Fei-fei Pu,Song Yin,Hong-ying Chen,Zhi Dai,Tian-xiu Qian,Cheng-cheng Wang,Hui Xu,Xiao-ying Wang.[J].Chinese Herbal Medicines (CHM),2015,7():
Oleuropein Improves Long Term Potentiation at Perforant Path-Dentate Gyrus Synapses in vivo
  
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中文关键词:  
英文关键词:Alzheimer’s disease  dentate gyrus  long term potentiation  oleuropein  population spike
基金项目:
Author NameAffiliation
Fei-fei Pu 1.?? Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
Song Yin 3.?? Department of Pharmacy, Maternal and Child Hospital of Xiangtan, Xiangtan 411104, China 
Hong-ying Chen 2.? China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, China 
Zhi Dai 2.? China Resources Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518110, China 
Tian-xiu Qian 1.?? Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
Cheng-cheng Wang 1.?? Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
Hui Xu 1.?? Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
Xiao-ying Wang 1.?? Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 
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中文摘要:
      
英文摘要:
      Objective To investigate the effect of oleuropein (OE) on long term potentiation (LTP) at hippocampal perforant path-dentate gyrus synapses in vivo. Methods An outer guide cannula, a monopolar recording electrode, and a bipolar stimulating electrode were implanted in the skull and extracellular recording technique was used to record the population spike in the dentate gyrus of anesthetized rats. Results Oleuropein significantly increased the basal synaptic transmission and the amplitude of population spike was increased from (117.6 ± 2.3)% to (134.9 ± 3.7)% after administration with OE. OE also accelerated LTP induction and maintenance, the population spike amplitude after high frequency stimulation was increased from (167.2 ± 12.8)% to (225.5 ± 15.5)% and the maintenance phase of LTP was from (182.1 ± 15.1)% to (210.5 ± 9.0)% respectively after administration with OE. Conclusion The present study showed that OE significantly improved different stages of LTP, which could be the molecular mechanism of its efficacy on attenuating AD-like pathology and delaying cognitive decline. OE can be a promising drug for AD and dementia.
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