, Huizhen Cheng 1, Xiaohang Li 1, Xue Li, Min Zhang, Dianxin Cui, Yijin Yang, Xiaojin Tian, Hongda Wang *, Wenzhi Yang *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404003]]></guid><cfi:id>97</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Effects of steaming process on rare saponins and efficacy of Panax ginseng, Panax notoginseng and Panax quinquefolium]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The steamed Panax ginseng C. A. Mey., Panax notoginseng (Burk.) F. H. Chen, and Panax quinquefolium L. not only facilitate storage, but also increase the content of rare saponins and enhance their clinical application value. The traditional steaming process has high energy consumption, low efficiency, and lacks standardized operating procedures and unified standards. This paper retrieves the research literature on the steaming process parameters, rare saponin increments, and efficacy enhancement results of ginseng plants. By summarizing the effects of different steaming processes on rare saponins and pharmacodynamics in P. ginseng, P. notoginseng and P. quinquefolium, we explored new steaming methods and established a new quality evaluation system to provide guarantee for the effectiveness and safety of clinical medication and provide scientific basis for its rational use.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenjie Zhao 1, Linlin Han 1, Tao Li, Jungjoon Lee, Yuqing Zhao *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenjie Zhao 1, Linlin Han 1, Tao Li, Jungjoon Lee, Yuqing Zhao *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404004]]></guid><cfi:id>96</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research progress on chemical diversity of saponins in Panax ginseng]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Saponins, the major bioactive components of Panax ginseng C. A. Mey., are gradually emerging as research hotspots owing to the possession of various pharmacological activities. This review updates the ginsenosides list from P. ginseng and the steam-processed ginseng (red ginseng and black ginseng) up to 271 by June of 2024, encompassing 243 saponins from different parts of P. ginseng (roots, stems, leaves, flowers, berries, and seeds), 103 from red ginseng, and 65 from black ginseng, respectively. Among 271 saponins, there are a total of 249 (1–249) dammarane type (with a–z subtypes) tetracyclic triterpene saponins reported from each part of P. ginseng and steam-processed ginseng, two (250–251) lanostane type tetracyclic triterpene saponins identified from red ginseng, 18 (252–269) oleanane type pentacyclic triterpenoid saponins discovered from each part of P. ginseng and steam-processed ginseng, and two (270–271) ursane type pentacyclic triterpenoid saponins reported from red ginseng. Overall, this review expounds on the chemical diversity of ginsenosides in various aspects, such as chemical structure, spatial distribution and subtype comparison, processed products, and transformation. This facilitates more indepth research on ginsenosides and contributes to the future development of ginseng.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiaoyu Geng a,b, Jia Wang a, Yuwei Liu a, Linxuan Liu a, Xuekun Liu b, Yan Zhao c, Cuizhu Wang a,*, Jinping Liu a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiaoyu Geng a,b, Jia Wang a, Yuwei Liu a, Linxuan Liu a, Xuekun Liu b, Yan Zhao c, Cuizhu Wang a,*, Jinping Liu a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404005]]></guid><cfi:id>95</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Mechanism of action of protopanaxadiol ginsenosides on hepatocellular carcinoma and network pharmacological analysis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally, posing a major challenge to global health care. Protopanaxadiol ginsenosides (PDs) have been believed to significantly improve liver diseases. PDs, such as Rg3, have been developed as a new class of anti-cancer drugs. Ginsenosides Rb1, Rd, Rg3, and Rh2 exhibit effective anti-inflammatory and anti-tumor activities. Studies have confirmed that PDs could be used to treat HCC. However, the mechanism of action of PDs on HCC remains unclear. In the study, we reviewed the anti-HCC effects and mechanisms of PDs including Rb1, Rd, Rg3, Rg5, Rh2, Rk1, and Compound K (CK). Then, we searched for relevant targets of PDs and HCC from databases and enriched them for analysis. Subsequently, molecular docking was simulated to reveal molecular mechanisms. We found that PDs may treat HCC through multiple signaling pathways and related targets. PDs could inhibit the proliferation, invasion, and metastasis of HCC while promoting apoptosis and inducing differentiation. In conclusion, this review and network pharmacological analysis might offer a direction for in-depth research on related mechanisms. These insights will aid in the direction of further pharmacological studies and the development of safe and effective clinical drugs.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yue Zhou a, Zi Wang a, Shen Ren a, Wei Li a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yue Zhou a, Zi Wang a, Shen Ren a, Wei Li a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404006]]></guid><cfi:id>94</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Network pharmacology for traditional Chinese medicine in era of artificial intelligence
artificial intelligence]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese Medicine Network Pharmacology (TCM-NP) is an interdisciplinary discipline that integrates information science, systems biology, network science and pharmacology, providing a systematic research methodology for TCM studies. With the development of artificial intelligence (AI) and multi-omics technologies, TCM-NP has entered a new era and can incorporate multimodal and high-dimensional data in the context of big data to enhance both theoretical foundations and technical capabilities. Despite its advancement, TCM-NP still faces challenges, particularly in ensuring the quality of data and research, as well as achieving more profound scientific discoveries. The field needs further innovation to obtain more precise and biomedically meaningful results. Overall research progress in TCM-NP depends on developing more accurate algorithms together with utilizing higher-quality and larger-scale data. This paper gives a perspective on the trends and characteristics of TCM-NP development and application in the era of AI.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Weibo Zhao, Boyang Wang, Shao Li *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Weibo Zhao, Boyang Wang, Shao Li *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404007]]></guid><cfi:id>93</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Treatment of constipation with Aloe and its compatibility prescriptions]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term efficacy is unsatisfactory. The pathogenesis of constipation is mainly attributed to dysfunction of zang-fu organs and imbalance of qi-blood and yin-yang, with the syndrome being asthenia in origin and asthenia in superficiality. Aloe is a traditional Chinese medicine with cold properties and a bitter taste, and one of the most commonly used herbs for constipation. Based on Aloe and its monomer components, combined with the existing compatibility studies of Aloe and several Chinese patent drugs represented by Aloe, this paper comprehensively and systematically introduced the research progress of Aloe and its compatibility prescriptions in the treatment of constipation from basic experiments to clinical observations, providing theoretical basis and medication guidance for the clinical rational application of Aloe and its prescriptions in the treatment of constipation. At the same time, it also provides the direction for future research on the mechanism of Aloe in the treatment of constipation.]]></description>
<pubDate>2024/11/13 14:19:55</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xianhui Shen a,1, Liping Gong a,1, Rongrong Li c, Nana Huang a, Huijie Zhang c, Siyi Chen d, Ying Liu d, Rong Sun a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xianhui Shen a,1, Liping Gong a,1, Rongrong Li c, Nana Huang a, Huijie Zhang c, Siyi Chen d, Ying Liu d, Rong Sun a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404008]]></guid><cfi:id>92</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Exploration of compatibility rules and discovery of active ingredients in TCM formulas by network pharmacology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404009]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Network pharmacology is an interdisciplinary field that utilizes computer science, technology, and biological networks to investigate the intricate interplay among compounds/ingredients, targets, and diseases. Within the realm of traditional Chinese medicine (TCM), network pharmacology serves as a scientific approach to elucidate the compatibility relationships and underlying mechanisms of action in TCM formulas. It facilitates the identification of potential active ingredients within these formulas, providing a comprehensive understanding of their holistic and systematic nature, which aligns with the holistic principles inherent in TCM theory. TCM formulas exhibit complexity due to their multicomponent characteristic, involving diverse targets and pathways. Consequently, investigating their material basis and mechanisms becomes challenging. Network pharmacology has emerged as a valuable approach in TCM formula research, leveraging its holistic and systematic advantages. The manuscript aims to provide an overview of the application of network pharmacology in studying TCM formula compatibility rules and explore future research directions. Specifically, we focus on how network pharmacology aids in interpreting TCM pharmacological theories and understanding formula compositions. Additionally, we elucidate the process of utilizing network pharmacology to identify active ingredients within TCM formulas. These findings not only offer novel research models and perspectives for integrating network pharmacology with TCM theory but also present new methodologies for investigating TCM formula compatibility. All in all, network pharmacology has become an indispensable and crucial tool in advancing TCM formula research.]]></description>
<pubDate>2024/11/13 0:00:00</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yishu Liu a, Xue Li a, Chao Chen a, Nan Ding a, Shiyu Ma b,*, Ming Yang a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yishu Liu a, Xue Li a, Chao Chen a, Nan Ding a, Shiyu Ma b,*, Ming Yang a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202404009]]></guid><cfi:id>91</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Comprehensive summary of material basis - Laying a foundation for substances of medicine food homology development]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenyuan Gao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenyuan Gao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403001]]></guid><cfi:id>90</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical composition, pharmacological activity and development strategies of Rubus chingii: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Raspberries are used for both food and medicine, but it has not yet attracted widespread attention. In this paper, the chemical constituen of the original plant raspberry. R. chingii is one of the new "Zhe Bawei" medicinal materials selected in 2017. ‘‘Zhe Bawei” refers to eight kinds of genuine medicinal materials in Zhejiang Province. The chemical constituents, pharmacological effects, processing, and application of Rubus chingii Hu were reviewed to provide a reference for its further development. Relevant literature in recent years was collected in databases such as China Knowledge Network, Web of Science, Elsevier, PubMed, and X-Mol, using ‘‘raspberry”, ‘‘Rubus chingii”, ‘‘traditional use”, ‘‘chemical composition”, ‘‘pharmacology”, etc. as keywords individually or in combination. The summary of pharmacological activities shows that the relationship between the pharmacological activities of raspberry is still not deep enough. More in-depth research should be carried out in this direction to explore the mechanism of action of its active ingredients and provide effective reference for the further development of the raspberry industry. In the future, with the participation of more researchers, it is expected to develop innovative drugs based on raspberry for the treatment of diseases.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiangmei Xiong a,1, Zheng Liu b,1, Xiance Che a, Xuemin Zhang c, Xia Li b,*, Wenyuan Gao a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiangmei Xiong a,1, Zheng Liu b,1, Xiance Che a, Xuemin Zhang c, Xia Li b,*, Wenyuan Gao a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403002]]></guid><cfi:id>89</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Ethnopharmacology, phytochemistry, pharmacology and product application of Platycodon grandiflorum: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Platycodonis Radix (Jiegeng in Chinese) is a well-known traditional Chinese medicine used for both medicinal and culinary purposes. Its historical use as an antitussive and expectorant has been extensively documented. Researchers, to date, have identified 219 chemical constituents in Platycodon grandiflorum (Jacq.) A. DC, encompassing 89 saponins, 11 flavonoids, 21 polysaccharides, 14 phenolic acids, six polyacetylenes, five sterols, 34 fatty acids, 17 amino acids, and 22 trace elements. Jiegeng exhibits diverse pharmacological effects, including antitussive and anti-phlegm properties, anti-cancer activity, antiinflammatory effects, immune regulation, antioxidant properties, anti-obesity, and antidiabetic effects. Additionally, Jiegeng shows potential in protecting the heart and liver. Beyond its medicinal benefits, Jiegeng is highly esteemed in culinary applications, and its global demand is on the rise. Its utilization has expanded beyond medicine and food to encompass daily necessities, cosmetics, agricultural supplies, and other fields. Currently, there are 18 272 patents related to P. grandiflorum. This comprehensive review summarizes the latest research published over the past 20 years, providing a robust foundation for further exploration of the medicinal and health benefits of P. grandiflorum.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lanying Zhang a,c, Xinrui Wanga,c, Jingze Zhang c, Dailin Liu a,c,*, Gang Bai b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lanying Zhang a,c, Xinrui Wanga,c, Jingze Zhang c, Dailin Liu a,c,*, Gang Bai b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403003]]></guid><cfi:id>88</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical constituents, pharmacological activities and quality evaluation methods of genus Hippocampus: A comprehensive review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The genus Hippocampus is a multi-origin animal species with high medicinal and healthcare values. About 57 species of Hippocampus spread worldwide, of which about 14 species can be used as medicine, showing anti-oxidation, anti-inflammation, anti-depressant, anti-hypertension, anti-prostatic hyperplasia, antivirus, anti-apoptotic, antifatigue, and so on. And those pharmacological effects are mainly related to their active ingredients, including amino acids, abundant proteins (peptides and oligopeptides), fatty acids, nucleosides, steroids, and other small molecular compounds. The main means of authentication of Hippocampus species are morphological identification, microscopic identification, thin layer chromatography method, fingerprint method and genomics method. This review will provide useful insight for exploration, further study and precise medication of Hippocampus in the future.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zhiyong Zhang a,b, Xiaoyang Zhang a,b, Xi Wang a,b, Xuting Guo a, Xinhao Yan a, Zheng Li a,b,c,*, Wenlong Li a,b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zhiyong Zhang a,b, Xiaoyang Zhang a,b, Xi Wang a,b, Xuting Guo a, Xinhao Yan a, Zheng Li a,b,c,*, Wenlong Li a,b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403004]]></guid><cfi:id>87</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Ethnopharmacology, chemical composition and functions of Cymbopogon citratus]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cymbopogon citratus in the gramineous family, also known as lemongrass (LG), is a perennial herb. LG, a drug and food homologous medicine, has a widely recorded medicinal value and food applications. To date, 158 LG compounds have been reported, including terpenoids, flavonoids, phenolic acids. Pharmacological and clinical studies have indicated that LG has antibacterial, neuroprotective, hypoglycemic, hypotensive, anti-inflammatory, and anti-tumor effects. This article reviews LG in ethnopharmacology, chemical composition, pharmacology, food, medicine, and daily chemical applications to provide a basis for the subsequent development of food and medicine.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiqin Dua,b,1, Meng Zhang a,b,1, Shuping Wang c, Jingyang Li d, Jingze Zhang a,b,*, Dailin Liu a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiqin Dua,b,1, Meng Zhang a,b,1, Shuping Wang c, Jingyang Li d, Jingze Zhang a,b,*, Dailin Liu a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403005]]></guid><cfi:id>86</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G. lucidum spores (GLS) are tiny germ cells released from the mushroom cap during the mature stage of growth. They contain all the genetic active substances of G. lucidum. G. lucidum spore oil (GLSO) is a lipid component extracted from broken-walled Ganoderma spores using supercritical CO2 extraction technology. GLSO contains fatty acids, Ganoderma triterpenes, sterols and other bioactive compounds. Previous studies have demonstrated that GLSO has a wide range of pharmacological properties, including anti-tumor, anti-aging, neuroprotection, immunomodulation, hepatoprotection and modulation of metabolic diseases. This review summarizes the research progress of GLSO over the past two decades in terms of its bioactive components, extraction and processing techniques, pharmacological effects and safety evaluation. This provides a solid foundation for further research and application of GLSO.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jianying Liu a, Binzhi Zhang a, Leqi Wang a,b, Shasha Li b,c, Qinqiang Long a,*, Xue Xiao a,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jianying Liu a, Binzhi Zhang a, Leqi Wang a,b, Shasha Li b,c, Qinqiang Long a,*, Xue Xiao a,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403006]]></guid><cfi:id>85</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biotransformation and pharmacological activities of platycosides from Platycodon grandiflorum roots]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[In Northeast China, Goubao pickle is a popular food fermented from the roots of Platycodon grandiflorum
as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of P. grandiflorum
may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation. In this study, we reviewed platycosides in chemical diversity, metabolic processes in vivo, biotransformation of platycosides in vitro, and pharmacological effects. Finally, we also discussed how to improve the bioactive secondary platycosides we desire by regulating enzymes from microorganisms in the future.]]></description>
<pubDate>2024/7/12 14:47:36</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lin Shi a, Tong Cui a, Xinyue Wang a, Rina Wu a,*, Junrui Wua, Yanqun Wang a, Weiming Wang b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lin Shi a, Tong Cui a, Xinyue Wang a, Rina Wu a,*, Junrui Wua, Yanqun Wang a, Weiming Wang b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202403007]]></guid><cfi:id>84</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Microbial interactions within Chinese traditional medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Juan Chen*, Luping Qin]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Juan Chen*, Luping Qin</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402001]]></guid><cfi:id>83</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Perspective and challenges of mycorrhizal symbiosis in orchid medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The family Orchidaceae is of the most diverse taxon in the plant kingdom, and most of its members are highly valuable herbal medicines. Orchids have a unique mycorrhizal symbiotic relationship with specific fungi for carbohydrate and nutrient supplies in their whole lifecycle. The large-scale cultivation of the medicinal plant Gastodia elata is a successful example of using mycorrhizal symbiotic technology. In this review, we adopted G. elata and Dendrobium officinale as examples to describe the characteristics of orchid mycorrhiza and mycorrhizal benefits for host plants’ growth and health (e.g. biotic and abiotic stress and secondary metabolite accumulation). The challenges in applying mycorrhizal technology to the cultivation of orchid medicinal plants in the future were also discussed. This review aims to serve as a theoretical guide for the cultivation of mycorrhizal technology in medicinal orchid plants.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chunyan Leng, Mengyan Hou, Yongmei Xing, Juan Chen*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chunyan Leng, Mengyan Hou, Yongmei Xing, Juan Chen*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402002]]></guid><cfi:id>82</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Rhizosphere microbial markers (micro-markers): A new physical examination indicator for traditional Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Rhizosphere microorganisms, as one of the most important components of the soil microbiota and plant holobiont, play a key role in the medicinal plant-soil ecosystem, which are closely related to the growth, adaptability, nutrient absorption, stress tolerance and pathogen resistance of host plants. In recent years, with the wide application of molecular biology and omics technologies, the outcomes of rhizosphere microorganisms on the health, biomass production and secondary metabolite biosynthesis of medicinal plants have received extensive attention. However, whether or to what extent rhizosphere microorganisms can contribute to the construction of the quality evaluation system of Chinese medicinal materials is still elusive. Based on the significant role of rhizosphere microbes in the survival and quality formation of medicinal plants, this paper proposed a new concept of rhizosphere microbial markers (micro-markers), expounded the relevant research methods and ideas of applying the new concept, highlighted the importance of micro-markers in the quality evaluation and control system of traditional Chinese medicines (TCMs), and introduced the potential value in soil environmental assessment, plant pest control and quality assessment of TCMs. It provides reference for developing ecological planting of TCMs and ensuring the production of high quality TCMs by regulating rhizosphere microbial communities.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Kailin Yang a,b, Yaping Zheng a,b, Kangmeng Sun a,b, Xinyan Wua,b, Zheng Zhang a, Chunnian He a,b,*, Peigen Xiao a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Kailin Yang a,b, Yaping Zheng a,b, Kangmeng Sun a,b, Xinyan Wua,b, Zheng Zhang a, Chunnian He a,b,*, Peigen Xiao a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402003]]></guid><cfi:id>81</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Effects of plants-associated microbiota on cultivation and quality of Chinese herbal medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Microbial resource influences the life activities of medicinal plants from several perspectives. Endophytes, rhizosphere microorganisms, and other environmental microorganisms play essential roles in medicinal plant growth and development, plant yield, and clinical efficacy. The microbiota can influence the biosynthesis of active compounds in medicinal plants by stimulating specific metabolic pathways. They induce host plants to improve their resistance to environmental stresses by accumulating secondary metabolites. Microorganisms can interact with their host plants to produce long-term, targeted selection results and improve their ability to adapt to the environment. Due to the interdependence and interaction between microorganisms and medicinal plants, Chinese herbal medicines (CHMs) quality is closely related to the associated microorganisms. This review summarizes the relationship between medicinal plants and their associated microorganisms, including their species, distribution, life activities, and metabolites. Microorganisms can aid in quality control, improve the efficacy of medicinal plants, and provide markers for identifying the origin and storage time of CHMs. Therefore, a comprehensive understanding of the relationship between microorganisms and medicinal plants will help to control the quality of CHMs from different perspectives.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yue Ouyang b,1, Qiqing Cheng b,c,1, Chunsong Cheng d, Ziyu Tang b, Yufeng Huang a, Eyu Tan a,e,f, Shaofeng Ma e, Xinheng Lin e, Ying Xie a,b,*, Hua Zhou a,b,f,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yue Ouyang b,1, Qiqing Cheng b,c,1, Chunsong Cheng d, Ziyu Tang b, Yufeng Huang a, Eyu Tan a,e,f, Shaofeng Ma e, Xinheng Lin e, Ying Xie a,b,*, Hua Zhou a,b,f,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402004]]></guid><cfi:id>80</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Roles of endophytic fungi in medicinal plant abiotic stress response and TCM quality development]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants, as medicinal materials and important drug components, have been used in traditional and folk medicine for ages. However, being sessile organisms, they are seriously affected by extreme environmental conditions and abiotic stresses such as salt, heavy metal, temperature, and water stresses. Medicinal plants usually produce specific secondary metabolites to survive such stresses, and these metabolites can often be used for treating human diseases. Recently, medicinal plants have been found to partner with endophytic fungi to form a long-term, stable, and win–win symbiotic relationship. Endophytic fungi can promote secondary metabolite accumulation in medicinal plants. The close relationship can improve host plant resistance to the abiotic stresses of soil salinity, drought, and extreme temperatures. Their symbiosis also sheds light on plant growth and active compound production. Here, we show that endophytic fungi can improve the host medicinal plant resistance to abiotic stress by regulating active compounds, reducing oxidative stress, and regulating the cell ion balance. We also identify the deficiencies and burning issues of available studies and present promising research topics for the future. This review provides guidance for endophytic fungi research to improve the ability of medicinal plants to resist abiotic stress. It also suggests ideas and methods for active compound accumulation in medicinal plants and medicinal material development during the response to abiotic stress.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jiahao Zhang a, Jiemiao Lu a, Yichun Zhu a, Xiaoxia Shen a,b, Bo Zhu a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jiahao Zhang a, Jiemiao Lu a, Yichun Zhu a, Xiaoxia Shen a,b, Bo Zhu a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402005]]></guid><cfi:id>79</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Shouhui Tongbian Capsule in treatment of constipation: Treatment and mechanism development]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402010]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Constipation is common in the diseases of the digestive system in clinics. With the change in diet structure and the increase in life pressure, the prevalence rate increases year by year. In traditional Chinese medicine (TCM), the location of the disease of constipation is in the large intestine, which is related to the dysfunction of lung, spleen, liver, kidney and other viscera. Its pathogenesis is conductive dysfunction of large intestine. Based on the theory, Shouhui Tongbian Capsule (SHTB) is composed of eight traditional Chinese medicines, including Polygoni multiflori Radix (Heshouwu in Chinese), Aloe (Luhui in Chinese), Cassiae Semen (Juemingzi in Chinese), Ginseng Radix et Rhizoma (Renshen in Chinese), Lycii Fructus (Gouqizi in Chinese), Asini Corii Colla (Ejiao in Chinese), Aurantii Fructus Immaturus (Zhishi in Chinese), and Atractylodis Macrocephalae Rhizoma (Baizhu in Chinese), which could help to release excessive turbid, and nourishing yin and supplementing qi in the treatment. This study has been carried out to review the latest advances of SHTB in the treatment of constipation. The results showed that significant effect of SHTB was found in the treatment of constipation, such as functional constipation, and constipation associated with tumor chemotherapy, colitis, type 2 diabetes and chronic cardiac failure. Besides, obvious adverse reactions were not observed. SHTB could effectively treat five types of constipation, provide direction for the future exploration of SHTB in the treatment of other types of constipation.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Liping Gong a,b, Hang Du a, Xin Guo c, Jianchao Li d, Xiaomin Zhu a, Xianhui Shen a, Zhiyan Huang b, Kaiyi Wu c, Guimin Zhang b,*, Rong Sun a,e,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Liping Gong a,b, Hang Du a, Xin Guo c, Jianchao Li d, Xiaomin Zhu a, Xianhui Shen a, Zhiyan Huang b, Kaiyi Wu c, Guimin Zhang b,*, Rong Sun a,e,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402010]]></guid><cfi:id>78</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in research and utilization of botanical pesticides for agricultural pest management in Inner Mongolia, China]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402011]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese herbal medicines not only cure human diseases, but also play an important role as insecticides. Compared with conventional chemical agents, traditional Chinese herbal medicines are characterized by low toxicity, low residues, and being eco friendly, and they have become a research hotspot. Traditional Chinese herbal medicines have tremendous flexibility and indefinite potential. Therefore, this paper reviewed the types of insecticides belonging to traditional Chinese herbal medicines in Inner Mongolia, China, including their traditional uses, secondary metabolites, biological activities, action mechanisms, application methods, and development status. In addition, the most relevant issues involved in the development of traditional Chinese herbal medicines was discussed. We believe that traditional Chinese herbal medicines can be better implemented and developed; such that its other advantages, such as an insect repellent, can be promoted. Moreover, this study lays a solid foundation for further research on traditional Chinese herbal medicines in Inner Mongolia, China.]]></description>
<pubDate>2024/4/23 14:27:20</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chunyan Guo a,c,d, Lingfei Wang g, Namuhan Chen c, Mingxu Zhang f, Junying Jia e, Lijuan Lv b,*, Minhui Li a,c,d,f,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chunyan Guo a,c,d, Lingfei Wang g, Namuhan Chen c, Mingxu Zhang f, Junying Jia e, Lijuan Lv b,*, Minhui Li a,c,d,f,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202402011]]></guid><cfi:id>77</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biosynthesis of natural products of medicinal plant: Progress, challenges and prospects]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2024/3/11 8:20:47</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shilin Chen]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shilin Chen</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401001]]></guid><cfi:id>76</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023 edition)]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization, led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles, research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles, Professional Committee on Extracellular Vesicle Research and Application, Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles. Based on the collation of relevant literature, we have adopted the Delphi method, the consensus meeting method combined with the nominal group method to form a discussion draft of "Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023)". The first draft was discussed in online and offline meetings on October 12, 14, November 2, 2022 and April and May 2023 on the current status of research, nomenclature, isolation methods, quality standards and research applications of extracellular vesicles of Chinese herbal medicines, and 13 consensus opinions were finally formed. At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles, held on May 26, 2023, Kewei Zhao, convenor of the consensus, presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles. The consensus
highlights the characteristics and advantages of Chinese medicine, inherits the essence, and keeps the righteousness and innovation, aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad, decode the mystery behind Chinese herbal vesicles together, establish a safe, effective and controllable accurate Chinese herbal vesicle prevention and treatment system, and build a bridge for Chinese medicine to the world.]]></description>
<pubDate>2024/3/11 8:20:47</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Qing Zhao a,b,1, Tong Wang c, Hongbin Wang d, Peng Cao e,a,b, Chengyu Jiang f, Hongzhi Qiao e, Lihua Peng g, Xingdong Lin a,b, Yunyao Jiang h, Honglei Jin d,b, Huantian Zhang i,b, Shengpeng Wang j, Yang Wang k, Ying Wang l, Xi Chen m, Junbing Fan l, Bo Li n, Geng Li o, Bifeng Liu p, Zhiyang Li q, Suhua Qi r, Mingzhen Zhang s, Jianjian Zheng t, Jiuyao Zhou d, Lei Zheng n,a,b,*, Kewei Zhao a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Qing Zhao a,b,1, Tong Wang c, Hongbin Wang d, Peng Cao e,a,b, Chengyu Jiang f, Hongzhi Qiao e, Lihua Peng g, Xingdong Lin a,b, Yunyao Jiang h, Honglei Jin d,b, Huantian Zhang i,b, Shengpeng Wang j, Yang Wang k, Ying Wang l, Xi Chen m, Junbing Fan l, Bo Li n, Geng Li o, Bifeng Liu p, Zhiyang Li q, Suhua Qi r, Mingzhen Zhang s, Jianjian Zheng t, Jiuyao Zhou d, Lei Zheng n,a,b,*, Kewei Zhao a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401002]]></guid><cfi:id>75</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Strategies on biosynthesis and production of bioactive compounds in medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and disease therapy. Compared with chemical synthesis and extraction, the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants, and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants. Here, we summarize the advances in strategies and methods concerning the biosynthesis and production of natural products of medicinal plants. The strategies and methods mainly include genetic engineering, plant cell culture engineering, metabolic engineering, and synthetic biology based on multiple ‘‘OMICS” technologies, with paradigms for the biosynthesis of terpenoids and alkaloids. We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products, exemplifying compounds such as vindoline (alkaloid), artemisinin and paclitaxel (terpenoids), to illustrate the power of biotechnology in medicinal plants.]]></description>
<pubDate>2024/3/11 8:20:47</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Miaoxian Guo a, Haizhou Lv a, Hongyu Chen a, Shuting Dong a, Jianhong Zhang a, Wanjing Liu a, Liu He a,b, Yimian Ma a,b, Hua Yu c, Shilin Chen d, Hongmei Luo a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Miaoxian Guo a, Haizhou Lv a, Hongyu Chen a, Shuting Dong a, Jianhong Zhang a, Wanjing Liu a, Liu He a,b, Yimian Ma a,b, Hua Yu c, Shilin Chen d, Hongmei Luo a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401003]]></guid><cfi:id>74</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Gain deeper insights into traditional Chinese medicines using multidimensional chromatography combined with chemometric approaches]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicines (TCMs) possess a rich historical background, unique theoretical framework, remarkable therapeutic efficacy, and abundant resources. However, the modernization and internationalization of TCMs have faced significant obstacles due to their diverse ingredients and unknown mechanisms. To gain deeper insights into the phytochemicals and ensure the quality control of TCMs, there is an urgent need to enhance analytical techniques. Currently, two-dimensional (2D) chromatography, which incorporates two independent separation mechanisms, demonstrates superior separation capabilities compared to the traditional one-dimensional (1D) separation system when analyzing TCMs samples. Over the past decade, new techniques have been continuously developed to gain actionable insights from complex samples. This review presents the recent advancements in the application of multidimensional chromatography for the quality evaluation of TCMs, encompassing 2D-gas chromatography (GC), 2D-liquid chromatography (LC), as well as emerging three-dimensional (3D)-GC, 3D-LC, and their associated data-processing approaches. These studies highlight the promising potential of multidimensional chromatographic separation for future phytochemical analysis. Nevertheless, the increased separation capability has resulted in higher-order data sets and greater demands for data-processing tools. Considering that multidimensional chromatography is still a relatively nascent research field, further hardware enhancements and the implementation of chemometric methods are necessary to foster its robust development.]]></description>
<pubDate>2024/3/11 8:20:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xinyue Yang a,1, Pingping Zeng a,1, Jin Wen a, Chuanlin Wang a, Liangyuan Yao b, Min He a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xinyue Yang a,1, Pingping Zeng a,1, Jin Wen a, Chuanlin Wang a, Liangyuan Yao b, Min He a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401004]]></guid><cfi:id>73</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Potential efficacy and mechanism of eight mild-natured and bitter-flavored TCMs based on gut microbiota: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The mild-natured and bitter-flavored traditional Chinese medicines (MB-TCMs) are an important class of TCMs that have been widely used in clinical practice and recognized as safe long-term treatments for chronic diseases. However, as an important class of TCMs, the panorama of pharmacological effects and the mechanisms of MB-TCMs have not been systemically reviewed. Compelling studies have shown that gut microbiota can mediate the therapeutic activity of TCMs and help to elucidate the core principles of TCM medicinal theory. In this systematic review, we found that MB-TCMs commonly participated in the modulation of metabolic syndrome, intestinal inflammation, nervous system disease and cardiovascular system disease in association with promoting the growth of beneficial bacteria Bacteroides, Akkermansia, Lactobacillus, Bifidobacterium, Roseburia as well as inhibiting the proliferation of harmful bacteria Helicobacter, Enterococcus, Desulfovibrio and Escherichia-Shigella. These alterations, correspondingly, enhance the generation of protective metabolites, mainly including short-chain fatty acids (SCFAs), bile acid (BAs), 5-hydroxytryptamine (5-HT), indole and gamma-aminobutyric acid (GABA), and inhibit the generation of harmful metabolites, such as proinflammatory factors trimethylamine oxide (TAMO) and lipopolysaccharide (LPS), to further exert multiplicative effects for the maintenance of human health through several different signaling pathways. Altogether, this present review has attempted to comprehensively summarize the relationship between MB-TCMs and gut microbiota by establishing the TCMs-gut microbiota-metabolite-signaling pathway-diseases axis, which may provide new insight into the study of TCM medicinal theories and their clinical applications.]]></description>
<pubDate>2024/3/11 8:20:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenquan Su a,1, Yanan Yang b,1, Xiaohui Zhao b, Jiale Cheng b, Yuan Li a, Shengxian Wu a,*, Chongming Wu b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenquan Su a,1, Yanan Yang b,1, Xiaohui Zhao b, Jiale Cheng b, Yuan Li a, Shengxian Wu a,*, Chongming Wu b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401005]]></guid><cfi:id>72</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Hypoxia inducible factor-1α related mechanism and TCM intervention in process of early fracture healing]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[As a common clinical disease, fracture is often accompanied by pain, swelling, bleeding as well as other symptoms and has a high disability rate, even threatening life, seriously endangering patients’ physical and psychological health and quality of life. Medical practitioners take many strategies for the treatment of fracture healing, including Traditional Chinese Medicine (TCM). In the early stage of fracture healing, the local fracture is often in a state of hypoxia, accompanied by the expression of hypoxia inducible factor-1α (HIF-1α), which is beneficial to wound healing. Through literature mining, we thought that hypoxia, HIF-1α and downstream factors affected the mechanism of fracture healing, as well as dominated this process. Therefore, we reviewed the local characteristics and related signaling pathways involved in the fracture healing process and summarized the intervention of TCM on these mechanisms, in order to inspirit the new strategy for fracture healing, as well as elaborate on the possible principles of
TCM in treating fractures based on the HIF molecular mechanism.]]></description>
<pubDate>2024/3/11 8:20:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenxian Zhang a,1,*, Fusen Yang b,1, Qikai Yan a,c,1, Jiahui Li b, Xiaogang Zhang a, Yiwei Jiang a, Jianye Dai b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenxian Zhang a,1,*, Fusen Yang b,1, Qikai Yan a,c,1, Jiahui Li b, Xiaogang Zhang a, Yiwei Jiang a, Jianye Dai b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401006]]></guid><cfi:id>71</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical composition and pharmacological activity of seco-prezizaane-type sesquiterpenes]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The seco-prezizaane-type sesquiterpenes (SPS), as a special class of sesquiterpenes with a highly oxidative five-ring cage structure and seven consecutive chiral centers, are isolated from the genus Illicium, which have a variety of biological activities, including neurotoxicity and neurotrophic effects, etc. This review summarizes the chemical constituents and pharmacological effects of SPS, and discusses the potential trend and scope of future research.]]></description>
<pubDate>2024/3/11 8:20:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ye Jin a, Yanqing Xie a, Peng Zhang a, Afsar Khan b, Zhihong Zhou a, Lu Liu a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ye Jin a, Yanqing Xie a, Peng Zhang a, Afsar Khan b, Zhihong Zhou a, Lu Liu a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202401007]]></guid><cfi:id>70</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Challenges of regenerative medicine: New strategies from traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2025/10/29 15:42:47</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jiuhong?Kang]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jiuhong?Kang</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504001]]></guid><cfi:id>69</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Natural compounds from traditional Chinese medicine regulating stem cell fate: Identification and therapeutic potential]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The problems of uncontrolled stem cell differentiation and the limited number of cells available represent significant obstacles to the advancement of stem cell research in the medical field. It is therefore imperative to control the potential of stem cells and to develop effective methods to regulate stem cell fate. A number of natural products derived from TCM have been shown to provide valuable insights into the regulation of biological signals and epigenetic mechanisms in stem cells. Furthermore, the structural modification of these natural products by synthetic means promises to unlock a wealth of possibilities in the field of precision regenerative medicine. However, a systematic and comprehensive review of these natural products has yet to be conducted. This article presents an overview of the natural products that have been identified as regulating the fate of stem cells. It includes a discussion of the classification, mechanism of action, and current prospects for the application of these natural products as lead compounds. This provides valuable insights for the advancement of TCM modernization and internationalization, precision regenerative medicine involving natural products and stem cells, the discovery of green lead compounds, and the development of new drugs.]]></description>
<pubDate>2025/10/29 15:42:47</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zhigao?Zhao?a?b, Yu?Ma?a, Shizhe?Wang?a, Mengyuan?Zhou?a, Yang?Tian?a, Li?Yang?b, Jian?Gu?c, Rui?Tan?a?b *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zhigao?Zhao?a?b, Yu?Ma?a, Shizhe?Wang?a, Mengyuan?Zhou?a, Yang?Tian?a, Li?Yang?b, Jian?Gu?c, Rui?Tan?a?b *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504002]]></guid><cfi:id>68</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Bioactive phytochemicals, pharmacological, and therapeutic potential of Dillenia indica: A comprehensive review of current research]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Dillenia indica, commonly known as “elephant apple”, is a tropical fruit-bearing tree with a rich history of medicinal use in traditional medicine across Southeast Asia and the Indian subcontinent. This review comprehensively examines current research on the pharmacological properties of D. indica, focusing on its diverse bioactive compounds, including flavonoids, tannins, saponins, and triterpenoids, which underpin its key biological activities such as antioxidant, anti-inflammatory, antimicrobial, anticancer, antidiabetic, and hepatoprotective properties. Flavonoids and tannins exhibit potent antioxidant activity, effectively scavenging free radicals and reducing oxidative stress; a mechanism implicated in metabolic disorders, cancer, and neurodegenerative diseases. Additionally, the plant demonstrates considerable anti-inflammatory effects by modulating key inflammatory pathways, including the inhibition of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Saponins and triterpenoids enhance its antimicrobial activity, supporting traditional uses for treating infections. Preclinical studies indicate that D. indica extracts can inhibit cancer cell proliferation and induce apoptosis in various cancer types, including breast, colorectal, and liver cancers. Furthermore, specific formulations may improve the bioavailability and targeted delivery of active constituents, thereby increasing therapeutic efficacy. Despite the promising findings in vitro and in vivo, there is a notable lack of well-designed clinical trials to validate these effects in humans. The plant is generally considered safe when consumed at recommended doses. However, excessive intake may lead to gastrointestinal discomfort and, in rare cases, hepatotoxicity. This review describes the therapeutic potential of D. indica as a natural agent while emphasizing the urgent need for comprehensive clinical trials, particularly those investigating pharmacodynamics profiles, to confirm its efficacy and safety.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lutfun?Nahar?a *, Emran?Habibi?b?c *, Chuanchom?Khuniad?c?d, Kulyash?Kalieva?e, Daijie?Wang?f, Hesamoddin?Arabnozari?b, Phanuphong?Chaiwut?g, Sarita?Sangthong?g, Tinnakorn?Theansungnoen?g, Rajat?Nath?h, Anupam Das?Talukdar?i, Satyajit D.?Sarker?c]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lutfun?Nahar?a *, Emran?Habibi?b?c *, Chuanchom?Khuniad?c?d, Kulyash?Kalieva?e, Daijie?Wang?f, Hesamoddin?Arabnozari?b, Phanuphong?Chaiwut?g, Sarita?Sangthong?g, Tinnakorn?Theansungnoen?g, Rajat?Nath?h, Anupam Das?Talukdar?i, Satyajit D.?Sarker?c</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504003]]></guid><cfi:id>67</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Decoding natural products for neuroprotection: Pathway networks and structural insights for drug development]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Neurodegenerative diseases (NDs), including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are progressive disorders marked by neuronal dysfunction and death, driven by pathological mechanisms such as oxidative stress, mitochondrial dysfunction, neuroinflammation, apoptosis, and protein misfolding. Despite scientific advances, current treatments remain largely palliative, underscoring the need for multitargeted therapeutic strategies. This narrative review synthesizes preclinical and clinical evidence to explore the neuroprotective potential of natural products, with a focus on their ability to modulate key molecular pathways implicated in NDs. A comprehensive literature search across Scopus, ScienceDirect, PubMed, MDPI, and Web of Science identified relevant studies. Bioactive compounds such as curcumin, resveratrol, ginsenosides, quercetin, and marine-derived molecules like fucoxanthin and phlorotannin demonstrated antioxidant, anti-inflammatory, anti-amyloidogenic, and mitochondrial-protective effects by modulating pathways including PI3K/Akt, NF-κB, and Nrf2/ARE, thereby mitigating neuronal damage and promoting cell survival. Natural products from diverse sources, including honey, ginseng, marine macroalgae, and cyanobacteria, exhibited broad-spectrum neuroprotective properties, with advances in nano-formulations improving bioavailability and brain penetration. Furthermore, emerging approaches such as gene-drug interaction studies and scaffold-based drug design offer promising avenues for enhancing clinical translation. While natural products provide a holistic, multitargeted approach to combat NDs, challenges related to bioavailability and therapeutic translation persist, necessitating future research that integrates advanced drug delivery systems, precision medicine, and synthetic modifications to develop innovative and effective treatment paradigms.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Suman?Ghosh?a?1, Ishita Debnath b 1, Sobhanjan Bhunia c, Sumit?Nandi?d, Sumel?Ashique?e, Aditi?Nayak?f, Susmita?Mallick?g, Souvik?Basak?g *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Suman?Ghosh?a?1, Ishita Debnath b 1, Sobhanjan Bhunia c, Sumit?Nandi?d, Sumel?Ashique?e, Aditi?Nayak?f, Susmita?Mallick?g, Souvik?Basak?g *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504004]]></guid><cfi:id>66</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Potential of Panax ginseng for bone health and osteoporosis management]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Panax ginseng is a medicinal and food-homologous herb with a long-standing reputation as a tonic. Extensive research has explored its potential in improving osteoporosis, a condition characterized by progressive bone loss that increases the risk of fractures. In this review, PubMed, Web of Science, Google Scholar, China National Knowledge Infrastructure, and Chinese Medical Journal Database are searched with no lower time limit up to August 2024. This review offers a comprehensive overview of how P. ginseng and its formulations can enhance bone health and alleviate osteoporosis. It also explores the signaling pathways influenced by compounds derived from P. ginseng in bone turnover. P. ginseng shows promise in regulating sex hormones, exerting antioxidant and anti-inflammatory effects, and enhancing bone turnover. It suppresses MAPKs and NF-κB pathways to inhibit bone resorption, while activating pathways like Wnt/β-catenin, AMPK, PI3K/Akt, and BMP/Smad to promote bone formation. In addition, this review describes the global production and trade of ginseng, the metabolism of P. ginseng after oral ingestion, and network pharmacology studies. Given its multi-target mechanisms, P. ginseng shows promise in the clinical management of osteoporosis. At doses below 10 g with sustained use (several months to one year), it may serve as a viable daily supplement for bone health maintenance. Furthermore, its synergistic interactions with conventional anti-osteoporosis drugs (e.g., bisphosphonates) could enhance therapeutic efficacy, positioning it as a complementary adjunct in clinical treatment regimens.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenjie?Fang, Kaisong?Huang, Jinlian?Hu *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenjie?Fang, Kaisong?Huang, Jinlian?Hu *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504005]]></guid><cfi:id>65</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Therapeutic potential and mechanisms of traditional Chinese medicine in regulating energy metabolism imbalance in heart failure]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Heart failure (HF) is a disease in which the heart fails to efficiently pump blood due to diminished cardiac function, which seriously affects the quality of life and prognosis of patients. In recent years, traditional Chinese medicine (TCM), as a national treasure of China, has been shown to regulate cardiac energy metabolism and has been widely used in the treatment of HF. This article summarised commonly used TCMs for the treatment of HF, mainly from the perspective of improving energy metabolism. The results showed that TCMs can enhance the cardiac energy supply and improve cardiac function by altering the heart’s preference for metabolic substrates, regulating the activity of key metabolic enzymes and the expression of related proteins, and attenuating impaired mitochondrial function. Among them, Astragali Radix (Huangqi in Chinese), Ginseng Radix et Rhizoma (Renshen in Chinese), Salviae Miltiorrhizae Radix et Rhizoma (Danshen in Chinese), and their extracts can exert significant cardioprotective effects. In addition, some TCM herbal formulas, such as Shengmai San and Zhenwu Tang, have been widely used in the treatment of HF. The application of these herbal extracts and formulas provides an effective option for the treatment of HF, but further studies are needed to clarify their mechanisms of action and clinical applications.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ailian Li a b, Xuexi?Wang?b *, Ruoyu?Yang?b, Jingping?Zhang?b, Xiaotong?Jiang?b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ailian Li a b, Xuexi?Wang?b *, Ruoyu?Yang?b, Jingping?Zhang?b, Xiaotong?Jiang?b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504006]]></guid><cfi:id>64</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[NLRP3 inflammasome in acute lung injury: Cumulative evidence for traditional Chinese medicine and natural products]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Acute lung injury (ALI) and its more severe manifestation, acute respiratory distress syndrome (ARDS), continue to pose a substantial challenge for contemporary society. Having been linked to the processes of injury and inflammation, NLRP3 inflammasome is activated by various stimuli, including inhaled allergens, pathogens, and environmental pollutants, subsequently contributing to the dysfunction of the innate immune system. Understanding how the innate immune NLRP3 inflammasome is altered during ALI may facilitate the identification of new therapeutic targets. To further enrich the role of NLRP3 inflammasome in treating ALI with traditional Chinese Medicine (TCM), this review aims to thoroughly summarize the latest scientific research achievements on the effects of NLRP3 inflammasome in ALI, and the existing underlying therapeutic targets from TCM and natural products.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yiman?Liu?1, Junyu?Meng?1, Jia?Liu, Fan?Zhang, Chen?An, Jian?Yang *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yiman?Liu?1, Junyu?Meng?1, Jia?Liu, Fan?Zhang, Chen?An, Jian?Yang *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504007]]></guid><cfi:id>63</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Target deconvolution strategies in TCM: Bridging medicinal properties with therapeutic efficacies]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The discovery and characterization of molecular targets from traditional Chinese medicine (TCM) represents a paradigm shift in contemporary drug development. This approach systematically bridges empirical TCM knowledge with modern pharmacological principles, establishing a robust framework for rational drug design. Through integrative systems-chemical biology approaches, we can now mechanistically elucidate the therapeutic basis of TCM’s bioactive properties, facilitating the accelerated identification of both novel molecular targets and conserved pharmacological pathways. This multidisciplinary strategy significantly enhances drug development efficiency while advancing therapeutic innovation to address critical unmet medical needs. With the rapid advancement of next-generation target deconvolution technologies and AI-driven computational platforms, TCM is poised to make increasingly substantial contributions to modern pharmacotherapy.]]></description>
<pubDate>2025/10/29 15:42:48</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yuanyuan?Hou, Min?Jiang, Gang?Bai *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yuanyuan?Hou, Min?Jiang, Gang?Bai *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202504008]]></guid><cfi:id>62</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Epigenetics and traditional Chinese medicine: A noteworthy research area]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2025/8/4 10:57:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Thomas Efferth]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Thomas Efferth</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503001]]></guid><cfi:id>61</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics. Thus, it is recognized as a valuable species of interest in the pharmaceutical and nutraceutical industries due to its important medicinal properties. Recent advances in omics technologies such as genomes, transcriptomics, proteomics, and metabolomics have considerably increased our understanding of the bioactives in G. lucidum. This review explores the application of molecular breeding techniques to enhance both the yield and quality of G. lucidum across the food, pharmaceutical, and industrial sectors. The article discusses the current state of research on the use of contemporary omics technologies which studies and highlights future research directions that may increase the production of bioactive compounds for their therapeutic potential. Additionally, predictive methods with computational studies have recently emerged as effective tools for investigating bioactive constituents in G. lucidum, providing an organized and cost-effective strategy for understanding their bioactivity, interactions, and possible therapeutic uses. Omics and machine learning techniques can be applied to identify the candidates for pharmaceutical applications and to enhance the production of bioactive compounds in G. lucidum. The quantification and production of the bioactive compounds can be streamlined by the integrating computational study of bioactive compounds with non-destructive predictive machine learning models of the same. Synergistically, these techniques have the potential to be a promising approach for the future prediction of the bioactive constituents, without compromising the integrity of the fungal organism.]]></description>
<pubDate>2025/8/4 10:57:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Sonali Khanal a,1, Anand Kumar b,1, Pankaj Kumar c, Pratibha Thakur d, Atul M. Chander e, Rachna Verma f,g, Ashwani Tapwal d, Vinay Chauhan c, Dinesh Kumar a,g,?, Deepak Kumar b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Sonali Khanal a,1, Anand Kumar b,1, Pankaj Kumar c, Pratibha Thakur d, Atul M. Chander e, Rachna Verma f,g, Ashwani Tapwal d, Vinay Chauhan c, Dinesh Kumar a,g,?, Deepak Kumar b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503002]]></guid><cfi:id>60</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Curcumae Rhizoma: An anti-cancer traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Curcumae Rhizoma, derived from the rhizome of Curcuma phaeocaulis, Curcuma kwangsiensis and Curcuma wenyujin, was called Ezhu in China. In the past, Curcumae Rhizoma extracts were obtained through water decoction or alternative methods, which showed significant anti-cancer effects. However, the mixed extracts contain various compound components of Curcumae Rhizoma, leading to an ambiguous mechanism of action for Curcumae Rhizoma extracts anti-cancer. Contemporary researchers have extracted the chemical components of Curcumae Rhizoma separately for experimental verification of its active ingredients in the anti-cancer field. Numerous studies demonstrated that curcumol, germacrone, b-elemene, and curcumin in Curcumae Rhizoma extracts have significant governing effects in anti-cancer activities. Pharmacological studies have shown that Curcumae Rhizoma suppresses cancer cell proliferation, invasion, and migration, triggering apoptosis and regulating cellular autophagy to achieve anticancer effects. Here, we summarized the research progress of Curcumae Rhizoma on anti-cancer effects from 2013 to 2022, aiming to explore the deeper molecular mechanisms of Curcumae Rhizoma’s active components in cancer treatment.]]></description>
<pubDate>2025/8/4 10:57:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yu Luo a, Lin Zhu a, Zhengyu Ren a, Jian Xiao b, Erwei Hao b, Jiahong Lu a, Jinmin Zhao c, Chun Yao b,?, Yitao Wang a,d, Hua Luo a,c,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yu Luo a, Lin Zhu a, Zhengyu Ren a, Jian Xiao b, Erwei Hao b, Jiahong Lu a, Jinmin Zhao c, Chun Yao b,?, Yitao Wang a,d, Hua Luo a,c,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503003]]></guid><cfi:id>59</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Mechanisms and benefits of phytochemicals as an alternative therapeutic strategy in female cancers]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cancer is a highly deadly disease, with breast cancer, cervical cancer, endometrial cancer, and ovarian cancer being the most prevalent in women. However, traditional cancer treatments present challenges due to their strong toxic side effects and adverse reactions. Numerous studies have demonstrated that natural products derived from various plants possess therapeutic and preventive properties against cancer. These phytochemicals have been extensively investigated as a potential alternative to conventional chemotherapy drugs, owing to their safety and efficacy. This article provides a comprehensive review of the recent advances in the chemoprevention and mechanisms of phytochemicals against the four major female cancers. The focus will be on how these phytochemicals regulate cancer cell proliferation, apoptosis, invasion, and metastasis to impede cancer progression. Given their extensive clinical applications, phytochemicals hold great promise in the field of cancer treatment. It hopes that this review will inspire more researchers to explore the potential of these natural compounds in combating female cancers.]]></description>
<pubDate>2025/8/4 10:57:12</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yufan Zhao a,b,c, Shimenghui Deng a,b,c, Danli Cao a,b,c, Caiji Lin a,b,c, Mengzhi Xu a,b,c, Jiaxing Wang a,b,c, Lingjie Luo a,b,c, Shulin Liu a,b,c,e,f,?, Huidi Liu a,b,c,d,f,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yufan Zhao a,b,c, Shimenghui Deng a,b,c, Danli Cao a,b,c, Caiji Lin a,b,c, Mengzhi Xu a,b,c, Jiaxing Wang a,b,c, Lingjie Luo a,b,c, Shulin Liu a,b,c,e,f,?, Huidi Liu a,b,c,d,f,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503004]]></guid><cfi:id>58</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research progress of regulating intestinal flora by traditional Chinese medicine in treating coronary heart disease]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Coronary atherosclerotic heart disease is a major cardiovascular condition driven by atherosclerosis, distinguished by chronic inflammation and dysregulated lipid metabolism. The gut microbiota plays an essential role in human health and disease, with research indicating a strong association between gut microbial metabolism and the development and progression of coronary heart disease. This article provides a review of the relationship between gut microbiota and coronary heart disease, as well as the mechanisms by which traditional Chinese medicine regulates digestive tract microbiota to treat coronary heart disease, which systematically explains how the gut microbiota, through metabolic products and immune regulation, contributes to the occurrence and progression of coronary heart disease, and summarizes recent advances in research on traditional Chinese medicine’s regulation of gut microbiota for treating coronary heart disease. It aims to provide further reference and insights for exploring the relationship between gut microbiota and coronary heart disease, as well as traditional Chinese medicine approaches for treating coronary heart disease.]]></description>
<pubDate>2025/8/4 10:57:12</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Qiwen Lu a, Sang Luo a, Chengyan Guan a, Hao Zhang a, Haoyue Jia a, Qiang Wan b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Qiwen Lu a, Sang Luo a, Chengyan Guan a, Hao Zhang a, Haoyue Jia a, Qiang Wan b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503005]]></guid><cfi:id>57</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Role of borneol as enhancer in drug formulation: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[As a traditional Chinese medicine (TCM), borneol has shown superior ability for anti-inflammatory and analgesic activities when coupled with other active ingredients from ancient times. Furthermore, borneol is believed to improve blood concentration and bioavailability of drugs. Thus, it has been paired with various TCM formulas since ancient time. The physiological barriers in human can cause significant limitations in drug efficiency as the drug is primarily restricted from entering into blood and brain. Borneol has been proven to enhance the permeability of biological barriers such as the blood–brain, transdermal, corneal, and intestinal barriers. Moreover, growing interest has been shown in the drug delivery system design for trans-barrier transport involving borneol. Nano drug delivery system with increased surface area and improved active sites, has been applied to increase the bioactivity of water insoluble drugs. Nano-drug delivery system has been used to enhance drug efficacy by reducing the time of action as compared to conventional administration approach of TCM formulas. Given its ability to enhance crossbarrier permeation and drug efficacy, borneol has been integrated into TCM formulas of drug delivery system for precise and prolonged targeting at tumor sites. However, the design and preparation of a drug delivery system consisting of borneol still face great challenges. Current research fails to unravel the difference in mechanism of action between nano-drug delivery systems comprised of borneol and conventional drug systems coupled with borneol. Enhanced penetration of borneol in drug delivery system is rarely verified compared to conventional administration with identical drug formulation consisting of borneol regarding dosage and medical indications. This study outlines the current state of research on the properties, formulation and pharmacological effects of borneol, allowing cross-comparison of borneol coupled with single compound and classical TCM formulas for various medical indications. This study aims to provide insights into the design of borneol-based enhanced cross-barrier delivery drug formulation, and the potential development of nano-drug system for TCM formulas with borneol for enhanced bioavailability.]]></description>
<pubDate>2025/8/4 10:57:12</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Manqun Tang a,b, Wenwei Zhong a,*, Liwei Guo c, Haoran Zeng c, Yuxin Pang a,b,d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Manqun Tang a,b, Wenwei Zhong a,*, Liwei Guo c, Haoran Zeng c, Yuxin Pang a,b,d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503006]]></guid><cfi:id>56</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Unveiling secrets of traditional Chinese medicine: Cutting-edge techniques in component analysis]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chemical component analysis is a critical challenge in Chinese herbal medicine research, involving the qualitative and quantitative identification of complex constituents in traditional Chinese medicine (TCM). However, traditional analytical methods are insufficient for efficient and comprehensive analysis of complex composition of TCM. Limitations exist in sample preparation, instrumental technology, data processing, and activity-related quality marker research. Recent advancements have significantly improved analytical precision, enabling more comprehensive profiling of TCM components. New pretreatment methods improve extraction efficiency and detection sensitivity, while novel instrumental technologies, such as mass spectrometry imaging, preserve spatial information lost in homogenization. AI enhances data interpretation, improving accuracy and efficiency. Online activity analysis links chemical composition with bioactivity, overcoming the limitations of purely chemical profiling and enabling a more comprehensive evaluation of TCM efficacy. This perspective provides an overview of the development trends in component analysis, aiming to advance the field and support TCM modernization.]]></description>
<pubDate>2025/8/4 10:57:12</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Tingting Zhou]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Tingting Zhou</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202503007]]></guid><cfi:id>55</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Epigenetics and traditional Chinese medicine: A noteworthy research area]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2025/4/28 8:26:43</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chunfu Wu]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chunfu Wu</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502001]]></guid><cfi:id>54</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Therapeutic potentials of natural products for post-traumatic stress disorder: A focus on epigenetics]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Post-traumatic stress disorder (PTSD) is a relatively common but complex mental illness with a range of diverse risk factors. Typical symptoms include the re-experience or avoidance of traumatic events, cognitive impairment, and hypervigilance. While the exact pathogenesis of PTSD is unclear, many studies indicate that epigenetic regulation plays a key role in its development. Specifically, numerous studies have indicated that the levels of histone acetylation and methylation, DNA methylation, and noncoding RNA are altered in PTSD patients. Further to this, natural products have been found to achieve epigenetic regulation of PTSD by regulating the expression of epigenetic enzymes, long noncoding RNA (lncRNA), and miRNA, thereby playing a role in improving PTSD symptoms. To date, however, no epigenetic regulation
related drugs have been used in the treatment of PTSD. Furthermore, while natural products that
can epigenetically regulate PTSD have received increasing levels of attention, there have not yet been any
systematic reports on the topic. Here, we summarized the roles and mechanisms of natural products in
the epigenetic regulation of PTSD, providing a novel and unique perspective that will help to guide the
development and application of new PTSD treatments.]]></description>
<pubDate>2025/4/28 8:26:43</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Meijing Xu, Minghui Cui, Yu Wang, Boru Li, Lijin Feng, Hang Xing *, Kuo Zhang *]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Meijing Xu, Minghui Cui, Yu Wang, Boru Li, Lijin Feng, Hang Xing *, Kuo Zhang *</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502002]]></guid><cfi:id>53</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Prevention and treatment of radiation injury by traditional Chinese medicine: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Nuclear radiation exposure events and tumor radiotherapy are highly susceptible to a range of psychological, physiological and other health problems, which can seriously affect patients’ quality of life. It has been shown that 87.5 % of tumor patients are exposed to varying degrees of radiation injury during radiotherapy. The treatment of radiation injury (RI) in modern medicine is limited to drug therapy, cell therapy, etc. Among them, the most chemical drugs cause many adverse reactions including fatigue, nausea, vomiting, etc., and there are very few drugs dedicated to the treatment of RI. Traditional Chinese medicine (TCM) is a rich natural medicinal resource, which has a wide range of pharmacological activities, multiple targets of action and minimal toxic side effects. Many studies have demonstrated that TCM and its compound preparations have enormous potential in the treatment of radiation induced comprehensive diseases. However, TCM is limited in clinical application due to its slow onset of action, complex active ingredients, and low bioavailability. Therefore, the article reviews the application, molecular mechanisms, and new dosage forms of TCM in the prevention and treatment of RI. On this basis, we will focus on discussing the development advantages and application prospects of the combination of traditional Chinese and Western medicine to achieve highly efficient treatment of RI. This review aims to provide scientific and effective drug delivery strategies and basic theoretical support for the clinical effective treatment of RI with TCM, and further promote the innovative development of TCM.]]></description>
<pubDate>2025/4/28 8:26:43</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lixue He a, Shixing Edi a, Jun Ma a, Zilin Kong a, Chunguang Dai a, Linfang Huang c, Rui Zeng a,b, Kaijun Gou b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lixue He a, Shixing Edi a, Jun Ma a, Zilin Kong a, Chunguang Dai a, Linfang Huang c, Rui Zeng a,b, Kaijun Gou b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502003]]></guid><cfi:id>52</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research advancements in molecular glues derived from natural product scaffolds: Chemistry, targets, and molecular mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The mechanism of action of traditional Chinese medicine (TCM) remains unclear. Historically, research on TCM has mainly focused on exploring the mechanisms of active components acting on single targets. However, it is insufficient to explain the complex mechanisms by which these active components in TCM treat diseases. In recent years, the emergence of molecular glues (MGs) theory has provided new strategies to address this issue. MGs are small molecules that can promote interactions between proteins at their interface. The characteristic of MGs is to establish connections between diverse protein structures, thereby enabling a chemically-mediated proximity effect that triggers a wide spectrum of biological functions. Natural products are the result of billions of years of evolutionary processes in the natural environment. Thus, the extensive structural diversity of natural products renders them a rich source of MGs, including polyketides, terpenoids, steroids, lignans, organic acids, alkaloids and other classes. Currently, several well-known natural MGs, including the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK506), as well as the anticancer agent taxol, have been incorporated into clinical practice. Meanwhile, the advancement of new technologies is propelling the discovery of novel MGs from natural products. Thus, we primarily summarize a growing variety of MGs from natural origins reported in recent years and categorize them based on the chemical structural types. Moreover, the main sources of TCM are natural products. The discovery of natural MGs promises to provide a new perspective for the elucidation of the molecular mechanism behind the efficiency of TCM. In summary, this review aims to provide insights from the perspective of natural products that could potentially influence TCM and modern drug development.]]></description>
<pubDate>2025/4/28 8:26:43</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Lina Yin a, Tingting Niu a, Ling Li b, Wei Yu a, Bo Han a, Asma Rehman c, Kewu Zeng a,b,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Lina Yin a, Tingting Niu a, Ling Li b, Wei Yu a, Bo Han a, Asma Rehman c, Kewu Zeng a,b,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502004]]></guid><cfi:id>51</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A systematical review on traditional Chinese medicine treating chronic diseases via regulating ferroptosis from the perspective of experimental evidence and clinical application]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Ferroptosis is a unique regulated form of cell death that is distinct from apoptosis, necrosis, and other well-characterized regulated cell death types, and plays an important role in the occurrence and development of chronic metabolic diseases, including diabetes, hypertension, hyperlipidemia, and nonalcoholic steatohepatitis. Recently, increasing evidence has supported traditional Chinese medicine (TCM) as a new hot spot for the treatment of chronic metabolic diseases by mediating ferroptosis. Unfortunately, few systematic reviews have described the importance of TCM in treating chronic metabolic diseases through the ferroptosis pathway. In the current review, the mechanism of ferroptosis and the roles of ferroptosis in chronic metabolic diseases are summarized. Additionally, this review illustrates that the regulation of ferroptosis by TCM could be an effective approach for treating chronic metabolic diseases based on experimental evidence and clinical application. In summary, this work will improve the understanding of ferroptosis and the ability of TCM to regulate ferroptosis in chronic metabolic diseases, thereby promoting the development and application of natural TCM.]]></description>
<pubDate>2025/4/28 8:26:43</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yuanyuan Zhang a, Fazhi Su a, Enlin Zhu c, Yanping Sun a, Haixue Kuang a,?, Qiuhong Wang a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yuanyuan Zhang a, Fazhi Su a, Enlin Zhu c, Yanping Sun a, Haixue Kuang a,?, Qiuhong Wang a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502005]]></guid><cfi:id>50</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Research and utilization status of Lophatherum gracile: A medicinal and food homologous plant]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Lophatheri Herba (Danzhuye in Chinese) is derived from the dried stems and leaves of Lophatherum gracile and has a long history of use as a medicinal and food source. Flavonoids and phenolic acids are the main active ingredients in Lophatheri Herba, which produce diuretic, anti-inflammatory, and antipyretic effects. Flavonoid glycosides and hydroxybenzoic acids are respectively the main structure in 44 flavonoids and 16 phenolic acids obtained from Lophatheri Herba. Modern pharmacological studies have found that the main chemical constituents of Lophatheri Herba play important roles in anti-inflammatory, cardioprotective, hepatoprotective and hypoglycaemic effects. Studies have demonstrated that flavonoid monomers, for example, luteolin, isoorientin, luteolin-7-O-b-D-glucoside and apigenin are more effective in exerting the above pharmacological effects. In addition, Lophatheri Herba is used in different food products as the main ingredient or as an accessory. This review describes Lophatheri Herba in terms of its chemical composition, pharmacological effects and efficacy, food development and applications, and clinical utility, and discusses the problems facing its use. This study provides valuable ideas and a scientific basis for the future development and use of L. gracile.]]></description>
<pubDate>2025/4/28 8:26:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Bin Yao a,b,1, Meng Zhang a,b,1, Shaolei Zhao a,b, Hongjian Yu a,d, Jingze Zhang a,b,c,*, Dailin Liu a,b,c,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Bin Yao a,b,1, Meng Zhang a,b,1, Shaolei Zhao a,b, Hongjian Yu a,d, Jingze Zhang a,b,c,*, Dailin Liu a,b,c,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502006]]></guid><cfi:id>49</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Natural polyphenols as novel interventions for aging and age-related diseases: Exploring efficacy, mechanisms of action and implications for future research]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Natural polyphenols are a group of components widely found in traditional Chinese medicines and have been demonstrated to delay or prevent the development of aging and age-related diseases in recent years. As far as we know, the studies of natural polyphenols in aging and aging-related diseases have never been extensively reviewed. In the present paper, we reviewed recent advances of natural polyphenols in aging and common age-related diseases and the current technological methods to improve the bioavailability of natural polyphenols. The results showed that natural polyphenols have the potential to prevent or treat aging and common age-related diseases through multiple mechanisms. Nanotechnology, structural modifications, and matrix processing could provide strong technical support for the development of natural polyphenols to prevent or treat aging and age-related diseases. In conclusion, natural polyphenols have important potential in the prevention and treatment of aging and agerelated diseases.]]></description>
<pubDate>2025/4/28 8:26:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenze Wu a,1, Yan Mi a,1, Qingqi Meng a, Ning Li b, Wei Li c, Pu Wang d,*, Yue Hou a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenze Wu a,1, Yan Mi a,1, Qingqi Meng a, Ning Li b, Wei Li c, Pu Wang d,*, Yue Hou a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502007]]></guid><cfi:id>48</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Modernization of charcoal drugs: Integrating research paradigms of carbon dots to gain new perspectives]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[With the modernization drive of traditional Chinese medicine (TCM), this perspective innovatively proposes integrating carbon dot research paradigms to facilitate the modernization of charcoal drugs in TCM. The research focuses on five core areas: analyzing and validating charcoal drugs components pharmacologically, exploring modern preparation methods, establishing a quality evaluation system, fixing preparation process parameters, and probing into the material basis. These steps aim to deepen the scientific understanding of the material basis of charcoal drugs, optimize its preparation process, and establish a comprehensive quality control system. This work provides a theoretical foundation and experimental evidence for the scientific understanding of charcoal drugs, further promoting their modernization and internationalization.]]></description>
<pubDate>2025/4/28 8:26:44</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Sichao Tian a, Zhanglu Hu a, Weidong Zhang a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Sichao Tian a, Zhanglu Hu a, Weidong Zhang a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202502008]]></guid><cfi:id>47</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Exploitation potential and deep-rooted conformational relationships of traditional Chinese medicine polysaccharides]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2025/2/6 16:13:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wenyuan Gao]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wenyuan Gao</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501001]]></guid><cfi:id>46</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Traditional Chinese herbal medicine in European Union: State of art, challenges, and future perspectives focusing on Italian market]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese herbal medicine (TCM) has been used in China for thousands of years as an integral part of the healthcare system.The use of botanical products deriving from plants from TCM has become very spread and rooted in European Union (EU), generating a manufacturing industry of pronounced size, in particular the segment of food supplements, but recently also medical devices and cosmetics based on plants from TCM, especially in Italy. Only seven Herbal Medicinal Products (HMP) based on plants from TCM are present in EU besides more than 100 monographs on TCM plants are present in the European Pharmacopoeia. Indeed, the number of herbal monographs of European Medicine Agency (EMA) which report the main data on safety and efficacy of medicinal plants from TCM are very limited and this could be a reason for the limited number of HMP based on herbal drugs used in TCM. It is clear that those botanicals based on TCM but not classified as HMP can represent a sort of ‘‘borderline” products. Very likely, they are present on the European market because of the simpler authorization when compared with HMP. Some examples of these categories (food supplements and medical devices) containing plants from TCM and marketed in Italy are reported in this review. Consequently, it is urgent the need to clarify their categorization, also fundamental for the consumer protection. It is imperative the establishment of EU quality standards and official registration for Chinese herbal medicinal products, even if they are marketed as food supplements, medicinal devices or cosmetics because the international quality standards International Organization for Standardization Technical Committee 249-Traditional Chinese Medicine (ISO/TC249) can harmonize the quality control and promote the trading internationally. Governmental organizations together with companies producing TCM should work together to accelerate the legislation of laws pertaining to TCM, and generate an environment where TCM does not just continue to exist but truly develop.]]></description>
<pubDate>2025/2/6 16:13:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Anna Rita Bilia a,*, Rebecca Ballerini a, Liping Qu b, Mei Wang c,d]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Anna Rita Bilia a,*, Rebecca Ballerini a, Liping Qu b, Mei Wang c,d</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501002]]></guid><cfi:id>45</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in phytochemistry, ananlysis methods and pharmacology of Eleutherococcus trifoliatus: A promising medicinal and edible resource with development value]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Eleutherococcus trifoliatus (Araliaceae) is called Baile or Lecai in China. E. trifoliatus is a medicinal and edible plant widely used in folk traditions. As a TCM, the dried herb of this species can remove damp heat and detoxicity, cure rheumatism, remove blood stasis, relieve pain, and alleviate cough and asthma symptoms. Many chemical compounds have been reported including diterpenoids, triterpenoids, phenylpropanoids, flavonoids, lignans, caffeoyl quinic acids, steroids, essential oils, etc., in which flavonoids, saponins, and caffeoyl quinic acids are the most bioactive components. In vitro and in vivo pharmacological experiments demonstrated that E. trifoliatus has anti-inflammatory, hypoglycemic, anticancer, antioxidant, antibacterial, anti-hyperalgesic, anti-fatigue, analgesic, and hemostatic effects. Here we reviewed E. trifoliatus in phytochemistry, analysis methods, and pharmacology.]]></description>
<pubDate>2025/2/6 16:13:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Maofang Lu a,1, Bin Wang a,1, Ling Dai b, Jian Wu c, Jiao Luo a, Changsoo Yook d, Xiangqian Liu a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Maofang Lu a,1, Bin Wang a,1, Ling Dai b, Jian Wu c, Jiao Luo a, Changsoo Yook d, Xiangqian Liu a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501003]]></guid><cfi:id>44</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Mass spectrometry imaging for unearthing and validating quality markers in traditional Chinese medicines]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Quality marker (Q-Marker) is an innovative concept and model for quality control of Traditional Chinese medicines (TCMs), which will navigate the new direction of quality development of TCMs. Yet, how to characterize the overall quality attributes of TCMs and their biological effects is still debating. In view of this key scientific issue, this paper proposes a research method based on mass spectrometry imaging (MSI) technology for the discovery and confirmation of TCMs Q-Marker. MSI is powerful in investigating the spatial distribution of molecules in a variety of samples, and visualizing the information obtained from MS. On this basis, combine with the five principles of TCMs Q-Marker validation, i.e., specificity, transmission and traceability, testability, prescription compatibility, and validity, were applied to confirm the finalized Q-Marker. It will lead the new direction of quality development of TCMs.]]></description>
<pubDate>2025/2/6 16:13:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zhiyun Wang a, Huajie Chang a, Qian Zhao b, Wenfeng Gou a, Yiliang Li a, Zhengwei Tu c,*, Wenbin Hou a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zhiyun Wang a, Huajie Chang a, Qian Zhao b, Wenfeng Gou a, Yiliang Li a, Zhengwei Tu c,*, Wenbin Hou a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501004]]></guid><cfi:id>43</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A comprehensive review of phytochemical approaches in treatment of acute myeloid leukemia: Associated pathways and molecular mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Acute myeloid leukemia (AML) is a type of cancer that affects the blood and bone marrow. This review conducts a thorough analysis of AML, addressing its genetic modification. The examination extends to the current therapeutic approaches employed for AML, shedding light on their efficacy and the notable side effects experienced by patients undergoing these treatments, leading to a low overall survival rate. Therefore, exploring alternative treatments, such as phytochemicals, is necessary. Furthermore, the review explores the complex landscape of phytochemicals, categorizing them based on their diverse properties, which include alkaloids, phenols, terpenoids, organo-sulfur compounds, and other compounds, including quinones, and elucidating their mechanisms of action. Special emphasis is placed on their involvement in critical signaling pathways, with a particular focus on how these phytochemicals impact AML when evaluated across a spectrum of cell lines. This in-depth exploration aims to uncover potential targets within the molecular landscape of AML where phytochemicals can exert their therapeutic effects. The review investigates the potential role of plant-derived phytochemicals as adjunctive therapies for AML. This exploration encompasses the identification of specific phytochemicals that exhibit promising anti-leukemic properties and evaluates their potential in clinical settings. Beyond conventional treatments, the review explores the integration of complementary and alternative medicine as a holistic approach to managing AML. The examination encompasses the synergy between conventional therapies and alternative interventions, exploring how these combined strategies may enhance overall therapeutic outcomes and mitigate side effects. From a forward-looking perspective, the overarching goal is to contribute to the evolving landscape of AML treatment by considering innovative approaches that harness the therapeutic potential of phytochemicals, both independently and in conjunction with established medical interventions.]]></description>
<pubDate>2025/2/6 16:13:53</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mouvanal Sajana a, T. S. Gopenath b, Basalingappa M. Kanthesh a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mouvanal Sajana a, T. S. Gopenath b, Basalingappa M. Kanthesh a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501005]]></guid><cfi:id>42</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Review of Astragalus membranaceus polysaccharides: Extraction process, structural features, bioactivities and applications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Astragalus membranaceus possesses the function of enhancing immunity, protecting the liver, diuretic, anti-aging, anti-stress, anti-hypertensive, and more extensive antibacterial effects. Polysaccharides, one kind of the major active ingredients of A. membranaceus, are considered to be responsible for their versatile use. Now, a systematic summary of research progress and prospects of polysaccharides from A. membranaceus polysaccharides (AMPs) is necessary to facilitate their further study and application. In this review, the optimal extraction methods, structural features, biological activities, and applications of AMPs were emphasized. The structure–activity relationships are also analyzed and elucidated. Solvent, ultrasonic, microwave, enzyme-assisted, ultra-high pressure, and combined methods have been used to extract AMPs. Among them, solvent extraction is the most commonly used method because it is simple and easy to operate, but the efficiency needs to be improved further. The ultra-high pressure method is the most efficient but has a low economic return. AMPs exhibited various bioactivities, including immunomodulation, antitumor, and antidiabete. The structure–activity relationships revealed that different structure configurations, chain conformations, and physical properties would have different bioactivities. However, the new method for purification of certain polysaccharides, detailed structure–activity relationships (SAR), mechanisms of bioactivities, and quality control of AMPs need to be extensively investigated.]]></description>
<pubDate>2025/2/6 16:13:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hongyue Tian a, Lingzhuo An a, Pengwang Wang a, Xuemin Zhang b, Wenyuan Gao a,c, Xia Li a,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hongyue Tian a, Lingzhuo An a, Pengwang Wang a, Xuemin Zhang b, Wenyuan Gao a,c, Xia Li a,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501006]]></guid><cfi:id>41</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Promotion of chronic wound healing by plant-derived active ingredients and research progress and potential of plant polysaccharide hydrogels]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Wound healing is a complex biochemical process. The use of herbal medicine in wound healing not only carries forward the wisdom of traditional medicine, with its anti-inflammatory and immune-regulating effects, but also reflects the direction of modern biopharmaceutical technology, such as its potential in developing new biomaterials like hydrogels. This article first outlines the inherent structural properties of healthy skin, along with the physiological characteristics related to chronic wounds in patients with diabetes and burns. Subsequently, the article delves into the latest advancements in clinical and experimental research on the impact of active constituents in herbal medicine on wound tissue regeneration, summarizing existing studies on the mechanisms of various herbal medicines in the healing of diabetic and burn wounds. Finally, the paper thoroughly examines the application and mechanisms of plant polysaccharide hydrogels containing active herbal compounds in chronic wound healing. The primary objective is to provide valuable resources for the clinical application and development of herbal medicine, thereby maximizing its therapeutic potential. It also represents the continuation of traditional medical wisdom, offering new possibilities for advancements in regenerative medicine and wound care.]]></description>
<pubDate>2025/2/6 16:13:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ru Yan a,b, Yanhong Wang a,b, Weinan Li a,b,*, Jialin Sun c,d,*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ru Yan a,b, Yanhong Wang a,b, Weinan Li a,b,*, Jialin Sun c,d,*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501007]]></guid><cfi:id>40</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Innovation theory, technical methods and industrial application of quality marker of traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501008]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Quality marker (Q-Marker) of traditional Chinese medicine (TCM) is a new concept of TCM quality research. Since it was proposed in 2016, it has aroused wide response from the industry and has become an innovative theory and technical method leading the quality research and quality control of TCM. This paper summarized the core connotation, theoretical basis and innovative value of Q-Marker, proposed the technical strategies and paths of the Q-Marker research, and showed the prospect of its application in the TCM industry. The paper provides references for TCM quality research, quality evaluation, quality control and scientific supervision and has important significance for promoting the quality standard and quality control level of TCM.]]></description>
<pubDate>2025/2/6 16:13:54</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Tiejun Zhang a, Gang Bai b, Changxiao Liu a,*?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Tiejun Zhang a, Gang Bai b, Changxiao Liu a,*?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202501008]]></guid><cfi:id>39</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[From empiricism to precision: SHINE strategy in anti-fibrotic drug discovery]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/8/7 8:02:09</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Wen Huang a,1,?, Zhaotong Cong b,1]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Wen Huang a,1,?, Zhaotong Cong b,1</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603001]]></guid><cfi:id>38</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Cardiometabolic reprogramming drives right ventricular dysfunction in pulmonary arterial hypertension: Novel mechanisms and therapeutic implications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[With the understanding on right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH),the perspective innovatively integrates research paradigms on targeting cardiometabolic reprogramming of RV protective therapies to break through the bottleneck of current PAH treatment. The research focuses on three core areas: analyzing and validating metabolic dysregulation in the RV of PAH, exploring cell-specific metabolic dysregulation in the heart of PAH, and probing into the therapeutic strategy for PAH targeting RV metabolism. These aspects aim to deepen the scientific understanding of cardiometabolic reprogramming of RV dysfunction in PAH. This work provides a theoretical foundation and experimental evidence for developing RV-directed therapies that complement existing PAH treatments and improve patient outcomes.]]></description>
<pubDate>2026/8/7 8:02:09</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Saihu Liu a, Mari Okazaki b, Yanling Wu a]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Saihu Liu a, Mari Okazaki b, Yanling Wu a</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603002]]></guid><cfi:id>37</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Innovative strategies for anti-fibrotic drugs discovery from traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Fibrotic diseases represent a major global health burden, with current therapies often limited by modest efficacy and substantial side effects. Traditional Chinese medicine (TCM) provides a rich yet underexplored reservoir for anti-fibrotic drug discovery, valued for its chemical diversity and extensive clinical history. Nonetheless, conventional approaches to deriving therapeutics from these multi-component formulas face significant challenges, including low tissue selectivity, limited target specificity, suboptimal scaffold optimization, and incomplete cross-scale validation. Here, we summarize recent advances in discovering TCM-derived anti-fibrotic compounds and highlight emerging strategies, including tissueoriented active compound discovery, fibrosis-target mining, scaffold optimization guided by targets and biosynthesis, and cross-scale validation. Building on these developments, we introduce the Smart Herbal-based Innovation and Translational Engine (SHINE), an intelligent discovery platform that prioritizes promising herbal candidates using modern computational and experimental methods; innovative development of optimized compounds or novel derivatives; a translational pipeline to unite preclinical findings and clinical validation; and a closed-loop feedback system where real-world evidence continuously informs drug repositioning and secondary development. SHINE bridges TCM principles with stateof-the-art drug discovery technologies, enabling the development of well-defined, mechanism-based small-molecule candidates from classical formulas. By integrating empirical herbal knowledge with advanced multi-omics, artificial intelligence, and biosynthetic engineering, SHINE aims to deliver firstin-class anti-fibrotic therapeutics with defined targets, improved safety, and demonstrable clinical efficacy.]]></description>
<pubDate>2026/8/7 8:02:09</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Guang Xin a,1, Tao Wang a,1, Qilong Zhou a, Sanyin Zhang b, Zeliang Wei a, Ke Li a, Wei Chen b, Dan Sun b, Shilin Chen b, Zhaotong Cong b,?, Wen Huang a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Guang Xin a,1, Tao Wang a,1, Qilong Zhou a, Sanyin Zhang b, Zeliang Wei a, Ke Li a, Wei Chen b, Dan Sun b, Shilin Chen b, Zhaotong Cong b,?, Wen Huang a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603003]]></guid><cfi:id>36</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Cardiometabolic reprogramming in pulmonary arterial hypertension:Implications for right ventricular dysfunction and therapeutic strategies]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Pulmonary arterial hypertension (PAH) is a progressive disease characterized by pulmonary arterial wall remodeling, right ventricular (RV) hypertrophy, and interstitial fibrosis, ultimately culminating in RV failure. The latter is the strong predictor of mortality in PAH. While current therapies primarily target the pulmonary vasculature and reduce RV afterload, they do not directly address the metabolic and structural maladaptation of the RV. Emerging evidence indicates that cardiometabolic reprogramming occurs in the RV of PAH patients, encompassing dysregulated glucose, lipid, and amino acid metabolism. These metabolic dysregulations are mirrored in preclinical models, where cardiomyocytes, endothelial cells, and fibroblasts exhibit reduced fatty acid oxidation, enhanced glycolysis, and altered mitochondrial function. Such alterations may promote cardiomyocyte lipotoxicity, impair contractile efficiency, disrupt endothelial barrier integrity, facilitate monocyte recruitment, and drive fibroblast proliferation and activation, collectively contributing to RV inflammation, fibrosis, and functional decline. Understanding these cellspecific metabolic reprogramming is critical, as they may represent both compensatory and pathogenic mechanisms during the progression from RV adaptation to maladaptation. This review provides a comprehensive overview of recent advances in elucidating metabolic dysregulation in the RV of PAH patients and relevant in vivo and in vitro models. The therapeutic potential of targeting these pathways using metabolic modulators, small molecules, and natural products is also discussed, with the goal of developing RV-directed therapies that complement existing PAH treatments and improve patient outcomes.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Guanghui Qian a,b, Peng Zhang a,b, Gaurav Choudhary a,b, Hongwei Yao a,b,c,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Guanghui Qian a,b, Peng Zhang a,b, Gaurav Choudhary a,b, Hongwei Yao a,b,c,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603004]]></guid><cfi:id>35</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Systems pharmacology of traditional Chinese medicine in fibrosis: From multi-target mechanisms to translational validation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Systems biology research has integrated network pharmacology with clinical data to investigate traditional Chinese Medicine (TCM) antifibrotic mechanisms across multiple biological pathways. These combined approaches draw on chemical-protein interaction databases, transcriptomic and metabolomic
profiling, protein–protein interaction networks, molecular docking, randomized trial and large cohort study evidence. Yinchenhao Decoction, Danggui Liuhuang Decoction, Curcumae Rhizoma (Ezhu in Chinese)-Astragali Radix (Huangqi in Chinese) herb pair, and Angelicae Sinensis Radix (Danggui in Chinese)-Chuanxiong Rhizoma (Chuanxiong in Chinese) herb pair regulate transforming growth factor-b (TGF-b)/mothers against decapentaplegic homolog (Smad), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), nuclear factor-jB (NF-jB), mitogen-activated protein kinase (MAPK), and janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways. Integration of these signals is associated with suppression of inflammation, altered regulation of apoptosis, modulation of cellular activation, and extracellular matrix remodeling in hepatic, cardiac, and pulmonary fibrosis models. This multi-layered framework offers a rational basis for hypothesis generation in drug repositioning and development of novel antifibrotic candidates, although clinical validation remains limited and further rigorous trials are warranted.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ahmed I. Foudah, Aftab Alam ?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ahmed I. Foudah, Aftab Alam ?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603005]]></guid><cfi:id>34</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Combatting pulmonary fibrosis with Astragalus membranaceus: A review of active components and multifaceted mechanisms]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Pulmonary fibrosis (PF) is a chronic progressive lung disease characterized by excessive deposition of extracellular matrix (ECM) and loss of lung function. Treatment options are limited and can only delay disease progression, making the development of novel therapeutic strategies crucial. Astragalus membranaceus (AM), a traditional Chinese medicinal herb renowned for its lung-tonifying and immunomodulatory properties, contains bioactive constituents such as flavonoids, saponins, and polysaccharides. These components exhibit anti-inflammatory, antioxidant, anti-fibrotic, and immunoregulatory activities, demonstrating therapeutic potential in PF. This review systematically elucidates the complex pathogenesis of PF, comprehensively summarizes the principal chemical constituents of AM, and highlights its multi-targeted anti-fibrotic mechanisms of action. Research demonstrates that AM and its bioactive constituents exert anti-fibrotic effects through multiple pharmacological actions: inhibiting fibroblast activation, reversing epithelial-mesenchymal transition (EMT), modulating immune-inflammatory responses, protecting alveolar epithelial cells (AECs), and ameliorating mitochondrial function. Through the synergistic interaction of its multiple components and multi-targeted effects, AM demonstrates significant advantages in combating PF. This review provides a comprehensive theoretical basis for deepening the understanding of AM anti-fibrotic mechanisms and offers practical guidance for developing novel anti- fibrotic agents based on traditional Chinese medicine and its bioactive constituents.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiujuan Sun a, Jingwen Zhao a, Yiteng Ma a, Zhihao Kong a, Guangyue Su a,b,c,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiujuan Sun a, Jingwen Zhao a, Yiteng Ma a, Zhihao Kong a, Guangyue Su a,b,c,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603006]]></guid><cfi:id>33</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Challenges and opportunities for ginseng-based medicines in treating cardiac fibrosis from mechanistic insights to clinical translation]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition and progressive myocardial remodeling, is a common pathological outcome of various cardiovascular diseases and lacks effective targeted anti-fibrotic therapies. Panax ginseng and its related preparations, including major ginsenosides (e.g., Rb1, Rg1, and Rg3), standardized extracts, and compound formulas, have garnered growing interest owing to their multi-component, multi-target pharmacological activities and integrative regulatory effects. This review systematically summarizes recent advances in the basic and clinical research of ginseng-based medicines in the prevention and treatment of cardiac fibrosis. Preclinical evidence demonstrates that ginseng and its active constituents attenuate key pathological processes, including oxidative stress, inflammatory responses, apoptosis, and autophagy dysregulation, primarily through modulation of signaling pathways such as TGF-b/Smad, NF-jB, and PI3K/Akt. These regulatory effects collectively contribute to the inhibition of fibroblast activation, reduction of collagen deposition, and improvement of myocardial structure and function. Emerging clinical studies further suggested potential benefits in improving cardiac function and modulating fibrosis-related biomarkers in patients with hypertension, coronary heart disease, and heart failure (HF). Despite these promising findings, several challenges hinder clinical translation, including low oral bioavailability, the mechanistic complexity of compound formulas, and insufficient high-quality clinical evidence. Future investigations should integrate novel drug delivery strategies, systems pharmacology approaches to elucidate holistic mechanisms, and well-designed randomized controlled trials to facilitate the development of ginseng-based medicines as potential therapeutic agents for cardiac fibrosis.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mengtao Zhi a,1, Ao Wang b,1, Hailian Quan a,?, Lan Hong a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mengtao Zhi a,1, Ao Wang b,1, Hailian Quan a,?, Lan Hong a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603007]]></guid><cfi:id>32</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Tanshinone IIA alleviates isoproterenol-induced myocardial injury via NR4A1/GATA4 pathway-mediated suppression of EndMT and oxidative stress]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603012]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Guanfeng Xu a,b,1, Hang Wu a,b,1, Jie Zhang b, Yaxuan Wang a,b, Chongyu Shao a,b, Jiehong Yang a,b, Jin Han b, Haitong Wan a,b,c,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Guanfeng Xu a,b,1, Hang Wu a,b,1, Jie Zhang b, Yaxuan Wang a,b, Chongyu Shao a,b, Jiehong Yang a,b, Jin Han b, Haitong Wan a,b,c,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603012]]></guid><cfi:id>31</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Multi-pathway targeting by natural products in chronic respiratory diseases: Opportunities, challenges, and future perspectives]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603013]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Chronic respiratory diseases (CRDs) are multifactorial disorders driven by dysregulated inflammation,oxidative stress, and tissue remodeling. Conventional single-target therapies are insufficient to halt disease progression, underscoring the demand for alternative therapeutic approaches. Natural products,including bioactive compounds, herbal extracts, and traditional Chinese medicine (TCM) formulas, arecharacterized by their inherent multi-target properties and represent a promising intervention strategyfor CRDs. This perspective emphasizes natural products as network modulators that can simultaneouslyregulate multiple signaling pathways. The integration of systems biology, network pharmacology, andartificial intelligence (AI) is crucial for deciphering their polypharmacological mechanisms. The clinicaltranslation of natural products is anticipated to benefit from the implementation of several key strategies,including multi-omics integration, AI, targeted delivery, and blockchain-based quality control. By shiftingfrom a reductionist to a network-centric view, natural products can fulfill their potential as nextgeneration therapeutics for CRDs.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Siqi Lin a,b,1, Lili Li c,1, Shiqing Zhuo a,b, Liang Yu a,b, Yu Huang a,b, Xiaofei Chen d,?, Huihui Ti a,b,e,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Siqi Lin a,b,1, Lili Li c,1, Shiqing Zhuo a,b, Liang Yu a,b, Yu Huang a,b, Xiaofei Chen d,?, Huihui Ti a,b,e,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603013]]></guid><cfi:id>30</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Puerarin as a multifaceted anticancer agent: Mechanisms, targets, and therapeutic potential across multiple cancers]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603014]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Puerarin (Pue), a key isoflavone from Pueraria lobata, has been traditionally used in Chinese medicine forcardiovascular, cerebrovascular, neurodegenerative, metabolic, and hepatic diseases. Recent studies indicate its anticancer potential across various malignancies. This review explores the current literature onPue’s anticancer activities, mechanisms of action, and molecular targets. Preclinical in vitro and in vivostudies suggest Pue’s effectiveness; however, challenges including standardization, selectivity, safety,and delivery hinder clinical translation. Specifically, dose optimization and rigorous standardizationare needed to fully elucidate Pue’s mechanisms, particularly in hormone-dependent cancers. The development of advanced drug delivery systems, such as nanosuspensions, nanoemulsions, and nanoparticles,is essential to improve Pue’s poor water solubility and stability, and to enhance targeted delivery. Studieshave shown that Pue can inhibit cancer cell proliferation, induce apoptosis, and suppress metastasis invarious cancer cell lines, including breast, colon, lung, and ovarian cancers. Pue’s anticancer mechanismsinvolve modulating multiple signaling pathways, including nuclear factor-jB (NF-jB), extracellular signal-regulated kinase (ERK), Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3), and Wnt signaling (Wnt), and targeting key molecules such as Caspases, Bcl-2-associated X protein (BAX), B-cell lymphoma-2 (BCL-2), matrix metalloproteinases (MMPs), and dual-specificity phosphatase 1 (DUSP1). Pue has also been found to enhance the efficacy of conventional chemotherapeuticagents such as cisplatin and oxaliplatin, and to overcome drug resistance. Overall, Pue shows promise as a multifaceted anticancer agent, which merits further investigation. This review provides a comprehensive overview of Pue’s anticancer effects, emphasizing its potential to guide future cancer treatment strategies.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Aida Alizamir a, Masoud Khanaghaei b, Farshad Mirzavi c, Ali Nokhodchi d, Laleh Ghavami e, Bita Taghizadeh f,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Aida Alizamir a, Masoud Khanaghaei b, Farshad Mirzavi c, Ali Nokhodchi d, Laleh Ghavami e, Bita Taghizadeh f,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603014]]></guid><cfi:id>29</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Plantago mechanisms for enhanced wound healing: A review on bioactive phytoconstituents]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603015]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Plantago (Plantaginaceae family) exhibits remarkable diversity with over 200 species. These plants areclosely associated with traditional medicine worldwide, particularly as a wound healing therapy.Recent research has revealed phytoconstituents in various Plantago species, including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, and polysaccharides. Despitethe advanced ongoing research on Plantago extracts, there is still a gap in the evaluation of their potentialas an effective topical product for chronic wounds and in the way phytoconstituents contribute to theoverall effect in a single comprehensive systematic review. Therefore, this review aims to explore thewound healing capabilities of Plantago and its phytoconstituents, as well as elucidate their mechanismsof action. Our analysis emphasizes the significant wound healing potential in 25 Plantago species, notablyPlantago major, Plantago lanceolata, Plantago australis, Plantago asiatica, and Plantago ovata. These plantspecies contain a diverse array of 57 phytoconstituents that collectively contribute to these activities. In conclusion, this review confirms the huge potential of Plantago genus as a topical wound healing agent.The healing mechanisms cover a wide array of effects such as anti-bacterial activity, anti-apoptosis, stimulation of collagen synthesis and deposition, promotion of angiogenesis, suppression of inflammatory response, inhibition of cyclooxygenase, inhibition of MAPKs phosphorylation, and enhancement of endogenous antioxidant enzyme activity. A study on the network pharmacology of such potential is worth investigating as further research.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Triana Hertiani a,?, Muhammad Khafi b, Latifa Amalia b,c, Muhamad Bayu Irawan b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Triana Hertiani a,?, Muhammad Khafi b, Latifa Amalia b,c, Muhamad Bayu Irawan b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603015]]></guid><cfi:id>28</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical components and pharmacological action for Helianthus tuberosus and predictive analysis on its Q-markers]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603016]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Helianthus tuberosus is a perennial herb that belongs to the Asteraceae family and Helianthus genus. It is cultivated in numerous northern and southern China regions, displaying numerous benefits such as its drought and frost resistance, ability to grow on most soils, and low fertilizer requirements. H. tuberosus contains various components, such as inulin, phenolic acids, terpenoids, flavonoids, steroids, phenylpropanoids, and other bioactive compounds with antioxidant, anti-inflammatory, antibacterial, antitumor, and immune-modulatory effects. In this paper, based on the new concept of quality marker (Qmarker) proposed by Academician Changxiao Liu, this study analyzed the relationship between plant affinity, chemical composition specificity, traditional medicinal properties, and chemical composition measurability of H. tuberosus, and predicted its Q-markers to provide a reference for the establishment of the quality evaluation system and comprehensive utilization of this herb.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiaofei Wang a, Shu Zhong a, Li Wang b, Xu Xu b,c,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiaofei Wang a, Shu Zhong a, Li Wang b, Xu Xu b,c,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603016]]></guid><cfi:id>27</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Amentoflavone: A safe and novel penetration enhancer for transdermal applications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603018]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective: Most of existing chemical penetration enhancers are along with obvious toxicity and skin irritation, new penetration enhancer is still to be developed yet. Amentoflavone is a flavonoid compound extracted from plant Selaginella tamariscina with high biocompatibility. However, its efficacy of penetration enhancers has not been studied.
Methods: For the first time, the influence of amentoflavone to the skin penetration of caffeine was investigated by the Franz diffusion cells. The interactions of amentoflavone with the skin lipid and keratin were determined to identify the underlying mechanisms by the Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), etc.
Results: Results showed that the penetration enhancement ratio (ER) of amentoflavone to model compound caffeine is nearly three times. The major mechanism was identified to be contributed to that, amentoflavone can not only change the keratin structure in stratum corneum (SC), but also undergo hydration interactions with intradermal components, therefore dissolving the lipid, loosening and reducing the barrier function of SC.
Conclusion: These results give new evidence to the potential of amentoflavone as the novel effective chemical enhancer for the skin meditated delivery of external molecules, and it can exert the dual effects of traditional Chinese medicine activity and penetration enhancement.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yunhao Ren a,b, Fengyuan Song a, Haobin Wang a, Lihua Peng a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yunhao Ren a,b, Fengyuan Song a, Haobin Wang a, Lihua Peng a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603018]]></guid><cfi:id>26</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Compatibility mechanism of Chrysanthemi Indici Flos compound against hepatocellular carcinoma based on balance of DNMTs/TET2]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603019]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective: At present, traditional Chinese medicine (TCM) compounds is widely used in tumor therapy. However, due to the current single and simplistic efficacy evaluation indicators that are detached from the guidance of TCM theory, the elucidation of its mechanisms of efficacy is hindered. Therefore, the compatibility mechanism of Chrysanthemi Indici Flos compound (YJHFF) against hepatocellular carcinoma based on DNA methyltransferases/DNA demethylase ten-eleven translocation 2 (DNMTs/TET2) balanced relationship was explored according to the concept of the overall balance of TCM.
Methods: This study screened the best compound compatibility ratio in the in vitro experiments, cell viability and DNMTs/TET2 balance were used as evaluation indicators to investigate the effects of single herb and different compatibility of compound on HepG2 and H22 cells. In vivo experiments were conduct on H22 liver orthotopic transplantation model mice. After treatment, the tumor tissues were observed by hematoxylin-eosin (HE), TUNEL and Ki67 immunohistochemical staining, respectively. The oxidative stress and liver function indicators in serum were detected by enzyme-linked immunosorbent assay. In addition, the proportion of tumor-infiltrating lymphocytes was detected by immunofluorescence staining. The mRNA expression levels of DNMTs and TET2 in tumor tissues were detected by RT-PCR.
Results: The results of in vitro experiments showed that the cell proliferation inhibition rate was highly consistent with the change trend of DNMTs/TET2 balance, accordingly, this study obtained the optimal formula YJHFF. In the in vivo experiments, the tumor growth inhibition rate of YJHFF in 5 g/kg was 62.97%. Extensive necrosis, increased apoptosis and inhibited proliferation activity were observed in tumor tissue. Furthermore, the serum SOD activity was significantly increased, MDA, ALT, AST and AFP levels were significantly decreased, suggesting YJHFF could systematically alleviated oxidative stress and improved liver function. Besides, the infiltration of CD3+ , CD4+ and CD8+ T lymphocytes increased significantly, indicating that the body’s anti-tumor immune response was enhanced. Finally, RT-PCR analysis confirmed that antitumor effects were closely related to the core mechanism of DNMTs/TET2 expression regulation and reconstruction of epigenetic balance.
Conclusion: This work confirmed the rationality and feasibility of the DNMTs/TET2 balance relationship as an evaluation indicator for the study of the compatibility mechanism of TCM compounds. The YJHFF screened under the guidance of DNMTs/TET2 balance has liver protection and tumor immune function, showing good anti-hepatocellular carcinoma effect.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zehui He 1, Cancan Guo 1, Fangping Zhang, Feifan Li, Yu Zhou, Leyi Ma, Xiaohui Wang, Yuefeng Bi ?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zehui He 1, Cancan Guo 1, Fangping Zhang, Feifan Li, Yu Zhou, Leyi Ma, Xiaohui Wang, Yuefeng Bi ?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603019]]></guid><cfi:id>25</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Protective effect and mechanism of extracts of fruit of Taxus chinensis on hippocampus of chronic unpredictable mild stress rats]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603020]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective: The ambitious research aimed to explore the protective impact and mechanism of the ethyl acetate extract of Taxus chinensis fruits (TCFE) on the hippocampi of rats subjected to chronic unpredictable mild stress (CUMS).
Methods: A total of 32 SD rats were randomly allocated into the control group, model group, TCFE group receiving 200 mg/(kg d) of TCFE, fluoxetine group receiving 2 mg/(kg d) of fluoxetine. The rats were induced with chronic unpredictable mild stress (CUMS) for 28 d, and concurrently administered the allocated drugs via gavage for the same duration. The body mass, performance in the open field test (OFT), and sugar-water preference rate of the rats in each group were assessed. The morphology of rat hippocampal tissues was examined using Hematoxylin-Eosin (HE) staining. Nissl staining was employed to observe hippocampal pathological changes, while ELISA was utilized to measure the levels of IL-1b, TNF-a, IL-6, and IL-18 in the hippocampus. Immunofluorescence was employed to identify the expression of the microglia (MG) marker Iba1 in the rat hippocampus. Furthermore, immunohistochemistry was utilized to detect the expression of Bax and Bcl-2 in the hippocampus. Real-time fluorescence quantitative PCR (qRT-PCR) was utilized to assess the expression levels of two apoptosis-related genes in the rat hippocampus. TUNEL assay was performed to detect tissue cell apoptosis in the rat hippocampus. Finally, Western blotting analysis was conducted to determine the expression of Bax and Bcl-2 proteins in the hippocampus.
Results: The consumption of TCFE significantly enhanced body weight (P < 0.05), sucrose preference rate (P < 0.05), and total movement distance in the open field test (P < 0.05). It also improved hippocampal neuronal structure integrity and attenuated loss. Moreover, TCFE regulated the excessive activation of hippocampal microglia in rats, inhibited the expression of IL-1b and TNF-a (P < 0.05), and modulated the Bax and Bcl-2 expression levels, leading to a significant alteration in the Bax/Bcl-2 ratio (P < 0.05).
Conclusion: TCFE shows promise in attenuating cell apoptosis through the modulation of the Bax/Bcl-2 ratio, suggesting a prospective approach for combating depression.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shunling Zhang a, Jiayi Zhang a, Fei Zhang b, Maoyuan Ni a, Linwei Zhong b, Meimei Chen b, Zhaoyang Yang b, Huangwei Lei b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shunling Zhang a, Jiayi Zhang a, Fei Zhang b, Maoyuan Ni a, Linwei Zhong b, Meimei Chen b, Zhaoyang Yang b, Huangwei Lei b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603020]]></guid><cfi:id>24</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Modern scientific connotation of a traditional Chinese medicine theory: Rice vinegar extract of Artemisia argyi exhibits excellent antifungal effects against dermatophytes]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603021]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective: Since ancient times, Artemisia argyi is commonly applied by folk to bathe and soak feet to disinfect and relieve itching. Moreover, abundant Chinese medical books recorded that ‘‘decocting A. argyi with bitter wine for treating dermatophytosis with excellence”. This research was designed to explore its scientific connotation.
Methods: The antifungal activity against three dermatophytes of eight extracts from A. argyi was assessed in vitro. A three-variable, three-level orthogonal design was conducted to obtain the best extraction procedure of rice vinegar extract (AARV). Subsequently, Trichophyton rubrum (T. rubrum)-induced dermatophytosis mice model was used to determined the efficacy of AARV topical treatment. And then, the widely targeted metabonomic technique was employed to analyze the potential antifungal material basis of AARV. Furthermore, the mechanism of AARV against dermatophytes was explored by physiological detections, transcriptomics and real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR).
Results: AARV was the most potent anti-dermatophytic extract from A. argyi in vitro, and the best extraction procedure of AARV was optimized to the solid–liquid ratio, extraction time and rice vinegar concentration of 1:14 g/mL, 2 h and 100%, respectively. Moreover, topical treatment with AARV could alleviate skin redness, swelling and ulceration in mice, increase the number of hair follicles, and prevent the invasion of dermatophytes in hair follicles. Compared with traditional water extract, 11 unique compoundswere characterized in AARV, including five alkaloids, two flavonoids, two phenols, one sesquiterpene and one triterpene. Further mechanistic studies revealed that AARV destroyed the mycelium morphology of T. rubrum, promoted reactive oxygen species (ROS) accumulation and inhibited antioxidant enzyme activity. In addition, malate dehydrogenase (MDH) and succinate dehydrogenase (SDH) activities also decreased significantly. Transcriptome data, RT-qPCR and the determination of ergosterol content elucidated that AARV suppressed dermatophyte growth by reducing cell membrane integrity through inhibition of ergosterol and cholesterol biosynthesis pathways. And it was attributed to the downregulation of sterol 14a-demethylase (CYP51), D7 -sterol 5- desaturase (ERG3), sterol 22-desaturase (ERG5), sterol 24-C-methyltransferase (ERG6), sterol-4acarboxylate 3-dehydrogenase (ERG26),3-keto steroid reductase (ERG27), cholestenol D-isomerase (EBP) mRNA expression.
Conclusion: The present study clarifies the modern scientific connotation of ‘‘decocting A. argyi with bitter wine, excellent for treating dermatophytosis” is that the rice vinegar extract of A. argyi exhibit excellent antifungal effects against dermatophytes. Importantly, it will provide the scientific support for the antidermatophytic scientific utilization of A. argyi.]]></description>
<pubDate>2026/8/7 8:02:10</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Le Chen a,c,1, Wenli Xu a,b,1, Chaowei Guo a,b, Jinglin Yang a,b, Xiaoying Hou d, Hongzhi Du a,b,?, Dahui Liu a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Le Chen a,c,1, Wenli Xu a,b,1, Chaowei Guo a,b, Jinglin Yang a,b, Xiaoying Hou d, Hongzhi Du a,b,?, Dahui Liu a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603021]]></guid><cfi:id>23</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Antibacterial and antibiofilm activity of novel nanofibers bandage formulated with Juniperus communis essential oil targeting antibiotic resistant bacterial strains]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603022]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Objective: The alarming increase in antimicrobial resistance (AMR) threatens current armament of antibiotics. This global threat to public health revived the search for plant-derived antimicrobial therapeutics.Juniperus communis L. has been used in folk medicine for centuries. This study aims to examine the antibacterial and antibiofilm activity of polycaprolactone (PCL) nanofiber bandages formulate with essential oil extracted from J. communis against clinically relevant ESKAPE (Escherichia coli, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae,Acinetobacterbaumanii, Pseudomonas aeruginosa, and Enterobacter cloacae) bacterial pathogens commonly causing nosocomial infections.
Methods: Bacterial growth curves and bactericidal assays were performed on antibiotic sensitive and resistant clinical bacterial strains collectively known as ESKAPE pathogens. Antibiofilm activity of Juniper essential oil (JEO) was tested against methicillin resistant S. aureus (MRSA) and E. coli individually in a 96-well plate, and the 96 well plate which contains the bacteria was incubated over night to allow biofilm formation and stained using crystal violet. The antibacterial activity of PCL-based nanofiber membrane formulated with various doses (2%, 4%, 6%, and 8%) of JEO was tested using disc diffusion method.
Results: JEO dilutions (50, 25 and 12.5 lL) demonstrated a dose-dependent antibacterial activity against tested strains and significantly reduced growth after 24 h. JEO also exerted antibiofilm activity against MRSA and E. coli strains that are resistant to antibiotics. Additionally, PCL nanofiber membranes formulated with 8% JEO inhibited MRSA growth as demonstrated by large zone of inhibition on agar plate.
Conclusion: JEO has antibacterial activity against ESKAPE pathogens. The potential application of JEO formulated in PCL nanofiber bandages is for wound dressing to treat surgical site infections, burns or skin ulcers.]]></description>
<pubDate>2026/8/7 8:02:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mohannad N. AbuHaweeleh a,1, Ahmad Hamdan a,1
,, Menatalla Metwally Said a, Maryam Hassiba a, Robin Augustine b, Anwarul Hassan c, Nahla O. Eltai d, Susu M. Zughaier a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mohannad N. AbuHaweeleh a,1, Ahmad Hamdan a,1
,, Menatalla Metwally Said a, Maryam Hassiba a, Robin Augustine b, Anwarul Hassan c, Nahla O. Eltai d, Susu M. Zughaier a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603022]]></guid><cfi:id>22</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Xuezhikang Capsule ameliorates ischemic stroke via multi-target modulation of neurovascular units]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603023]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/8/7 8:02:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Xiaowen Zhang a,b,1, Chengchen Hou a,1, Yuqi Wang a, Yang Chen a, Ling Li a, Lan Xue c, Chunhui Hao c, Xi Liu c,?, Kewu Zeng a,d,e,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Xiaowen Zhang a,b,1, Chengchen Hou a,1, Yuqi Wang a, Yang Chen a, Ling Li a, Lan Xue c, Chunhui Hao c, Xi Liu c,?, Kewu Zeng a,d,e,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603023]]></guid><cfi:id>21</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Hepatoprotective effects of ginsenoside Rb1 from Panax ginseng on early liver injury via DNA repair activation and nuclear envelope stabilization]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603024]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/8/7 8:02:11</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Fei Gao a, Haiyun Gao a, Yun Lin b, Longyan Chen a, Zheng Qi a,*, Miao Yu a.*]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Fei Gao a, Haiyun Gao a, Yun Lin b, Longyan Chen a, Zheng Qi a,*, Miao Yu a.*</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202603024]]></guid><cfi:id>20</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[New draft: Elucidating complex efficacy of traditional Chinese medicine in combating respiratory viral diseases]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/5/18 16:30:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Nanshan Zhong]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Nanshan Zhong</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602001]]></guid><cfi:id>19</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Future prospects of antiviral research in traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Traditional Chinese medicine (TCM) has a long history of treating viral diseases through holistic approaches and multi-component formulations. In response to emerging global viral threats like coronavirus disease-2019 (COVID-19), TCM has demonstrated significant potential in both antiviral and immune-modulatory roles. This review summarizes the current state of TCM antiviral research, highlighting advances in identifying active components and elucidating their mechanisms, which include direct viral inhibition and immune regulation. Technological innovations, including artificial intelligence (AI)-driven drug discovery and advanced extraction methods, are accelerating the development of TCM antiviral products. However, challenges remain in standardization, mechanistic validation, and international regulatory acceptance. Looking ahead, research should prioritize systems pharmacology, the development of multi-dimensional evaluation models, standardized clinical trials, and global health integration. By addressing these challenges, TCM can play a vital role in worldwide antiviral strategies and public health.]]></description>
<pubDate>2026/5/18 16:30:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Kexin Wang a,b, Zifeng Yang a,b,]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Kexin Wang a,b, Zifeng Yang a,b,</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602002]]></guid><cfi:id>18</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Anti-influenza formula medicines based on warm disease theory of traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Warm disease, characterized primarily by fever, is caused by exogenous pathogenic factors, such as Influenza. Ancient medical books have documented treatment strategies, and many formulas and herbs have been identified as effective against influenza. Treatment on acute flu-induced pneumonia should consider suppressing viral replication and mitigating the tissue damage mediated by the immune system.
Traditional Chinese medicines (TCMs) have superiority since their multi-ingredients and multi-targets.
There are many formulas containing anti-influenza components and anti-inflammation components.
TCM showed less resistance during application. Many formulas are common for clinic use like
Lianhuaqingwen Capsule, Fufang Xiangru Liquid, and Shengjiang Powder. Their efficacy in viral elimination and inflammation regulation has been evaluated, leading to the identification of effective phytochemicals that elucidate their anti-flu mechanisms. This review introduces some Chinese patent
medicines based on warm disease theory and reviews their current research process.]]></description>
<pubDate>2026/5/18 16:30:25</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mengjie Xiao a,h, Tao Huang a, Shengle Qin b, Tianbo Zhang g, Runfeng Li c, Xin Zhao a, Luping Lin d,, Zifeng Yang c,d,e,f,]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mengjie Xiao a,h, Tao Huang a, Shengle Qin b, Tianbo Zhang g, Runfeng Li c, Xin Zhao a, Luping Lin d,, Zifeng Yang c,d,e,f,</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602003]]></guid><cfi:id>17</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advancement of Astragali Radix in anti-tumor: Active components and
combination therapy]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602010]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Natural products continue to serve as indispensable sources for anti-tumor drug discovery, accounting for approximately 40% of United States Food and Drug Administration (U.S. FDA) FDA-approved anti-tumor agents despite advancements in biologic therapies. Among these natural products, Astragali Radix (AR, Huangqi in Chinese) has emerged as a particularly promising candidate for tumor treatment due to its well-documented anti-tumor properties. Contemporary research has identified three principal bioactive compounds responsible for these therapeutic effects: Astragalus polysaccharides, total Astragalus flavonoids, and astragalosides. These compounds demonstrate multimodal anti-tumor activity against five major malignancies, including lung, breast, liver, colorectal, and cervical cancers, through coordinated modulation of critical cellular processes including apoptosis induction, cell cycle arrest, and metastasis suppression. Critical studies have revealed that AR-based combination therapies can synergistically enhance conventional treatments (chemotherapy/radiotherapy). This is achieved by simultaneously addressing two critical challenges in tumor treatment: Reducing treatment-related toxicity and overcoming multidrug resistance through chemosensitization effects in vivo. This review synthesizes current knowledge on AR’s anti-tumor components, their molecular mechanisms, and therapeutic targets. It emphasizes the synergistic benefits of integrating AR with existing tumor treatments and proposes future research directions to advance its clinical translation. By bridging traditional herbal knowledge with modern scientific rigor, this work aims to accelerate the development of AR-based therapies as safer, more effective options for cancer patients.]]></description>
<pubDate>2026/5/18 16:30:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jiaxin Jiang a,1, Min Li b,1, Qiwen Lu a, Gongjian Dai c, Qichen Zhan d, Jing Chen e,?, Xuan Han a]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jiaxin Jiang a,1, Min Li b,1, Qiwen Lu a, Gongjian Dai c, Qichen Zhan d, Jing Chen e,?, Xuan Han a</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602010]]></guid><cfi:id>16</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Herbal remedies for hepatic diseases: A review of medicinal herbs in the treatment of liver disorders]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602011]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants have been integral to human healthcare for centuries, offering a vast repository of bioactive compounds with therapeutic potential. This comprehensive review underscores the significance of medicinal herbs in maintaining hepatic homeostasis and addresses their efficacy in treating liver disorders, including cancer, hepatitis, cirrhosis, and liver failure. The exploration begins with an examination of the historical importance of medicinal plants in diverse traditional healing practices, emphasizing their contributions to human well-being. Subsequently, the review delves into the specific hepatoprotective properties of herbs, unravelling their potential to mitigate liver disorders, their versatile antiinflammatory, antioxidant, and anti-cancer attributes, along with their immunomodulatory and antioxidant effects, set the stage for understanding their roles in managing hepatitis and other liver disorders. Furthermore, the review discusses anti-fibrotic and hepatoprotective qualities, antioxidant-rich composition guarding against hepatotoxicity, and their anti-inflammatory and anti-cancerous actions relevant to liver disorders. Many medicinal plants, known for their hepatoprotective and anti-inflammatory properties, are explored for their potential therapeutic benefits in liver failure. Understanding the pivotal role of medicinal plants in liver health enriches our appreciation for traditional healing practices and lays the groundwork for developing novel therapeutic approaches for both human and veterinary liver health.]]></description>
<pubDate>2026/5/18 16:30:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Istuti Saraswat, Anjana Goel, Jyoti Gupta]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Istuti Saraswat, Anjana Goel, Jyoti Gupta</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602011]]></guid><cfi:id>15</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Genus Cucumis: Traditional uses, phytochemistry, pharmacology, clinical application, and toxicology]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602012]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[The genus Cucumis L. (Cucurbitaceae), flourishes across temperate, tropical, and subtropical regions. Species within the genus have a long-standing history in traditional ethnomedicinal practices throughout Asia and Africa, addressing a wide spectrum of ailments, including gastrointestinal, metabolic, urogenital, hepatic, dermatological, cardiovascular, respiratory, inflammatory, and infectious disorders. Despite this extensive traditional use, the full therapeutic potential of Cucumis remains underexplored.
This review comprehensively explores the traditional ethnomedicinal applications, phytochemical composition, pharmacological activities, clinical evidence, and toxicological profiles of Cucumis species. A systematic survey of internationally recognized scientific databases and authoritative repositories, including
Web of Science, Scopus, PubMed, ScienceDirect, and Google Scholar, and revealed over 428 bioactive
compounds spanning through diverse phytochemical classes. These classes include steroids, triterpenoids (predominantly cucurbitacins), flavonoids (particularly C,O-glycosylflavones), coumarins, other
phenolics, and additional secondary metabolites. Collectively, these compounds demonstrate multifaceted bioactivities, encompassing anti-inflammatory, antihypertensive, anti-diabetic, anti-cancer,
organ-protective, antimicrobial, and antiviral properties, as validated through in vitro, in vivo, and limited
clinical studies. Nonetheless, the molecular mechanisms underpinning these pharmacological effects
remain inadequately elucidated.
By integrating traditional ethnomedicinal knowledge with contemporary research approaches, this
review highlights the necessity of advancing scientific insight into the genus Cucumis and its bioactive
constituents. Future research should focus on comprehensive phytochemical profiling, mechanistic elucidation, clinical evaluations, and rigorous toxicological assessments to ensure the safe and effective
application of various Cucumis species in modern herbal medicine.]]></description>
<pubDate>2026/5/18 16:30:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Hesham M. El-Sayed a, Engy A. Mahrous b, Dalia M. Rasheed a, Essam Abdel-Sattar b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Hesham M. El-Sayed a, Engy A. Mahrous b, Dalia M. Rasheed a, Essam Abdel-Sattar b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602012]]></guid><cfi:id>14</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Chemical composition, antitumor properties and underlying mechanism of Sophora flavescens flavonoids: A review]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602014]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Sophora flavescens is a widely used medicinal plant in traditional Chinese medicine, particularly known for its rich flavonoid content. Historically used in traditional medicine, this herb has been documented in the Shennong’s Classic of Materia Medica (Shennong Bencao Jing) for its effects in clearing heat, eliminating dampness, and serving as an anthelmintic and diuretic, for treating various conditions, including dysentery, jaundice, and skin diseases. Recent research on S. flavescens has expanded, particularly concerning its flavonoid compounds, which exhibit significant pharmacological activities, including antimicrobial, antioxidant, hepatoprotective, hypoglycemic, and antitumor effects. This review systematically summarizes the chemical constituents of S. flavescens, identifying over 130 flavonoid compounds, primarily isoprenylflavonoids, with a specific focus on their antitumor activities. Studies have shown that representative compounds, such as kurarinone and kushenol G, selectively exhibit cytotoxic effects against various cancer cell lines (e.g., HepG2, A549, MCF-7) while sparing normal cells. The antitumor mechanisms are primarily attributed to apoptosis induction, modulation of oxidative stress, and regulation of multiple signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway and the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. Furthermore, safety assessments indicate that while the overall toxicity of flavonoids from S. flavescens is relatively low, certain compounds may pose hepatotoxic risks at high doses, warranting further attention in clinical applications. This review aims to provide an in-depth analysis and discussion of the chemical diversity, antitumor efficacy, and mechanisms of action of S. flavescens flavonoids, establishing a theoretical foundation and research direction for the development of novel anticancer drugs.]]></description>
<pubDate>2026/5/18 16:30:26</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zhongyuan Guo a,b,1, Gaoyue Dong c,1, Xiaoqian Liu b, Huimin Gao b, Liangmian Chen b, Hong Yang c,?, Zhimin Wang a,b]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zhongyuan Guo a,b,1, Gaoyue Dong c,1, Xiaoqian Liu b, Huimin Gao b, Liangmian Chen b, Hong Yang c,?, Zhimin Wang a,b</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602014]]></guid><cfi:id>13</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Rhein/Fe3+ nanoassembly for triple-negative breast cancer treatment via a ferroptosis and immunogenic death]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602021]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/5/18 16:30:28</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shuntao Liang a,c,1, Licheng Gan a,d,1, Xiaomei Tao c, Fei Xia a,b, Qingchao Tu a, Linying Zhong a, Yuanfeng Fu a, Yinan Liu a, Yuqing Meng a, Qiaoli Shi a, Junzhe Zhang a, Jigang Wang a,d,?, Chong Qiu a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shuntao Liang a,c,1, Licheng Gan a,d,1, Xiaomei Tao c, Fei Xia a,b, Qingchao Tu a, Linying Zhong a, Yuanfeng Fu a, Yinan Liu a, Yuqing Meng a, Qiaoli Shi a, Junzhe Zhang a, Jigang Wang a,d,?, Chong Qiu a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602021]]></guid><cfi:id>12</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Biosynthetic pathway analysis of ginsenoiside Rh1 to notoginsenoside R2]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602022]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/5/18 16:30:28</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Rubing Wang a,b,1, Yanan Zhang a,b,1, Huanyu Zhang a,b, Wenqi Yang a,b, Yaowu Su a,b, Hongyan Jing c, Juan Wang a,b,?, Wenyuan Gao a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Rubing Wang a,b,1, Yanan Zhang a,b,1, Huanyu Zhang a,b, Wenqi Yang a,b, Yaowu Su a,b, Hongyan Jing c, Juan Wang a,b,?, Wenyuan Gao a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602022]]></guid><cfi:id>11</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Diverse alkaloids with anti-inflammatory activity discovered from Thalictrum baicalense]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602023]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/5/18 16:30:28</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jinyuan Yang a, Zhaojing Chen a, Jingjing Xue a, Yikun Ren a, Zhanlin Li a, Dahong Li?a, Yating Sun b,?, Huiming Hua a]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jinyuan Yang a, Zhaojing Chen a, Jingjing Xue a, Yikun Ren a, Zhanlin Li a, Dahong Li?a, Yating Sun b,?, Huiming Hua a</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202602023]]></guid><cfi:id>10</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Synthetic biology empowers development of traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601001]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[]]></description>
<pubDate>2026/1/26 16:03:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Chun Li]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Chun Li</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601001]]></guid><cfi:id>9</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601002]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants synthesize structurally diverse pharmacologically active natural products through conserved precursor pathways, which are further diversified by lineage-specific tailoring enzymes. Although the biosynthetic pathways of well-studied compounds (e.g., berberine, paclitaxel, and ginsenosides) have been extensively characterized, most bioactive components in Traditional Chinese Medicine (TCM) remain poorly understood. The emerging discipline of Herbgenomics has significantly advanced biosynthetic gene discovery and pathway elucidation. By employing genomics-driven strategies such as biosynthetic gene cluster mining, co-expression analysis, and integrated transcriptome-metabolome profiling, Herbgenomics enables systematic identification of key biosynthetic enzymes and uncovers evolutionary mechanisms (e.g., whole-genome and tandem gene duplications) driving metabolic innovation. Furthermore, it provides a foundation for drug development by leveraging gene-encoded natural diverse components and genome-wide pan-receptor platforms (e.g., pan-GPCR). Through the integration of pathway analysis, regulatory mechanisms, molecular breeding, and synthetic biology, Herbgenomics establishes a comprehensive framework for exploring and engineering TCM natural product biosynthesis, offering a sustainable pathway to the discovery and production of bioactive compounds.]]></description>
<pubDate>2026/1/26 16:03:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Jing Wang a, Jingyuan Song b, Shilin Chen c,?, Zhichao Xu a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Jing Wang a, Jingyuan Song b, Shilin Chen c,?, Zhichao Xu a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601002]]></guid><cfi:id>8</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advanced applications of synthetic biology technology in biosynthesis of bioactive compounds from medicinal plants]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601003]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Medicinal plants serve as valuable sources of bioactive compounds with critical applications across pharmaceutical, agricultural, and industrial sectors. Compared to chemical synthesis and plant extraction, synthetic biology offers a green, efficient, and sustainable alternative for producing bioactive compounds, which represents a state of art technology. However, this technology still faces several challenges, including overly long metabolic pathways, inadequate catalytic efficiency of key enzymes in the pathway, and incompatibility between gene elements and host cells, leading to low yields of target bioactive compounds. The development and application of regulatory tools in synthetic biology hold great promise for overcoming these obstacles. This review first summarizes the classification and biosynthesis of bioactive compounds based on structural types. Subsequently, recent advancements are outlined in regulation tools and their application in the heterologous production of bioactive compounds. This review aims to establish a foundation for the efficient production of bioactive compounds based on microbial cell factories. This not only has significant practical implications for reducing the resource consumption and environmental impact of traditional production methods, but also highlights the central role of synthetic biology in promoting the sustainable production of bioactive compounds derived from medicinal plants.]]></description>
<pubDate>2026/1/26 16:03:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Yingjun Liu a,1, Anying Ji a,1, Haiyang Jia b, Huan Sun a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Yingjun Liu a,1, Anying Ji a,1, Haiyang Jia b, Huan Sun a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601003]]></guid><cfi:id>7</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[From natural laboratory to drug discovery: Chemical structures, bioactivities, and biosynthesis of meroterpenoids from Ganoderma species]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601004]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Meroterpenoids are secondary metabolites partially derived from the terpenoid biosynthetic pathway, and are widely distributed in plants, animals, and fungi. These natural products possess complex backbone structures and diverse bioactivities. Ganoderma meroterpenoids (GMs) form a distinct group of meroterpenoids were characterized by the presence of 1,2,4-trisubstituted phenyl and polyunsaturated terpene moieties. Various Ganoderma species have been extensively studied, leading to the discovery of several structurally unique meroterpenoids with significant pharmacological activities. After the first isolation and identification of GMs in 2 000, over 300 compounds from 14 species have been characterized for their structures and biological activities. The structures and activities of some GMs from different Ganoderma species vary greatly, probably due to significant differences in the genome and transcriptome of different Ganoderma species. We predicted the related enzymes based on the reported Ganoderma genome and proposed the biosynthetic pathway related to GMs. The results presented in this review provide a scientific foundation for the comprehensive exploration and utilization of diverse Ganoderma resources.]]></description>
<pubDate>2026/1/26 16:03:18</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Shuang Peng a,1, Jianzhao Qi a,b,1, Chao Lin b, Zhichao Xu a,b, Zhenhao Li c,?, Chengwei Liu a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Shuang Peng a,1, Jianzhao Qi a,b,1, Chao Lin b, Zhichao Xu a,b, Zhenhao Li c,?, Chengwei Liu a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601004]]></guid><cfi:id>6</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Advances in microbial biosynthesis of indirubin]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601005]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Indirubin (IND), a bisindole alkaloid with remarkable pharmacological activities, has attracted significant attention in the pharmaceutical field due to its antileukemic, anti-inflammatory, and immunomodulatory properties. Currently, indirubin primarily relies on plant extraction and chemical synthesis, which are hindered by complex processes, low yields, and poor environmental compatibility. These challenges pose serious obstacles to clinical supply and sustainable industrial development. In recent years, microbial synthesis technology, which is based on synthetic biology and metabolic engineering, has provided a novel approach for the efficient production of indirubin. This method offers several advantages, including high efficiency, environmental sustainability, and eco-friendliness. Hence, this manuscript systematically summarizes the biosynthesis mechanisms of indirubin, the catalytic characteristics of key enzymes, the construction strategies of engineered bacteria, and the progress in fermentation condition. To address challenges such as the difficult separation of indirubin isomers, by-product inhibition, and industrialization bottlenecks, potential solutions are proposed, aiming to promote the green biomanufacturing of indirubin.]]></description>
<pubDate>2026/1/26 16:03:19</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Keqian Li a,1, Fangyu Xiang a,1, Xin Yang a, Mengqi Liu a, Rui Long a, Li Han a, Ming Yang b, Dingku a,c,?, Yanan He a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Keqian Li a,1, Fangyu Xiang a,1, Xin Yang a, Mengqi Liu a, Rui Long a, Li Han a, Ming Yang b, Dingku a,c,?, Yanan He a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601005]]></guid><cfi:id>5</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[A review of Siraitia grosvenorii: Applications, breeding, and biosynthesis of mogrosides]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601006]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Siraitia grosvenorii is a premier food-medicine homologous species recognised by China’s National Health Commission and produces mogrosides as its primary active component. These compounds exhibit biological activities, including the regulation of blood sugar, fat metabolism, and immune function regulation. They are classified as high-intensity, non-nutritive sweeteners with significant medicinal potential and nutritional value. This review systematically explores the applications of S. grosvenorii in traditional medicine and foods, with a focus on advances in the conservation of germplasm resources and the traditional breeding of elite varieties, mogroside biosynthetic pathways and the characterization of key genes, and synthetic biology platforms for mogroside production. We have identified the low content of mogroside V in S. grosvenorii as the main reason for its limited application. To address this issue, we propose two strategic approaches: enhancing mogroside content in vivo through molecular design breeding and developing three synthetic biology platforms for mogrosides synthesis to increase yields. These solutions offer viable ways to reduce production costs and expand the commercial use of S. grosvenorii medicines and sweeteners.]]></description>
<pubDate>2026/1/26 16:03:19</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Zuliang Luo a,b, Yimei Zang a, Jiaxian Su a, Qi Tang b,c, Limei Pan d, Xiaojun Ma a, Chongnan Wang a,?, Changming Mo e,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Zuliang Luo a,b, Yimei Zang a, Jiaxian Su a, Qi Tang b,c, Limei Pan d, Xiaojun Ma a, Chongnan Wang a,?, Changming Mo e,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601006]]></guid><cfi:id>4</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Natural novel vitamin C derivative, 2-O-b-D-glucopyranosyl-L-ascorbic acid: Resources, biosynthesis, and applications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601007]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[As the only naturally occurring stable derivative of L-ascorbic acid (AA; vitamin C), 2-O-b-Dglucopyranosyl-L-ascorbic acid (AA-2bG) is hydrolyzed in vivo to release active AA. AA-2bG exhibits strong antioxidant and antiphotoaging effects comparable to those of AA, and it plays a key role in maintaining organismal health. Owing to its superior stability and bioavailability, AA-2bG is considered as a promising, longer-lasting natural alternative to conventional vitamin C. It was first identified and is particularly abundant in Lycii Fructus (Gouqizi in Chinese) but has been detected in several crop plants. This review offers a comprehensive overview of recent advances in AA-2bG research, covering key aspects including discovery, structure, natural sources, extraction and detection methods, chemical and in vitro enzymatic synthesis, biosynthetic pathways, as well as applications in health care, skin care, and functional foods. Additionally, we highlight strategies for leveraging plant resources and enhancing AA-2bG biosynthesis, which are expected to accelerate future research and support the sustainable development and utilization of AA-2bG and other high-value natural products.]]></description>
<pubDate>2026/1/26 16:03:19</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Mengyue Wang a,1, Haotian Wu a,1, Li Xiang a, Ranran Gao a, Qinggang Yin a, Yang Chu a, Lan Wu a, Yanyan Su b, Gangqiang Dong b,?, Yuhua Shi a,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Mengyue Wang a,1, Haotian Wu a,1, Li Xiang a, Ranran Gao a, Qinggang Yin a, Yang Chu a, Lan Wu a, Yanyan Su b, Gangqiang Dong b,?, Yuhua Shi a,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601007]]></guid><cfi:id>3</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Protein S-acylation: Pathological mechanisms and novel therapeutic targets for diabetic complications]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601010]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Diabetes involves multi-organ complications that seriously threaten human life and health, and has become a major public health problem of global concern. Unfortunately, clinical management strategies for diabetic complications are still in their ‘‘infancy”, restricted by a limited understanding of their complex pathological mechanism. As is well established, lipid metabolism disorder is the characteristic pathological factors of diabetes, but the detailed molecular mechanisms driving the progression of multi-organ complications remain obscure. Protein S-acylation (often referred to as S-palmitoylation) is a reversible lipid modification that reversibly binds fatty acids to protein-specific cysteine (Cys) residues through palmitoyl acyl transferases (PATs, also known as DHHCs) and deacylation enzymes, which is involved in the pathological progression of a variety of complex diseases such as cancer, neurological disorders and metabolic syndrome. Notably, recent studies have shown that protein S-acylation drives the progression of diabetes and its multiple complications, and targeted intervention in the protein Sacylation process significantly alleviates the progression of diabetes and its complications, suggesting that protein S-acylation may be a common pathological link and intervention target of diabetes complications. Therefore, this review systematically comprehends the contribution of protein S-acylation to the progression of diabetes and its complications, summarizes the influence of the diabetic environment on S-acylation related enzymes, as well as providing an in-depth analysis of current drugs, measures, and challenges in targeting S-acylation. Finally, the accessibility of targeting protein S-acylation to prevent
diabetes and its complications and the focus of future in-depth studies are envisioned, with a view to providing comprehensive and in-depth references and rationale for future novel strategies targeting protein S-acylation to prevent and treat diabetes and its multi-organ complications.]]></description>
<pubDate>2026/1/26 16:03:19</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Ruiting Liu a,b,1, Nuo Xu a,b,1, Xuejiao Song a,b, Yanying Li a,b, Jie Bu a,b, Runtao Su a,b, Hong Guo a,b, Chen Jiang c,d, Pengwei Zhuang a,b,c,d, Yanjun Zhang a,b,c,d,?, Qingsheng Yin a,b,?]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Ruiting Liu a,b,1, Nuo Xu a,b,1, Xuejiao Song a,b, Yanying Li a,b, Jie Bu a,b, Runtao Su a,b, Hong Guo a,b, Chen Jiang c,d, Pengwei Zhuang a,b,c,d, Yanjun Zhang a,b,c,d,?, Qingsheng Yin a,b,?</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601010]]></guid><cfi:id>2</cfi:id><cfi:read>true</cfi:read></item>
<item>
<title xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="text"><![CDATA[Contribution of proteomics and metabolomics data to understanding of health benefits of tea]]></title>
<link><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601011]]></link>
<description xmlns:cf="http://www.microsoft.com/schemas/rss/core/2005" cf:type="html"><![CDATA[Tea is the second most widely consumed non-alcoholic beverage globally. While most teas originate from Camellia sinensis (L.) Kuntze plants, rooibos and honeybush teas are produced from Aspalathus linearis (Burm.f.) R.Dahlgren and Cyclopia species tea plants. Interest in tea and tea-derived components, has increased due to their well-known health benefits. The mechanisms of these health benefits are however poorly understood. Proteomics and metabolomics provide valuable tools to assess the mechanisms of the therapeutic effects of tea in disease treatment. This review summarizes the role played by proteomic and metabolomic studies in investigating the health benefits of C. sinensis, A. linearis, and Cyclopia spp. teas. Surprisingly, no proteomic and metabolomic studies investigating the health benefits of A. linearis and Cyclopia spp. teas and/or their components were identified in a literature search. However, 25 studies using proteomics and 16 studies using metabolomics to investigate the health benefits of C. sinensis teas and/or their components were identified in a literature search. Proteomics and metabolomics have been valuable tools for investigating the health benefits of C. sinensis teas and tea components, and will likely also prove valuable for investigating the effects of A. linearis and Cyclopia spp. teas on human health.]]></description>
<pubDate>2026/1/26 16:03:19</pubDate>
<category><![CDATA[Reviews]]></category>
<author><![CDATA[Danicke Willemse ?, Mariam Rado, Mariska Lilly]]></author>
<atom:author xmlns:atom="http://www.w3.org/2005/Atom">
<atom:name>Danicke Willemse ?, Mariam Rado, Mariska Lilly</atom:name>
</atom:author>
<guid><![CDATA[https://www.tiprpress.com/chmen/article/abstract/CHM202601011]]></guid><cfi:id>1</cfi:id><cfi:read>true</cfi:read></item>
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