Bioactive xanthones from whole plants of Gentianella acuta
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Abstract:
Objective To study the constituents from the whole plants of Gentianella acuta and their biological activity. Methods The compounds were isolated by multiple chromatographic methods and the structures of mentioned isolates were determined by routine NMR experiments and chemical methods. Results A phytochemical investigation to obtain intestine motility inhibitor resulted in the isolation of one new xanthone glycoside, gentixanthonoside A (1), along with nine tetrahydroxanthones, 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (3), amarellin E (4), amarellin F (5), swertiachoside B (6), amarellin D (7), amarellin C (8), amarellin A (9), and amarellin B (10) from the whole plants of G. acuta. Conclusion Compounds 2–10 showed significant reduce effects on contraction tension at 40 μM.
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National Natural Science Foundation of China (81673688).
