Ying-yi Pan,Zhe-ping Song,Guo-fu Zhu,Yuan-zhang Zhu,Yi Lu,Wen-long Li,Jie Cao,Zhi-hong Cheng.Antipyretic Effects of Liposoluble Fractions of Viola yedoensis[J].Chinese Herbal Medicines (CHM),2015,7():
Antipyretic Effects of Liposoluble Fractions of Viola yedoensis
  
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中文关键词:  
英文关键词:anti-complement  antipyretic effect  heat-clearing  Viola yedoensis
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Author NameAffiliation
Ying-yi Pan 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Zhe-ping Song 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Guo-fu Zhu 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Yuan-zhang Zhu 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Yi Lu 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Wen-long Li 1. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Jie Cao 2.Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China 
Zhi-hong Cheng 2.Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China 
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中文摘要:
      
英文摘要:
      Objective To clarify the antipyretic effect of the Chinese materia medica, Violae Herba (Viola yedoensis), and its active fractions by examining the effects of V. yedoensis extracts with differing polarities on body temperature, total white blood cell (WBC) count, WBC differential count, and total serum complement of rabbits with lipopolysaccharide (LPS)-induced fever. Methods The rabbits were treated with water and ethanolic extracts of V. yedoensis, as well as petroleum ether, ethyl acetate, and n-butanol fractions of the ethanolic extract at low-, mid- and high- doses. The LPS was injected via the ear vein of rabbits in model and treatment groups 30 min post-gavage. Their body temperature was measured at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, and 6.0 h after the LPS challenge to calculate the temperature changes and thermal response index. After the last temperature measurement, blood samples were collected to determine the blood cell counts and total serum complement (CH50) level. Results Compared with the model group, body temperature was significantly lower in the low-dose ethanolic extract group, low- and mid-dose petroleum ether fraction groups, and all three ethyl acetate fraction groups. Serum CH50 levels were lower in all treatment groups, except the ethanolic extract groups, than that in the model group, with no significant difference. V. yedoensis had no significant effect on the blood cells of febrile rabbits challenged with LPS for 6 h. Conclusion The antipyretic effects of V. yedoensis are strong, and its active fractions are the petroleum ether and ethyl acetate fractions of ethanolic extract.
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