Chemical Constituents from Kalanchoe hybrida and their Cytotoxicity
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Abstract:
Objective Kalanchoe hybrida (Crassulaceae) is naturalized throughout all the island of Taiwan, China. The preliminary bioassay-guided fractionation of the crude extract of K. hybrida exhibited that the chloroform and n-butanol fractions possessed potent cytotoxicity against MCF-7, NCI-H460, and SF-268 tumor cell lines at 50 μg/mL concentration. Therefore, K. hybrida was selected as a target and the chemical constituents from the chloroform and n-butanol fractions of the crude extracts of K. hybrida were identified. The potential constituents were examined for their cytotoxicity against the tumor cell lines. Methods A combination of conventional chromatographic techniques was performed on the crude extract of K. hybrida. The chemical structures of the purified constituents were identified on the basis of spectroscopic and spectrometric analysis. Results The purification results had led to the characterization of totally 37 compounds. The isolated compounds 1, 2, and 4-12 were examined for their cytotoxicity in vitro, and bufadienolides 4-8 and flavonol glycoside 11 displayed significant cytotoxicity towards all the tested tumor cell lines among these tested compounds. Conclusion The results indicated that these principles should be responsible for the bioactivity of corresponding partial fractions. The potential constituents could be further investigated to explore the new natural lead drugs.
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The authors wish to thank the Ministry of Science and Technology, Taiwan, China for the financial support. This study is supported in part by Taiwan Department of Health Clinical Trial and Research Center of Excellence.
Ping-Chung Kuo, Hsin-Yi Hung, Yu-Ren Liao, Yu-Yi Chan, Tian-Shung Wu . Chemical Constituents from Kalanchoe hybrida and their Cytotoxicity[J]. Chinese Herbal Medicines (CHM),2018,10(2):230-234
