Yang Chen,Jun-hui Shen,Jian Ni,Meng-jie Xu,Hao-ran Dou,Jing Fu,Xiao-xu Dong.[J].Chinese Herbal Medicines (CHM),2015,7():
Concentration Prediction of Total Flavonoids in Aurantii Fructus Extraction Process: Locally Weighted Regression versus Kinetic Model Equation Based on Ficks Law
  
DOI:
中文关键词:  
英文关键词:Aurantii Fructus  kinetic model  locally weighted regression  total flavonoids prediction
基金项目:
Author NameAffiliation
Yang Chen 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
Jun-hui Shen 2. Information Centre, Beijing University of Chinese Medicine, Beijing 100029, China 
Jian Ni 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
Meng-jie Xu 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
Hao-ran Dou 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
Jing Fu 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
Xiao-xu Dong 1.???? School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China 
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中文摘要:
      
英文摘要:
      Objective To predict the total flavonoids concentration of Aurantii Fructus fried with bran in its extraction process. Methods Ultraviolet spectrophotometry was used to determine the concentration of total flavonoids in different extraction time (t ) and solvent load (M ). Then the predicted procedure was carried out using the following data: 1) based on Ficks second law, the parameters of the kinetic model could be deduced and the equation was established; 2) Locally weighted regression (LWR) code was developed in the WEKA software environment to predict the concentration. And then we used both methods to predict the concentration of total flavonoids in new experiments. Results After comparing the predicted results with the experimental data, the LWR model had better accuracy and performance in the prediction. Conclusion LWR is applied to analyze the extraction process of Chinese herb for the first time, and it is totally fit for the extraction. LWR-based system is a more simple and accurate way to predict than the established equation. It is a good choice especially for a process which exists no clearly rules, and can be used in the real-time control during the process.
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