Peng Guo,Chong-ming Wu.[J].Chinese Herbal Medicines (CHM),2017,9(4):300-306
Gut Microbiota Brings a Novel Way to Illuminate Mechanisms of Natural Products in vivo
  
DOI:10.1016/S1674-6384(17)60109-6
中文关键词:  
英文关键词:bioavailability  herbal medicines  in situ/direct function  in vivo mechanism  microbiota  natural products  remote regulation
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Author NameAffiliation
Peng Guo Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 
Chong-ming Wu Pharmacology and Toxicology Research Center, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China 
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英文摘要:
      Poor bioavailability and undefined major/direct targets are two major obstacles for herbal medicines and natural products (NPs) to elucidate their precise mechanisms in vivo. Gut microbiota is an important bridge between eukayotic body and environment, which can interact with a majority of medicines with poor bioavailability and mediate their in vivo pharmacological activities. There are two main modes through which gut microbiota may mediate the pharmacological effects of NPs. First, gut microbiota catabolizes the NPs in herbal medicines into secondary metabolites with higher bioavialability and/or higher activity, facilitating the NPs enter circulation and exert beneficial impact at the pathological spot. Second, herbal medicines and NPs can favorably shift the compositional structure of gut microbiota, thereby performing remote functions to diseased organs/tissues via the systemic impaction of gut microbiota. In this review, the potential pathways were summarized through which gut microbes facilitate the pharmacological functions of herbal medicines and NPs and highlight the significance of gut microbiota in clarifying the in vivo mechanisms of herbal medicines and NPs.
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